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Gene: Dmel\Tdc2

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General Information
Symbol
Dmel\Tdc2
Species
D. melanogaster
Name
Tyrosine decarboxylase 2
Annotation Symbol
CG30446
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050446
Gene Model Status
Current
Stock Availability
6 publicly available
Enzyme Name (EC)
Tyrosine decarboxylase (4.1.1.25)
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
TDC, dTdc2
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:6,684,745..6,689,974 [-]
Recombination map
2-55
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
Pyridoxal phosphate-dependent decarboxylase; Aromatic-L-amino-acid decarboxylase; Pyridoxal phosphate-dependent transferase, major domain; Pyridoxal phosphate-dependent transferase domain 1; Pyridoxal phosphate-dependent transferase; Pyridoxal-phosphate binding site
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
carboxy-lyase activity; pyridoxal phosphate binding; tyrosine decarboxylase activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
L-tyrosine = tyramine + CO(2) (4.1.1.25)
Summaries
Gene Group Membership
CARBOXY-LYASES -
Carboxy-lyases are involved in the the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). (Adapted from FBrf0238856).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Tdc2 or the JBrowse view of Dmel\Tdc2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tdc2-RA
FBtr0086142
NM_165483
2303
637
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Tdc2-PA
FBpp0085475
72.0
637
7.12
NP_724489
AAM70812
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tdc2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
carboxy-lyase activity
inferred from electronic annotation with InterPro:IPR002129, InterPro:IPR010977, InterPro:IPR021115
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
pyridoxal phosphate binding
inferred from electronic annotation with InterPro:IPR002129
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
tyrosine decarboxylase activity
inferred from sequence or structural similarity
(Cole et al., 2005)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
behavioral response to cocaine
inferred from mutant phenotype
(Hardie et al., 2007)
locomotor rhythm
inferred from mutant phenotype
(Huang et al., 2013)
locomotory behavior
inferred from mutant phenotype
(Hardie et al., 2007)
oviposition
inferred from mutant phenotype
(Cole et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cellular amino acid metabolic process
inferred from electronic annotation with InterPro:IPR010977
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron | subset of thoracico-abdominal ganglion
(Rezával et al., 2014)
neuron | subset of adult brain
(Rezával et al., 2014)
Additional Descriptive Data
Tdc2-protein is expressed in around 38 neurons along the abdominal ventral midline of the thoracico-abdominal ganglion in females. The number and position of labeled neurons in the male thoracico-abdominal ganglion differs slightly.
(Rezával et al., 2014)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GMR16B04-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult pars intercerebralis
(Kunst et al., 2014)
Reporter: P{Tdc2A-lexA-VP16}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
octopaminergic neuron | restricted
(Burke et al., 2012)
adult central complex | restricted
(Burke et al., 2012)
octopaminergic neuron
(Wasserman et al., 2015)
Reporter: P{Tdc2-GAL4.C}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
(FlyBase Curators, 2017)
adult stage
(FlyBase Curators, 2017)
octopaminergic neuron
(FlyBase Curators, 2017)
tyraminergic neuron
(FlyBase Curators, 2017)
larval stage
motor neuron
(Koon and Budnik, 2012)
first instar larval stage
octopaminergic neuron
(Koon et al., 2011)
second instar larval stage
octopaminergic neuron
(Koon et al., 2011)
third instar larval stage
octopaminergic neuron
(Koon et al., 2011, Honjo and Furukubo-Tokunaga, 2009)
tyraminergic neuron
(Honjo and Furukubo-Tokunaga, 2009)
tyraminergic neuron | subset of ventral nerve cord
(Selcho et al., 2014)
tyraminergic neuron | subset of embryonic/larval protocerebrum
(Selcho et al., 2014)
tyraminergic neuron | subset of calyx of larval mushroom body
(Selcho et al., 2014)
tyraminergic neuron | subset of vertical lobe of larval mushroom body
(Selcho et al., 2014)
tyraminergic neuron | subset of embryonic/larval deutocerebrum
(Selcho et al., 2014)
tyraminergic neuron | subset of embryonic/larval antennal lobe
(Selcho et al., 2014)
tyraminergic neuron | subset of embryonic/larval subesophageal ganglion
(Selcho et al., 2014)
octopaminergic VM neuron | subset of larval gnathal neuromere
(Selcho et al., 2014)
octopaminergic neuron | subset of embryonic/larval subesophageal ganglion
(Selcho et al., 2014)
early third instar larval stage
octopaminergic neuron
(Koon et al., 2011)
adult stage
adult abdominal neuromere | restricted
(Brembs et al., 2007)
adult thoracic neuromere | restricted
(Brembs et al., 2007)
adult brain | restricted
(Kahsai and Winther, 2011, Busch et al., 2009)
octopaminergic VM neuron
(Busch et al., 2009)
octopaminergic AL2 neuron
(Burke et al., 2012, Schneider et al., 2012, Busch et al., 2009)
octopaminergic VL neuron
(Busch et al., 2009)
octopaminergic ASM neuron
(Burke et al., 2012, Busch et al., 2009)
octopaminergic neuron
(Matsuo et al., 2016, Boerner and Duch, 2010, Crocker et al., 2010)
aminergic neuron | subset
(Boerner and Duch, 2010)
octopaminergic neuron | subset
(Schneider et al., 2012, Certel et al., 2010)
tyraminergic neuron | subset
(Certel et al., 2010)
VUM neuron | subset
(Certel et al., 2010)
subesophageal ganglion | restricted
(Certel et al., 2010)
supraesophageal ganglion | restricted
(Certel et al., 2010)
adult protocerebrum | medial | restricted | ventral
(Certel et al., 2010)
octopaminergic neuron of adult brain
(Zhou et al., 2012)
neuron of adult brain
(Schneider et al., 2012)
neuron of thoracico-abdominal ganglion
(Schneider et al., 2012)
octopaminergic VPM1 neuron
(Certel et al., 2010)
octopaminergic VUM neuron
(Certel et al., 2010)
fan-shaped body | central
(Kahsai and Winther, 2011)
fan-shaped body | ventral
(Kahsai and Winther, 2011)
octopaminergic neuron | restricted
(Burke et al., 2012)
octopaminergic VUMa2 neuron
(Burke et al., 2012)
octopaminergic VPM3 neuron
(Burke et al., 2012)
octopaminergic VPM4 neuron
(Burke et al., 2012)
octopaminergic VPM5 neuron
(Burke et al., 2012)
mushroom body calyx
(Burke et al., 2012)
mushroom body spur
(Burke et al., 2012)
mushroom body gamma-lobe
(Burke et al., 2012)
neuron | subset of thoracico-abdominal ganglion
(Rezával et al., 2014)
motor neuron | subset of adult abdominal segment 6

Comment: innervating abdominal 6 dorsal muscle 133

(Rezával et al., 2014)
giant fiber neuron
(Matsuo et al., 2016)
antennal mechanosensory and motor center AMMC P3b neuron
(Matsuo et al., 2016)
antennal mechanosensory and motor center AMMC Db2 neuron
(Matsuo et al., 2016)
adult stage | male
octopaminergic neuron of adult antennal lobe
(Zhou et al., 2008)
octopaminergic neuron of adult gnathal ganglion
(Zhou et al., 2008)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tdc2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Allele of Tdc2
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Tdc2RO54
0
Yes
Other relevant insertions
Transgenic Constructs ( 6 )
Deletions and Duplications ( 13 )
Summary of Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DDC
6 of 15
Yes
No
Hsap\HDC
3 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ddc
5 of 15
Yes
No
Mmus\Hdc
3 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Ddc
4 of 13
Yes
No
Rnor\Hdc
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\ddc
2 of 12
Yes
No
Xtro\hdc
2 of 12
Yes
No
Danio rerio (Zebrafish) (2)
Drer\ddc
5 of 15
Yes
No
Drer\hdc
3 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\tdc-1
15 of 15
Yes
Yes
Cele\hdl-1
5 of 15
No
Yes
Cele\bas-1
3 of 15
No
No
Cele\basl-1
3 of 15
No
No
Cele\hdl-2
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AAS
8 of 9
Yes
No
Atha\TYRDC
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190454 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Tdc2
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005586
Drosophila simulans
Dsim\GD10312
Drosophila sechellia
Dsec\GM20861
Drosophila erecta
Dere\GG10812
Drosophila yakuba
Dyak\GE24598
Drosophila ananassae
Dana\GF13800
Drosophila pseudoobscura pseudoobscura
Dpse\GA15851
Drosophila persimilis
Dper\GL10988
Drosophila willistoni
Dwil\GK23145
Drosophila virilis
Dvir\GJ20190
Drosophila mojavensis
Dmoj\GI20238
Drosophila grimshawi
Dgri\GH20147
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503FY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017624
Musca domestica
House fly
Mdoa\17017622
Glossina morsitans
Tsetse fly
Gmor\GMOY001160
Glossina morsitans
Tsetse fly
Gmor\GMOY006436
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09991
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09993
Mayetiola destructor
Hessian fly
Mdes\Mdes004467
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003462
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018302
Anopheles darlingi
American malaria mosquito
Adar\ADAC002421
Anopheles darlingi
American malaria mosquito
Adar\ADAC002431
Anopheles gambiae
Malaria mosquito
Agam\AGAP007302
Anopheles gambiae
Malaria mosquito
Agam\AGAP007305
Anopheles gambiae
Malaria mosquito
Agam\AGAP012771
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010568
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010562
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05UW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006804
Bombyx mori
Silkmoth
Bmor\BGIBMGA002958
Bombyx mori
Silkmoth
Bmor\BGIBMGA003199
Danaus plexippus
Monarch butterfly
Dple\DPOGS205057-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211076-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211220-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211221-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012487
Heliconius melpomene
Postman butterfly
Hmel\HMEL007928
Heliconius melpomene
Postman butterfly
Hmel\HMEL012488
Heliconius melpomene
Postman butterfly
Hmel\HMEL011364
Heliconius melpomene
Postman butterfly
Hmel\HMEL002217
Apis florea
Little honeybee
Aflo\3564137716
Apis florea
Little honeybee
Aflo\2787189172
Apis florea
Little honeybee
Aflo\2787189092
Apis florea
Little honeybee
Aflo\3564137780
Apis mellifera
Western honey bee
Amel\Ddc
Apis mellifera
Western honey bee
Amel\GB55831
Apis mellifera
Western honey bee
Amel\GB45939
Apis mellifera
Western honey bee
Amel\GB55830
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10316
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10227
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13927
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13926
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10317
Bombus terrestris
Buff-tailed bumblebee
Bter\15215367
Bombus terrestris
Buff-tailed bumblebee
Bter\15215366
Bombus terrestris
Buff-tailed bumblebee
Bter\15214401
Bombus terrestris
Buff-tailed bumblebee
Bter\15213003
Bombus terrestris
Buff-tailed bumblebee
Bter\15213005
Linepithema humile
Argentine ant
Lhum\LH20332
Linepithema humile
Argentine ant
Lhum\LH20333
Linepithema humile
Argentine ant
Lhum\LH19592
Linepithema humile
Argentine ant
Lhum\LH19591
Linepithema humile
Argentine ant
Lhum\LH20345
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003a8
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003a7
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0019ba
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0019b9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002600
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002601
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021102
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002599
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07302
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04320
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07300
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07298
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07299
Tribolium castaneum
Red flour beetle
Tcas\TC030580
Tribolium castaneum
Red flour beetle
Tcas\TC013402
Tribolium castaneum
Red flour beetle
Tcas\TC012567
Tribolium castaneum
Red flour beetle
Tcas\TC013401
Tribolium castaneum
Red flour beetle
Tcas\TC013480
Tribolium castaneum
Red flour beetle
Tcas\TC014317
Pediculus humanus
Human body louse
Phum\PHUM248840
Pediculus humanus
Human body louse
Phum\PHUM248850
Pediculus humanus
Human body louse
Phum\PHUM258570
Rhodnius prolixus
Kissing bug
Rpro\RPRC003262
Rhodnius prolixus
Kissing bug
Rpro\RPRC004898
Rhodnius prolixus
Kissing bug
Rpro\RPRC006023
Rhodnius prolixus
Kissing bug
Rpro\RPRC011470
Rhodnius prolixus
Kissing bug
Rpro\RPRC005884
Cimex lectularius
Bed bug
Clec\CLEC012979
Cimex lectularius
Bed bug
Clec\CLEC007017
Cimex lectularius
Bed bug
Clec\CLEC005236
Cimex lectularius
Bed bug
Clec\CLEC001776
Cimex lectularius
Bed bug
Clec\CLEC002149
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI52551
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009626
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001761
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05486
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05077
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04575
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05078
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02CJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009715
Strigamia maritima
European centipede
Smar\SMAR006669
Strigamia maritima
European centipede
Smar\SMAR000988
Ixodes scapularis
Black-legged tick
Isca\ISCW012649
Ixodes scapularis
Black-legged tick
Isca\ISCW003015
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68904.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81141.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g07500
Tetranychus urticae
Two-spotted spider mite
Turt\tetur247g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g02430
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g00750
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00420
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304481
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_221579
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327058
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_188046
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_212927
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300121
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_19266
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03KI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aadc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ddc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tdc1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ddc_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aadc_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hdc_3
Ciona intestinalis
Vase tunicate
Cint\LOC100182530
Ciona intestinalis
Vase tunicate
Cint\hdcl
Gallus gallus
Domestic chicken
Ggal\HDC
Gallus gallus
Domestic chicken
Ggal\DDC
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    DDC; dopa decarboxylase
    6 of 15
    107930
    HDC; histidine decarboxylase
    3 of 15
    142704
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Tdc2
    suppressible
    Tdc1
    (Hardie et al., 2007, Cole et al., 2005)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-55
    Cytogenetic map
    42C4-42C4
    Sequence location
    2R:6,684,745..6,689,974 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    42C4-42C4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    42C3-42C3
    (Cole et al., 2005)
    Location inferred from deficiency mapping.
    (Cole et al., 2005)
    Experimentally Determined Recombination Data
    Location
    2-55
    (FlyBase, 2016)
    2-56.0
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (6)
    Genomic Clones (18)
    cDNA Clones (4)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Huang et al., 2013, Pech et al., 2013)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: Tdc2 CG30446
      (Cole et al., 2005)
      Source for database merge of
      Additional comments
      Annotation CG3686 split into CG30445 and CG30446 in release 3 of the genome annotation.
      (FlyBase Genome Annotators, 2002-2003)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 28 )
      Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      InterPro - A database of protein families, domains and functional sites
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Linkouts
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc - Genes from a BioCyc PGDB for Dmel
      Flygut - An atlas of the Drosophila adult midgut
      FlyMine - An integrated database for Drosophila genomics
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Synonyms and Secondary IDs (14)
      Reported As
      Symbol Synonym
      CG30446
      (Meadows, 2018.4.4, Perkins et al., 2009.1.15)
      CG3686
      (Fulton et al., 2001)
      TDC
      (Bogomolova et al., 2009, Gruntenko et al., 2004, Gruntenko et al., 2003, Wolf and Heberlein, 2003, Chentsova et al., 2002, Rothenfluh and Heberlein, 2002, Andretic et al., 1999, Gruntenko et al., 1999, McClung and Hirsh, 1999, McClung and Hirsh, 1999)
      TDC2
      (Vogt et al., 2014, Shearin et al., 2013, Keene and Masek, 2012, Honjo and Furukubo-Tokunaga, 2009)
      TdC2
      (Diesner and Neupert, 2018)
      Tdc
      (Singh et al., 2014)
      Tdc2
      (Croset et al., 2018, Diesner and Neupert, 2018, Hartenstein et al., 2018, Pyakurel et al., 2018, Strother et al., 2018, Abruzzi et al., 2017, Asahina, 2017, Dinges et al., 2017, Tomita et al., 2017, Transgenic RNAi Project members, 2017-, Crocker et al., 2016, Huang et al., 2016, Li et al., 2016, Ma et al., 2016, Deady and Sun, 2015, Landayan and Wolf, 2015, Shankar et al., 2015, Yang et al., 2015, Rezával et al., 2014, Chen et al., 2013, Pech et al., 2013, Perisse et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Zwarts et al., 2012, Kahsai and Winther, 2011, Koon et al., 2011, Sprecher et al., 2011, Crocker et al., 2010, Blumenthal, 2009, Dankert et al., 2009, Crocker and Sehgal, 2008, Hoyer et al., 2008, Zhou et al., 2008, Brembs et al., 2007, Hardie et al., 2007)
      dTdc2
      (Claßen and Scholz, 2018, Middleton et al., 2006, Cole et al., 2005)
      tdc
      (Nässel et al., 2008)
      tdc2
      (Li et al., 2017, Zhang et al., 2013, Marella et al., 2012, Busch and Tanimoto, 2010)
      Name Synonyms
      Tyrosine decarboxylase
      (Livingstone and Tempel, 1983)
      Tyrosine decarboxylase 2
      (Rezával et al., 2014, Kahsai and Winther, 2011, Cole et al., 2005)
      tyrosine decarboxylase
      (Crocker et al., 2010, Bogomolova et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Nässel et al., 2008, Rothenfluh and Heberlein, 2002, Raushenbakh et al., 2001)
      tyrosine decarboxylase 2
      (Asahina, 2017, Ma et al., 2016, Yang et al., 2015, Hoyer et al., 2008, Vömel and Wegener, 2008)
      Secondary FlyBase IDs
      • FBgn0033091
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (111)