FB2020_06, released Dec 22, 2020

Gene: Dmel\CG30158

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General Information
Symbol
Dmel\CG30158
Species
D. melanogaster
Name
Annotation Symbol
CG30158
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050158
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
42D6-42E1
Sequence location
2R:6,891,760..6,922,613 [+]
Recombination map

2-55

RefSeq locus
NT_033778 REGION:6891760..6922613
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GDP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR020849
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAS GTPASES -
The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG30158 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG30158-RA
FBtr0086165
NM_144058
3657
280
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG30158-PA
FBpp0085498
30.2
280
9.73
NP_652315
AAF57410
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG30158 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG30158 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG30158
Transgenic constructs containing regulatory region of CG30158
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RASD1
2 of 15
Yes
No
Hsap\RASD2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rasd1
2 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
Rnor\Rasd1
1 of 13
Yes
No
Rnor\Rasd2
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\ras-dva2
3 of 12
Yes
No
Xtro\ras-dva1
2 of 12
No
No
Xtro\rasd1
1 of 12
No
No
Xtro\rasd2
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\rasd4
4 of 15
Yes
No
Drer\rasd3
3 of 15
No
No
Drer\rasd1
1 of 15
No
No
Drer\rasd2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ssr-2
9 of 15
Yes
Yes
Cele\D1081.4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\RSR1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190EXU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005613
Drosophila simulans
Dsim\GD10434
Drosophila sechellia
Dsec\GM20906
Drosophila erecta
Dere\GG23233
Drosophila yakuba
Dyak\GE19084
Drosophila ananassae
Dana\GF13148
Drosophila pseudoobscura pseudoobscura
Dpse\GA15685
Drosophila persimilis
Dper\GL11127
Drosophila willistoni
Dwil\GK20887
Drosophila virilis
Dvir\GJ17556
Drosophila mojavensis
Dmoj\GI19720
Drosophila grimshawi
Dgri\GH22014
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DIF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019081
Glossina morsitans
Tsetse fly
Gmor\GMOY002445
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09060
Mayetiola destructor
Hessian fly
Mdes\Mdes011148
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007766
Anopheles darlingi
American malaria mosquito
Adar\ADAC010659
Anopheles gambiae
Malaria mosquito
Agam\AGAP005248
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018718
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GEC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2241033716
Apis mellifera
Western honey bee
Amel\GB53387
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10379
Bombus terrestris
Buff-tailed bumblebee
Bter\15207457
Linepithema humile
Argentine ant
Lhum\LH20218
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002801
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002305
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11105
Tribolium castaneum
Red flour beetle
Tcas\TC003668
Pediculus humanus
Human body louse
Phum\PHUM192620
Rhodnius prolixus
Kissing bug
Rpro\RPRC003248
Cimex lectularius
Bed bug
Clec\CLEC012628
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002901
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05948
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GEW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006211
Strigamia maritima
European centipede
Smar\SMAR013067
Ixodes scapularis
Black-legged tick
Isca\ISCW003069
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74399.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65329.1
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0U2W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RasD1/2L2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RasDL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RasD1/2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RasD1/2L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ras/Dva
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RasD
Gallus gallus
Domestic chicken
Ggal\RASD2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000021552
Gallus gallus
Domestic chicken
Ggal\RASD1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (10)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG13375
5 of 10
CG8641
2 of 10
CG8500
1 of 10
Rala
1 of 10
Rap1
1 of 10
Rap2l
1 of 10
Ras64B
1 of 10
Ras85D
1 of 10
Rheb
1 of 10
Ric
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map

    2-55

    Cytogenetic map
    42D6-42E1
    Sequence location
    2R:6,891,760..6,922,613 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    42D6-42E1
    Limits computationally determined from genome sequence between P{lacW}ublk03203&P{PZ}CG328709967 and P{EP}EP2303&P{EP}EP2105
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-55

    (FlyBase, 2016)

    2-56.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (45)
    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: CG30158 BcDNA:RE28276

    (FlyBase, 1996-)

    Source for merge of: CG15243 CG15244 CG9464

    (FlyBase Genome Annotators, 2002-2003)
    Additional comments

    Annotations CG15243, CG15244 and CG9464 merged as CG30158 in release 3 of the genome annotation.

    (FlyBase Genome Annotators, 2002-2003)

    Source for merge of CG30158 BcDNA:RE28276 was a shared cDNA ( date:030728 ).

    (FlyBase, 1996-)
    Other Comments
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 34 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    BcDNA:RE28276
    CG15243
    CG15244
    CG30158
    (Gene Disruption Project members, 2018-, Miller et al., 2018, Clandinin and Owens, 2016-, Diez et al., 2011, Kong et al., 2010, Garrett et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2008, Bakal et al., 2007)
    CG9464
    Name Synonyms
    Secondary FlyBase IDs
    • FBgn0033116
    • FBgn0040675
    • FBgn0040676
    • FBgn0063683
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (32)