FlyBase Gene Report: Dmel\Sgf29

General Information

Symbol

Dmel\Sgf29

Species

D. melanogaster

Name

SAGA-associated factor 29kDa

Annotation Symbol

CG30390

Feature Type

protein_coding_gene

FlyBase ID

FBgn0050390

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes. [Date last reviewed: 2019-08-01]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dSgf29

Key Links

Genomic Location

Cytogenetic map

57D8-57D8

Sequence location

2R:21,292,239..21,293,646 [-]

Recombination map

2-94

RefSeq locus

NT_033778 REGION:21292239..21293646

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables methylated histone binding

inferred from biological aspect of ancestor with PANTHER:PTN000488952

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:25156

(FlyBase Curators, 2008--)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from direct assay

(Suganuma et al., 2008)

involved_in histone acetylation

inferred from direct assay

(Suganuma et al., 2008)

involved_in histone H3 acetylation

inferred from direct assay

(Guelman et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in histone H3 acetylation

inferred from biological aspect of ancestor with PANTHER:PTN000488952

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of Ada2/Gcn5/Ada3 transcription activator complex

inferred from direct assay

(Suganuma et al., 2012)

inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738

(Suganuma et al., 2008)

part_of H3 histone acetyltransferase complex

inferred from direct assay

(Torres-Zelada et al., 2019)

located_in nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

part_of SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of Ada2/Gcn5/Ada3 transcription activator complex

inferred from biological aspect of ancestor with PANTHER:PTN000488952

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of SAGA complex

inferred from biological aspect of ancestor with PANTHER:PTN000488952

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ATAC COMPLEX

SAGA COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ATAC COMPLEX -: The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126).
SAGA COMPLEX -: The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sgf29 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sgf29-RA

FBtr0071617

NM_166436

1027

289

Sgf29-RB

FBtr0342888

NM_001299744

1150

289

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Sgf29-PA

FBpp0071543

32.1

289

8.95

NP_726051

AAF46707

Sgf29-PB

FBpp0309689

32.1

289

8.95

NP_001286673

AHN56468

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

289 aa isoforms: Sgf29-PA, Sgf29-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W2I4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sgf29 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Ada2/Gcn5/Ada3 transcription activator complex

inferred from direct assay

(Suganuma et al., 2012)

inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738

(Suganuma et al., 2008)

part_of H3 histone acetyltransferase complex

inferred from direct assay

(Torres-Zelada et al., 2019)

located_in nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

part_of SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sgf29 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sgf29

View exonic expression by tissue for Dmel\Sgf29

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0050390

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG30390-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0050390

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sgf29

Transgenic constructs containing regulatory region of Sgf29

Deletions and Duplications ( 2 )

Disrupted in

Df(2R)Exel6074

(Ryder, 2004.4.26)

Df(2R)Exel6075

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sgf29^GD10067

viable, with Scer\GAL4^Mef2.PR

Sgf29^GD10067

viable, with Scer\GAL4^pnr-MD237

Sgf29^GD10067

viable, with Scer\GAL4^tin.CΔ4

Sgf29^GD10067

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SGF29

13 of 15

Yes

Hsap\LOC388242

1 of 15

Yes

Hsap\LOC613038

1 of 15

Yes

Hsap\TEK

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Sgf29

13 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Sgf29

13 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\sgf29

9 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\sgf29

13 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\Y17G9B.8

13 of 15

Yes

Cele\T22B7.4

6 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\SGF29a

6 of 9

Yes

Atha\SGF29b

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\SGF29

3 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\sgf29

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190D1P )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15811

Drosophila persimilis

Dper\GL10755

Drosophila willistoni

Dwil\GK21485

Drosophila virilis

Dvir\GJ22385

Drosophila mojavensis

Dmoj\GI20536

Drosophila grimshawi

Dgri\GH21249

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915097E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17016231

Glossina morsitans

Tsetse fly

Gmor\GMOY006170

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06831

Mayetiola destructor

Hessian fly

Mdes\Mdes004696

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010025

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009448

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013687

Anopheles darlingi

American malaria mosquito

Adar\ADAC001473

Anopheles gambiae

Malaria mosquito

Agam\AGAP005116

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004580

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0A5W )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001871

Danaus plexippus

Monarch butterfly

Dple\DPOGS214657-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007686

Apis florea

Little honeybee

Aflo\4074801492

Apis mellifera

Western honey bee

Amel\LOC408702

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16390

Bombus terrestris

Buff-tailed bumblebee

Bter\15209211

Linepithema humile

Argentine ant

Lhum\LH16450

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000b4e

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008976

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003409

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08769

Tribolium castaneum

Red flour beetle

Tcas\TC008842

Pediculus humanus

Human body louse

Phum\PHUM037540

Rhodnius prolixus

Kissing bug

Rpro\RPRC005276

Rhodnius prolixus

Kissing bug

Rpro\RPRC005193

Rhodnius prolixus

Kissing bug

Rpro\RPRC003077

Cimex lectularius

Bed bug

Clec\CLEC010632

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002035

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08113

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0A1W )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008942

Ixodes scapularis

Black-legged tick

Isca\ISCW014696

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76307.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57408.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur09g03270

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_190655

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0G88 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ccdc101

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012953

Gallus gallus

Domestic chicken

Ggal\CCDC101

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SGF29; SAGA complex associated factor 29

13 of 15

613374

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sgf29 - Ada1-2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - Ada2a

anti tag coimmunoprecipitation, molecular sieving, peptide massfingerprinting

(Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008)

Sgf29 - Ada2b

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, affinity chromatography technology, molecular sieving, multidimensional protein identification technology

(Soffers et al., 2019, Weake et al., 2011, Weake et al., 2009, Weake et al., 2008)

Sgf29 - Ada3

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011, Weake et al., 2009)

Sgf29 - Atac1

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011, Weake et al., 2009)

Sgf29 - Atac2

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, molecular sieving

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Weake et al., 2009, Suganuma et al., 2008)

Sgf29 - Atxn7

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2014, Weake et al., 2009)

Sgf29 - Chrac-14

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - D12

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Suganuma et al., 2010)

Sgf29 - Gcn5

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011, Weake et al., 2009)

Sgf29 - Hcf

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - MBD-R2

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - Mocs2B

experimental knowledge based, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Weake et al., 2009, Suganuma et al., 2008)

Sgf29 - NC2β

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - Nipped-A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - PolE4

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - Rcd1

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - ReepA

experimental knowledge based

(Guruharsha et al., 2011)

Sgf29 - Saf6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - Sf3b3

anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Stegeman et al., 2016)

Sgf29 - Sf3b5

anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Stegeman et al., 2016)

Sgf29 - Sgf11

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - Spt20

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016, Weake et al., 2009)

Sgf29 - Spt3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016, Weake et al., 2009)

Sgf29 - Spt7

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - Taf10b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - Taf12

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - Taf9

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - e(y)2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - not

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - wda

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Sgf29 - wds

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63063

DroID - A comprehensive database of gene and protein interactions.

FBgn0050390

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37429

MIST (protein-protein) - An integrated Molecular Interaction Database

Sgf29

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-94

Cytogenetic map

57D8-57D8

Sequence location

2R:21,292,239..21,293,646 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57D8-57D8

Limits computationally determined from genome sequence between P{EP}CG4266^EP2258 and P{EP}CG30394^EP962&P{lacW}dom^k08108

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-94

(FlyBase, 2016)

2-101.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

36637

y¹ sc^* v¹ sev²¹; P{TRiP.GL00597}attP40

39000

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01916}attP2

81414

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS03969}attP40

VDRC

v101326

P{KK107577}VIE-260B

v41740

w¹¹¹⁸; P{GD10067}v41740

v41739

w¹¹¹⁸; P{GD10067}v41739/CyO

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH55624

Other clones

FI01566

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0050390

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LP02508

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0050390

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37429

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Sgf29 CG30390

(Weake et al., 2009)

Source for database merge of

Additional comments

Annotation CG10509 split into CG30390 and CG30392 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37429

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BI623388

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information