Gene Dmel\Takl1

FlyGene Wiki Help Close All Open All

General Information

Symbol

Dmel\Takl1

Species

D. melanogaster

Name

Tak1-like 1

Annotation symbol

CG31421

Feature type

protein_coding_gene

FlyBase ID

FBgn0046689

Gene Model Status

Current

Stock availability

5 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

92F13-92F13

Sequence location

3R:16,596,550..16,598,323 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Tak1-like 1 is referred to in FlyBase by the symbol Dmel\Takl1 (CG31421, FBgn0046689). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: MAP kinase kinase kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein phosphorylation. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1628541_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Takl1. Gene sequence location is 3R:16596550..16598323.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

92F13-92F13

Limits computationally determined from genome sequence between P{PZ}l(3)10585¹⁰⁵⁸⁵ and P{EP}Synd^EP409

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

92F5-92F8

(Manning, 2001.10.11)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Takl1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Takl1-RA

FBtr0083996

NM_169924

1323

393

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Takl1-PA

FBpp0083400

45.2

393

6.91

NP_732554

AAN13830

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Serine/threonine-protein kinase, active site (IPR008271)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P83104

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		5.95
Larval Midgut		148
Larval Hindgut		136.8
Larval Malpighian Tubules		98
Larval Fat Body		4
Larval Salivary Gland		9
Larval Trachea		6.775
Larval Carcass		9.05
Adult Head		8
Adult Eye		5.175
Adult Brain		4.7
Adult Thoracic-Abdominal Ganglion		4.7
Adult Crop		5
Adult Midgut		236.4
Adult Hindgut		145.7
Adult Malpighian Tubules		79.2
Adult Fat Body		10.4
Adult Salivary Gland		12.8
Adult Heart		5.875
Adult VirginFemale Spermatheca		9
Adult InseminatedFemale Spermatheca		4.2
Adult Ovary		6.5
Adult Testis		5.9
Adult Male Accessory Gland		4.3
Adult Carcass		6.6
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	8
NA	Eye	5.175
NA	Brain	4.7
5.95	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	4.7
NA	Crop	5
148	Midgut	236.4
136.8	Hindgut	145.7
98	Malpighian Tubules	79.2
4	Fat Body	no informative data
9	Salivary Gland	no informative data
NA	Heart	5.875
6.775	Trachea	NA
NA	VirginFemale Spermatheca	9
NA	InseminatedFemale Spermatheca	4.2
NA	Ovary	6.5
NA	Testis	5.9
NA	Male Accessory Gland	4.3
9.05	Carcass	6.6

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		83
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		(83)
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		(31)
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		83
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		83
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		83
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		(83)
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		83
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		83
digestive system, 1-day adult		25
digestive system, 4-day adult		22
digestive system, 20-day adult		31
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during late larval stages, during early pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		(29)
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		3
embryo 18-20hr		9
embryo 20-22hr		8
embryo 22-24hr		8
larva L1		1
larva L2		0
larva L3 12hr old		3
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		17
larva L3 puffstage 7-9		22
white prepupae new		8
white prepupae 12hr		29
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		3
pupae 4d postWPP		9
adult male 01day		3
adult male 05day		4
adult male 30day		2
adult female 01day		2
adult female 05day		1
adult female 30day		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		5
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		19
Cadmium 50 mM 48 hrs, 4-day adult		3
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		3
Paraquat 10 mM 48 hrs, 4-day adult		4
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0046689

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31421-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Takl1^GD10255

Phenotype manifest in

Allele

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of Takl1	Class	Mutagen	Stocks	Known lesion
Takl1^c04375			2	--
Takl1^c04453			1	--

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Takl1	Mutagen	Stocks	Known lesion
Takl1^GD10255	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Takl1^JF01204	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Takl1^KK106001	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Takl1^NIG.31421R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}Syp^c04375

PBac{PB}Takl1^c04453

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(FlyBase Curators et al., 2004-)

MAP kinase kinase kinase activity

inferred from sequence or structural similarity with Tak1 AND inferred from sequence or structural similarity with human MAP3K7

(FlyBase Genome Annotators, 2002-2003)

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

Biological Process

CV term

Evidence

References

protein phosphorylation

inferred from sequence or structural similarity with Tak1 AND inferred from sequence or structural similarity with human MAP3K7

(FlyBase Genome Annotators, 2002-2003)

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

Takl1 - CG6933

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Takl1 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0046689

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

318725

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

P83104

Orthologs

OrthoDB Orthologs (16) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG651F9M

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

EOG6KHFN1

Orthologs in Drosophila Species (EOG651F9M)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (EOG6KHFN1)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\Y105C5A.24

Caenorhabditis elegans

Nematode

Cele\mom-4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_002696gn

Danio rerio

Zebrafish

Drer\map3k7

Xenopus tropicalis

Western clawed frog

Xtro\map3k7

Gallus gallus

Domestic chicken

Ggal\MAP3K7

Mus musculus

House mouse

Mmus\Map3k7

Rattus norvegicus

Norway rat

Rnor\Map3k7

Homo sapiens

Human

Hsap\ENSG00000135341

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\ENSG00000135341

AAA Orthologs (7) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16242

Drosophila persimilis

Dper\GL27129

Stocks & Reagents

Stocks Listed in FlyBase ( 5 )

Bloomington

31263

y¹ v¹; P{TRiP.JF01204}attP2

11414

w¹¹¹⁸; PBac{PB}Syp^c04375 Takl1^c04375/TM6B, Tb¹

v25760

w¹¹¹⁸; P{GD10255}v25760

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 6 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0046689

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318725

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

New annotation (CG31421) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_169924

RefSeq (Proteins)

•

NP_732554

DDBJ / EMBL / GenBank

•

AAN13830

Entrez Gene - A searchable database of RefSeq genes.

•

318725

UniProtKB/Swiss-Prot

•

P83104

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Serine/threonine-protein kinase, active site (IPR008271)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0046689

DRSC - Results from RNAi screens.

•

FBgn0046689

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0046689

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31421-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0046689

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318725

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

318725

modMine - Data generated by the modENCODE project.

•

FBgn0046689

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

P83104

Synonyms & Secondary IDs ( 7 )

Reported As

Symbol Synonym

anon-AE003732.1

CG31421

(Ni et al., 2008, Keleman et al., 2009.8.5)

FBgn0046689

(Lehmann et al., 2010)

TAKL1

(Manning, 2001.10.11)

Takl1

(Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

extra2

(Robertson, 2001.1.8)

Tak1-like 1

(Manning, 2001.10.11)

Secondary FlyBase IDs

FBgn0043537
FBgn0051421

References ( 18 )

Research paper

Lehmann et al., 2010, BMC Evol. Biol. 10: 156: Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. [FBrf0211127]
Lesch et al., 2010, Genetics 186(3): 943--957: A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. [FBrf0212282]
Ni et al., 2008, Nat. Methods 5(1): 49--51: Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]

Review

Manning et al., 2002, Trends Biochem. Sci. 27(10): 514--520: Evolution of protein kinase signaling from yeast to man. [FBrf0183159]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project: DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Gene Disruption Project members, 2001-, (Computer file): (Computer file) [FBrf0132177]
Manning, 2001.10.11, Novel kinase: TAKL.: Novel kinase: TAKL. [FBrf0139873]
Robertson, 2001.1.8, FlyBase error report on Mo n Jan 8 14:31:14 2001.: FlyBase error report on Mo n Jan 8 14:31:14 2001. [FBrf0133242]

FlyBase analysis

FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations.: Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Protein sequence record

Swiss-Prot Project Members, 2002.3.1, UniProtKB: P83104: Putative mitogen-activated protein kinase kinase kinase 7 (EC 2.7.1.-). [FBrf0140155]