FlyBase Gene Report: Dmel\Obp83cd

General Information

Symbol

Dmel\Obp83cd

Species

D. melanogaster

Name

Odorant-binding protein 83cd

Annotation Symbol

CG15582

Feature Type

protein_coding_gene

FlyBase ID

FBgn0046878

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Obp83c, Obp83d, 83c, 83d

Key Links

Genomic Location

Cytogenetic map

83D4-83D4

Sequence location

3R:6,108,134..6,109,733 [+]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:6108134..6109733

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables odorant binding

inferred from sequence or structural similarity with FLYBASE:lush; FB:FBgn0020277

(Vieira and Rozas, 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in sensory perception of chemical stimulus

inferred from sequence or structural similarity with FLYBASE:lush; FB:FBgn0020277

(Vieira and Rozas, 2011)

involved_in sensory perception of smell

inferred from biological aspect of ancestor with PANTHER:PTN000220814

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence model

(Vieira and Rozas, 2011)

Gene Group (FlyBase)

ODORANT BINDING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ODORANT BINDING PROTEINS -: Odorant Binding Proteins (OBP) are small (10 to 30 kDa) proteins secreted by auxiliary cells surrounding the olfactory receptor neurons. OBPs are characterized by a specific protein domain that comprises six α-helices joined by three disulfide bonds. Although the full function of the OBPs is not well established, it is believed that they may act as molecular carriers that transport odorants and deliver them to the olfactory receptors located on the sensory neurons. (Adapted from FBrf0205523).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Obp83cd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VNL1)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Obp83cd-RA

FBtr0078584

NM_141355

899

242

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Obp83cd-PA

FBpp0078233

28.0

242

6.49

NP_649612

AAF51919

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VNL1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Obp83cd using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Obp83cd_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic/larval fat body

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Obp83cd-lacZ.c}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

labellar taste bristle

(Galindo and Smith, 2001)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Obp83cd in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Obp83cd

View exonic expression by tissue for Dmel\Obp83cd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0046878

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40746/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046878

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046878

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046878

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15582

Flygut - An atlas of the Drosophila adult midgut

FBgn0046878

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Obp83cd

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Obp83cd

Transgenic constructs containing regulatory region of Obp83cd

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Obp83cd^GD748

viable, with Scer\GAL4^Mef2.PR

Obp83cd^GD748

viable, with Scer\GAL4^pnr-MD237

Obp83cd^GD748

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (0)

No records found.

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (0)

No records found.

Rattus norvegicus (Norway rat) (0)

No records found.

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (0)

No records found.

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (29)

Gene Symbol

Score

Source

Alignment

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046878

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83D4-83D4

Sequence location

3R:6,108,134..6,109,733 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83D4-83D4

Limits computationally determined from genome sequence between P{lacW}cas^j1C2 and P{PZ}lab⁰¹²⁴¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85945

w¹¹¹⁸; PBac{PB}Obp83cd^c01174

42844

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02536}attP40

VDRC

v106866

P{KK110200}VIE-260B

v42726

w¹¹¹⁸; P{GD748}v42726

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE67916

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0046878

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0046878

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40746

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

"Obp83c" and "Obp83d" were treated as separate genes in FBrf0141547, but in FBrf0151320 it was reported that they form a single gene with two six-cysteine OBP motifs joined together. RT-PCR with primers that cross the boundary of the two six-cysteine motifs produces a single band, confirming that "Obp83c" and "Obp83d" are encoded by a single transcript. This is also supported by direct sequencing of the PCR products. The single gene that incorporates "Obp83c" and "Obp83d" is named Obp83cd to reflect its hybrid nature.

(Zhou et al., 2004)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40746

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VNL1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VNL1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VNL1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0046878

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0046878

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40746/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0046878

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Obp83cd_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0046878

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0046878

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15582

Flygut - An atlas of the Drosophila adult midgut

FBgn0046878

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40746

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG15582

MARRVEL_MODEL - MARRVEL (model organism gene)

40746

modMine - A data warehouse for the modENCODE project

FBgn0046878

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0046878

DRSC - Results frm RNAi screens

FBgn0046878

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0046878

FlyMine - An integrated database for Drosophila genomics

FBgn0046878

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

83c

(Smith, 2002.1.14, Galindo and Smith, 2001)

83c-1

(Graham and Davies, 2002)

83c-2

(Graham and Davies, 2002)

83d

(Smith, 2002.1.14, Galindo and Smith, 2001)

CG15582

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wittkopp et al., 2008, Landry et al., 2005, Wittkopp et al., 2004, Zhou et al., 2004, Graham, 2002.6.18, Robertson, 2000.4.16, Robertson, 2000.8.17)

DmelObp83cd

(Vieira and Rozas, 2011)

OBP83c

(Rihani et al., 2021)

Obp83c

(Mackay et al., 2005, Hekmat-Scafe, 2002.3.5, Hekmat-Scafe et al., 2002)

Obp83cd

(He et al., 2019, Crocker et al., 2016, Bischof and FlyORF project members, 2014.6.20, Menuz et al., 2014, Librado and Rozas, 2013, Martin et al., 2013, Short and Lazzaro, 2013, Japanese National Institute of Genetics, 2012.5.21, Zhou et al., 2009, Wittkopp et al., 2008, Vieira et al., 2007)

Obp83d

(Hekmat-Scafe, 2002.3.5, Hekmat-Scafe et al., 2002)

Name Synonyms

Odorant-binding protein 83c

(Galindo and Smith, 2001)

Odorant-binding protein 83cd

Odorant-binding protein 83d

(Galindo and Smith, 2001)

odorant receptor 83cd

(Pospisilik et al., 2010)

Secondary FlyBase IDs