FlyBase Gene Report: Dmel\GEFmeso

General Information

Symbol

Dmel\GEFmeso

Species

D. melanogaster

Name

Guanine nucleotide exchange factor in mesoderm

Annotation Symbol

CG30115

Feature Type

protein_coding_gene

FlyBase ID

FBgn0050115

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Snapshot

Guanine nucleotide exchange factor in mesoderm (GEFmeso) encodes a protein that regulates the products of Rala and Cdc42. It is involved in leg morphogenesis and wing vein specification. [Date last reviewed: 2019-07-11]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:18,554,119..18,611,777 [-]

Recombination map

2-86

RefSeq locus

NT_033778 REGION:18554119..18611777

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from physical interaction with FLYBASE:Cdc42; FB:FBgn0010341

(Blanke and Jackle, 2006)

enables small GTPase binding

inferred from direct assay

(Blanke and Jackle, 2006)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Greenberg and Hatini, 2011)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Blanke and Jackle, 2006)

involved_in regulation of Cdc42 protein signal transduction

inferred from physical interaction with FLYBASE:Cdc42; FB:FBgn0010341

(Blanke and Jackle, 2006)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

There is no information supporting a Cellular Component term for this gene. (Based on a review of available data on: 2013-08-23 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\GEFmeso for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

GEFmeso-RE

FBtr0300421

NM_176223

5909

1549

GEFmeso-RF

FBtr0310055

NM_001274146

6170

878

GEFmeso-RG

FBtr0340387

NM_137499

5600

1237

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

GEFmeso-PE

FBpp0289650

171.7

1549

7.34

NP_788403

AAF57673

GEFmeso-PF

FBpp0301756

96.4

878

7.42

NP_001261075

AGB93607

GEFmeso-PG

FBpp0309333

138.7

1237

7.54

NP_611343

AAF57674

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GEFmeso using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)

fat body primordium

Comment: reported as fat body specific anlage

(Fisher et al., 2012)

fat body/gonad primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic stomatogastric nervous system

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic stage 5

mesoderm anlage

(Blanke and Jackle, 2006)

embryonic stage 7

organism | pair rule expression pattern

(Blanke and Jackle, 2006)

embryonic stage 11

somatic mesoderm

(Blanke and Jackle, 2006)

visceral mesoderm

(Blanke and Jackle, 2006)

embryonic stage 16

embryonic/larval apodeme

(Blanke and Jackle, 2006)

embryonic/larval dorsal vessel

(Blanke and Jackle, 2006)

muscle attachment site

(Blanke and Jackle, 2006)

third instar larval stage

wing disc

(Blanke and Jackle, 2006)

eye disc

(Blanke and Jackle, 2006)

ventral thoracic disc

(Blanke and Jackle, 2006)

prepupal stage P3

joint

(Greenberg and Hatini, 2011)

Additional Descriptive Data

Expression in stage P3 pupal leg discs is restricted to presumptive leg joints.

(Greenberg and Hatini, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GEFmeso in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\GEFmeso

View exonic expression by tissue for Dmel\GEFmeso

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0050115

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0050115

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG30115-RD

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30115

Flygut - An atlas of the Drosophila adult midgut

FBgn0050115

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\GEFmeso

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of GEFmeso

Transgenic constructs containing regulatory region of GEFmeso

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage, with Scer\GAL4^Act5C.PU

GEFmeso^UAS.cBa

lethal - all die before end of larval stage, with Scer\GAL4^T80

GEFmeso^UAS.cBa

lethal - all die before end of pupal stage, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG

GEFmeso^DHPH.UAS

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

GEFmeso^GD8852

partially lethal - majority die, with Scer\GAL4^pnr-MD237

GEFmeso^GD8852

viable, with Scer\GAL4^tin.CΔ4

GEFmeso^GD8852

Other Phenotypes

Allele

some die during larval stage, with Scer\GAL4^Act5C.PU

GEFmeso^UAS.cBa

some die during larval stage, with Scer\GAL4^T80

GEFmeso^UAS.cBa

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

GEFmeso^GD8852

some die during pupal stage, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG

GEFmeso^DHPH.UAS

some die during pupal stage, with Scer\GAL4^pnr-MD237

GEFmeso^GD8852

Phenotype manifest in

Allele

crossvein, with Scer\GAL4^en-e16E

crossvein | increased number, with Scer\GAL4^en-e16E

mesoderm, with Scer\GAL4^nullo.PG

GEFmeso^DHPH.UAS

mesoderm, with Scer\GAL4^V3

GEFmeso^DHPH.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PLEKHG2

8 of 15

Yes

Hsap\PLEKHG1

7 of 15

Yes

Hsap\PLEKHG3

5 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Plekhg2

8 of 15

Yes

Mmus\Plekhg3

7 of 15

Yes

Mmus\Plekhg1

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (6)

Rnor\Plekhg1

7 of 13

Yes

Rnor\Plekhg2

6 of 13

Yes

Rnor\Arhgef40

1 of 13

Rnor\Plekhg3

1 of 13

Yes

Rnor\Plekhn1

1 of 13

Rnor\RGD1563354

1 of 13

Xenopus tropicalis (Western clawed frog) (5)

Xtro\plekhg1

4 of 12

Yes

Xtro\plekhg3

3 of 12

Yes

Xtro\arhgef40

1 of 12

Xtro\plekhg2

1 of 12

Yes

Xtro\plekhn1

1 of 12

Danio rerio (Zebrafish) (13)

Drer\plekhg2

3 of 15

Yes

Drer\plekhg3

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\mcf2l2

1 of 15

Drer\pex13

1 of 15

Drer\plekhg1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\uig-1

8 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CDC24

2 of 15

Yes

Scer\PEX13

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\pex13

1 of 12

Yes

Spom\scd1

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900RU )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15660

Drosophila persimilis

Dper\GL17446

Drosophila willistoni

Dwil\GK19539

Drosophila virilis

Dvir\GJ21156

Drosophila mojavensis

Dmoj\GI19581

Drosophila grimshawi

Dgri\GH21609

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17024936

Glossina morsitans

Tsetse fly

Gmor\GMOY006989

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03857

Mayetiola destructor

Hessian fly

Mdes\Mdes006537

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001244

Anopheles darlingi

American malaria mosquito

Adar\ADAC001903

Anopheles gambiae

Malaria mosquito

Agam\AGAP007685

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018471

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00DE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000109

Danaus plexippus

Monarch butterfly

Dple\DPOGS211984-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014991

Apis florea

Little honeybee

Aflo\2805027204

Apis mellifera

Western honey bee

Amel\GB44247

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23686

Bombus terrestris

Buff-tailed bumblebee

Bter\15207269

Linepithema humile

Argentine ant

Lhum\LH25170

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0014c9

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002753

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12276

Tribolium castaneum

Red flour beetle

Tcas\TC003092

Rhodnius prolixus

Kissing bug

Rpro\RPRC004338

Cimex lectularius

Bed bug

Clec\CLEC005151

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI36304

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17522

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00CO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003766

Ixodes scapularis

Black-legged tick

Isca\ISCW013397

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82310.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82312.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82311.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur14g03860

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_327333

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_120723

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_31894

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_30584

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_251490

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00JV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Plekhg1

Gallus gallus

Domestic chicken

Ggal\PLEKHG1

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026450

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (9)

Gene Symbol

Score

Source

Alignment

sif

2 of 10

Vav

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PLEKHG2; pleckstrin homology and RhoGEF domain containing G2

8 of 15

611893

LEUKODYSTROPHY AND ACQUIRED MICROCEPHALY WITH OR WITHOUT DYSTONIA; LDAMD

PLEKHG1; pleckstrin homology and RhoGEF domain containing G1

7 of 15

PLEKHG3; pleckstrin homology and RhoGEF domain containing G3

5 of 15

617940

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

GEFmeso - Cdc42

enzymatic study, pull down, autoradiography

(Sundaram, 2015, Blanke and Jackle, 2006)

GEFmeso - Rac1

enzymatic study

(Sundaram, 2015)

GEFmeso - Rala

pull down, autoradiography, two hybrid

(Blanke and Jackle, 2006)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62808

DroID - A comprehensive database of gene and protein interactions.

FBgn0050115

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37134

MIST (protein-protein) - An integrated Molecular Interaction Database

GEFmeso

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-86

Cytogenetic map

55D3-55E1

Sequence location

2R:18,554,119..18,611,777 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55D3-55E1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-86

(FlyBase, 2016)

2-90.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

17169

w¹¹¹⁸; P{EP}GEFmeso^EP437

29143

w¹¹¹⁸; Mi{ET1}GEFmeso^MB10683

42545

y¹ v¹; P{TRiP.HMJ02116}attP40

43818

y¹ w^*; Mi{MIC}GEFmeso^MI07372

44820

y¹ w^*; Mi{MIC}GEFmeso^MI08763

38139

y¹ w^*; Mi{MIC}GEFmeso^MI04600/SM6a

76168

y¹ w^*; Mi{Trojan-GAL4.1}GEFmeso^{MI04600-TG4.1}

VDRC

v39952

w¹¹¹⁸ P{GD8852}v39952

Genomic Clones (34)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (68)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI17866

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0050115

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0050115

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37134

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: GEFmeso CG30115

(Blanke and Jackle, 2006)

Source for database merge of

Source for merge of: CG18430 CG5503

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG18430 and CG5503 merged as CG30115 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37134

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0050115

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0050115

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30115

Flygut - An atlas of the Drosophila adult midgut

FBgn0050115

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37134

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003092

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG30115

modMine - A data warehouse for the modENCODE project

FBgn0050115

Linkouts

BioGRID - A database of protein and genetic interactions.

62808

DroID - A comprehensive database of gene and protein interactions.

FBgn0050115

DRSC - Results frm RNAi screens

FBgn0050115

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0050115

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG30115-RD

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0050115

FlyMine - An integrated database for Drosophila genomics

FBgn0050115

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37134

MIST (protein-protein) - An integrated Molecular Interaction Database

GEFmeso

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG18430

CG30115

(Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Greenberg and Hatini, 2011, Luo et al., 2011, Frise et al., 2010, Ni et al., 2010.12.1, Bakal et al., 2007, Blanke and Jackle, 2006)

CG5503

(Foley and O'Farrell, 2004)

GEFmeso

(Yanagawa et al., 2020, Kim et al., 2019, Gene Disruption Project members, 2016-, Seyres et al., 2016, Kavi et al., 2015, Sundaram, 2015, Takahara and Takahashi, 2015, Pézeron et al., 2014, Blanke and Jackle, 2006)

Name Synonyms

Guanine nucleotide exchange factor in mesoderm

Secondary FlyBase IDs

FBgn0034358
FBgn0034359

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (48)

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