Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Isoform A forms homotetramer. Isoform B forms homodimer.
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is involved in catalytic reaction and UDP-Gal binding.
The alpha subunit loop in the ricin B-type lectin domain regulates substrate specificity and modulates the substrate access to the active site. In isoform A, the alpha subunit loop is composed of positively charged residues and acts on negatively charged substrates. In isoform B, the alpha subunit loop is composed of negatively charged residues and acts on positively charged substrates.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgant9 using the Feature Mapper tool.
Comment: enriched in presumptive notum, hinge and ventral wing pouch
Alternative splicing of the eighth coding exon of Pgant9 has important functional consquences. Form "A" uses the upstream alternative exon and form "B" uses the downstream exon. qPCR in wandering third instar larvae shows that Pgant9A transcripts are the predominant forms in midgut, hindgut, tracha, Malpighian tubule, and CNS while Pgant9B transcripts are more abundant in salivary gland.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pgant9 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Pgant9 CG30463
Source for merge of: CG8463 CG15713 CG8456
Annotations CG8463, CG15713 and CG8456 merged as CG30463 in release 3 of the genome annotation.