FB2022_03, released June 9, 2022

Gene: Dmel\Tre1

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General Information
Symbol
Dmel\Tre1
Species
D. melanogaster
Name
Trapped in endoderm 1
Annotation Symbol
CG3171
Feature Type
protein_coding_gene
FlyBase ID
FBgn0046687
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Trapped in endoderm 1 (Tre1) encodes a G protein-coupled receptor of the rhodopsin class. Its functions include primordial germ cell/pole cell migration and programmed cell death, central nervous system stem cell division orientation, and mating/courtship behavior. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)
All Summaries
Also Known As

sctt, Tre-1

Key Links
Genomic Location
Cytogenetic map
5A11-5A12
Sequence location
Recombination map
1-12
RefSeq locus
NC_004354 REGION:5673830..5679977
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables G protein-coupled receptor activity
inferred from electronic annotation with InterPro:IPR000276
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in germ cell development
inferred from mutant phenotype
(Coffman et al., 2002)
involved_in germ cell migration
inferred from mutant phenotype
(Kamps et al., 2010, Kunwar et al., 2003, Coffman et al., 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in ectopic germ cell programmed cell death
traceable author statement
(Coffman, 2003)
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN001200905
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in germ cell migration
traceable author statement
(Coffman, 2003)
involved_in pole cell migration
traceable author statement
(Raz, 2004)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Yoshiura et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (Q9NDM2)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Trapped in endoderm 1 (Tre1) encodes a G protein-coupled receptor of the rhodopsin class. Its functions include primordial germ cell/pole cell migration and programmed cell death, central nervous system stem cell division orientation, and mating/courtship behavior. [Date last reviewed: 2018-11-08]
Gene Group (FlyBase)
CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -
The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
Protein Function (UniProtKB)
Essential for the first active step of germ cell migration: transepithelial migration of germ cells through the posterior midgut (PMG) epithelium.
(UniProt, Q9NDM2)
Summary (Interactive Fly)

G-protein coupled receptor - links cell polarity, modulation of cell adhesion, and invasion during germ cell migration

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Tre1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9NDM2)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tre1-RA
FBtr0070848
NM_080053
1634
392
Tre1-RB
FBtr0308339
NM_001258605
1499
392
Tre1-RC
FBtr0340222
NM_001297972
1655
399
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tre1-PA
FBpp0070813
43.8
392
9.06
Q9NDM2
NP_524792
AAF46059
Tre1-PB
FBpp0300658
43.8
392
9.06
Q9NDM2
NP_001245534
AFH07248
Tre1-PC
FBpp0309197
44.7
399
8.93
X2JIG6
NP_001284901
AHN59372
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

392 aa isoforms: Tre1-PA, Tre1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tre1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
pole plasm

Comment: maternally deposited

(Fisher et al., 2012)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 3
pole plasm | posterior

Comment: maternally deposited

(Kunwar et al., 2003)
organism | posterior

Comment: maternally deposited

(Kunwar et al., 2003)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 6 -- 9
primordial germ cell
(Kunwar et al., 2003)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9
somatic mesoderm
(Kunwar et al., 2003)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
cardiogenic mesoderm
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)
embryonic glioblast of ventral nerve cord primordium

Comment: reported as glioblasts of ventral nervous system

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
lymph gland primordium

Comment: reported as lymph gland specific anlage

(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
pericardial cell primordium

Comment: reported as pericardial cell specific anlage

(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
salivary gland body primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13
midline glial cell
(Kunwar et al., 2003)
amnioserosa
(Kunwar et al., 2003)
presumptive embryonic/larval central nervous system
(Kunwar et al., 2003)
cardiogenic mesoderm
(Kunwar et al., 2003)
embryonic/larval copper cell
(Kunwar et al., 2003)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic midgut chamber
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic/larval circulatory system
(Fisher et al., 2012)
embryonic/larval dorsal vessel
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
embryonic/larval pericardial cell
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
midline glial cell
(Kearney et al., 2004)
Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

Tre1 transcript is maternally deposited; at early embryonic stages Tre1 transcript is localized to the posterior pole of the embryo. By embryonic stage 6, expression is restricted to pole cells, and has degraded elsewhere in the embryo. At embryonic stage 9, Tre1 transcript is expressed in pole cells, and also widely distributed in somatic tissues. At stage 13, Tre1 transcript is expressed in a variety of tissues, including the amnioserosa, the developing central nervous system, midline glial cells, cardiac mesoderm primordium, and in cuprophilic cells.

(Kunwar et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Yoshiura et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tre1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tre1
Transgenic constructs containing regulatory region of Tre1
Aberrations (Deficiencies and Duplications) ( 3 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL429BD
lethal, with Scer\GAL4c355
lethal, with Scer\GAL4nub.PU
partially lethal - majority die, with Scer\GAL4hs.2sev
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | recessive | rescuable maternal effect
fertile
male sterile | maternal effect | recessive
Other Phenotypes
Allele
abnormal chemosensitive behavior
abnormal heat stress response | female
abnormal neuroanatomy | embryonic stage
abnormal starvation stress response | female
abnormal starvation stress response | male
decreased fecundity | female | recessive
short lived | male
visible, with Scer\GAL4c355
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4hs.2sev
wild-type
wild-type, with Scer\GAL4dpp.blk1
Phenotype manifest in
Allele
embryonic neuroblast
eye, with Scer\GAL4hs.2sev
germline cell | ectopic | embryonic stage | maternal effect
germline cell | non-rescuable maternal effect
germline cell | rescuable maternal effect
gonad
macrochaeta, with Scer\GAL4c355
presumptive embryonic/larval central nervous system
primordial germ cell | embryonic stage, with Scer\GAL4VP16.nos.UTR
primordial germ cell | embryonic stage (with Tre1KO)
primordial germ cell | embryonic stage (with Tre1sctt)
primordial germ cell | embryonic stage (with Tre1ΔEP5)
primordial germ cell | embryonic stage (with Tre1ΔEP19)
primordial germ cell | embryonic stage | maternal effect
wing, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GPR84
7 of 15
Yes
Yes
1  
Hsap\MTNR1A
6 of 15
No
Yes
Hsap\MTNR1B
5 of 15
No
Yes
Hsap\GPR50
4 of 15
No
Yes
Hsap\AGTR1
1 of 15
No
Yes
Hsap\AGTR2
1 of 15
No
Yes
Hsap\APLNR
1 of 15
No
Yes
Hsap\BDKRB1
1 of 15
No
Yes
Hsap\BDKRB2
1 of 15
No
Yes
Hsap\GPR15
1 of 15
No
Yes
Hsap\GPR25
1 of 15
No
Yes
Hsap\GPR75
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gpr50
5 of 15
Yes
Yes
Mmus\Gpr84
5 of 15
Yes
No
Mmus\Mtnr1a
5 of 15
Yes
Yes
Mmus\Mtnr1b
5 of 15
Yes
Yes
Mmus\Agtr1a
1 of 15
No
Yes
Mmus\Agtr1b
1 of 15
No
Yes
Mmus\Agtr2
1 of 15
No
Yes
Mmus\Aplnr
1 of 15
No
Yes
Mmus\Bdkrb1
1 of 15
No
Yes
Mmus\Bdkrb2
1 of 15
No
Yes
Mmus\Gpr15
1 of 15
No
Yes
Mmus\Gpr25
1 of 15
No
Yes
Mmus\Gpr75
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (13)
Rnor\Gpr84
6 of 13
Yes
Yes
Rnor\Mtnr1a
4 of 13
No
Yes
Rnor\Gpr50
3 of 13
No
Yes
Rnor\Mtnr1b
3 of 13
No
Yes
Rnor\Agtr1a
1 of 13
No
Yes
Rnor\Agtr1b
1 of 13
No
Yes
Rnor\Agtr2
1 of 13
No
Yes
Rnor\Aplnr
1 of 13
No
Yes
Rnor\Bdkrb1
1 of 13
No
Yes
Rnor\Bdkrb2
1 of 13
No
Yes
Rnor\Gpr15
1 of 13
No
Yes
Rnor\Gpr25
1 of 13
No
Yes
Rnor\Gpr75
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\gpr84
4 of 12
Yes
Yes
Xtro\LOC100486065
4 of 12
Yes
Yes
Xtro\mtnr1c
4 of 12
Yes
Yes
Xtro\mtnr1a
2 of 12
No
Yes
Xtro\mtnr1b
2 of 12
No
Yes
Xtro\LOC100490436
1 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\mtnr1bb
7 of 15
Yes
Yes
Drer\gpr84
5 of 15
No
No
Drer\mtnr1aa
5 of 15
No
Yes
Drer\mtnr1ab
5 of 15
No
Yes
Drer\mtnr1ba
5 of 15
No
Yes
Drer\mtnr1c
5 of 15
No
Yes
Drer\mtnr1al
4 of 15
No
Yes
Drer\agtr1a
1 of 15
No
Yes
Drer\agtr1b
1 of 15
No
Yes
Drer\agtr2
1 of 15
No
Yes
Drer\aplnr2
1 of 15
No
Yes
Drer\aplnra
1 of 15
No
Yes
Drer\aplnrb
1 of 15
No
Yes
Drer\bdkrb1
1 of 15
No
Yes
Drer\bdkrb2
1 of 15
No
Yes
Drer\ccr2
1 of 15
No
Yes
Drer\gpr25
1 of 15
No
Yes
Drer\gpr75
1 of 15
No
Yes
Drer\si:cabz01093077.1
1 of 15
No
Yes
Drer\si:ch211-207g17.3
1 of 15
No
Yes
Drer\si:dkey-63b1.1
1 of 15
No
Yes
Drer\taar10c
1 of 15
No
Yes
Drer\taar10d
1 of 15
No
Yes
Drer\tmtops2a
1 of 15
No
No
Drer\tmtops2b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\npr-25
1 of 15
Yes
Yes
Cele\npr-29
1 of 15
Yes
Yes
Cele\npr-30
1 of 15
Yes
Yes
Cele\npr-31
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
moody
5 of 10
CG4313
3 of 10
Lkr
1 of 10
sNPF-R
1 of 10
TkR86C
1 of 10
TkR99D
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    MTNR1B; melatonin receptor 1B
    model of  type 2 diabetes mellitus
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GPR84; G protein-coupled receptor 84
    7 of 15
    606383
         
        MTNR1A; melatonin receptor 1A
        6 of 15
        600665
            MTNR1B; melatonin receptor 1B
            5 of 15
            600804
            GPR50; G protein-coupled receptor 50
            4 of 15
            300207
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Tre1 - Gαo
                anti tag coimmunoprecipitation, western blot
                (Yoshiura et al., 2012)
                Tre1 - PIP5K59B
                anti tag coimmunoprecipitation, anti tag western blot
                (Kim et al., 2021)
                Tre1 - lin-28
                experimental knowledge based
                (Guruharsha et al., 2011)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                repo
                enhanceable
                Tre1
                (Yoshiura et al., 2012)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                X
                Recombination map
                1-12
                Cytogenetic map
                5A11-5A12
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                5A11-5A12
                Limits computationally determined from genome sequence between P{EP}CG3249EP1400 and P{EP}Tre1EP496
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                5A10-5B1
                (Isono, 2000.5.12)
                Experimentally Determined Recombination Data
                Location

                1-12

                (FlyBase, 2016)

                1-14.4

                (Comeron et al., 2012)

                1-

                (Coffman et al., 2002)
                Left of (cM)
                (Kamps et al., 2010)
                Right of (cM)
                Notes

                Tre1 maps within 1 map unit of cv.

                (Coffman et al., 2002)
                Stocks and Reagents
                Stocks (9)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (103)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of

                Source for merge of: CG3171 BEST:LD12308

                (Bayraktaroglu, 2000.11.2)

                Source for merge of: Tre1 sctt

                (Andersen and Coffman, 2005)

                Source for merge of: Tre1 anon-WO0170980.16 anon-WO0170980.17 anon-WO0170981.1

                (FlyBase, 1996-)
                Additional comments

                Although FBrf0128502 reported that Tre1, which maps extremely close to Gr5a, mediates the trehalose response, the balance of evidence suggests that Gr5a, rather than Tre1, encodes a trehalose receptor.

                (Dahanukar et al., 2001)

                The "CG15779"/"Gr5a" gene corresponds to the "Trehalose-sensitivity" complementation group as opposed to the "CG3171" gene, as was reported in FBrf0128502.

                (Isono, 2001.9.22)

                Expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data suggest that the "Gr5a" and not "CG3171" corresponds to the "Tre" (Trehalose-sensitivity) locus.

                (Ueno et al., 2001)

                Source for merge of Tre1 anon-WO0170980.16 anon-WO0170980.17 anon-WO0170981.1 was sequence comparison ( date:051113 ).

                (FlyBase, 1996-)

                Evidence from FBrf0138267 (expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data) suggests that the CG15779 gene prediction (Gr5a) corresponds to the "Trehalose-sensitivity" locus, mutation of which results in low sensitivity to trehalose. The "Trehalose-sensitivity" locus does not correspond to "Tre1" from FBrf0128502 which corresponds to the CG3171 gene prediction (which is adjacent to and divergently transcribed from CG15779). Mutation of Tre1 may also affect the sensitivity of flies to trehalose since mutants affecting Tre1 also show low sensitivity to trehalose which can be rescued by overexpression of Tre1 (FBrf0128502).

                (FlyBase, 1992-)
                Other Comments

                Tre1 directs transepithelial migration of germ cells in the embryo.

                (Kunwar et al., 2003)

                Mutation of Tre1 disrupts both germ cell migration and the death of germ cells ectopic to the gonad in embryos. This phenotype is only seen if the mother is homozygous mutant, and while zygotic expression of Tre1+ can rescue the germ cell migration defect it does not rescue the cell death defect of ectopic germ cells.

                (Coffman et al., 2002)

                FlyBase curator comment: FBrf0139891, FBrf0138267 and FBrf0141681 argue that the trehalose-responsive gene that maps to this part of the genome is in fact Gr5a which maps adjacent to, and is transcribed divergently from, Tre1.

                (Ishimoto et al., 2000)

                FlyBase curator comment: This gene was described as "Trehalose receptor 1" in the AB034204 record (though not in related paper FBrf0128502). FBrf0139891, FBrf0138267 and FBrf0141681 argue that the trehalose-response gene in fact maps to Gr5a, not Tre1, so the name "Trehalose receptor 1" has not been adopted for this gene.

                (Ishimoto, 1999.10.29)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 69 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                modMine - A data warehouse for the modENCODE project
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (19)
                Reported As
                Symbol Synonym
                BEST:LD12308
                CG 3171
                (VanKirk et al., 2017)
                CG3171
                (Hosono et al., 2015, Ni et al., 2011.7.19, Kamps et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Chen et al., 2008, Grieder et al., 2007, Hauser et al., 2006, Hauser et al., 2006, Molnar et al., 2006, Ueno et al., 2006, Isono et al., 2005, Schwabe et al., 2005, Bryson-Richardson et al., 2004, Kearney et al., 2004, Kunwar et al., 2003, Norga et al., 2003, Isono, 2001.9.22, Ueno et al., 2001, Bayraktaroglu, 2000.11.2, Brody and Cravchik, 2000)
                LD12308
                (Toba et al., 1999)
                TRE
                (Tian and Smith-Bolton, 2021)
                Tre
                (Jayanandanan et al., 2011)
                Tre-1
                (Dorogova et al., 2020, Zhang et al., 2013, Burnett et al., 2004)
                Tre1
                (Kubick et al., 2021, O'Connor et al., 2021, Rao and Deng, 2019.10.23, Trcek and Lehmann, 2019, Camuglia et al., 2018, Franz et al., 2017, Luu et al., 2016, Grotewiel and Bettinger, 2015, Jones and Macdonald, 2015, Pflanz et al., 2015, Bischof and FlyORF project members, 2014.6.20, Pruitt et al., 2013, Caers et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Yoshiura et al., 2012, Chen et al., 2008, Kunwar et al., 2008, Yatsu et al., 2008, Dahanukar et al., 2007, Grieder et al., 2007, Molnar et al., 2006, Montell, 2006, Ramos et al., 2006, Rollmann et al., 2006, Bainton et al., 2005, Daneman and Barres, 2005, Starz-Gaiano and Montell, 2004)
                anon-WO0170980.16
                anon-WO0170980.17
                anon-WO0170981.1
                sctt
                (Kamps and Coffman, 2005, Coffman, 2003, Kunwar et al., 2003, Coffman et al., 2002)
                tre-1
                (Santos and Lehmann, 2004)
                tre1
                (Thuma et al., 2018, LeBlanc and Lehmann, 2017, Pflanz et al., 2015, Yoshiura et al., 2012, Kamps et al., 2010, Renault and Lehmann, 2006, Andersen and Coffman, 2005, Kamps and Coffman, 2005, Schwabe et al., 2005, Kunwar et al., 2003, Kunwar et al., 2003, Smith, 2001, Vanden Broeck, 2001)
                Name Synonyms
                G protein coupled receptor
                (Isono, 2000.5.12)
                Trapped in endoderm 1
                (Saad and Hipfner, 2021, Sun et al., 2020, Luu et al., 2016, Caers et al., 2012, Kamps et al., 2010, Magwire et al., 2010, Dahanukar et al., 2007)
                scattershot
                (Coffman et al., 2002)
                trapped in endoderm 1
                (Yoshiura et al., 2012, Kunwar et al., 2008, Montell, 2006, Rollmann et al., 2006)
                trapped in endoderm-1
                (Kunwar et al., 2003)
                Secondary FlyBase IDs
                • FBgn0026580
                • FBgn0029786
                • FBgn0046493
                • FBgn0046572
                • FBgn0046580
                • FBgn0064143
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                References (111)