Gene: Dmel\Tre1
sctt, Tre-1
G-protein coupled receptor - links cell polarity, modulation of cell adhesion, and invasion during germ cell migration
Please see the JBrowse view of Dmel\Tre1 for information on other features
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Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tre1 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as dorsal vessel specific anlage
Comment: reported as glioblasts of ventral nervous system
Comment: reported as lymph gland specific anlage
Comment: reported as pericardial cell specific anlage
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
Expression pattern inferred from unspecified enhancer trap line.
Tre1 transcript is maternally deposited; at early embryonic stages Tre1 transcript is localized to the posterior pole of the embryo. By embryonic stage 6, expression is restricted to pole cells, and has degraded elsewhere in the embryo. At embryonic stage 9, Tre1 transcript is expressed in pole cells, and also widely distributed in somatic tissues. At stage 13, Tre1 transcript is expressed in a variety of tissues, including the amnioserosa, the developing central nervous system, midline glial cells, cardiac mesoderm primordium, and in cuprophilic cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Tre1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG3171 BEST:LD12308
Source for merge of: Tre1 sctt
Source for merge of: Tre1 anon-WO0170980.16 anon-WO0170980.17 anon-WO0170981.1
Although FBrf0128502 reported that Tre1, which maps extremely close to Gr5a, mediates the trehalose response, the balance of evidence suggests that Gr5a, rather than Tre1, encodes a trehalose receptor.
The "CG15779"/"Gr5a" gene corresponds to the "Trehalose-sensitivity" complementation group as opposed to the "CG3171" gene, as was reported in FBrf0128502.
Expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data suggest that the "Gr5a" and not "CG3171" corresponds to the "Tre" (Trehalose-sensitivity) locus.
Source for merge of Tre1 anon-WO0170980.16 anon-WO0170980.17 anon-WO0170981.1 was sequence comparison ( date:051113 ).
Evidence from FBrf0138267 (expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data) suggests that the CG15779 gene prediction (Gr5a) corresponds to the "Trehalose-sensitivity" locus, mutation of which results in low sensitivity to trehalose. The "Trehalose-sensitivity" locus does not correspond to "Tre1" from FBrf0128502 which corresponds to the CG3171 gene prediction (which is adjacent to and divergently transcribed from CG15779). Mutation of Tre1 may also affect the sensitivity of flies to trehalose since mutants affecting Tre1 also show low sensitivity to trehalose which can be rescued by overexpression of Tre1 (FBrf0128502).
Tre1 directs transepithelial migration of germ cells in the embryo.
Mutation of Tre1 disrupts both germ cell migration and the death of germ cells ectopic to the gonad in embryos. This phenotype is only seen if the mother is homozygous mutant, and while zygotic expression of Tre1+ can rescue the germ cell migration defect it does not rescue the cell death defect of ectopic germ cells.
FlyBase curator comment: FBrf0139891, FBrf0138267 and FBrf0141681 argue that the trehalose-responsive gene that maps to this part of the genome is in fact Gr5a which maps adjacent to, and is transcribed divergently from, Tre1.
FlyBase curator comment: This gene was described as "Trehalose receptor 1" in the AB034204 record (though not in related paper FBrf0128502). FBrf0139891, FBrf0138267 and FBrf0141681 argue that the trehalose-response gene in fact maps to Gr5a, not Tre1, so the name "Trehalose receptor 1" has not been adopted for this gene.
