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Gene Dmel\CG30273

General Information
Symbol	Dmel\CG30273	Species	D. melanogaster
Name		Annotation symbol	CG30273
Feature type	protein_coding_gene	FlyBase ID	FBgn0050273
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58F4-58F4	Sequence location	2R:18,554,660..18,555,443 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG30273 (FBgn0050273). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: LPS-induced tumor necrosis factor alpha factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult Malpighian tubules, larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1640540_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG30273. Gene sequence location is 2R:18554661..18555445.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58F4-58F4   Limits computationally determined from genome sequence between P{EP}EP718EP718 and P{EP}ppaEP698&P{EP}EP2184
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG30273 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG30273-RA FBtr0071866  NM_166542   657   128
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG30273-PA   FBpp0071777   14.0   128   7.68     NP_726223   AAM71112
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • LPS-induced tumor necrosis factor alpha factor (IPR006629)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAM71112   AI107048   AI293467   AI297587   AI405740   BP548958   BT122125   CO275928   CO294611   CO342806   EC197507   EC254878   EL879277
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MME9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
[an error occurred while processing this directive] FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
[an error occurred while processing this directive]
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050273 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30273-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG30273GD3815 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG30273 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG30273 Class Mutagen Stocks Known lesion CG30273GD3815 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG30273NIG.30273R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3815} NA P{NIG.30273R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a biological process, cellular component or molecular function term for this gene. (Based on a review of available data on: 2012-06-22)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG30273 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0050273
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61RQFK Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6ZKHJ2 Arthropod inclusive ortholog search EOG61VHKP Metazoa inclusive ortholog search EOG6NGVJ2
Orthologs in Drosophila Species (EOG61RQFK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG30273     Drosophila simulans   Dsim\GD11689 Y   Drosophila sechellia   Dsec\GM15936 Y   Drosophila erecta   Dere\GG22779 Y   Drosophila yakuba   Dyak\GE14008 Y   Drosophila ananassae   Dana\GF11635 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15742 Y   Drosophila persimilis   Dper\GL11366 Y   Drosophila willistoni   Dwil\GK21444 Y   Drosophila virilis   Dvir\GJ22033 Y   Drosophila mojavensis   Dmoj\GI20307 Y   Drosophila grimshawi   Dgri\GH19768 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6ZKHJ2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC725688 Y Apis mellifera Western honey bee  Amel\LOC551998 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021007 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000550 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17121 Y Atta cephalotes Leafcutter ant  Acep\ACEP12142 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12237 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19632 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19630 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19633 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23552 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16414 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16260 Y Linepithema humile Argentine ant  Lhum\LH16749 Y Linepithema humile Argentine ant  Lhum\LH18386 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23542 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20846 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17771 Y Solenopsis invicta Red fire ant  Sinv\SINV10618 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI23122 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006651 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009512 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI46913 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000883 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000885 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000886 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000884 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000541 Y Pediculus humanus Human body louse  Phum\PHUM131500 Y Pediculus humanus Human body louse  Phum\PHUM603960 Y Pediculus humanus Human body louse  Phum\PHUM581980 Y Tribolium castaneum Red flour beetle  Tcas\TC003371 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6NGVJ2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\si:ch211-202h22.7 Y Danio rerio Zebrafish  Drer\si:ch211-202h22.9 Y Danio rerio Zebrafish  Drer\ENSDARG00000076069 Y Danio rerio Zebrafish  Drer\si:ch211-202h22.8 Y Danio rerio Zebrafish  Drer\ENSDARG00000075902 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11689 Drosophila sechellia Dsec\GM15936 Drosophila erecta Dere\GG22779 Drosophila yakuba Dyak\GE14008 Drosophila ananassae Dana\GF11635 Drosophila pseudoobscura pseudoobscura Dpse\GA15742 Drosophila persimilis Dper\GL11366 Drosophila willistoni Dwil\GK21444 Drosophila virilis Dvir\GJ22033 Drosophila mojavensis Dmoj\GI20307 Drosophila grimshawi Dgri\GH19768
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v10302 w1118; P{GD3815}v10302
Genomic Clones ( 1 )
	BACR11M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	FI14103
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06337 GH25860 LP06622 LP11920
Other clones	214501.60 CK01.144C.E2 EK119149 EK207305 EP15537 FGM002G12 IP09279
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0050273 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 246520
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Annotation CG13515 split into CG30269 and CG30273 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166542 RefSeq (Proteins) • NP_726223 DDBJ / EMBL / GenBank • AAM71112 AI405740 Entrez Gene - A searchable database of RefSeq genes. • 246520 UniProtKB/TrEMBL • Q8MME9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • LPS-induced tumor necrosis factor alpha factor (IPR006629)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0050273 DRSC - Results from RNAi screens. • FBgn0050273 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050273 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30273-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0050273 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 246520 modMine - Data generated by the modENCODE project. • FBgn0050273
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG13515 (Ponting et al., 2001, ) CG30273 (Luo et al., 2011, Bartkuhn et al., 2009, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
	FBgn0034762
References ( 14 )
Research paper	Bono et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 7878--7883 Postmating transcriptional changes in reproductive tracts of con- and heterospecifically mated Drosophila mojavensis females. [FBrf0213680] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Bartkuhn et al., 2009, EMBO J. 28(7): 877--888 Active promoters and insulators are marked by the centrosomal protein 190. [FBrf0207850] Ponting et al., 2001, Genome Res. 11(12): 1996--2008 Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. [FBrf0141558]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]