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Gene Dmel\CG1109

General Information
Symbol	Dmel\CG1109	Species	D. melanogaster
Name		Annotation symbol	CG1109
Feature type	protein_coding_gene	FlyBase ID	FBgn0046222
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83B8-83B8	Sequence location	3R:1,486,359..1,491,168 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG1109 (FBgn0046222). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: G-protein beta WD-40 repeat; WD40 repeat; WD40 repeat 2; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623656_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG1109. Gene sequence location is 3R:1486359..1491168.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA12162 BKN20307
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B8-83B8   Limits computationally determined from genome sequence between P{lacW}Atus1938 and P{lacW}casj1C2
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG1109 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG1109-RA FBtr0078713  NM_169091   3073   807 CG1109-RB FBtr0078714  NM_169092   3060   807
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG1109-PA   FBpp0078362   90.5   807   9.08     NP_730982   AAF51974 CG1109-PB   FBpp0078363   90.5   807   9.08     NP_730983   AAN13257
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392592   AA438519   AA438523   AA441337   AA539133   AA696396   AA697056   AA735590   AA820413   AA941977   AA942281   AE014297 AAF51974   AE014297 AAN13257   AI455415   AI944636   AY051695 AAK93119   BF497483   BF497564   BF502652   BF503486   BF505720   BG634690   BI162158   BI228649   BI235681   BI236452   BI239407   BI243217   BI243968   BI354708   BI376067   BI639728   CO185790   CO292071   CO322442   CO330509   CO335775   CZ478159   EC090322   EC194634   EC201084   EC223501   EC250889   EC265010   EV576086   EV576868   EV590129   GH941856   GH942018   GH942890   GH943828   GH943904   GH944687   GH945453   GH945502   GH945682   GH946202   GH946223   GH947140   GH947538   GH947699   GH947822   GH951499   GH951536   GH951987   GH952003   GH952125   GH953130   GH954229   GH955484   GH960318   GH960924   GH963820   GH964302   GH966267   GH966777   GH968496   GH968760   GH970415   GH970770   GH974448   GH975405   GH975595   GH978211   GH978889   GH978947   GH980389   GH980768   GH980963   GH981155   GH983386   GH983613   GH983808   GH983994
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VNG2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0046222    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0046222 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0046222 expression level Developmental Stage   Expression Level embryo 00-02hr    4936 embryo 02-04hr    4163 embryo 04-06hr    4229 embryo 06-08hr    3861 embryo 08-10hr    2649 embryo 10-12hr    2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9    1406 white prepupae new    1451 white prepupae 12hr    1719 white prepupae 24hr    2045 pupae 2d postWPP    1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day    1766 adult female 05day    2547 adult female 30day    2838 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4936) embryo 02-04hr  (4163) embryo 04-06hr  (4229) embryo 06-08hr  (3861) embryo 08-10hr  (2649) embryo 10-12hr  (2147) embryo 12-14hr  (1332) embryo 14-16hr  (1357) embryo 16-18hr  (916) embryo 18-20hr  (902) embryo 20-22hr  (910) embryo 22-24hr  (809) larva L1  (1209) larva L2  (884) larva L3 12hr old  (856) larva L3 puffstage 1-2  (833) larva L3 puffstage 3-6  (1232) larva L3 puffstage 7-9  (1406) white prepupae new  (1451) white prepupae 12hr  (1719) white prepupae 24hr  (2045) pupae 2d postWPP  (1454) pupae 3d postWPP  (1000) pupae 4d postWPP  (850) adult male 01day  (1064) adult male 05day  (1254) adult male 30day  (1316) adult female 01day  (1766) adult female 05day  (2547) adult female 30day  (2838) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4936) embryo 02-04hr  (4163) embryo 04-06hr  (4229) embryo 06-08hr  (3861) embryo 08-10hr  (2649) embryo 10-12hr  (2147) embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9  1406 white prepupae new  1451 white prepupae 12hr  (1719) white prepupae 24hr  (2045) pupae 2d postWPP  1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day  (1766) adult female 05day  (2547) adult female 30day  (2838) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4936 embryo 02-04hr    4163 embryo 04-06hr    4229 embryo 06-08hr    3861 embryo 08-10hr    2649 embryo 10-12hr    2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9    1406 white prepupae new    1451 white prepupae 12hr    1719 white prepupae 24hr    2045 pupae 2d postWPP    1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day    1766 adult female 05day    2547 adult female 30day    2838 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4936 embryo 02-04hr    4163 embryo 04-06hr    4229 embryo 06-08hr    3861 embryo 08-10hr    2649 embryo 10-12hr    2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9    1406 white prepupae new    1451 white prepupae 12hr    1719 white prepupae 24hr    2045 pupae 2d postWPP    1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day    1766 adult female 05day    2547 adult female 30day    2838 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0046222 expression level Developmental Stage   Expression Level embryo 00-02hr    4936 embryo 02-04hr    4163 embryo 04-06hr    4229 embryo 06-08hr    3861 embryo 08-10hr    2649 embryo 10-12hr    2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9    1406 white prepupae new    1451 white prepupae 12hr    1719 white prepupae 24hr    2045 pupae 2d postWPP    1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day    1766 adult female 05day    2547 adult female 30day    2838 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4936) embryo 02-04hr  (4163) embryo 04-06hr  (4229) embryo 06-08hr  (3861) embryo 08-10hr  (2649) embryo 10-12hr  (2147) embryo 12-14hr  (1332) embryo 14-16hr  (1357) embryo 16-18hr  (916) embryo 18-20hr  (902) embryo 20-22hr  (910) embryo 22-24hr  (809) larva L1  (1209) larva L2  (884) larva L3 12hr old  (856) larva L3 puffstage 1-2  (833) larva L3 puffstage 3-6  (1232) larva L3 puffstage 7-9  (1406) white prepupae new  (1451) white prepupae 12hr  (1719) white prepupae 24hr  (2045) pupae 2d postWPP  (1454) pupae 3d postWPP  (1000) pupae 4d postWPP  (850) adult male 01day  (1064) adult male 05day  (1254) adult male 30day  (1316) adult female 01day  (1766) adult female 05day  (2547) adult female 30day  (2838) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4936) embryo 02-04hr  (4163) embryo 04-06hr  (4229) embryo 06-08hr  (3861) embryo 08-10hr  (2649) embryo 10-12hr  2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9  1406 white prepupae new  1451 white prepupae 12hr  1719 white prepupae 24hr  2045 pupae 2d postWPP  1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day  1766 adult female 05day  (2547) adult female 30day  (2838) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4936 embryo 02-04hr    4163 embryo 04-06hr    4229 embryo 06-08hr    3861 embryo 08-10hr    2649 embryo 10-12hr    2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9    1406 white prepupae new    1451 white prepupae 12hr    1719 white prepupae 24hr    2045 pupae 2d postWPP    1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day    1766 adult female 05day    2547 adult female 30day    2838 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4936 embryo 02-04hr    4163 embryo 04-06hr    4229 embryo 06-08hr    3861 embryo 08-10hr    2649 embryo 10-12hr    2147 embryo 12-14hr    1332 embryo 14-16hr    1357 embryo 16-18hr    916 embryo 18-20hr    902 embryo 20-22hr    910 embryo 22-24hr    809 larva L1    1209 larva L2    884 larva L3 12hr old    856 larva L3 puffstage 1-2    833 larva L3 puffstage 3-6    1232 larva L3 puffstage 7-9    1406 white prepupae new    1451 white prepupae 12hr    1719 white prepupae 24hr    2045 pupae 2d postWPP    1454 pupae 3d postWPP    1000 pupae 4d postWPP    850 adult male 01day    1064 adult male 05day    1254 adult male 30day    1316 adult female 01day    1766 adult female 05day    2547 adult female 30day    2838 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0046222    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0046222 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0046222 expression level Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0046222 expression level Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    61 Larval Hindgut    72.1 Larval Malpighian Tubules    78.2 Larval Fat Body    68 Larval Salivary Gland    94.1 Larval Trachea    50.45 Larval Carcass    72.175 Adult Head    36.3 Adult Eye    41.35 Adult Brain    57.3 Adult Thoracic-Abdominal Ganglion    55 Adult Crop    62.6 Adult Midgut    37.6 Adult Hindgut    48.1 Adult Malpighian Tubules    51.9 Adult Fat Body    81 Adult Salivary Gland    65.4 Adult Heart    49.075 Adult VirginFemale Spermatheca    83.8 Adult InseminatedFemale Spermatheca    85.1 Adult Ovary    105 Adult Testis    42.6 Adult Male Accessory Gland    99.4 Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    36.3   NA  Eye    41.35   NA  Brain    57.3   158.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55   NA  Crop    62.6   61  Midgut    37.6   72.1  Hindgut    48.1   78.2  Malpighian Tubules    51.9   68  Fat Body    81   94.1  Salivary Gland    65.4   NA  Heart    49.075   50.45  Trachea    NA   NA  VirginFemale Spermatheca    83.8   NA  InseminatedFemale Spermatheca    85.1   NA  Ovary    105   NA  Testis    42.6   NA  Male Accessory Gland    99.4   72.175  Carcass    39.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046222 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1109-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG1109 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pharate adult stage P15(ii), with Scer\GAL4pnr-MD237 CG1109GD7195 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG1109GD7195 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG1109 Class Mutagen Stocks Known lesion CG1109DG23504 P-element activity 1 -- CG1109e00264 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG1109 Class Mutagen Stocks Known lesion CG1109GD7195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1109KK100211 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7283 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7195} NA P{KK100211} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}CG1109DG23504 NA PBac{RB}CG1109e00264 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG1109 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0046222 DroID - A comprehensive database of gene and protein interactions. • FBgn0046222 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40698
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16340 Dere\GG12984 Dgri\GH19503 Dmoj\GI23774 Dper\GL24512 Dpse\GA10752 Dsec\GM10830 Dsim\GD19809 Dvir\GJ23956 Dwil\GK13364 Dyak\GE10153
Curated drosophilid orthologs	Dpse\GA10752
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009887-PA Aedes aegypti (mosquito) AGAP001362-PA Anopheles gambiae (mosquito) XP_397060.2 Apis mellifera (honey bee) XP_001952829.1 Acyrthosiphon pisum (pea aphid) XP_001898532.1 Brugia malayi (roundworm nematode) BGIBMGA008884-PA Bombyx mori (silk worm) ENSBTAP00000007859 Bos taurus (bovine) CN16423 Caenorhabditis brenneri (small nematode) CN20764 Caenorhabditis brenneri (small nematode) CBP30846 Caenorhabditis briggsae (nematode) CE21113 Caenorhabditis elegans (worm) ENSCAFP00000006428 Canis familiaris (dog) ENSCINP00000013797 Ciona intestinalis (sea squirt) JA15707 Caenorhabditis japonica (nematode) CMO072C Cyanidioschyzon merolae (red alga) cn03591 Cryptococcus neoformans (yeast-like fungus) CPIJ007510 Culex pipens (mosquito) ENSCPOP00000012418 Cavia porcellus (guinea pig) 167492 Chlamidomonas reinhardtii (green alga) RP29092 Caenorhabditis remanei (nematode) ENSCSAVP00000004966 Ciona savignyi (sedentary tunicate) 149680 Capitella spl (polychaete worm) 195849 Daphnia pulex (daphnia) ENSDARP00000093789 Danio rerio (zebra fish) ENSECAP00000001312 Equus caballus (horse) ENSGACP00000002060 Gymnopilus aculeatus (mushroom) ENSGALP00000003172 Gallus gallus (chicken) GL50803_16900 Giardia lamblia (flagellated protozoan) ENSP00000325377 Homo sapiens (human) 125354 Lottia gigantea (owl limpet) ENSMODP00000023263 Monodelphis domestica (gray opossum) ENSMMUP00000025334 Macaca mulatta (rhesus monkey) ENSMUSP00000025264 Mus musculus (house mouse) ENSOANP00000019955 Ornithorynchus anatinus (platypus) ENSORLP00000008960 Oryzias latipes (japanese killifish) PHUM004548-PA Pediculus humanus (human body louse) ENSPPYP00000014237 Pongo pygmaeus (orangutan) 131550 Phytophthora sojae (root rot pathogen) ENSPTRP00000021298 Pan troglodytes (chimpanzee) ENSRNOP00000017075 Rattus norvegicus (norway rat) 5062382 Sorghum bicolor (sorghum) Smp_049510 Schistosoma mansoni (trematode parasite) XP_969187.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007575 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024684 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12345 NV50281 NV18881 NV18514 LH16860 ISCW005214 FBgn0228033 FBgn0215373 FBgn0211043 FBgn0191298 FBgn0165776 JGI_V11_195849 FBgn0070808 FBgn0162101 FBgn0146499 FBgn0126968 FBgn0105257 FBgn0093361 CPIJ007510 BGIBMGA008884 ACYPI003722 GB15134 AGAP001362 AAEL009887 PHUM247160 GLEAN_13939
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	20470 y1 w67c23; P{wHy}CG1109DG23504/TM3, Sb1 Ser1
Harvard	- PBac{RB}CG1109e00264
VDRC	v16186 w1118 P{GD7195}v16186
Genomic Clones ( 1 )
	BACR03P13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 90 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24014
Other clones	DPiM_LD24014
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08006 AT11660 AT11760 AT18447 AT19480 AT30988 GM07605 GM09018 GM27983 LD12315 LD12320 LD12852 LD16233 LD17221 LD21583 LD26389 LD27350 RE26258 RE31588 RE32510 RE35885 RE40784 RE41792 RE63992 SD22388
Other clones	62325 71187 192289 194082 542718 bs02h09 CK01.10A.E6 Dmel_dig_004981_0690_2242 Dmel_dig_008521_0684_0668 Dmel_neb_010624_0427_2498 EK012151 EK188138 EK199122 EK295436 EN11157 RE01551 RP004096329 RP004118010 RP004134332 RP004149310 RP004150218 RP004150643 RP004157495 RP004165045 RP004203166 RP004204688 RP004205625 RP004206967 RP004208940 RP004209111 RP004211010 RP004212793 RP004221690 RP004224767 RP004227564 RP004230198 RP004230311 RP004235356 RP004235941 RP004237775 RP004238924 RP004241520 RP004245621 RP004247045 RP004253934 RP004255451 RP004255463 RP004260168 RP004261730 RP004262806 RP004339182 RP004343278 RP004362717 RP004422258 RP004428243 RP004450487 RP004454092 RP004475029 RP004481553 RP004505332 RP004511148 RP004540330 RP004546474
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0046222 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40698
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BcDNA:LD24014 CG1109 (FlyBase, 1996-)
Additional comments	Source for merge of BcDNA:LD24014 CG1109 was a shared cDNA (LD24014) (date:020402). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169091 NM_169092 RefSeq (Proteins) • NP_730982 NP_730983 DDBJ / EMBL / GenBank • AA820413 AAF51974 AAK93119 AAN13257 AI455415 AI944636 AY051695 CZ478159 Entrez Gene - A searchable database of RefSeq genes. • 40698 UniProtKB/TrEMBL • Q9VNG2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0046222 DroID - A comprehensive database of gene and protein interactions. • FBgn0046222 DRSC - Results from RNAi screens. • FBgn0046222 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046222 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1109-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0046222 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40698 InParanoid A subset of ortholog calls from InParanoid. • AAEL009887-PA Aedes aegypti (mosquito) AGAP001362-PA Anopheles gambiae (mosquito) XP_397060.2 Apis mellifera (honey bee) XP_001952829.1 Acyrthosiphon pisum (pea aphid) XP_001898532.1 Brugia malayi (roundworm nematode) BGIBMGA008884-PA Bombyx mori (silk worm) ENSBTAP00000007859 Bos taurus (bovine) CN16423 Caenorhabditis brenneri (small nematode) CN20764 Caenorhabditis brenneri (small nematode) CBP30846 Caenorhabditis briggsae (nematode) CE21113 Caenorhabditis elegans (worm) ENSCAFP00000006428 Canis familiaris (dog) ENSCINP00000013797 Ciona intestinalis (sea squirt) JA15707 Caenorhabditis japonica (nematode) CMO072C Cyanidioschyzon merolae (red alga) cn03591 Cryptococcus neoformans (yeast-like fungus) CPIJ007510 Culex pipens (mosquito) ENSCPOP00000012418 Cavia porcellus (guinea pig) 167492 Chlamidomonas reinhardtii (green alga) RP29092 Caenorhabditis remanei (nematode) ENSCSAVP00000004966 Ciona savignyi (sedentary tunicate) 149680 Capitella spl (polychaete worm) 195849 Daphnia pulex (daphnia) ENSDARP00000093789 Danio rerio (zebra fish) ENSECAP00000001312 Equus caballus (horse) ENSGACP00000002060 Gymnopilus aculeatus (mushroom) ENSGALP00000003172 Gallus gallus (chicken) GL50803_16900 Giardia lamblia (flagellated protozoan) ENSP00000325377 Homo sapiens (human) 125354 Lottia gigantea (owl limpet) ENSMODP00000023263 Monodelphis domestica (gray opossum) ENSMMUP00000025334 Macaca mulatta (rhesus monkey) ENSMUSP00000025264 Mus musculus (house mouse) ENSOANP00000019955 Ornithorynchus anatinus (platypus) ENSORLP00000008960 Oryzias latipes (japanese killifish) PHUM004548-PA Pediculus humanus (human body louse) ENSPPYP00000014237 Pongo pygmaeus (orangutan) 131550 Phytophthora sojae (root rot pathogen) ENSPTRP00000021298 Pan troglodytes (chimpanzee) ENSRNOP00000017075 Rattus norvegicus (norway rat) 5062382 Sorghum bicolor (sorghum) Smp_049510 Schistosoma mansoni (trematode parasite) XP_969187.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007575 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024684 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40698 modMine - Data generated by the modENCODE project. • FBgn0046222 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12345 NV50281 NV18881 NV18514 LH16860 ISCW005214 FBgn0228033 FBgn0215373 FBgn0211043 FBgn0191298 FBgn0165776 JGI_V11_195849 FBgn0070808 FBgn0162101 FBgn0146499 FBgn0126968 FBgn0105257 FBgn0093361 CPIJ007510 BGIBMGA008884 ACYPI003722 GB15134 AGAP001362 AAEL009887 PHUM247160 GLEAN_13939
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:LD24014   CG1109 (Keleman et al., 2009.8.5, Doumanis et al., 2009)
Name Synonym
Secondary FlyBase IDs
	FBgn0037361
References ( 17 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Doumanis et al., 2009, PLoS ONE 4(9): e7275 RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. [FBrf0209128]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Gelbart, 2008.3.31, DG.xml DG.xml [FBrf0204101] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Myrick et al., 2005.5.16, Deletion Generator Project genomic insertion collection. Deletion Generator Project genomic insertion collection. [FBrf0188490] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Zheng, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126702]