FlyBase Gene Report: Dmel\Pp1-Y2

General Information

Symbol

Dmel\Pp1-Y2

Species

D. melanogaster

Name

Protein phosphatase 1, Y-linked 2

Annotation Symbol

CG40448

Feature Type

protein_coding_gene

FlyBase ID

FBgn0046698

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Pp1Y2

Key Links

Genomic Location

Cytogenetic map

Sequence location

Y:3,539,437..3,540,722 [-]

Recombination map

Y-

RefSeq locus

NC_024512 REGION:3539437..3540722

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein serine/threonine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000185233

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:9283

(FlyBase Curators, 2008--)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein dephosphorylation

inferred from sequence or structural similarity with HGNC:9283

(FlyBase Curators, 2008--)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000185233

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:9283

(FlyBase Curators, 2008--)

located_in nucleus

inferred from sequence or structural similarity with HGNC:9283

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000185231

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pp1-Y2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 6.01

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pp1-Y2-RC

FBtr0346673

NM_001015497

1286

313

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Pp1-Y2-PC

FBpp0312286

35.9

313

7.33

NP_001015497

EAL24523

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pp1-Y2 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

testis

(Adám et al., 2010)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

P-stage

organism

(Adám et al., 2010)

adult stage | male

organism

(Adám et al., 2010)

Additional Descriptive Data

Pp1-Y2 transcript is detected in pupae and in male adult, but not in embryos, larvae, or adult female adults.In situ analysis of male adults shows that expression of PpD1-Y2 transcript is testis-specific.

(Adám et al., 2010)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pp1-Y2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pp1-Y2

View exonic expression by tissue for Dmel\Pp1-Y2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0046698

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG40448-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0046698

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pp1-Y2

Transgenic constructs containing regulatory region of Pp1-Y2

Deletions and Duplications ( 4 )

Not disrupted in

Df(YL)F11

(Hafezi et al., 2020)

Df(YL)F16

(Hafezi et al., 2020)

Df(YL)F52

(Hafezi et al., 2020)

Df(YL)F63

(Hafezi et al., 2020)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PPP1CA

5 of 15

Yes

Hsap\PPP1CC

5 of 15

Yes

4 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\PPP6C

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ppp1ca

5 of 15

Yes

4 of 15

3 of 15

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (12)

Rnor\Ppp1cc

5 of 13

Yes

Rnor\Ppp1ca

4 of 13

Rnor\Ppp1cb

4 of 13

Rnor\LOC100363225

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\ppp1cb

4 of 12

Yes

Xtro\ppp1cc

4 of 12

Yes

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (16)

Drer\ppp1caa

6 of 15

Yes

5 of 15

5 of 15

4 of 15

4 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (45)

Cele\gsp-2

6 of 15

Yes

Cele\F52H3.6

5 of 15

Yes

Cele\pph-1

5 of 15

Yes

Cele\ZK938.1

5 of 15

Cele\C09H5.7

4 of 15

Yes

Cele\C30A5.4

4 of 15

Yes

Cele\F25B3.4

4 of 15

Cele\gsp-1

4 of 15

Cele\gsp-3

4 of 15

Yes

Cele\gsp-4

4 of 15

Yes

Cele\R13A5.11

4 of 15

Yes

Cele\T16G12.7

4 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (11)

Atha\TOPP3

4 of 9

Yes

Atha\TOPP4

4 of 9

Yes

Atha\TOPP7

4 of 9

Yes

3 of 9

3 of 9

3 of 9

2 of 9

2 of 9

Yes

Atha\TOPP9

2 of 9

Yes

Atha\BSL1

1 of 9

Yes

Atha\BSU1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\GLC7

7 of 15

Yes

Scer\PPZ1

5 of 15

Yes

Scer\PPZ2

4 of 15

Yes

Scer\PPQ1

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\dis2

4 of 12

Yes

Spom\pzh1

3 of 12

Spom\sds21

2 of 12

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BYY )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila erecta

Dere\GG12985

Drosophila yakuba

Dyak\GE19822

Drosophila ananassae

Dana\GF19572

Drosophila pseudoobscura pseudoobscura

Dpse\GA25003

Drosophila persimilis

Dper\GL16957

Drosophila willistoni

Dwil\GK15929

Drosophila virilis

Dvir\GJ21755

Drosophila mojavensis

Dmoj\GI18733

Drosophila grimshawi

Dgri\GH21132

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07JN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008501

Danaus plexippus

Monarch butterfly

Dple\DPOGS206670-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012302

Apis florea

Little honeybee

Aflo\2417179862

Apis florea

Little honeybee

Aflo\2251559860

Apis mellifera

Western honey bee

Amel\LOC409430

Apis mellifera

Western honey bee

Amel\LOC409804

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22022

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20446

Bombus terrestris

Buff-tailed bumblebee

Bter\15210649

Bombus terrestris

Buff-tailed bumblebee

Bter\15203407

Linepithema humile

Argentine ant

Lhum\LH12603

Linepithema humile

Argentine ant

Lhum\LH10743

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000227

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004180

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001441

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08326

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15321

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08406

Pediculus humanus

Human body louse

Phum\PHUM570660

Rhodnius prolixus

Kissing bug

Rpro\RPRC000214

Rhodnius prolixus

Kissing bug

Rpro\RPRC002352

Cimex lectularius

Bed bug

Clec\CLEC011563

Cimex lectularius

Bed bug

Clec\CLEC006871

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005202

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004455

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03910

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12258

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07EY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013031

Strigamia maritima

European centipede

Smar\SMAR011276

Ixodes scapularis

Black-legged tick

Isca\ISCW012293

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70178.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77822.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g03360

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g05120

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_194510

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_231787

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EKF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ppp1cb

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pp1L

Ciona intestinalis

Vase tunicate

Cint\LOC100187079

Ciona intestinalis

Vase tunicate

Cint\LOC100178587

Gallus gallus

Domestic chicken

Ggal\PPP1CB

Gallus gallus

Domestic chicken

Ggal\PPP1CC

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (18)

Gene Symbol

Score

Source

Alignment

flw

6 of 10

6 of 10

6 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

2 of 10

2 of 10

2 of 10

mts

2 of 10

Pp2B-14D

2 of 10

Pp4-19C

2 of 10

PpD3

2 of 10

PpV

2 of 10

rdgC

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP1CA; protein phosphatase 1 catalytic subunit alpha

5 of 15

176875

PPP1CC; protein phosphatase 1 catalytic subunit gamma

5 of 15

176914

PPP1CB; protein phosphatase 1 catalytic subunit beta

4 of 15

600590

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 2; NSLH2

Noonan syndrome-like disorder with loose anagen hair 2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046698

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3355173

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

Y-

Cytogenetic map

Sequence location

Y:3,539,437..3,540,722 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

h1-h25B

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

Y-

(de Carvalho, 2001.10.4)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Bloomington

57236

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04622}attP40

VDRC

v109147

P{KK115898}VIE-260B

v341644

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00740}attP40/CyO-GFP

Genomic Clones (0)

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP26157

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0046698

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3355173

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Pp1-Y2 CG40448

(FlyBase, 1996-)

Additional comments

The Pp1-Y2 gene may have been derived from a related phosphoprotein phosphatase gene by retroposition and subsequent tandem duplication.

(Miskei et al., 2011)

Source for merge of Pp1-Y2 CG40448 was sequence comparison ( date:031111 ).

(FlyBase, 1996-)

Other Comments

Sequence of transcript(s) changed in r6 genomic release relative to r5 release.

(FlyBase Genome Annotators, 2014)

New annotation (CG40448) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3355173

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Flygut - An atlas of the Drosophila adult midgut

FBgn0046698

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3355173

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG40448

modMine - A data warehouse for the modENCODE project

FBgn0046698

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q5K375

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046698

DRSC - Results frm RNAi screens

FBgn0046698

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0046698

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG40448-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0046698

FlyMine - An integrated database for Drosophila genomics

FBgn0046698

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3355173

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG40448

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Drosophila Heterochromatin Genome Project, 2007)

DmPp1-Y2

(Cohen et al., 2005)

PP1-Y2

(Hafezi et al., 2020, Xue et al., 2019)

Pp1-Y2

(Zhang et al., 2020, Gärtner et al., 2019, Agrawal and Hardin, 2016, Hoskins et al., 2015, dos Santos, 2014, FlyBase Genome Annotators, 2014, Pogson et al., 2014, Singh et al., 2014, Adám et al., 2010, Koerich et al., 2008, Diaz-Castillo and Golic, 2007, Carvalho and Clark, 2005)

Pp1Y2

(Abad et al., 2004)

Name Synonyms

Pp1-Y2

Protein phosphatase 1, Y-linked 2

Secondary FlyBase IDs

FBgn0058448
FBan0040448

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (32)

The following external sites may use different assemblies or annotations than FlyBase.

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