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Gene Dmel\CG30158

General Information
Symbol	Dmel\CG30158	Species	D. melanogaster
Name		Annotation symbol	CG30158
Feature type	protein_coding_gene	FlyBase ID	FBgn0050158
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42D6-42E1	Sequence location	2R:2,779,265..2,810,118 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG30158 (FBgn0050158). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTP binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: GTP catabolic process; small GTPase mediated signal transduction. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Ras type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1641077_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG30158. Gene sequence location is 2R:2779265..2810118.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42D6-42E1   Limits computationally determined from genome sequence between P{lacW}ublk03203&P{PZ}CG328709967 and P{EP}EP2303&P{EP}EP2105
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG30158 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG30158-RA FBtr0086165  NM_144058   3657   280
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG30158-PA   FBpp0085498   30.2   280   9.73     NP_652315   AAF57410
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Small GTPase superfamily, Ras type (IPR020849)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57410   AY129454 AAM76196   BI165335   BI232244   BI633172   BP549013   BP549014   CO324210   CO327577   CZ484748   CZ486526   CZ489551   EC066983   EC090023   EC215411   EC215806   EC236499   EC254542
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z6R7 Q8MQJ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain    540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain  (540.4) Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain    540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain    540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain    540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain  540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain    540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.475 Larval Midgut    1.8 Larval Hindgut    0.7 Larval Malpighian Tubules    0.5 Larval Fat Body    2.2 Larval Salivary Gland    1 Larval Trachea    1.9 Larval Carcass    0.6 Adult Head    106.4 Adult Eye    13.025 Adult Brain    540.4 Adult Thoracic-Abdominal Ganglion    224.4 Adult Crop    1.2 Adult Midgut    1 Adult Hindgut    0.9 Adult Malpighian Tubules    1 Adult Fat Body    1 Adult Salivary Gland    1.9 Adult Heart    0.425 Adult VirginFemale Spermatheca    0.9 Adult InseminatedFemale Spermatheca    0.6 Adult Ovary    0.4 Adult Testis    0.4 Adult Male Accessory Gland    1 Adult Carcass    0.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    106.4   NA  Eye    no informative data   NA  Brain    540.4   159.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    224.4   NA  Crop    1.2   1.8  Midgut    1   0.7  Hindgut    0.9   0.5  Malpighian Tubules    1   2.2  Fat Body    1   1  Salivary Gland    1.9   NA  Heart    0.425   1.9  Trachea    NA   NA  VirginFemale Spermatheca    0.9   NA  InseminatedFemale Spermatheca    0.6   NA  Ovary    0.4   NA  Testis    0.4   NA  Male Accessory Gland    1   0.6  Carcass    0.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	BDGP expression data • RE28276 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050158 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30158-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG30158GD8669 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CG30158 Class Mutagen Stocks Known lesion CG30158f06824 piggyBac transposase 2 -- CG30158f02240 piggyBac transposase 1 -- CG30158f03920 piggyBac transposase 1 -- CG30158MB04149 1 -- CG30158NP1113 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG30158 Class Mutagen Stocks Known lesion CG30158GD8669 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG30158JF01655 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG30158KK109540 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6051 (Ryder, 2004.4.26) Df(2R)Δ42E (Lin et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8669} NA P{KK109540} NA P{TRiP.JF01655} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG30158f02240 NA PBac{WH}CG30158f03920 NA PBac{WH}CG30158f06824 NA insertion of enhancer trap binary system Mi{ET1}CG30158MB04149 No P{GawB}CG30158NP1113 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR020849 (FlyBase Curators et al., 2004-) GTP binding inferred from sequence or structural similarity with UniProtKB:Q96D21 (FlyBase Genome Annotators, 2002-2003)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR020849 (FlyBase Curators et al., 2004-) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR020849 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG30158 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72565 DroID - A comprehensive database of gene and protein interactions. • FBgn0050158 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 50149
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SXNZT Dipteran inclusive ortholog search EOG6W0XP3 Insect inclusive ortholog search EOG631ZV1 Arthropod inclusive ortholog search EOG66HDSK Metazoa inclusive ortholog search EOG6ZKXF9
Orthologs in Drosophila Species (EOG6SXNZT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG30158     Drosophila simulans   Dsim\GD10434 Y   Drosophila sechellia   Dsec\GM20906 Y   Drosophila erecta   Dere\GG23233 Y   Drosophila yakuba   Dyak\GE19084 Y   Drosophila ananassae   Dana\GF13148 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15685 Y   Drosophila persimilis   Dper\GL11127 Y   Drosophila willistoni   Dwil\GK20887 Y   Drosophila virilis   Dvir\GJ17556 Y   Drosophila mojavensis   Dmoj\GI19720 Y   Drosophila grimshawi   Dgri\GH22014 Y
Orthologs in non-Drosophila Dipterans (EOG6W0XP3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007766   Anopheles gambiae Malaria mosquito  Agam\AGAP005248   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018718
Orthologs in non-Dipteran Insects (EOG631ZV1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53387   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002305   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16801   Atta cephalotes Leafcutter ant  Acep\ACEP17069   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23209   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16165   Linepithema humile Argentine ant  Lhum\LH20218   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11089   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11088   Solenopsis invicta Red fire ant  Sinv\SINV11377   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002901   Pediculus humanus Human body louse  Phum\PHUM192620   Tribolium castaneum Red flour beetle  Tcas\TC003668
Orthologs in non-Insect Arthropods (EOG66HDSK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW003069
Orthologs in non-Arthropod Metazoa (EOG6ZKXF9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ssr-2 Y Xenopus tropicalis Western clawed frog  Xtro\ras-dva Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10434 Drosophila sechellia Dsec\GM20906 Drosophila erecta Dere\GG23233 Drosophila yakuba Dyak\GE19084 Drosophila ananassae Dana\GF13148 Drosophila pseudoobscura pseudoobscura Dpse\GA15685 Drosophila persimilis Dper\GL11127 Drosophila willistoni Dwil\GK20887 Drosophila virilis Dvir\GJ17556 Drosophila mojavensis Dmoj\GI19720 Drosophila grimshawi Dgri\GH22014
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	31162 y1 v1; P{TRiP.JF01655}attP2 24291 w1118; Mi{ET1}CG30158MB04149 19014 w1118; PBac{WH}CG30158f06824/CyO
Harvard	- PBac{WH}CG30158f02240 - PBac{WH}CG30158f03920 - PBac{WH}CG30158f06824
Kyoto	103889 y* w*; P{GawB}CG30158NP1113 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v104798 P{KK109540}VIE-260B v32434 w1118; P{GD8669}v32434
Genomic Clones ( 3 )
	BACR04F03 BACR29G01 BACR36G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE28276
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE05206 SD27176
Other clones	97450 162588 174666 178365 214319.14 EK193003 EP07558 FGM003B05
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0050158 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 50149
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG15243 CG15244 CG9464 (FlyBase Genome Annotators, 2002-2003) Source for merge of: CG30158 BcDNA:RE28276 (FlyBase, 1996-)
Additional comments	Annotations CG15243, CG15244 and CG9464 merged as CG30158 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG30158 BcDNA:RE28276 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_144058 RefSeq (Proteins) • NP_652315 DDBJ / EMBL / GenBank • AAF57410 AAM76196 AY129454 BI232244 CZ484748 CZ486526 CZ489551 Entrez Gene - A searchable database of RefSeq genes. • 50149 UniProtKB/TrEMBL • A1Z6R7 Q8MQJ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Small GTPase superfamily, Ras type (IPR020849) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE28276
Linkouts
	BioGRID - A database of protein and genetic interactions • 72565 DroID - A comprehensive database of gene and protein interactions. • FBgn0050158 DRSC - Results from RNAi screens. • FBgn0050158 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050158 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30158-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0050158 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 50149 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 50149 modMine - Data generated by the modENCODE project. • FBgn0050158
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	BcDNA:RE28276   CG9464   CG15243   CG15244   CG30158 (Bakal et al., 2007, Keleman et al., 2009.8.5, Garrett et al., 2009, Ni et al., 2008)
Name Synonym
Secondary FlyBase IDs
	FBgn0033116 FBgn0040675 FBgn0040676 FBgn0063683
References ( 20 )
Research paper	Garrett et al., 2009, BMC Genomics 10: 489 Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. [FBrf0209216] Ni et al., 2008, Nat. Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Lin et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(36): 12831--12836 A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. [FBrf0188263]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Bakal et al., 2007, Science 316(5832): Supporting online material. [FBrf0204776] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Bellen, 2007.8.28, Set756.xml Set756.xml [FBrf0200263] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]