FlyBase Gene Report: Dmel\Wsck

General Information

Symbol

Dmel\Wsck

Species

D. melanogaster

Name

Wsck

Annotation Symbol

CG31127

Feature Type

protein_coding_gene

FlyBase ID

FBgn0046685

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Probably lacks tyrosine-protein kinase activity. (UniProt, P83097)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

96A13-96A13

Sequence location

3R:24,627,066..24,630,075 [-]

Recombination map

3-85

RefSeq locus

NT_033777 REGION:24627066..24630075

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables signaling receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

NOT enables protein kinase activity

inferred from key residues

(Anamika et al., 2009)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in innate immune response

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in transmembrane receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extrinsic component of cytoplasmic side of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PUTATIVE PSEUDOKINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. (P83097)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PUTATIVE PSEUDOKINASES -: Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).

Protein Function (UniProtKB)

Probably lacks tyrosine-protein kinase activity.

(UniProt, P83097)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Wsck for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P83097)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Wsck-RA

FBtr0084669

NM_170155

2895

791

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Wsck-PA

FBpp0084049

88.5

791

6.44

NP_733018

AAN14006

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The protein kinase domain is predicted to be catalytically inactive.

(UniProt, P83097)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P83097

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wsck using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Wsck_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Wsck in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Wsck

View exonic expression by tissue for Dmel\Wsck

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318600/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046685

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046685

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046685

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31127

Flygut - An atlas of the Drosophila adult midgut

FBgn0046685

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Wsck

Transgenic constructs containing regulatory region of Wsck

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel7357

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Wsck^GD243

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Wsck^GD243

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

Wsck^GD243

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (29)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\STYK1

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (29)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Styk1

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (26)

Rnor\Styk1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (25)

Xtro\styk1

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\pdgfrl

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (37)

Drer\si:ch73-206d17.1

2 of 15

Yes

Drer\styk1a

2 of 15

Yes

Drer\styk1b

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\pdgfra

1 of 15

Drer\pdgfrb

1 of 15

Drer\pdgfrl

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch1073-391i24.1

1 of 15

Drer\tek

1 of 15

Drer\tie1

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (34)

Cele\R151.1

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\F55H12.2

1 of 15

Yes

Cele\F55H12.5

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\Y50D4B.6

1 of 15

Cele\Y71G12B.31

1 of 15

Cele\zig-13

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (21)

Gene Symbol

Score

Source

Alignment

Abl

1 of 10

Ack

1 of 10

Ack-like

1 of 10

Btk29A

1 of 10

btl

1 of 10

Cad96Ca

1 of 10

CG3277

1 of 10

Csk

1 of 10

drpr

1 of 10

FER

1 of 10

htl

1 of 10

Lar

1 of 10

Ptp36E

1 of 10

Ptp69D

1 of 10

Pvr

1 of 10

Ret

1 of 10

Shark

1 of 10

Src42A

1 of 10

Src64B

1 of 10

Tie

1 of 10

tor

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046685

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-85

Cytogenetic map

96A13-96A13

Sequence location

3R:24,627,066..24,630,075 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96A13-96A13

Limits computationally determined from genome sequence between P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² and P{EP}CycB3^EP3127

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-85

(FlyBase, 2016)

3-84.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

35247

y¹ sc^* v¹ sev²¹; P{TRiP.GL00134}attP2

42628

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02463}attP40

VDRC

v330605

P{VSH330605}attP40

v341349

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00404}attP40/CyO-GFP

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0046685

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0046685

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

318600

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG31127 BcDNA:SD05152

(FlyBase, 1996-)

Source for merge of: Wsck CG31127

(FlyBase, 1996-)

Source for merge of: CG31127 BcDNA:LD25626

(FlyBase, 1996-)

Additional comments

Source for merge of CG31127 BcDNA:SD05152 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of Wsck CG31127 was sequence comparison ( date:050106 ).

(FlyBase, 1996-)

Source for merge of CG31127 BcDNA:LD25626 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Other Comments

New annotation (CG31127) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

318600

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P83097

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P83097

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P83097

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0046685

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318600/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046685

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Wsck_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046685

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046685

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31127

Flygut - An atlas of the Drosophila adult midgut

FBgn0046685

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

318600

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014160

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG31127

MARRVEL_MODEL - MARRVEL (model organism gene)

318600

modMine - A data warehouse for the modENCODE project

FBgn0046685

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046685

DRSC - Results frm RNAi screens

FBgn0046685

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0046685

FlyMine - An integrated database for Drosophila genomics

FBgn0046685

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

BcDNA:LD25626

BcDNA:SD05152

CG31127

(Meadows, 2018.10.31, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Lee et al., 2009, Lee et al., 2008, FlyBase, 1996-)

WSCK

(Manning et al., 2002, Manning, 2001.10.15)

Wsck

(Sopko et al., 2014, Ozkan et al., 2013, Yin et al., 2013)

Name Synonyms

Wsck

Secondary FlyBase IDs

FBgn0046778
FBgn0051127
FBgn0064782

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (32)

The following external sites may use different assemblies or annotations than FlyBase.

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