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Gene Dmel\Tret1-1

General Information
Symbol	Dmel\Tret1-1	Species	D. melanogaster
Name	Trehalose transporter 1-1	Annotation symbol	CG30035
Feature type	protein_coding_gene	FlyBase ID	FBgn0050035
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CG7801
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48B6-48B7	Sequence location	2R:7,553,259..7,562,287 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Trehalose transporter 1-1 is referred to in FlyBase by the symbol Dmel\Tret1-1 (CG30035, FBgn0050035). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: glucose transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: trehalose transport. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: General substrate transporter; Major facilitator superfamily domain; Major facilitator superfamily domain, general substrate transporter; Sugar transporter, conserved site; Sugar/inositol transporter. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1627582_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG30035. Gene sequence location is 2R:7553259..7562287.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features HFA07048 BKN31741 HFA07046
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48B6-48B7   Limits computationally determined from genome sequence between P{lacW}oho48Ak06524 and P{EP}walEP825&P{PZ}wal02516
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tret1-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tret1-1-RA FBtr0088073  NM_136849   3146   857 Tret1-1-RB FBtr0088074  NM_165845   2075   489
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tret1-1-PA   FBpp0087178   95.2   857   8.46     NP_610693   AAF58632 Tret1-1-PB   FBpp0087179   53.0   489   8.68     NP_725068   AAF58631
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sugar/inositol transporter (IPR003663) Sugar transporter, conserved site (IPR005829) Major facilitator superfamily domain, general substrate transporter (IPR016196) General substrate transporter (IPR005828) Major facilitator superfamily domain (IPR020846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699004   AA801511   AA801563   AA801861   AA949872   AA990903   AE013599 AAF58631   AE013599 AAF58632   AI063240   AI063939   AI109421   AI114095   AI134092   AI134789   AI259836   AI297511   AI389529   AI404026   AI405749   AK283564   AY122079   BG639304   BI166287   BI168195   BI172235   BI213729   BI230835   BI231039   BI236089   BI237199   BI239662   BI240321   BI242642   BI362041   BI363667   BI366310   BI367721   BI367834   BI369266   BI484050   BI567283   BI567318   BI567941   BI569738   BI573994   BI573995   BI574758   BI574855   BI576240   BI576555   BI582079   BI582084   BI586649   BI588166   BI588169   BI588302   BI589615   BI589645   BI590035   BI590640   BI604557   BI605526   BI605894   BI608261   BI619823   BI620177   BI621047   BI621660   BI622200   BI628737   BI628962   BI629833   BT003466 AAO39469   BT010286 AAQ23604   CK661390   CK662273   CO180279   CO188034   CO262858   CO268985   CO288381   CO300012   CO317759   CO318972   CO319535   CO342259   EC059169   EC078756   EC079958   EC081553   EC082027   EC199783   EC204191   EC206650   EC214799   EC215808   EC243051   EC254814   EL879185   EL881440   EV580086   EV586531
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z8N1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0050035    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0050035 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0050035 expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr    3135 embryo 08-10hr    5018 embryo 10-12hr    5211 embryo 12-14hr    2304 embryo 14-16hr    1942 embryo 16-18hr    1617 embryo 18-20hr    1825 embryo 20-22hr    7181 embryo 22-24hr    6372 larva L1    3341 larva L2    2624 larva L3 12hr old    4095 larva L3 puffstage 1-2    4513 larva L3 puffstage 3-6    4923 larva L3 puffstage 7-9    2544 white prepupae new    1726 white prepupae 12hr    3326 white prepupae 24hr    982 pupae 2d postWPP    1571 pupae 3d postWPP    1877 pupae 4d postWPP    11460 adult male 01day    7981 adult male 05day    7746 adult male 30day    5312 adult female 01day    4653 adult female 05day    2646 adult female 30day    2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr  (129) embryo 04-06hr  (446) embryo 06-08hr  (3135) embryo 08-10hr  (5018) embryo 10-12hr  (5211) embryo 12-14hr  (2304) embryo 14-16hr  (1942) embryo 16-18hr  (1617) embryo 18-20hr  (1825) embryo 20-22hr  (7181) embryo 22-24hr  (6372) larva L1  (3341) larva L2  (2624) larva L3 12hr old  (4095) larva L3 puffstage 1-2  (4513) larva L3 puffstage 3-6  (4923) larva L3 puffstage 7-9  (2544) white prepupae new  (1726) white prepupae 12hr  (3326) white prepupae 24hr  (982) pupae 2d postWPP  (1571) pupae 3d postWPP  (1877) pupae 4d postWPP  (11460) adult male 01day  (7981) adult male 05day  (7746) adult male 30day  (5312) adult female 01day  (4653) adult female 05day  (2646) adult female 30day  (2067) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr  (3135) embryo 08-10hr  (5018) embryo 10-12hr  (5211) embryo 12-14hr  (2304) embryo 14-16hr  (1942) embryo 16-18hr  (1617) embryo 18-20hr  (1825) embryo 20-22hr  (7181) embryo 22-24hr  (6372) larva L1  (3341) larva L2  (2624) larva L3 12hr old  (4095) larva L3 puffstage 1-2  (4513) larva L3 puffstage 3-6  (4923) larva L3 puffstage 7-9  (2544) white prepupae new  (1726) white prepupae 12hr  (3326) white prepupae 24hr    982 pupae 2d postWPP  (1571) pupae 3d postWPP  (1877) pupae 4d postWPP  (11460) adult male 01day  (7981) adult male 05day  (7746) adult male 30day  (5312) adult female 01day  (4653) adult female 05day  (2646) adult female 30day  (2067) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr    3135 embryo 08-10hr    5018 embryo 10-12hr    5211 embryo 12-14hr    2304 embryo 14-16hr    1942 embryo 16-18hr    1617 embryo 18-20hr    1825 embryo 20-22hr    7181 embryo 22-24hr    6372 larva L1    3341 larva L2    2624 larva L3 12hr old    4095 larva L3 puffstage 1-2    4513 larva L3 puffstage 3-6    4923 larva L3 puffstage 7-9    2544 white prepupae new    1726 white prepupae 12hr    3326 white prepupae 24hr    982 pupae 2d postWPP    1571 pupae 3d postWPP    1877 pupae 4d postWPP  (11460) adult male 01day    7981 adult male 05day    7746 adult male 30day    5312 adult female 01day    4653 adult female 05day    2646 adult female 30day    2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr    3135 embryo 08-10hr    5018 embryo 10-12hr    5211 embryo 12-14hr    2304 embryo 14-16hr    1942 embryo 16-18hr    1617 embryo 18-20hr    1825 embryo 20-22hr    7181 embryo 22-24hr    6372 larva L1    3341 larva L2    2624 larva L3 12hr old    4095 larva L3 puffstage 1-2    4513 larva L3 puffstage 3-6    4923 larva L3 puffstage 7-9    2544 white prepupae new    1726 white prepupae 12hr    3326 white prepupae 24hr    982 pupae 2d postWPP    1571 pupae 3d postWPP    1877 pupae 4d postWPP    11460 adult male 01day    7981 adult male 05day    7746 adult male 30day    5312 adult female 01day    4653 adult female 05day    2646 adult female 30day    2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0050035 expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr    3135 embryo 08-10hr    5018 embryo 10-12hr    5211 embryo 12-14hr    2304 embryo 14-16hr    1942 embryo 16-18hr    1617 embryo 18-20hr    1825 embryo 20-22hr    7181 embryo 22-24hr    6372 larva L1    3341 larva L2    2624 larva L3 12hr old    4095 larva L3 puffstage 1-2    4513 larva L3 puffstage 3-6    4923 larva L3 puffstage 7-9    2544 white prepupae new    1726 white prepupae 12hr    3326 white prepupae 24hr    982 pupae 2d postWPP    1571 pupae 3d postWPP    1877 pupae 4d postWPP    11460 adult male 01day    7981 adult male 05day    7746 adult male 30day    5312 adult female 01day    4653 adult female 05day    2646 adult female 30day    2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr  129 embryo 04-06hr  (446) embryo 06-08hr  (3135) embryo 08-10hr  (5018) embryo 10-12hr  (5211) embryo 12-14hr  (2304) embryo 14-16hr  (1942) embryo 16-18hr  (1617) embryo 18-20hr  (1825) embryo 20-22hr  (7181) embryo 22-24hr  (6372) larva L1  (3341) larva L2  (2624) larva L3 12hr old  (4095) larva L3 puffstage 1-2  (4513) larva L3 puffstage 3-6  (4923) larva L3 puffstage 7-9  (2544) white prepupae new  (1726) white prepupae 12hr  (3326) white prepupae 24hr  (982) pupae 2d postWPP  (1571) pupae 3d postWPP  (1877) pupae 4d postWPP  (11460) adult male 01day  (7981) adult male 05day  (7746) adult male 30day  (5312) adult female 01day  (4653) adult female 05day  (2646) adult female 30day  (2067) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr  (3135) embryo 08-10hr  (5018) embryo 10-12hr  (5211) embryo 12-14hr  2304 embryo 14-16hr  1942 embryo 16-18hr  1617 embryo 18-20hr  1825 embryo 20-22hr  (7181) embryo 22-24hr  (6372) larva L1  (3341) larva L2  (2624) larva L3 12hr old  (4095) larva L3 puffstage 1-2  (4513) larva L3 puffstage 3-6  (4923) larva L3 puffstage 7-9  (2544) white prepupae new  1726 white prepupae 12hr  (3326) white prepupae 24hr    982 pupae 2d postWPP  1571 pupae 3d postWPP  1877 pupae 4d postWPP  (11460) adult male 01day  (7981) adult male 05day  (7746) adult male 30day  (5312) adult female 01day  (4653) adult female 05day  (2646) adult female 30day  2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr    3135 embryo 08-10hr    5018 embryo 10-12hr    5211 embryo 12-14hr    2304 embryo 14-16hr    1942 embryo 16-18hr    1617 embryo 18-20hr    1825 embryo 20-22hr    7181 embryo 22-24hr    6372 larva L1    3341 larva L2    2624 larva L3 12hr old    4095 larva L3 puffstage 1-2    4513 larva L3 puffstage 3-6    4923 larva L3 puffstage 7-9    2544 white prepupae new    1726 white prepupae 12hr    3326 white prepupae 24hr    982 pupae 2d postWPP    1571 pupae 3d postWPP    1877 pupae 4d postWPP  11460 adult male 01day    7981 adult male 05day    7746 adult male 30day    5312 adult female 01day    4653 adult female 05day    2646 adult female 30day    2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    129 embryo 04-06hr    446 embryo 06-08hr    3135 embryo 08-10hr    5018 embryo 10-12hr    5211 embryo 12-14hr    2304 embryo 14-16hr    1942 embryo 16-18hr    1617 embryo 18-20hr    1825 embryo 20-22hr    7181 embryo 22-24hr    6372 larva L1    3341 larva L2    2624 larva L3 12hr old    4095 larva L3 puffstage 1-2    4513 larva L3 puffstage 3-6    4923 larva L3 puffstage 7-9    2544 white prepupae new    1726 white prepupae 12hr    3326 white prepupae 24hr    982 pupae 2d postWPP    1571 pupae 3d postWPP    1877 pupae 4d postWPP    11460 adult male 01day    7981 adult male 05day    7746 adult male 30day    5312 adult female 01day    4653 adult female 05day    2646 adult female 30day    2067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0050035    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0050035 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0050035 expression level Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body    2968.1 Larval Salivary Gland    529.3 Larval Trachea    78.825 Larval Carcass    820.875 Adult Head    1422.6 Adult Eye    660.95 Adult Brain    1031.1 Adult Thoracic-Abdominal Ganglion    1129.2 Adult Crop    826.5 Adult Midgut    220.1 Adult Hindgut    1820.8 Adult Malpighian Tubules    2827.6 Adult Fat Body    5005 Adult Salivary Gland    1558.1 Adult Heart    2609.075 Adult VirginFemale Spermatheca    4725.9 Adult InseminatedFemale Spermatheca    4320.1 Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass    2494 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body  (2968.1) Larval Salivary Gland  529.3 Larval Trachea    78.825 Larval Carcass  (820.875) Adult Head  (1422.6) Adult Eye  (660.95) Adult Brain  (1031.1) Adult Thoracic-Abdominal Ganglion  (1129.2) Adult Crop  (826.5) Adult Midgut    220.1 Adult Hindgut  (1820.8) Adult Malpighian Tubules  (2827.6) Adult Fat Body  (5005) Adult Salivary Gland  (1558.1) Adult Heart  (2609.075) Adult VirginFemale Spermatheca  (4725.9) Adult InseminatedFemale Spermatheca  (4320.1) Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass  (2494) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body  (2968.1) Larval Salivary Gland    529.3 Larval Trachea    78.825 Larval Carcass    820.875 Adult Head  (1422.6) Adult Eye    660.95 Adult Brain  1031.1 Adult Thoracic-Abdominal Ganglion  (1129.2) Adult Crop    826.5 Adult Midgut    220.1 Adult Hindgut  (1820.8) Adult Malpighian Tubules  (2827.6) Adult Fat Body  (5005) Adult Salivary Gland  (1558.1) Adult Heart  (2609.075) Adult VirginFemale Spermatheca  (4725.9) Adult InseminatedFemale Spermatheca  (4320.1) Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass  (2494) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body    2968.1 Larval Salivary Gland    529.3 Larval Trachea    78.825 Larval Carcass    820.875 Adult Head    1422.6 Adult Eye    660.95 Adult Brain    1031.1 Adult Thoracic-Abdominal Ganglion    1129.2 Adult Crop    826.5 Adult Midgut    220.1 Adult Hindgut    1820.8 Adult Malpighian Tubules    2827.6 Adult Fat Body    5005 Adult Salivary Gland    1558.1 Adult Heart    2609.075 Adult VirginFemale Spermatheca    4725.9 Adult InseminatedFemale Spermatheca    4320.1 Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass    2494 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0050035 expression level Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body    2968.1 Larval Salivary Gland    529.3 Larval Trachea    78.825 Larval Carcass    820.875 Adult Head    1422.6 Adult Eye    660.95 Adult Brain    1031.1 Adult Thoracic-Abdominal Ganglion    1129.2 Adult Crop    826.5 Adult Midgut    220.1 Adult Hindgut    1820.8 Adult Malpighian Tubules    2827.6 Adult Fat Body    5005 Adult Salivary Gland    1558.1 Adult Heart    2609.075 Adult VirginFemale Spermatheca    4725.9 Adult InseminatedFemale Spermatheca    4320.1 Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass    2494 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body  (2968.1) Larval Salivary Gland  529.3 Larval Trachea    78.825 Larval Carcass  (820.875) Adult Head  (1422.6) Adult Eye  660.95 Adult Brain  (1031.1) Adult Thoracic-Abdominal Ganglion  (1129.2) Adult Crop  (826.5) Adult Midgut    220.1 Adult Hindgut  (1820.8) Adult Malpighian Tubules  (2827.6) Adult Fat Body  (5005) Adult Salivary Gland  (1558.1) Adult Heart  (2609.075) Adult VirginFemale Spermatheca  (4725.9) Adult InseminatedFemale Spermatheca  (4320.1) Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass  (2494) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body  (2968.1) Larval Salivary Gland    529.3 Larval Trachea    78.825 Larval Carcass    820.875 Adult Head  1422.6 Adult Eye    660.95 Adult Brain  1031.1 Adult Thoracic-Abdominal Ganglion  1129.2 Adult Crop    826.5 Adult Midgut    220.1 Adult Hindgut  (1820.8) Adult Malpighian Tubules  (2827.6) Adult Fat Body  (5005) Adult Salivary Gland  1558.1 Adult Heart  (2609.075) Adult VirginFemale Spermatheca  (4725.9) Adult InseminatedFemale Spermatheca  (4320.1) Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass  (2494) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.9 Larval Midgut    175.3 Larval Hindgut    405.3 Larval Malpighian Tubules    18 Larval Fat Body    2968.1 Larval Salivary Gland    529.3 Larval Trachea    78.825 Larval Carcass    820.875 Adult Head    1422.6 Adult Eye    660.95 Adult Brain    1031.1 Adult Thoracic-Abdominal Ganglion    1129.2 Adult Crop    826.5 Adult Midgut    220.1 Adult Hindgut    1820.8 Adult Malpighian Tubules    2827.6 Adult Fat Body    5005 Adult Salivary Gland    1558.1 Adult Heart    2609.075 Adult VirginFemale Spermatheca    4725.9 Adult InseminatedFemale Spermatheca    4320.1 Adult Ovary    138 Adult Testis    66.2 Adult Male Accessory Gland    192.4 Adult Carcass    2494 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1422.6   NA  Eye    660.95   NA  Brain    1031.1   346.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1129.2   NA  Crop    826.5   175.3  Midgut    220.1   405.3  Hindgut    1820.8   18  Malpighian Tubules    2827.6   2968.1  Fat Body    5005   529.3  Salivary Gland    1558.1   NA  Heart    2609.075   78.825  Trachea    NA   NA  VirginFemale Spermatheca    4725.9   NA  InseminatedFemale Spermatheca    4320.1   NA  Ovary    138   NA  Testis    66.2   NA  Male Accessory Gland    192.4   820.875  Carcass    2494 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050035 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30035-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tret1-1 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Tret1-1GD3500 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Tret1-1 Class Mutagen Stocks Known lesion Tret1-1HP20718 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tret1-1 Class Mutagen Stocks Known lesion Tret1-1GD17787 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Tret1-1GD3500 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tret1-1KK111741 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{Switch2}Roc2GSG10703 NA PBac{PB}Roc2c00839 NA insertion of enhancer trap P{lacW}l(2)SH2141SH2141 No insertion of mobile activating element P{EPg}Tret1-1HP20718 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
trehalose transport inferred from direct assay (Kanamori et al., 2010)
Cellular Component
CV term Evidence References
membrane inferred from direct assay (Kanamori et al., 2010)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
glucose transmembrane transporter activity inferred from sequence or structural similarity with EMBL:AJ245935 (FlyBase, 1992-)
Biological Process
CV term Evidence References
carbohydrate transport inferred from sequence or structural similarity with EMBL:AJ245935 (FlyBase, 1992-) transmembrane transport inferred from electronic annotation with InterPro:IPR003663, InterPro:IPR005828, InterPro:IPR005829 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with EMBL:AJ245935 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tret1-1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62035 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0050035 DroID - A comprehensive database of gene and protein interactions. • FBgn0050035 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36248
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dmir\CG30035 (Bachtrog and Andolfatto, 2006) Dpse\GA15593
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000567-PA Aedes aegypti (mosquito) AGAP005563-PA Anopheles gambiae (mosquito) XP_001950990.1 Acyrthosiphon pisum (pea aphid) At1g75220.1 Arabidopsis thaliana (wall cress) BGIBMGA003739-PA Bombyx mori (silk worm) CN17256 Caenorhabditis brenneri (small nematode) CBP29605 Caenorhabditis briggsae (nematode) CE33672 Caenorhabditis elegans (worm) ENSCINP00000003039 Ciona intestinalis (sea squirt) ENSCINP00000019539 Ciona intestinalis (sea squirt) cn01089 Cryptococcus neoformans (yeast-like fungus) CPIJ004516 Culex pipens (mosquito) 102641 Chlamidomonas reinhardtii (green alga) RP07183 Caenorhabditis remanei (nematode) ENSCSAVP00000010642 Ciona savignyi (sedentary tunicate) ENSCSAVP00000018093 Ciona savignyi (sedentary tunicate) ISCW024553-PA Ixodes scapularis (deer tick) LmjF24.0680 Leishmania major (virus) 10586 Monocosta brevicollis (choanoflagellate) 204860 Nematostella vectensis (starlet anemone) LOC_Os05g50280.1 Oryza sativa (asian rice) 29494 Ostreococcus tauri (green alga) 151328 Physcomitrella patens (moss) 154781 Physcomitrella patens (moss) 187073 Physcomitrella patens (moss) 756426 Populus trichocarpa (black cottonwood) 764739 Populus trichocarpa (black cottonwood) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17456 LH11300 ISCW024553 ISCW010927 ISCW008444 ISCW004892 FBgn0230119 FBgn0224097 FBgn0207506 FBgn0182571 FBgn0182570 FBgn0177919 FBgn0176180 FBgn0176179 FBgn0171004 JGI_V11_311075 JGI_V11_110580 JGI_V11_304267 FBgn0075610 FBgn0149028 FBgn0141311 FBgn0033644 FBgn0128854 FBgn0112404 FBgn0090148 FBgn0090147 CPIJ004516 BGIBMGA003740 BGIBMGA003739 ACYPI009720 ACYPI000812 GB13688 AGAP005563 AAEL000567 PHUM616040 GLEAN_04741 GLEAN_00121 GLEAN_13653
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	21925 w1118; P{EPg}Tret1-1HP20718
VDRC	v103045 P{KK111741}VIE-260B v8126 w1118; P{GD3500}v8126 v52360 w1118 P{GD17787}v52360 v52361 w1118 P{GD17787}v52361
Genomic Clones ( 2 )
	BACR35F01 BACR38D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 95 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT19440 LP03341 RH04286
Other clones	DPiM_LP03341
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02807 GH04061 GH08612 GH10775 GH11450 GH12336 GH20735 GH23609 GH25870 GM03494 HL02695 HL06673 HL06681 LD29920 LD34416 LP11823 LP20863 LP22357 RE06361 RE08776 RE14541 RE15283 RE17925 RE19215 RE32087 RE33381 RE36220 RE37142 RE40038 RE46494 RE48580 RE51820 RE53531 RE53682 RE55388 RE67076 RH01878 RH03070 RH03116 RH03586 RH12453 RH19978 RH19983 RH26585 RH26726 RH27401 RH29268 RH29273 RH29463 RH32765 RH33142 RH37191 RH37446 RH39255 RH50942 RH51253 RH52322 RH53041 RH54036 RH57266 RH57737 RH58754 RH69968 RH71164 RH71903
Other clones	50975 147008 164534 174686 183169 214279.24 CK01.8B.B12 CK01.42D.G5 CK01.86C.H4 CK01.102D.D10 CK01.122A.B8 Dmel_dig_005233_0714_1055 Dmel_neb_012745_0089_3044 EC01345 EK036327 EK068362 EK086545 EK093240 EK177226 EK269019 EK275653 EK278807 EP14312 IP09167 IP11221 RH09429
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0050035 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36248
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tret1-1 CG30035 (Kanamori et al., 2010)
Source for database merge of	Source for merge of: CG7797 CG7801 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG7797 and CG7801 merged as CG30035 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136849 NM_165845 RefSeq (Proteins) • NP_610693 NP_725068 DDBJ / EMBL / GenBank • AAF58631 AAF58632 AAO39469 AAQ23604 AI259836 BG639304 BI590640 BT003466 BT010286 Entrez Gene - A searchable database of RefSeq genes. • 36248 UniProtKB/TrEMBL • A1Z8N1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sugar/inositol transporter (IPR003663) Sugar transporter, conserved site (IPR005829) Major facilitator superfamily domain, general substrate transporter (IPR016196) General substrate transporter (IPR005828) Major facilitator superfamily domain (IPR020846)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62035 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0050035 DroID - A comprehensive database of gene and protein interactions. • FBgn0050035 DRSC - Results from RNAi screens. • FBgn0050035 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050035 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30035-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0050035 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36248 InParanoid A subset of ortholog calls from InParanoid. • AAEL000567-PA Aedes aegypti (mosquito) AGAP005563-PA Anopheles gambiae (mosquito) XP_001950990.1 Acyrthosiphon pisum (pea aphid) At1g75220.1 Arabidopsis thaliana (wall cress) BGIBMGA003739-PA Bombyx mori (silk worm) CN17256 Caenorhabditis brenneri (small nematode) CBP29605 Caenorhabditis briggsae (nematode) CE33672 Caenorhabditis elegans (worm) ENSCINP00000003039 Ciona intestinalis (sea squirt) ENSCINP00000019539 Ciona intestinalis (sea squirt) cn01089 Cryptococcus neoformans (yeast-like fungus) CPIJ004516 Culex pipens (mosquito) 102641 Chlamidomonas reinhardtii (green alga) RP07183 Caenorhabditis remanei (nematode) ENSCSAVP00000010642 Ciona savignyi (sedentary tunicate) ENSCSAVP00000018093 Ciona savignyi (sedentary tunicate) ISCW024553-PA Ixodes scapularis (deer tick) LmjF24.0680 Leishmania major (virus) 10586 Monocosta brevicollis (choanoflagellate) 204860 Nematostella vectensis (starlet anemone) LOC_Os05g50280.1 Oryza sativa (asian rice) 29494 Ostreococcus tauri (green alga) 151328 Physcomitrella patens (moss) 154781 Physcomitrella patens (moss) 187073 Physcomitrella patens (moss) 756426 Populus trichocarpa (black cottonwood) 764739 Populus trichocarpa (black cottonwood) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36248 modMine - Data generated by the modENCODE project. • FBgn0050035 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17456 LH11300 ISCW024553 ISCW010927 ISCW008444 ISCW004892 FBgn0230119 FBgn0224097 FBgn0207506 FBgn0182571 FBgn0182570 FBgn0177919 FBgn0176180 FBgn0176179 FBgn0171004 JGI_V11_311075 JGI_V11_110580 JGI_V11_304267 FBgn0075610 FBgn0149028 FBgn0141311 FBgn0033644 FBgn0128854 FBgn0112404 FBgn0090148 FBgn0090147 CPIJ004516 BGIBMGA003740 BGIBMGA003739 ACYPI009720 ACYPI000812 GB13688 AGAP005563 AAEL000567 PHUM616040 GLEAN_04741 GLEAN_00121 GLEAN_13653
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG7797 (Goldman and Arbeitman, 2007) CG7801 (Roxstrom-Lindquist et al., 2004, Lai et al., 2007) CG30035 (Kanamori et al., 2010, Nicholson et al., 2008, Goldman and Arbeitman, 2007, Kadener et al., 2007, Toledano-Katchalski et al., 2007, Reynolds et al., 2008, Keleman et al., 2009.8.5, Kadam et al., 2009, Rehwinkel et al., 2005, Zhan et al., 2011, Cunha et al., 2010) DmTret1-1 (Kanamori et al., 2010) Tret1-1
Name Synonym	CG7797 (Goldman and Arbeitman, 2007) Trehalose transporter 1-1
Secondary FlyBase IDs
	FBgn0033642 FBgn0033643
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Kanamori et al., 2010, Insect Biochem. Mol. Biol. 40(1): 30--37 The trehalose transporter 1 gene sequence is conserved in insects and encodes proteins with different kinetic properties involved in trehalose import into peripheral tissues. [FBrf0210033] Show all research papers ...