FB2021_02, released April 13, 2021

Gene: Dmel\CG30122

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General Information
Symbol
Dmel\CG30122
Species
D. melanogaster
Name
Annotation Symbol
CG30122
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050122
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
55E3-55E3
Sequence location
2R:18,632,328..18,639,270 [-]
Recombination map
2-86
RefSeq locus
NT_033778 REGION:18632328..18639270
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred by curator from GO:0071011
(Herold et al., 2009)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\CG30122 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG30122-RB
FBtr0086660
NM_137510
4620
1271
CG30122-RC
FBtr0300923
NM_001169725
4623
1272
CG30122-RD
FBtr0300924
NM_001169726
4620
1271
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG30122-PB
FBpp0085841
140.5
1271
4.64
NP_611354
AAF57660
CG30122-PC
FBpp0290145
140.6
1272
4.64
NP_001163196
ACZ94468
CG30122-PD
FBpp0290146
140.4
1271
4.64
NP_001163197
ACZ94469
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG30122 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG30122 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG30122
Transgenic constructs containing regulatory region of CG30122
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(2R)edl-S0520
(Schwarz et al., 2018)
Df(2R)Exel7157
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(2R)Ex212
(Murthy et al., 2005)
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HNRNPUL1
11 of 15
Yes
Yes
Hsap\HNRNPU
10 of 15
No
Yes
Hsap\HNRNPUL2
8 of 15
No
Yes
Hsap\HNRNPUL2-BSCL2
1 of 15
No
Yes
Hsap\RNF123
1 of 15
No
No
Hsap\RSPRY1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hnrnpul1
11 of 15
Yes
Yes
Mmus\Hnrnpu
11 of 15
Yes
Yes
Mmus\Hnrnpul2
7 of 15
No
Yes
Mmus\Rnf123
1 of 15
No
No
Mmus\Rspry1
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Hnrnpul1
9 of 13
Yes
Yes
Rnor\Hnrnpu
9 of 13
Yes
Yes
Rnor\Hnrnpul2
7 of 13
No
Yes
Rnor\Rnf123
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\hnrnpu
6 of 12
Yes
Yes
Xtro\hnrnpul2
5 of 12
No
Yes
Xtro\hnrnpul1
4 of 12
No
Yes
Xtro\rnf123
1 of 12
No
No
Xtro\rspry1
1 of 12
No
No
Danio rerio (Zebrafish) (6)
Drer\hnrnpub
11 of 15
Yes
Yes
Drer\hnrnpul1
11 of 15
Yes
Yes
Drer\hnrnpua
8 of 15
No
Yes
Drer\hnrnpul1l
7 of 15
No
Yes
Drer\si:ch211-107m4.1
6 of 15
No
Yes
Drer\rspry1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\hrpu-1
8 of 15
Yes
Yes
Cele\acin-1
1 of 15
No
No
Cele\F16A11.1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\TRO
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919047K )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006619
Drosophila simulans
Dsim\GD25377
Drosophila sechellia
Dsec\GM19891
Drosophila erecta
Dere\GG20960
Drosophila yakuba
Dyak\GE13899
Drosophila ananassae
Dana\GF11942
Drosophila pseudoobscura pseudoobscura
Dpse\GA24297
Drosophila persimilis
Dper\GL16796
Drosophila willistoni
Dwil\GK21907
Drosophila virilis
Dvir\GJ21813
Drosophila mojavensis
Dmoj\GI18786
Drosophila grimshawi
Dgri\GH20069
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504MN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018415
Glossina morsitans
Tsetse fly
Gmor\GMOY009352
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09374
Mayetiola destructor
Hessian fly
Mdes\Mdes008289
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011089
Anopheles darlingi
American malaria mosquito
Adar\ADAC005484
Anopheles gambiae
Malaria mosquito
Agam\AGAP005305
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009187
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07B6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000103
Danaus plexippus
Monarch butterfly
Dple\DPOGS205868-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015003
Apis florea
Little honeybee
Aflo\2478935668
Apis mellifera
Western honey bee
Amel\GB41701
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12084
Bombus terrestris
Buff-tailed bumblebee
Bter\15207529
Linepithema humile
Argentine ant
Lhum\LH15977
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001118
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008716
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02754
Tribolium castaneum
Red flour beetle
Tcas\TC003021
Pediculus humanus
Human body louse
Phum\PHUM163920
Rhodnius prolixus
Kissing bug
Rpro\RPRC005722
Cimex lectularius
Bed bug
Clec\CLEC005130
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13217
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0769 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007274
Ixodes scapularis
Black-legged tick
Isca\ISCW001427
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69215.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_262452
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_216229
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_30537
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG6752
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    CG30122KK100713
    exacerbates  neurodegenerative disease
    modeled by TBPHΔ23, TBPHdsRNA.UAS.cUa
    (Appocher et al., 2017)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HNRNPUL1; heterogeneous nuclear ribonucleoprotein U like 1
    11 of 15
    605800
        HNRNPU; heterogeneous nuclear ribonucleoprotein U
        10 of 15
        602869
        HNRNPUL2; heterogeneous nuclear ribonucleoprotein U like 2
        8 of 15
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            CG30122 - Drep2
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Andlauer et al., 2014)
            CG30122 - InR
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - Myc
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - Pdk1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - Pi3K21B
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - Pi3K92E
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - Pten
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - S6kII
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - Tsc1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - foxo
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - gig
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            CG30122 - kel
            proximity-dependent biotin identification, Identification by mass spectrometry
            (Mannix et al., 2019)
            CG30122 - osk
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Hurd et al., 2016)
            CG30122 - rictor
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            TBPH
            enhanceable
            CG30122
            (Appocher et al., 2017)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-86
            Cytogenetic map
            55E3-55E3
            Sequence location
            2R:18,632,328..18,639,270 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            55E3-55E3
            Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)0370903709
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-86

            (FlyBase, 2016)

            2-91.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (7)
            Genomic Clones (27)
            cDNA Clones (75)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: CG18610 CG5477

              (BDGP Project Members, 2000-)

              Source for merge of: CG5477 CG18610

              (FlyBase, 1996-)
              Additional comments

              FlyBase curator comment: Correspondence with author Alfonso revealed that 'SAF-A' = 'CG30122'.

              (Alfonso and Maggert, 2008)

              Annotations CG18610, CG5477 merged as CG30122 in release 3 of the genome annotation.

              (FlyBase Genome Annotators, 2002-2003)

              Source for merge of CG5477 CG18610 was a shared cDNA ( date:010720 ).

              (FlyBase, 1996-)
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 52 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (8)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (70)