FB2025_05 , released December 11, 2025
Gene: Dmel\Pgant9
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General Information
Symbol
Dmel\Pgant9
Species
D. melanogaster
Name
Polypeptide N-Acetylgalactosaminyltransferase 9
Annotation Symbol
CG30463
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050463
Gene Model Status
Current
Stock Availability
16 publicly available
Enzyme Name (EC)
polypeptide N-acetylgalactosaminyltransferase (2.4.1.41)
Gene Summary
Polypeptide N-Acetylgalactosaminyltransferase 9 (Pgant9) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-α-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars. Pgant9-mediated glycosylation of cargo proteins is essential for proper secretory granule morphology and maturation in the salivary gland. [Date last reviewed: 2025-03-20] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
53D1-53D4
Sequence location
Recombination map
2-80
RefSeq locus
NT_033778 REGION:16673235..16732916
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables polypeptide N-acetylgalactosaminyltransferase activity
inferred from direct assay
(Ji et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables polypeptide N-acetylgalactosaminyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN004287905
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in protein O-linked glycosylation via N-acetyl-galactosamine
inferred from direct assay
(Ji et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein O-linked glycosylation
inferred from biological aspect of ancestor with PANTHER:PTN004287905
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in Golgi cisterna
inferred from direct assay
(Lowe et al., 2014)
located_in Golgi membrane
inferred from direct assay
(Ji et al., 2018)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN000187024
(GO Reference Genome Project, 2011-)
located_in Golgi apparatus
inferred from sequence or structural similarity with UniProtKB:Q14435
(Gene Ontology Curators, 2002-)
located_in membrane
inferred from sequence model
(FlyBase Curators, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. (Q8MRC9)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
polypeptide N-acetylgalactosaminyltransferase activity
(1) L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+) (2.4.1.41)
(2) L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+) (2.4.1.41)
Summaries
Gene Snapshot
Polypeptide N-Acetylgalactosaminyltransferase 9 (Pgant9) encodes a Golgi transmembrane protein that catalyzes the attachment of N-acetyl-α-D-galactosamine (GalNAc) to the hydroxyl group of serine or threonine residues in selected membrane or secreted proteins. This O-linked GalNAc glycan is known as the Tn antigen and can be further elongated with additional sugars. Pgant9-mediated glycosylation of cargo proteins is essential for proper secretory granule morphology and maturation in the salivary gland. [Date last reviewed: 2025-03-20]
Gene Group (FlyBase)
POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASES -
Polypeptide N-acetylgalactosaminyltransferase catalyze the transfer of N-Acetylgalactosamine (GalNAc) from UDP-GalNAc to serine and threonine acceptor sites and initiate mucin-type O-glycosylation. (Adapted from FBrf0151358 and FBrf0190815).
Pathway (FlyBase)
PROTEIN O-GalNAcYLATION -
Protein O-linked GalNAcylation is a post-translational modification that occurs in the Golgi apparatus. The synthesis of O-linked GalNAc glycans (also known as mucin-type O-glycans) begins with the attachment of a N-acetyl-galactosamine (GalNAc) via an α-glycosidic bond to the hydroxyl group of serine or threonine residues in secreted and membrane proteins; this monosaccharide O-glycan is known as the Tn antigen. The O-linked GalNAc can be extended by the addition of a galactose, forming the core 1 T antigen. A glucuronic acid can be further attached to the galactose resulting in the formation of a linear glycan. In D. melanogaster, Tn and T antigens are the most prevalent type of O-glycans and are involved in a broad range of processes, including cell recognition, adhesion and signaling. (Adapted from FBrf0244700 and FBrf0243014.)
Protein Function (UniProtKB)
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:30158631). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:30158631).
(UniProt, Q8MRC9)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Pgant9 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8MRC9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pgant9-RA
FBtr0087112
NM_166188
5876
650
Pgant9-RB
FBtr0087113
NM_166189
4051
647
Pgant9-RC
FBtr0113379
NM_001103871
4109
647
Pgant9-RD
FBtr0113380
NM_001103872
4060
650
Pgant9-RE
FBtr0113381
NM_001103873
1199
264
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pgant9-PA
FBpp0086258
73.2
650
7.95
Q8MRC9
NP_725602
AAF57966
Pgant9-PB
FBpp0086259
72.9
647
6.76
NP_725603
AAF57964
Pgant9-PC
FBpp0112291
72.9
647
6.76
NP_001097341
ABV53822
Pgant9-PD
FBpp0112292
73.2
650
7.95
Q8MRC9
NP_001097342
ABV53823
Pgant9-PE
FBpp0112293
30.3
264
6.50
NP_001097343
ABV53824
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

650 aa isoforms: Pgant9-PA, Pgant9-PD
647 aa isoforms: Pgant9-PB, Pgant9-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Isoform A forms homotetramer. Isoform B forms homodimer.

(UniProt, Q8MRC9)
Domain

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is involved in catalytic reaction and UDP-Gal binding.

The alpha subunit loop in the ricin B-type lectin domain regulates substrate specificity and modulates the substrate access to the active site. In isoform A, the alpha subunit loop is composed of positively charged residues and acts on negatively charged substrates. In isoform B, the alpha subunit loop is composed of negatively charged residues and acts on positively charged substrates.

(UniProt, Q8MRC9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgant9 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Tian and Ten Hagen, 2006)
embryonic stage 4 -- 6
organism | ubiquitous

Comment: very slight anterior enrichment

(Tian and Ten Hagen, 2006)
embryonic stage 9 -- 10
amnioserosa primordium
(Tian and Ten Hagen, 2006)
embryonic stage 9 -- 11
anterior midgut primordium
(Tian and Ten Hagen, 2006)
embryonic stage 11 -- 13
amnioserosa
(Tian and Ten Hagen, 2006)
embryonic stage 12 -- 15
salivary gland body primordium
(Tian and Ten Hagen, 2006)
embryonic stage 14 -- 17
organism | posterior
(Tian and Ten Hagen, 2006)
embryonic stage 16 -- 17
embryonic/larval salivary gland
(Tian and Ten Hagen, 2006)
third instar larval stage
wing disc | intense | ubiquitous

Comment: enriched in presumptive notum, hinge and ventral wing pouch

(Tian and Ten Hagen, 2006)
haltere disc | intense | ubiquitous
(Tian and Ten Hagen, 2006)
leg disc | ubiquitous
(Tian and Ten Hagen, 2006)
eye disc | ubiquitous

Comment: specific to presumptive eye

(Tian and Ten Hagen, 2006)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval midgut

Comment: form A more abundant

(Ji et al., 2018)
embryonic/larval hindgut

Comment: form A more abundant

(Ji et al., 2018)
embryonic/larval tracheal section

Comment: form A more abundant

(Ji et al., 2018)
embryonic/larval Malpighian tubule

Comment: form A more abundant

(Ji et al., 2018)
larval central nervous system

Comment: form A more abundant

(Ji et al., 2018)
embryonic/larval salivary gland

Comment: form B more abundant

(Ji et al., 2018)
Additional Descriptive Data

Alternative splicing of the eighth coding exon of Pgant9 has important functional consquences. Form "A" uses the upstream alternative exon and form "B" uses the downstream exon. qPCR in wandering third instar larvae shows that Pgant9A transcripts are the predominant forms in midgut, hindgut, tracha, Malpighian tubule, and CNS while Pgant9B transcripts are more abundant in salivary gland.

(Ji et al., 2018)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in Golgi cisterna
inferred from direct assay
(Lowe et al., 2014)
located_in Golgi membrane
inferred from direct assay
(Ji et al., 2018)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pgant9 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pgant9
Transgenic constructs containing regulatory region of Pgant9
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)Exel6064
(Ji et al., 2018, Ryder, 2004.4.26)
Gene partially disrupted in
Dp(2;2)SM5
(Miller et al., 2018)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\GALNT4
6 of 14
Yes
Yes
Hsap\GALNT5
6 of 14
Yes
Yes
Hsap\GALNT12
6 of 14
Yes
Yes
Hsap\GALNT13
6 of 14
Yes
No
Hsap\GALNT1
5 of 14
No
No
Hsap\GALNT15
5 of 14
No
Yes
Hsap\GALNT16
5 of 14
No
Yes
Hsap\POC1B-GALNT4
5 of 14
No
Yes
Hsap\GALNT3
4 of 14
No
No
Hsap\GALNT6
4 of 14
No
Yes
Hsap\GALNT7
4 of 14
No
No
Hsap\GALNT11
4 of 14
No
No
1  
Hsap\GALNT14
4 of 14
No
No
Hsap\GALNTL5
4 of 14
No
No
Hsap\GALNT2
3 of 14
No
No
3  
Hsap\GALNT8
3 of 14
No
Yes
Hsap\GALNT9
3 of 14
No
No
Hsap\GALNT10
3 of 14
No
No
Hsap\GALNT17
3 of 14
No
No
Hsap\GALNT18
3 of 14
No
Yes
Hsap\GALNTL6
3 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Galnt5
6 of 14
Yes
Yes
Rnor\Galnt13
6 of 14
Yes
No
Rnor\Galnt1
5 of 14
No
No
Rnor\Galnt12
5 of 14
No
Yes
Rnor\Galnt16
5 of 14
No
Yes
Rnor\Galnt3
4 of 14
No
No
Rnor\Galnt6
4 of 14
No
Yes
Rnor\Galnt7
4 of 14
No
No
Rnor\Galnt11
4 of 14
No
No
Rnor\Galnt14
4 of 14
No
No
Rnor\Galntl5
4 of 14
No
No
Rnor\Galnt2
3 of 14
No
No
Rnor\Galnt9
3 of 14
No
Yes
Rnor\Galnt10
3 of 14
No
No
Rnor\Galnt15
3 of 14
No
Yes
Rnor\Galnt18
3 of 14
No
Yes
Rnor\Galnt4
1 of 14
No
Yes
Rnor\Galnt8
1 of 14
No
Yes
Rnor\Galnt17
1 of 14
No
Yes
Rnor\Galntl6
1 of 14
No
No
Mus musculus (laboratory mouse) (19)
Mmus\Galnt4
6 of 14
Yes
Yes
Mmus\Galnt12
6 of 14
Yes
Yes
Mmus\Galnt13
6 of 14
Yes
No
Mmus\Galnt1
5 of 14
No
No
Mmus\Galnt5
5 of 14
No
Yes
Mmus\Galnt6
5 of 14
No
Yes
Mmus\Galnt15
5 of 14
No
Yes
Mmus\Galnt16
5 of 14
No
Yes
Mmus\Galnt3
4 of 14
No
No
Mmus\Galnt7
4 of 14
No
No
Mmus\Galnt11
4 of 14
No
No
Mmus\Galnt14
4 of 14
No
No
Mmus\Galntl5
4 of 14
No
No
Mmus\Galnt2
3 of 14
No
No
Mmus\Galnt9
3 of 14
No
Yes
Mmus\Galnt10
3 of 14
No
No
Mmus\Galnt17
3 of 14
No
No
Mmus\Galnt18
3 of 14
No
Yes
Mmus\Galntl6
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (28)
Xtro\galnt4
4 of 13
Yes
Yes
Xtro\galnt13
3 of 13
No
No
Xtro\pde1a
3 of 13
No
No
Xtro\galnt5
2 of 13
No
Yes
Xtro\galnt6.2
2 of 13
No
Yes
Xtro\galnt7
2 of 13
No
No
Xtro\galnt11
2 of 13
No
No
Xtro\galnt12
2 of 13
No
Yes
Xtro\galnt15
2 of 13
No
Yes
Xtro\adgrb3
1 of 13
No
Yes
Xtro\alpl
1 of 13
No
No
Xtro\anxa10
1 of 13
No
No
Xtro\dapk2
1 of 13
No
Yes
Xtro\ddr2
1 of 13
No
No
Xtro\fam177b
1 of 13
No
No
Xtro\galnt1
1 of 13
No
No
Xtro\galnt2
1 of 13
No
No
Xtro\galnt3
1 of 13
No
No
Xtro\galnt6.1
1 of 13
No
Yes
Xtro\galnt6.3
1 of 13
No
Yes
Xtro\galnt9
1 of 13
No
No
Xtro\galnt14
1 of 13
No
No
Xtro\galnt16
1 of 13
No
No
Xtro\galnt18
1 of 13
No
No
Xtro\LOC100489081
1 of 13
No
No
Xtro\mknk1
1 of 13
No
No
Xtro\nodal5
1 of 13
No
Yes
Xtro\znf414
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\galnt12
6 of 14
Yes
Yes
Drer\galnt1
5 of 14
No
No
Drer\galnt6
5 of 14
No
Yes
Drer\galnt13
5 of 14
No
No
Drer\galnt16
5 of 14
No
Yes
Drer\poc1bl
5 of 14
No
Yes
Drer\galnt3
4 of 14
No
Yes
Drer\galnt14
4 of 14
No
No
Drer\galnt5
3 of 14
No
Yes
Drer\galnt7
3 of 14
No
No
Drer\galnt8a.2
3 of 14
No
Yes
Drer\galnt8b.1
3 of 14
No
Yes
Drer\galnt8b.2
3 of 14
No
Yes
Drer\galnt9
3 of 14
No
No
Drer\galnt11
3 of 14
No
No
Drer\galnt17
3 of 14
No
Yes
Drer\galnt18b
3 of 14
No
Yes
Drer\galntl6
3 of 14
No
No
Drer\galnt2
2 of 14
No
No
Drer\galnt8a.1
2 of 14
No
Yes
Drer\galnt10
2 of 14
No
Yes
Drer\galnt18a
2 of 14
No
Yes
Drer\LOC103910015
2 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\gly-5
13 of 14
Yes
Yes
Cele\gly-3
5 of 14
No
No
Cele\gly-7
3 of 14
No
No
Cele\gly-8
3 of 14
No
No
Cele\gly-4
2 of 14
No
No
Cele\gly-6
2 of 14
No
No
Cele\gly-9
2 of 14
No
No
Cele\gly-11
2 of 14
No
No
Cele\gly-10
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (14)
Agam\AgaP_AGAP006881
5 of 12
Yes
Yes
Agam\AgaP_AGAP012256
5 of 12
Yes
Yes
Agam\AgaP_AGAP008613
4 of 12
No
No
Agam\AgaP_AGAP012253
4 of 12
No
Yes
Agam\AgaP_AGAP000656
3 of 12
No
No
Agam\AgaP_AGAP004429
3 of 12
No
No
Agam\AgaP_AGAP006925
3 of 12
No
No
Agam\AgaP_AGAP008229
3 of 12
No
No
Agam\AgaP_AGAP010078
3 of 12
No
No
Agam\AgaP_AGAP010367
3 of 12
No
No
Agam\AgaP_AGAP011984
3 of 12
No
No
Agam\AgaP_AGAP012414
3 of 12
No
No
Agam\AgaP_AGAP004375
2 of 12
No
No
Agam\AgaP_AGAP012254
2 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pgant9. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
Pgant5
6 of 13
CG31776
5 of 13
Pgant2
5 of 13
Pgant4
5 of 13
Pgant6
5 of 13
Pgant7
5 of 13
Pgant8
5 of 13
Pgant35A
5 of 13
CG7304
4 of 13
CG7579
4 of 13
CG10000
4 of 13
Pgant1
4 of 13
Pgant3
4 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GALNT4; polypeptide N-acetylgalactosaminyltransferase 4
    6 of 14
    603565
        GALNT5; polypeptide N-acetylgalactosaminyltransferase 5
        6 of 14
        615129
            GALNT12; polypeptide N-acetylgalactosaminyltransferase 12
            6 of 14
            610290
              GALNT13; polypeptide N-acetylgalactosaminyltransferase 13
              6 of 14
              608369
                  GALNT1; polypeptide N-acetylgalactosaminyltransferase 1
                  5 of 14
                  602273
                      GALNT15; polypeptide N-acetylgalactosaminyltransferase 15
                      5 of 14
                      615131
                          GALNT16; polypeptide N-acetylgalactosaminyltransferase 16
                          5 of 14
                          615132
                              POC1B-GALNT4; POC1B-GALNT4 readthrough
                              5 of 14
                                  GALNT3; polypeptide N-acetylgalactosaminyltransferase 3
                                  4 of 14
                                  601756
                                  GALNT6; polypeptide N-acetylgalactosaminyltransferase 6
                                  4 of 14
                                  605148
                                      GALNT7; polypeptide N-acetylgalactosaminyltransferase 7
                                      4 of 14
                                      605005
                                          GALNT11; polypeptide N-acetylgalactosaminyltransferase 11
                                          4 of 14
                                          615130
                                               
                                              GALNT14; polypeptide N-acetylgalactosaminyltransferase 14
                                              4 of 14
                                              608225
                                                  GALNTL5; polypeptide N-acetylgalactosaminyltransferase like 5
                                                  4 of 14
                                                  615133
                                                      GALNT2; polypeptide N-acetylgalactosaminyltransferase 2
                                                      3 of 14
                                                      602274
                                                       
                                                      GALNT8; polypeptide N-acetylgalactosaminyltransferase 8
                                                      3 of 14
                                                      606250
                                                          GALNT9; polypeptide N-acetylgalactosaminyltransferase 9
                                                          3 of 14
                                                          606251
                                                              GALNT10; polypeptide N-acetylgalactosaminyltransferase 10
                                                              3 of 14
                                                              608043
                                                                  GALNT17; polypeptide N-acetylgalactosaminyltransferase 17
                                                                  3 of 14
                                                                  615137
                                                                      GALNT18; polypeptide N-acetylgalactosaminyltransferase 18
                                                                      3 of 14
                                                                      615136
                                                                          GALNTL6; polypeptide N-acetylgalactosaminyltransferase like 6
                                                                          3 of 14
                                                                          615138
                                                                              Functional Complementation Data
                                                                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                              Interactions
                                                                              Summary of Physical Interactions
                                                                              Interaction Browsers
                                                                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                                              Please see the Physical Interaction reports below for full details
                                                                              protein-protein
                                                                              Physical Interaction
                                                                              Assay
                                                                              References
                                                                              Pgant9 - Sgs3
                                                                              enzymatic study, autoradiography
                                                                              (Ji et al., 2018)
                                                                              Summary of Genetic Interactions
                                                                              Interaction Browsers
                                                                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                                              Please look at the allele data for full details of the genetic interactions
                                                                              Starting gene(s)
                                                                              Interaction type
                                                                              Interacting gene(s)
                                                                              Reference
                                                                              Starting gene(s)
                                                                              Interaction type
                                                                              Interacting gene(s)
                                                                              Reference
                                                                              brm
                                                                              suppressible
                                                                              Pgant9
                                                                              (Tegeder et al., 2019)
                                                                              External Data
                                                                              Subunit Structure (UniProtKB)
                                                                              Isoform A forms homotetramer. Isoform B forms homodimer.
                                                                              (UniProt, Q8MRC9 )
                                                                              Linkouts
                                                                              BioGRID - A database of protein and genetic interactions.
                                                                              DroID - A comprehensive database of gene and protein interactions.
                                                                              Pathways
                                                                              Signaling Pathways (FlyBase)
                                                                              Metabolic Pathways
                                                                              FlyBase
                                                                              PROTEIN O-GalNAcYLATION
                                                                              External Links
                                                                              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                                                              KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                              External Data
                                                                              Linkouts
                                                                              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                              Class of Gene
                                                                              Genomic Location and Detailed Mapping Data
                                                                              Chromosome (arm)
                                                                              2R
                                                                              Recombination map
                                                                              2-80
                                                                              Cytogenetic map
                                                                              53D1-53D4
                                                                              Sequence location
                                                                              FlyBase Computed Cytological Location
                                                                              Cytogenetic map
                                                                              Evidence for location
                                                                              53D1-53D4
                                                                              Limits computationally determined from genome sequence between P{PZ}Sema-2a03021&P{PZ}Cdk405428 and P{EP}BEST:SD02913EP2148&P{lacW}Dekk09907
                                                                              Experimentally Determined Cytological Location
                                                                              Cytogenetic map
                                                                              Notes
                                                                              References
                                                                              Experimentally Determined Recombination Data
                                                                              Location

                                                                              2-80

                                                                              (FlyBase, 2016)

                                                                              2-84.1

                                                                              (Comeron et al., 2012)
                                                                              Left of (cM)
                                                                              Right of (cM)
                                                                              Notes
                                                                              Stocks and Reagents
                                                                              Stocks (16)
                                                                              Genomic Clones (52)
                                                                              cDNA Clones (39)
                                                                               

                                                                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                              cDNA clones, fully sequenced
                                                                              BDGP DGC clones
                                                                              Other clones
                                                                                Drosophila Genomics Resource Center cDNA clones

                                                                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                                cDNA Clones, End Sequenced (ESTs)
                                                                                BDGP DGC clones
                                                                                Other clones
                                                                                RNAi and Array Information
                                                                                Linkouts
                                                                                DRSC - Results frm RNAi screens
                                                                                Antibody Information
                                                                                Laboratory Generated Antibodies
                                                                                 

                                                                                polyclonal

                                                                                (Zhang and Ten Hagen, 2024, Ji et al., 2018)
                                                                                Commercially Available Antibodies
                                                                                 
                                                                                Cell Line Information
                                                                                Publicly Available Cell Lines
                                                                                 
                                                                                  Other Stable Cell Lines
                                                                                   
                                                                                    Other Comments
                                                                                    Relationship to Other Genes
                                                                                    Source for database merge of

                                                                                    Source for merge of: CG8463 CG15713 CG8456

                                                                                    (FlyBase Genome Annotators, 2002-2003)
                                                                                    Additional comments

                                                                                    Annotations CG8463, CG15713 and CG8456 merged as CG30463 in release 3 of the genome annotation.

                                                                                    (FlyBase Genome Annotators, 2002-2003)
                                                                                    Nomenclature History
                                                                                    Source for database identify of

                                                                                    Source for identity of: Pgant9 CG30463

                                                                                    (Ji et al., 2018)
                                                                                    Nomenclature comments
                                                                                    Etymology
                                                                                    Synonyms and Secondary IDs (9)
                                                                                    Datasets (0)
                                                                                    Study focus (0)
                                                                                    Experimental Role
                                                                                    Project
                                                                                    Project Type
                                                                                    Title
                                                                                    Study result (0)
                                                                                    Result
                                                                                    Result Type
                                                                                    Title
                                                                                    External Crossreferences and Linkouts ( 64 )
                                                                                    Sequence Crossreferences
                                                                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                                    Other crossreferences
                                                                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                                    FlyMine - An integrated database for Drosophila genomics
                                                                                    InterPro - A database of protein families, domains and functional sites
                                                                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                                    PDB - An information portal to biological macromolecular structures
                                                                                    Linkouts
                                                                                    BioGRID - A database of protein and genetic interactions.
                                                                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                    DroID - A comprehensive database of gene and protein interactions.
                                                                                    DRSC - Results frm RNAi screens
                                                                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                                                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                                    Flygut - An atlas of the Drosophila adult midgut
                                                                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                                    References (76)