FB2020_06, released Dec 22, 2020

Gene: Dmel\Tango11

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General Information
Symbol
Dmel\Tango11
Species
D. melanogaster
Name
Transport and Golgi organization 11
Annotation Symbol
CG30404
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050404
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

Transport and Golgi organization

Key Links
Genomic Location
Cytogenetic map
57F10-57F10
Sequence location
2R:21,716,780..21,719,963 [-]
Recombination map

2-96

RefSeq locus
NT_033778 REGION:21716780..21719963
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data before: 2006-08-03 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in protein secretion
inferred from mutant phenotype
(Bard et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in endoplasmic reticulum membrane
inferred from direct assay
(assigned by UniProt )
(Bard et al., 2006)
located_in endoplasmic reticulum
inferred from direct assay
(Bard et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Tango11 family. (Q961C9)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
May play a role in mitochondrial and peroxisomal fission.
(UniProt, Q961C9)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Tango11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tango11-RA
FBtr0071746
NM_166481
1629
277
Tango11-RB
FBtr0071747
NM_166482
1682
277
Tango11-RC
FBtr0342965
NM_001299768
1007
93
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Tango11-PA
FBpp0071660
31.5
277
6.13
NP_726111
AAM71012
Tango11-PB
FBpp0071661
31.5
277
6.13
NP_726112
AAM71013
Tango11-PC
FBpp0309735
10.9
93
10.35
NP_001286697
AHN56492
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

277 aa isoforms: Tango11-PA, Tango11-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tango11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
gonad
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in endoplasmic reticulum membrane
inferred from direct assay
(assigned by UniProt )
(Bard et al., 2006)
located_in endoplasmic reticulum
inferred from direct assay
(Bard et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tango11 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tango11
Transgenic constructs containing regulatory region of Tango11
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MFF
10 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mff
9 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\LOC102556337
7 of 13
Yes
Yes
Rnor\Mff
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\mff
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\mff
12 of 15
Yes
Yes
Drer\zgc:110130
10 of 15
No
Yes
Drer\LOC100000713
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\mff-2
3 of 15
Yes
Yes
Cele\F11C1.7
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190CR5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003476
Drosophila simulans
Dsim\GD25169
Drosophila sechellia
Dsec\GM15690
Drosophila erecta
Dere\GG20746
Drosophila yakuba
Dyak\GE13678
Drosophila ananassae
Dana\GF11620
Drosophila pseudoobscura pseudoobscura
Dpse\GA15821
Drosophila persimilis
Dper\GL17521
Drosophila willistoni
Dwil\GK15656
Drosophila virilis
Dvir\GJ20601
Drosophila mojavensis
Dmoj\GI20865
Drosophila grimshawi
Dgri\GH20782
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915087W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011550
Glossina morsitans
Tsetse fly
Gmor\GMOY000680
Mayetiola destructor
Hessian fly
Mdes\Mdes001761
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002700
Anopheles darlingi
American malaria mosquito
Adar\ADAC008375
Anopheles gambiae
Malaria mosquito
Agam\AGAP001746
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016253
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08SP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001339
Danaus plexippus
Monarch butterfly
Dple\DPOGS204305-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015161
Apis florea
Little honeybee
Aflo\2312246372
Apis mellifera
Western honey bee
Amel\Tango11
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21163
Bombus terrestris
Buff-tailed bumblebee
Bter\15213736
Linepithema humile
Argentine ant
Lhum\LH23408
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0030e6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019448
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06207
Tribolium castaneum
Red flour beetle
Tcas\TC014559
Pediculus humanus
Human body louse
Phum\PHUM167430
Rhodnius prolixus
Kissing bug
Rpro\RPRC002956
Cimex lectularius
Bed bug
Clec\CLEC011962
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008683
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02359
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08OG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010980
Ixodes scapularis
Black-legged tick
Isca\ISCW021807
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77422.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00710
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00730
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DK2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005835gn
Ciona intestinalis
Vase tunicate
Cint\LOC100184063
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023694
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003079
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MFF; mitochondrial fission factor
    10 of 15
    614785
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Tango11 - SelG
      two hybrid
      (Hu et al., 2017.6.13)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map

      2-96

      Cytogenetic map
      57F10-57F10
      Sequence location
      2R:21,716,780..21,719,963 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      57F10-57F10
      Limits computationally determined from genome sequence between P{EP}Tim10EP541&P{lacW}l(2)k09617k09617 and P{PZ}l(2)0783707837
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-96

      (FlyBase, 2016)

      2-102.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (10)
      Genomic Clones (18)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (70)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Tango11 CG30404

      (Bard et al., 2006)
      Source for database merge of

      Source for merge of: CG30404 BEST:LD33633

      (Rana, 2004.7.8)

      Source for merge of: CG30404 anon- EST:fe1F11

      (FlyBase, 1996-)

      Source for merge of: CG30404 BcDNA:LD22567

      (FlyBase, 1996-)
      Additional comments

      Source for merge of CG30404 anon- EST:fe1F11 was sequence comparison ( date:030707 ).

      (FlyBase, 1996-)

      Source for merge of CG30404 BcDNA:LD22567 was a shared cDNA ( date:030728 ).

      (FlyBase, 1996-)
      Other Comments

      The larval lethality and developmental rate phenotypes described for Tango111 and Tango112 were recapitulated in 6 other unspecified deletion alleles of the Tango11 gene.

      (McDaniel and Karpen, 2011.7.27)

      dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.

      (Bard et al., 2006)

      dsRNA directed against Tango11 inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.

      (Bard et al., 2006)

      New annotation (CG30404) in release 3 of the genome annotation.

      (FlyBase Genome Annotators, 2002-2003)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 44 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DPiM - Drosophila Protein interaction map
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (10)
      Reported As
      Symbol Synonym
      BEST:LD33633
      BcDNA:LD22567
      CG30404
      (Hosono et al., 2015, Fukuoh et al., 2014, White-Grindley et al., 2014, Cui et al., 2013, Debattisti and Scorrano, 2013, Jaspers et al., 2012, Ni et al., 2010.12.1, Perkins et al., 2009, Bard et al., 2006, Molnar et al., 2006, Laviolette et al., 2005, Giot et al., 2003)
      TANGO11
      (Bard et al., 2006)
      Tango11
      (Hu et al., 2017.6.13, Sarov et al., 2016, White-Grindley et al., 2014, Debattisti and Scorrano, 2013, McDaniel and Karpen, 2011.7.27)
      anon-EST:fe1F11
      tango11
      (Hatsuda, 2012)
      Name Synonyms
      Transport and Golgi organization
      (Jaspers et al., 2012, Bard et al., 2006)
      Transport and Golgi organization 11
      anon-fast-evolving-1F11
      tango11
      (Cui et al., 2013)
      Secondary FlyBase IDs
      • FBgn0025252
      • FBgn0045785
      • FBgn0046223
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (45)