Gene Dmel\Haspin

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General Information

Symbol

Dmel\Haspin

Species

D. melanogaster

Name

Haspin

Annotation symbol

CG40080

Feature type

protein_coding_gene

FlyBase ID

FBgn0046706

Gene Model Status

Current

Stock availability

1 publicly available

Genomic Location

Chromosome (arm)

2RHet

Recombination map

Cytogenetic map

Sequence location

2RHet:3,199,376..3,234,607 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Haspin is referred to in FlyBase by the symbol Dmel\Haspin (CG40080, FBgn0046706). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein serine/threonine kinase activity. It is reported to be involved in the biological process: protein phosphorylation. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Domain of unknown function DUF3635; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Haspin. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Haspin. Gene sequence location is 2RHet:3199376..3234607.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

h45-h46

(determined by in situ hybridisation)

(Rossi et al., 2007)

Heterochromatic, cytological location not yet determined.

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Haspin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Haspin-RA

FBtr0113784

NM_001015349

1815

566

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Haspin-PA

FBpp0112507

65.3

566

8.39

NP_001015349

EAA46104

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Domain of unknown function DUF3635 (IPR024604)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P83103

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

embryonic stage 13 -- 16

amnioserosa

(Fisher et al., 2012)

plasmatocyte

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		59
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		(59)
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		59
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		59
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		59
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		(59)
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		59
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		19
central nervous system, larvae L3		19
central nervous system, pupae P8		15
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		6
head, mated 20-day female		4
head, mated 1-day male		4
head, mated 4-day male		10
head, mated 20-day male		9
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		3
fat body, larvae L3 wandering		1
fat body, white prepupae		6
fat body, pupae P8		5
carcass, larvae L3 wandering		9
carcass, 1-day adult		3
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		59
ovary, mated 4-day female		26
testis, mated 4-day male		8
accessory gland, mated 4-day male		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		(31)
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		13
embryo 02-04hr		23
embryo 04-06hr		31
embryo 06-08hr		14
embryo 08-10hr		20
embryo 10-12hr		14
embryo 12-14hr		19
embryo 14-16hr		3
embryo 16-18hr		9
embryo 18-20hr		2
embryo 20-22hr		8
embryo 22-24hr		15
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		6
white prepupae new		8
white prepupae 12hr		8
white prepupae 24hr		9
pupae 2d postWPP		7
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		3
adult male 05day		2
adult male 30day		1
adult female 01day		1
adult female 05day		13
adult female 30day		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		38
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		37
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(27)
Schneider line 2 Sg4		(30)
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		(38)
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		(37)
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		38
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		37
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		38
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		37
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		38
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		37
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		(38)
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		(37)
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		38
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		37
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		27
Schneider line 2 Sg4		30
embryonic 1182-4H		5
embryonic GM2		23
embryonic Kc167		38
embryonic S1		12
embryonic S3		18
leg disc CME L1		16
wing disc CME-W2		37
wing disc ML-DmD8		12
wing disc ML-DmD9		8
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		18
wing disc ML-DmD32		16
haltere disc ML-DmD17-c3		22
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		18
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		14
CNS ML-DmBG2-c2		18
tumorous blood cells mbn2		24
ovary fGS/OSS		8
ovary OSC		11
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		39
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		(39)
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		39
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		39
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		39
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		(39)
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		39
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		2
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		13
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		39
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(Graveley et al., 2011)

mE1_20_mRNA_expression_cluster_06

External Data & Images

Linkouts

BDGP expression data

•

LD07633

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0046706

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG40080-RA

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for Haspin

Stages(s) 13-16

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Haspin	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Haspin	Class	Mutagen	Stocks	Known lesion
Haspin^GL00176		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Disrupted in

Df(2R)34-2

(Coulthard et al., 2010)

Df(2R)247

(Coulthard et al., 2010)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{TRiP.GL00176}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

There is no information supporting a cellular component term for this gene.

(Based on a review of available data before: 2006)

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(FlyBase Curators et al., 2004-)

protein kinase activity

inferred from electronic annotation with InterPro:IPR000719

(FlyBase Curators et al., 2004-)

protein serine/threonine kinase activity

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

Biological Process

CV term

Evidence

References

protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719

(FlyBase Curators et al., 2004-)

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Haspin allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0046706

Orthologs

OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG67H68T

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

EOG6J104G

Arthropod inclusive ortholog search

EOG6V6WZ0

Metazoa inclusive ortholog search

EOG657J18

Orthologs in Drosophila Species (EOG67H68T)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Haspin

Drosophila ananassae

Dana\GF16653

Drosophila pseudoobscura pseudoobscura

Dpse\GA25640

Drosophila persimilis

Dper\GL21152

Drosophila willistoni

Dwil\GK23382

Drosophila virilis

Dvir\GJ22035

Drosophila mojavensis

Dmoj\GI19532

Drosophila grimshawi

Dgri\GH13564

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (EOG6J104G)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB45351

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG015025

Atta cephalotes

Leafcutter ant

Acep\ACEP21999

Atta cephalotes

Leafcutter ant

Acep\ACEP22001

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO14697

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL23286

Linepithema humile

Argentine ant

Lhum\LH23242

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB14329

Solenopsis invicta

Red fire ant

Sinv\SINV15141

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007417

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001029

Bombyx mori

Silkmoth

Bmor\BGIBMGA011311

Pediculus humanus

Human body louse

Phum\PHUM452880

Tribolium castaneum

Red flour beetle

Tcas\TC011145

Orthologs in non-Insect Arthropods (EOG6V6WZ0)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Deer tick

Isca\ISCW021594

Orthologs in non-Arthropod Metazoa (EOG657J18)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\Y18H1A.10

Caenorhabditis elegans

Nematode

Cele\F22H10.5

Caenorhabditis elegans

Nematode

Cele\C01H6.9

Caenorhabditis elegans

Nematode

Cele\Y40A1A.1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_008024gn

Danio rerio

Zebrafish

Drer\si:dkeyp-26a9.2

Mus musculus

House mouse

Mmus\ENSMUSG00000050107

Homo sapiens

Human

Hsap\GSG2

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\GSG2

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

Bloomington

35276

y¹ sc^* v¹; P{TRiP.GL00176}attP2

Genomic Clones ( 0 )

cDNA Clones ( 46 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

LD07633

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0046706

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

3355064

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Haspin BcDNA:LD07633

(FlyBase, 1996-)

Source for merge of: Haspin CG40080

(FlyBase, 1996-)

Additional comments

Source for merge of Haspin BcDNA:LD07633 was a shared cDNA (date:030206).

(FlyBase, 1996-)

Source for merge of Haspin CG40080 was a shared cDNA (date:030728).

(FlyBase, 1996-)

Other Comments

New annotation (CG40080) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_001015349

RefSeq (Proteins)

•

NP_001015349

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

3355064

UniProtKB/Swiss-Prot

•

P83103

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Domain of unknown function DUF3635 (IPR024604)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

LD07633

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0046706

DRSC - Results from RNAi screens.

•

FBgn0046706

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0046706

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG40080-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0046706

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

3355064

modMine - Data generated by the modENCODE project.

•

FBgn0046706

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

BcDNA:LD07633

CG40080

(Rossi et al., 2007, Drosophila Heterochromatin Genome Project, 2007, Ni et al., 2011.7.19)

Haspin

(Coulthard et al., 2010)

haspin

(Rossi et al., 2007)

Name Synonym

Haspin

(Manning, 2001.10.11)

Secondary FlyBase IDs

FBan0040080
FBgn0058080
FBgn0063167

References ( 15 )

Research paper

Coulthard et al., 2010, Genetics 185(2): 479--495: Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. [FBrf0211235]
Rossi et al., 2007, Genetics 175(2): 595--607: Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. [FBrf0192814]
Higgins, 2001, Protein Sci. 10(8): 1677--1684: Haspin-like proteins: A new family of evolutionarily conserved putative eukaryotic protein kinases. [FBrf0141836]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]

Personal communication to FlyBase

Ni et al., 2011.7.19, TRiP germline vector pVALIUM21.: TRiP germline vector pVALIUM21. [FBrf0214641]
Drosophila Heterochromatin Genome Project, 2007, Release 5.2 of the annotated Drosophila melanogaster heterochromatin.: Release 5.2 of the annotated Drosophila melanogaster heterochromatin. [FBrf0199188]
Drosophila Heterochromatin Genome Project, 2004, Release 3.2 of the annotated Drosophila melanogaster heterochromatin.: Release 3.2 of the annotated Drosophila melanogaster heterochromatin. [FBrf0173307]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Manning, 2001.10.11, Novel kinase: Haspin.: Novel kinase: Haspin. [FBrf0139872]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase.: Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]

Protein sequence record

Swiss-Prot Project Members, 2002.3.1, UniProtKB: P83103: Putative serine/threonine-protein kinase Haspin homolog (EC 2.7.1.-). [FBrf0140158]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]