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Gene Dmel\Liprin-α

General Information
Symbol	Dmel\Liprin-α	Species	D. melanogaster
Name	Liprin-α	Annotation symbol	CG11199
Feature type	protein_coding_gene	FlyBase ID	FBgn0046704
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Dliprin-α, Liprin-alpha
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27A1-27A2	Sequence location	2L:6,723,903..6,732,766 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Liprin-α is referred to in FlyBase by the symbol Dmel\Liprin-α (CG11199, FBgn0046704). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: R7 cell development; synapse assembly; regulation of axon extension involved in axon guidance; axon guidance; GO:0048676; anterograde synaptic vesicle transport; synaptic growth at neuromuscular junction; retinal ganglion cell axon guidance; axon target recognition; photoreceptor cell morphogenesis. 26 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; medulla; bouton; neuromuscular junction; synaptic vesicle. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Sterile alpha motif domain; Sterile alpha motif, type 1; Sterile alpha motif, type 2; Sterile alpha motif/pointed domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632099_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Liprin-alpha. Gene sequence location is 2L:6723903..6732766.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms axon extension
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27A1-27A2
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Liprin-α for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.44 Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Liprin-α-RA FBtr0079300  NM_135223   4466   1201 Liprin-α-RB FBtr0079301  NM_164707   4937   1201 Liprin-α-RC FBtr0329941  NM_001273224   5970   1158 Liprin-α-RD FBtr0329942  NM_001273225   4949   1205 Liprin-α-RE FBtr0329943  NM_001273226   4466   1214
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Liprin-α-PA   FBpp0078930   134.7   1201   6.18     NP_609067   AAF52430 Liprin-α-PB   FBpp0078931   134.7   1201   6.18     NP_723208   AAN10596 Liprin-α-PC   FBpp0302973   129.8   1158   6.26     NP_001260153   AGB92689 Liprin-α-PD   FBpp0302974   135.1   1205   6.23     NP_001260154   AGB92690 Liprin-α-PE   FBpp0302975   136.0   1214   6.08     NP_001260155   AGB92691
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sterile alpha motif domain (IPR001660) Sterile alpha motif, type 2 (IPR011510) Sterile alpha motif, type 1 (IPR021129) Sterile alpha motif/pointed domain (IPR013761)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201349   AA941967   AA941968   AA978903   AE014134 AAF52430   AE014134 AAN10596   AE014134 AGB92689   AE014134 AGB92690   AE014134 AGB92691   AI238606   AI296190   AW943165   BF490481   BF491890   BF493362   BF501123   BF504048   BG638695   BI228257   BI239275   BT004484 AAO42648   CO153626   CO186448   CO186500   CO270025   CO290816   CO294821   CO297962   CO304581   CO311220   CO311235   CO311803   CO316127   CZ467482   CZ467483   CZ478541   CZ489408   EC058945   EC063873   EC068804   EC069023   EC069037   EC073884   EC076785   EC089310   EC194807   EC202395   EC213302   EC214200   EC217658   EC225206   EC231753   EC236230   EC237823   EC245175   EC248083   EC260169   EC262716   GH969257   GH972080
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VM93
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic brain   (Kaufmann et al., 2002) presumptive embryonic/larval peripheral nervous system   (Kaufmann et al., 2002) presumptive embryonic/larval central nervous system   (Kaufmann et al., 2002) ventral nerve cord   (Kaufmann et al., 2002) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 4 -- 17     (Kaufmann et al., 2002) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) larval stage   embryonic/larval central nervous system   (Kaufmann et al., 2002) embryonic/larval somatic muscle   (Kaufmann et al., 2002)
Additional Descriptive Data
	Liprin-α transcripts are abundant in embryos from the cellular blastoderm stage through to hatching. Highest transcript levels are seen in the developing peripheral and central nervous systems. Late in embryogenesis, no Liprin-α transcripts are observed outside of the nervous system. Expression is also observed in the larval body wall muscle and CNS. (Kaufmann et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   neuromuscular junction   (Kaufmann et al., 2002) embryonic/larval central nervous system   (Kaufmann et al., 2002) synapse   (Kaufmann et al., 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	In late embryos, the highest levels of Liprin-α protein are observed in the neuropil of the ventral nerve cord. It is present in both longitudinal and commissural neuropil in stage 16 but becomes restricted to longitudinal neuropil in stage 17 embryos and first instar larvae. In larvae, Liprin-α is found at neuromuscular junctions. It is present in synapses and not along axons. It is abundant both on presynaptic and postsynaptic sides of the neuromuscular junction. It is also observed in the larval CNS. (Kaufmann et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
focal adhesion inferred from direct assay (Weng et al., 2011) presynaptic active zone inferred from direct assay (Owald et al., 2010, Fouquet et al., 2009) protein complex inferred from direct assay (Astigarraga et al., 2010) synapse inferred from direct assay (Kaufmann et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    69.25 Larval Midgut    62.5 Larval Hindgut    49.6 Larval Malpighian Tubules    44.1 Larval Fat Body    35.8 Larval Salivary Gland    44.8 Larval Trachea    26.575 Larval Carcass    33.425 Adult Head    41.3 Adult Eye    23.6 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    43.9 Adult Crop    49.5 Adult Midgut    68.1 Adult Hindgut    39.5 Adult Malpighian Tubules    41.6 Adult Fat Body    40.2 Adult Salivary Gland    43 Adult Heart    24.65 Adult VirginFemale Spermatheca    16.3 Adult InseminatedFemale Spermatheca    20.6 Adult Ovary    271.9 Adult Testis    99.6 Adult Male Accessory Gland    28.8 Adult Carcass    35.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    41.3   NA  Eye    23.6   NA  Brain    78.1   69.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    43.9   NA  Crop    49.5   62.5  Midgut    68.1   49.6  Hindgut    39.5   44.1  Malpighian Tubules    41.6   35.8  Fat Body    40.2   44.8  Salivary Gland    no informative data   NA  Heart    24.65   26.575  Trachea    NA   NA  VirginFemale Spermatheca    16.3   NA  InseminatedFemale Spermatheca    20.6   NA  Ovary    271.9   NA  Testis    99.6   NA  Male Accessory Gland    no informative data   33.425  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8  (27) head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8  27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    25 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    25 ovary, mated 4-day female    25 testis, mated 4-day male    15 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (33) embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (33) embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    15 embryo 04-06hr    12 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    22 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    10 adult female 01day    14 adult female 05day    21 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3  (31) wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2  (31) ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3  31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2  31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    17 embryonic 1182-4H    23 embryonic GM2    23 embryonic Kc167    20 embryonic S1    23 embryonic S3    15 leg disc CME L1    16 wing disc CME-W2    11 wing disc ML-DmD8    12 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    11 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD33094 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046704 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11199-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Liprin-α1 lethal (with Liprin-α1) Liprin-αE lethal (with Liprin-αE) Liprin-α1 Liprin-αF lethal (with Liprin-αF) Liprin-αE partially lethal - majority die | recessive Liprin-αoos Sterility Allele male sterile | recessive Liprin-αoos Other Phenotypes Allele neuroanatomy defective Liprin-αoos neuroanatomy defective (with Liprin-α1J-0) Liprin-αR117 neuroanatomy defective (with Liprin-αF3ex15) Liprin-αR60 neuroanatomy defective (with Liprin-αR60) Liprin-αF3ex15 neuroanatomy defective (with Liprin-αR117) Liprin-α1J-0 neuroanatomy defective | pupal stage | somatic clone Liprin-αE neuroanatomy defective | somatic clone Liprin-α1 Liprin-αE Liprin-αF Liprin-αoos Liprin-αR60 neuroanatomy defective | third instar larval stage (with Liprin-αF3ex15) Liprin-αR60 neuroanatomy defective | third instar larval stage (with Liprin-αR60) Liprin-αF3ex15 neurophysiology defective (with Liprin-α1J-0) Liprin-αF3ex15 neurophysiology defective (with Liprin-αF3ex15) Liprin-α1J-0 Liprin-αR117 neurophysiology defective (with Liprin-αR117) Liprin-αF3ex15 Phenotype manifest in Allele bouton (with Liprin-α1J-0) Liprin-αR117 bouton (with Liprin-αF3ex15) Liprin-αR60 bouton (with Liprin-αR60) Liprin-αF3ex15 bouton (with Liprin-αR117) Liprin-α1J-0 embryonic/larval neuromuscular junction | third instar larval stage (with Liprin-αF3ex15) Liprin-αR60 embryonic/larval neuromuscular junction | third instar larval stage (with Liprin-αR60) Liprin-αF3ex15 eye photoreceptor cell | somatic clone Liprin-αR60 Liprin-α1 Liprin-αE Liprin-αF medulla Liprin-αoos neuromuscular junction (with Liprin-α1J-0) Liprin-αR117 neuromuscular junction (with Liprin-αF3ex15) Liprin-αR117 Liprin-αR60 neuromuscular junction (with Liprin-αR60) Liprin-αF3ex15 neuromuscular junction (with Liprin-αR117) Liprin-α1J-0 Liprin-αF3ex15 NMJ bouton | larval stage Liprin-αoos optic cartridge | somatic clone Liprin-αR60 Liprin-α1 Liprin-αE Liprin-αF photoreceptor cell R4 | pupal stage | somatic clone Liprin-αE photoreceptor cell R7 Liprin-αoos photoreceptor cell R7 | cell non-autonomous | somatic clone Liprin-αE photoreceptor cell R7 | somatic clone Liprin-αE Liprin-αoos synaptic vesicle (with Liprin-α1J-0) Liprin-αF3ex15 synaptic vesicle (with Liprin-αF3ex15) Liprin-α1J-0
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of Liprin-α Class Mutagen Stocks Known lesion Liprin-αc01829 piggyBac transposase 1 -- Liprin-αd09320 1 -- Liprin-αDG23609 P-element activity 1 -- Liprin-αe00687 piggyBac transposase 1 -- Liprin-αEY21217 P-element activity 1 -- Liprin-αf06690 piggyBac transposase 1 -- Liprin-αF3ex15 P-element activity 1 Yes Liprin-αR60 P-element activity 1 Yes Liprin-α1 ethyl methanesulfonate 0 -- Liprin-α1J-0-ex49 P-element activity 0 Yes Liprin-α1J-0 Delta2-3 0 -- Liprin-αc01832 piggyBac transposase 0 -- Liprin-αE ethyl methanesulfonate 0 -- Liprin-αF3 Delta2-3 0 Yes Liprin-αF ethyl methanesulfonate 0 -- Liprin-αoos 0 Yes Liprin-αR117 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Liprin-α Class Mutagen Stocks Known lesion Liprin-αGD7232 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Liprin-αKK100116 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Liprin-αdsRNA.IR.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Liprin-αScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes Liprin-αScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Liprin-αScer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Liprin-αScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Liprin-αScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Liprin-αΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7027 (Ryder, 2004.4.26) Df(2L)Liprin-α-77ex17 (Kaufmann et al., 2002) Df(2L)Liprin-α-77ex63 (Kaufmann et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Liprin-α.YFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}homerEP2141 NA P{EPgy2}Liprin-αEY21217 NA P{XP}Liprin-αd09320 NA insertion of enhancer trap P{lacW}l(2)SH2221SH2221 No P{lacW}Liprin-α1J-0 No P{lacW}Liprin-αF3 No miscellaneous insertions P{?lacW}Liprin-αF3ex15 NA P{wHy}Liprin-αDG23609 NA PBac{PB}Liprin-αc01829 NA PBac{PB}Liprin-αc01832 NA PBac{RB}Liprin-αe00687 NA PBac{WH}Liprin-αf06690 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Liprin-β (Astigarraga et al., 2010) inferred from physical interaction with Liprin-γ (Astigarraga et al., 2010)
Biological Process
CV term Evidence References
anterograde synaptic vesicle transport inferred from mutant phenotype (Miller et al., 2005) axon extension inferred from mutant phenotype (Prakash et al., 2009) axon guidance inferred from mutant phenotype (Prakash et al., 2009) axon target recognition inferred from mutant phenotype (Choe et al., 2006, Astigarraga et al., 2010) photoreceptor cell morphogenesis inferred from mutant phenotype (Hofmeyer et al., 2002, Hofmeyer et al., 2006) R7 cell development inferred from mutant phenotype (Hofmeyer et al., 2006) regulation of axon extension involved in axon guidance inferred from mutant phenotype (Prakash et al., 2009) retinal ganglion cell axon guidance inferred from mutant phenotype (Choe et al., 2006) synapse assembly inferred from mutant phenotype (Kaufmann et al., 2002) synaptic growth at neuromuscular junction inferred from mutant phenotype (Astigarraga et al., 2010)
Cellular Component
CV term Evidence References
focal adhesion inferred from direct assay (Weng et al., 2011) presynaptic active zone inferred from direct assay (Owald et al., 2010, Fouquet et al., 2009) protein complex inferred from direct assay (Astigarraga et al., 2010) synapse inferred from direct assay (Kaufmann et al., 2002)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Liprin-α - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - CG4806 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - CG7564 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Cg25C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Cypl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Fmr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - PP2A-B' anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - Ski6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - mRpL10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Liprin-α - ssx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Liprin-α allele Gene References Liprin-α1J-0 Lar (Kaufmann et al., 2002) mr (van Roessel et al., 2004) Liprin-αR117 Lar (Kaufmann et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 74442 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0046704 DroID - A comprehensive database of gene and protein interactions. • FBgn0046704 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 249072
Orthologs
OrthoDB Orthologs (60) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69GM20 Dipteran inclusive ortholog search EOG6SXNMG Insect inclusive ortholog search EOG6CJTC7 Arthropod inclusive ortholog search EOG676HF9 Metazoa inclusive ortholog search EOG6SBSQN
Orthologs in Drosophila Species (EOG69GM20)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Liprin-α     Drosophila simulans   Dsim\GD23428 Y   Drosophila sechellia   Dsec\GM16210 Y   Drosophila erecta   Dere\GG10430 Y   Drosophila yakuba   Dyak\GE14088 Y   Drosophila ananassae   Dana\GF14949 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10833 Y   Drosophila persimilis   Dper\GL25785 Y   Drosophila willistoni   Dwil\GK24804 Y   Drosophila virilis   Dvir\GJ12463 Y   Drosophila mojavensis   Dmoj\GI11283 Y   Drosophila grimshawi   Dgri\GH10707 Y
Orthologs in non-Drosophila Dipterans (EOG6SXNMG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008058   Anopheles gambiae Malaria mosquito  Agam\AGAP001469   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016635
Orthologs in non-Dipteran Insects (EOG6CJTC7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54198   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002014   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19397   Atta cephalotes Leafcutter ant  Acep\ACEP17220   Atta cephalotes Leafcutter ant  Acep\ACEP27984   Atta cephalotes Leafcutter ant  Acep\ACEP17219   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20698   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19951   Linepithema humile Argentine ant  Lhum\LH17025   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18998   Solenopsis invicta Red fire ant  Sinv\SINV20376   Solenopsis invicta Red fire ant  Sinv\SINV20379   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003760   Bombyx mori Silkmoth  Bmor\BGIBMGA011331   Pediculus humanus Human body louse  Phum\PHUM599790   Tribolium castaneum Red flour beetle  Tcas\TC012918
Orthologs in non-Insect Arthropods (EOG676HF9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\dnaK   Ixodes scapularis Deer tick  Isca\ISCW017497
Orthologs in non-Arthropod Metazoa (EOG6SBSQN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\syd-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026761gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026548gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026070gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012547gn   Danio rerio Zebrafish  Drer\ppfia4   Danio rerio Zebrafish  Drer\ENSDARG00000077053   Danio rerio Zebrafish  Drer\si:ch211-107n23.1   Danio rerio Zebrafish  Drer\zgc:171298   Xenopus tropicalis Western clawed frog  Xtro\ppfia1   Xenopus tropicalis Western clawed frog  Xtro\ppfia3   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014532   Gallus gallus Domestic chicken  Ggal\PPFIA1   Gallus gallus Domestic chicken  Ggal\PPFIA2   Gallus gallus Domestic chicken  Ggal\PPFIA4   Mus musculus House mouse  Mmus\Ppfia2   Mus musculus House mouse  Mmus\Ppfia1   Mus musculus House mouse  Mmus\Ppfia3   Mus musculus House mouse  Mmus\Ppfia4   Rattus norvegicus Norway rat  Rnor\Ppfia4   Rattus norvegicus Norway rat  Rnor\Ppfia1   Rattus norvegicus Norway rat  Rnor\Ppfia3   Rattus norvegicus Norway rat  Rnor\Ppfia2   Homo sapiens Human  Hsap\PPFIA3   Homo sapiens Human  Hsap\PPFIA2   Homo sapiens Human  Hsap\PPFIA1   Homo sapiens Human  Hsap\PPFIA4
Human Orthologs (4)
Gene OMIM HGNC Hsap\PPFIA3     Hsap\PPFIA2     Hsap\PPFIA1     Hsap\PPFIA4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23428 Drosophila sechellia Dsec\GM16210 Drosophila erecta Dere\GG10430 Drosophila yakuba Dyak\GE14088 Drosophila ananassae Dana\GF14949 Drosophila pseudoobscura pseudoobscura Dpse\GA10833 Drosophila persimilis Dper\GL25785 Drosophila willistoni Dwil\GK24804 Drosophila virilis Dvir\GJ12463 Drosophila mojavensis Dmoj\GI11283 Drosophila grimshawi Dgri\GH10707
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	8563 Liprin-αF3ex15/In(2LR)Gla, wgGla-1 Bc1 22459 y1 w67c23; P{EPgy2}Liprin-αEY21217/CyO 8561 w*; Df(2L)Liprin-αR60, Liprin-αR60/CyO, P{ActGFP}JMR1
Harvard	- P{XP}Liprin-αd09320 - PBac{PB}Liprin-αc01829 - PBac{RB}Liprin-αe00687 - PBac{WH}Liprin-αf06690
Kyoto	114596 yd2 w1118 P{ey-FLP.N}2; P{wHy}Liprin-αDG23609 P{neoFRT}40A/CyO y+
VDRC	v106588 P{KK100116}VIE-260B v51707 w1118; P{GD7232}v51707
Genomic Clones ( 1 )
	BACR22N03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33094
Other clones	DPiM_LD33094
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01693 AT05328 AT16356 AT26960 AT28655 GH14683 LD04314 LD27334 LD33119 LP10025 RE25735 RE35725
Other clones	EK019832 EK020331 EK075236 EK097150 EK171020 EK207761 EK223763 EK223841 EK226551 EK245213 EK263724 EN02454 RP004402813 RP004443835
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0046704 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 249072
Antibody Information
	polyclonal (Kaufmann et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Liprin-α oos CG11199 (Hofmeyer, 2002.5.30)
Additional comments
Other Comments
	Liprin-α activity is required cell-autonomously in R cell axons, acting before synapse formation, to allow axons to extend to their targets in the lamina. (Choe et al., 2006) Liprin-α may act both downstream of and in parallel to Lar. (Hofmeyer et al., 2006) Mutations in Liprin-α prevent R7 photoreceptor axons from reaching their normal target layer. R7 photoreceptors lacking Liprin-α differentiate correctly, as monitored by their rhabdomere position and the expression of their characteristic opsins, R3 and R4. However, R7 axons stop precociously in the R8 terminal layer. Differentiation of R1 to R6 and their termination in the lamina are not affected in Liprin-α mutants. (Hofmeyer et al., 2002) Identification: Binding partner to the cytoplasmic domain of Lar in a yeast two hybrid screen. (Kaufmann et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135223 NM_164707 NM_001273224 NM_001273225 NM_001273226 RefSeq (Proteins) • NP_609067 NP_723208 NP_001260153 NP_001260154 NP_001260155 DDBJ / EMBL / GenBank • AA201349 AA941968 AA978903 AAF52430 AAN10596 AAO42648 AGB92689 AGB92690 AGB92691 AI238606 AI296190 AW943165 BT004484 CZ467482 CZ467483 CZ478541 CZ489408 Entrez Gene - A searchable database of RefSeq genes. • 249072 UniProtKB/TrEMBL • Q9VM93
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sterile alpha motif domain (IPR001660) Sterile alpha motif, type 2 (IPR011510) Sterile alpha motif, type 1 (IPR021129) Sterile alpha motif/pointed domain (IPR013761) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD33094
Linkouts
	BioGRID - A database of protein and genetic interactions • 74442 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0046704 DroID - A comprehensive database of gene and protein interactions. • FBgn0046704 DRSC - Results from RNAi screens. • FBgn0046704 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046704 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11199-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0046704 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 249072 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/liprin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 249072 modMine - Data generated by the modENCODE project. • FBgn0046704
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG11199 (Jin, 2002, Tzolovsky et al., 2002, Keleman et al., 2009.8.5) DLiprin (Diagana et al., 2002) Dliprin-α (van Roessel et al., 2004) DLiprin-α (Owald et al., 2010, Owald et al., 2012) LIP (Miśkiewicz et al., 2011) LIP1   LIP.1 (Kaufmann et al., 1998) Liprin-alpha (Jungreis et al., 2011, Wasbrough et al., 2010) Liprin-α (Hofmeyer et al., 2007, Cho et al., 2005, Choe et al., 2006, Hofmeyer et al., 2006, Hofmeyer, 2006, Zhang et al., 2006, Astigarraga et al., 2008, Weng et al., 2011, Fouquet et al., 2009, Hofmeyer and Treisman, 2009, Buffin and Gho, 2010, Astigarraga et al., 2010, Owald et al., 2012) lip-α (Johnson et al., 2009) lpr (Dickman and Davis, 2009) oos (Hofmeyer et al., 2002, )
Name Synonym	Dliprin (Ackley and Jin, 2004, Zhen and Jin, 2004) dliprin-α (Broadie and Richmond, 2002) Dliprin-α (Baran and Jin, 2002, Kaufmann et al., 2002) LAR-interacting protein 1 (Kaufmann et al., 1998) Liprin-a (Tong et al., 2011) Liprin-alpha (Chase, 2001, Giot et al., 2003, Holbrook and Herman, 2008) liprin-alpha (Johnson et al., 2009) liprin-α (Hofmeyer et al., 2005) Liprin-α (Miśkiewicz et al., 2011, Liebl and Featherstone, 2008, Weng et al., 2011, Yonekura et al., 2007, Prakash et al., 2009) out of step (Hofmeyer et al., 2002)
Secondary FlyBase IDs
	FBgn0024747 FBgn0031852 FBgn0061489
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 9 ) Review  ( 7 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Owald et al., 2012, Nat. Neurosci. 15(9): 1219--1226 Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. [FBrf0219330] Miśkiewicz et al., 2011, Neuron 72(5): 776--788 ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot. [FBrf0216903] Tong et al., 2011, Neuron 71(3): 447--459 Rich Regulates Target Specificity of Photoreceptor Cells and N-Cadherin Trafficking in the Drosophila Visual System via Rab6. [FBrf0214681] Weng et al., 2011, J. Neurosci. 31(12): 4421--4433 The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction during Drosophila Motor Axon Guidance. [FBrf0213321] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...