FlyBase Gene Report: Dmel\Obp83g

General Information

Symbol

Dmel\Obp83g

Species

D. melanogaster

Name

Odorant-binding protein 83g

Annotation Symbol

CG31558

Feature Type

protein_coding_gene

FlyBase ID

FBgn0046875

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

83g, Obp83f, DmelObp83g

Key Links

Genomic Location

Cytogenetic map

83D4-83D4

Sequence location

3R:6,111,671..6,112,302 [-]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:6111671..6112302

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables odorant binding

inferred from electronic annotation with InterPro:IPR006170, InterPro:IPR036728

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with FLYBASE:lush; FB:FBgn0020277

(Vieira and Rozas, 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in sensory perception of chemical stimulus

inferred from sequence or structural similarity with FLYBASE:lush; FB:FBgn0020277

(Vieira and Rozas, 2011)

involved_in sensory perception of smell

inferred from biological aspect of ancestor with PANTHER:PTN000220814

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence model

(Vieira and Rozas, 2011)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000220814

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ODORANT BINDING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ODORANT BINDING PROTEINS -: Odorant Binding Proteins (OBP) are small (10 to 30 kDa) proteins secreted by auxiliary cells surrounding the olfactory receptor neurons. OBPs are characterized by a specific protein domain that comprises six α-helices joined by three disulfide bonds. Although the full function of the OBPs is not well established, it is believed that they may act as molecular carriers that transport odorants and deliver them to the olfactory receptors located on the sensory neurons. (Adapted from FBrf0205523).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Obp83g for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8MZ07)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Obp83g-RA

FBtr0078617

NM_169126

569

146

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Obp83g-PA

FBpp0078266

16.9

146

6.34

Q8MZ07

NP_731043

AAN13232

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8MZ07

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Obp83g using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Obp83g_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.09

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Obp83g in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Obp83g

View exonic expression by tissue for Dmel\Obp83g

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

170878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046875

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046875

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046875

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31558

Flygut - An atlas of the Drosophila adult midgut

FBgn0046875

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Obp83g

Transgenic constructs containing regulatory region of Obp83g

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

flightless, with Scer\GAL4^Mef2.PR

Obp83g^GD2816

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (43)

Agam\OBP9

4 of 12

Yes

Agam\AgaP_AGAP008278

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\OBP28

2 of 12

Agam\AgaP_AGAP008279

1 of 12

Yes

Agam\AgaP_AGAP008280

1 of 12

Yes

Agam\AgaP_AGAP008281

1 of 12

Yes

Agam\AgaP_AGAP008282

1 of 12

Yes

Agam\AgaP_AGAP008283

1 of 12

Yes

Agam\AgaP_AGAP008284

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\OBP33

1 of 12

Yes

Agam\OBP34

1 of 12

Agam\OBP35

1 of 12

Yes

Agam\OBP36

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\OBP45

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Obp83g. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (30)

6 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046875

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83D4-83D4

Sequence location

3R:6,111,671..6,112,302 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83D4-83D4

Limits computationally determined from genome sequence between P{lacW}cas^j1C2 and P{PZ}lab⁰¹²⁴¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

58515

y¹ w^*; Mi{MIC}Obp83g^MI12371

VDRC

v330608

P{VSH330608}attP40

v330609

P{VSH330609}attP40

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE27306

Other clones

DPiM_RE27306

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0046875

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0046875

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Obp83g BcDNA:RE27306

(FlyBase, 1996-)

Additional comments

Source for merge of Obp83g BcDNA:RE27306 was a shared cDNA ( date:030728 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

FlyBase curator comment: The gene referred to as "Obp83f" in FBrf0151704 is not the same gene as the one referred to as "Obp83f" in FBrf0141547. The gene referred to as "Obp83f" in FBrf0151704 corresponds to FBgn0046875 which is referred to in FlyBase with the symbol Obp83g (and corresponds to release 3 annotation CG31558).

(Hekmat-Scafe et al., 2002)

FlyBase curator comment: The gene referred to as "Obp83f" in FBrf0151651 is not the same gene as the one referred to as "Obp83f" in FBrf0141547. The gene referred to as "Obp83f" in FBrf0151651 corresponds to FBgn0046875 which is referred to in FlyBase with the symbol Obp83g (and corresponds to release 3 annotation CG31558).

(Hekmat-Scafe, 2002.3.5)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

83g

(Graham and Davies, 2002, Smith, 2002.1.14, Galindo and Smith, 2001)

BcDNA:RE27306

CG15583

(Graham, 2002.6.18, Vogt et al., 2002, Ponting et al., 2001, Robertson, 2000.4.16, Robertson, 2000.8.17)

CG31558

(Meadows, 2018.10.31)

DmelObp83g

(Vieira and Rozas, 2011, Sánchez-Gracia et al., 2009)

Obp83f

(Hekmat-Scafe, 2002.3.5, Hekmat-Scafe et al., 2002)

Obp83g

(Park et al., 2024, Rihani et al., 2021, He et al., 2019, Menuz et al., 2014, Librado and Rozas, 2013, Zhou et al., 2009, Vieira et al., 2007)

obp83g

(Riveron et al., 2013)

Name Synonyms

Odorant-binding protein 83g

(Galindo and Smith, 2001)

Secondary FlyBase IDs

FBgn0037401
FBgn0051558
FBgn0063042

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

170878

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8MZ07

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8MZ07

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8MZ07

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

170878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046875

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046875

FlyMine - An integrated database for Drosophila genomics

FBgn0046875

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31558

MARRVEL_MODEL - MARRVEL (model organism gene)

170878

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0046875

DroID - A comprehensive database of gene and protein interactions.

FBgn0046875

DRSC - Results frm RNAi screens

FBgn0046875

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Obp83g_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046875

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0046875

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31558

Flygut - An atlas of the Drosophila adult midgut

FBgn0046875

References (39)

The following external sites may use different assemblies or annotations than FlyBase.

-0.09

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