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Gene Dmel\Cyp12d1-p

General Information
Symbol	Dmel\Cyp12d1-p	Species	D. melanogaster
Name	Cyp12d1-p	Annotation symbol	CG30489
Feature type	protein_coding_gene	FlyBase ID	FBgn0050489
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	Cyp12d1, 12d1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47D4-47D4	Sequence location	2R:7,007,471..7,009,389 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyp12d1-p is referred to in FlyBase by the symbol Dmel\Cyp12d1-p (CG30489, FBgn0050489). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: electron carrier activity. There is experimental evidence that it is involved in the biological process: response to insecticide; response to DDT. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome P450; Cytochrome P450, E-class, group I; Cytochrome P450, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Cyp12d1-p. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Cyp12d1-p. Gene sequence location is 2R:7007471..7009389.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47D4-47D4   Limits computationally determined from genome sequence between P{lacW}l(2)k15826k15826&P{EP}EP471 and P{EP}shnEP2359&P{EP}shnEP644
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyp12d1-p for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Cyp12d1-d and Cyp12d1-p derived from a tandem duplication of Cyp12d1 in the melanogaster group (FBrf0219004). In most Drosophila melanogaster strains tested, there is a single Cyp12d1 gene instead of two tandemly duplicated copies (FBrf0219004). Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyp12d1-p-RA FBtr0089419  NM_136791   1741   521
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyp12d1-p-PA   FBpp0088437   60.2   521   9.55     NP_610635   AAM68745
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567770   AA698375   AA698380   AA698511   AA802777   AA942250   AE013599 AAM68745   AI402682   AI402683   AY061415   AY081961 AAL89789   BI216029   BI228648   BI231906   BI233037   BI637741   BI640364   BI640949   BI641717   BT001433   BT031280
UniProtKB/Swiss-Prot	P82712
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
[an error occurred while processing this directive]
modENCODE Development RNA-Seq
[an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
[an error occurred while processing this directive]
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    36 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    127 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3  (36) Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (127) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    36 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (127) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    36 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    127 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    36 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    127 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3  (36) Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (127) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    36 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3  127 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    36 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    127 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_04 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • LD34576 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050489 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30489-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele chemical resistant, with Scer\GAL4Cyp6g1.HR Cyp12d1-pScer\UAS.cDa Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Cyp12d1-p Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyp12d1-p Class Mutagen Stocks Known lesion Cyp12d1-pKK116233 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cyp12d1-pNIG.30489R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cyp12d1-pScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6059 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK116233} NA P{NIG.30489R} NA P{UAS-Cyp12d1-p.D} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to DDT inferred from mutant phenotype (Daborn et al., 2007) response to insecticide inferred from mutant phenotype (Daborn et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from sequence or structural similarity (Dunkov, 2000.10.12) inferred from sequence or structural similarity with Cyp12a5 AND inferred from sequence or structural similarity with UniProtKB:O18635 (FlyBase Genome Annotators, 2002-2003) non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 2000.10.1) heme binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) iron ion binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity (Dunkov, 2000.10.12, Degtyarenko, 2000.9.19) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cyp12d1-p - ATPsyn-γ experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Aats-asp experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Aats-glupro experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG10425 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG10996 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG11210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG11534 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG11679 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG12262 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG12264 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG14262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG1444 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG1516 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG17259 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG1907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG2064 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG2789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG3008 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG33303 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG3523 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG3700 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG4169 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG5190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG5525 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG5805 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG5854 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG7033 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG8010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG8258 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - CG8950 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CG9547 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Ca-P60A experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Cctγ experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Chc experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Cnx99A experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - EfTuM experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Gadd34 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Gfat2 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Gie experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Glt experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Gp93 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Gs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Hip1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Jon65Aiv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Kap-α3 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Kr-h2 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - LKR experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - MRP experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Mec2 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Mpcp experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Nup50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Odc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Ost48 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - OstΔ experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Past1 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Pen experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Pis anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Pp2A-29B experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Pten anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Rab1 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Rab5 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Cyp12d1-p - Rab7 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Ranbp9 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Rheb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - RpS10b experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Rpn1 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Rpn3 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Rpp30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Rpt1 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Rpt2 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Sc2 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Sec61α experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Sply anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - Sucb experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Tapδ experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Tcp-1ζ experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Tcp-1η experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - Vps4 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - bor experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - cathD experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - cdc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - frc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - hop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - l(1)G0156 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - ldbr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - nemy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyp12d1-p - r experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - scf experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - sec63 experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - skap experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - wal experimental knowledge based (Guruharsha et al., 2011) Cyp12d1-p - βCop experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyp12d1-p allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0050489
Orthologs
OrthoDB Orthologs (32) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FN53D Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6R4XZ7 Arthropod inclusive ortholog search EOG6R2299 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6FN53D)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cyp12d1-d     Drosophila melanogaster fruit fly  Dmel\Cyp12d1-p     Drosophila simulans   Dsim\GD25945   Y Drosophila simulans   Dsim\GD25944   Y Drosophila sechellia   Dsec\GM20476   Y Drosophila erecta   Dere\GG22701   Y Drosophila erecta   Dere\GG22700   Y Drosophila yakuba   Dyak\GE13056   Y Drosophila ananassae   Dana\GF12441   Y Drosophila ananassae   Dana\GF12440   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA15876   Y Drosophila persimilis   Dper\GL20645   Y Drosophila willistoni   Dwil\GK20660   Y Drosophila virilis   Dvir\GJ13146   Y Drosophila mojavensis   Dmoj\GI13002   Y Drosophila grimshawi   Dgri\GH15396   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6R4XZ7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013694 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16942 Y Atta cephalotes Leafcutter ant  Acep\ACEP21373 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19269 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14481 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20031 Y Linepithema humile Argentine ant  Lhum\LH17599 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20836 Y Solenopsis invicta Red fire ant  Sinv\SINV13068 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005356 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001277 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001276 Y Pediculus humanus Human body louse  Phum\PHUM120320 Y Tribolium castaneum Red flour beetle  Tcas\CYP12H1 Y
Orthologs in non-Insect Arthropods (EOG6R2299)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_319971 Y Ixodes scapularis Deer tick  Isca\ISCW001527 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR13D20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH21068 LD34576 LP12934
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH21946 GH21947 GM06292 HL01746 HL04361 HL04373 HL04839 LD26353 RE22823 RE24877 RE26257 RE29311 SD19809 SD23193 SD23991 SD25285
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0050489 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 246648
Antibody Information
	polyclonal (Festucci-Buselli et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Two "Cyp12d1" genes are present in a tandem duplication at 47D; Cyp12d1-p (proximal) and Cyp12d1-d (distal). The release 3.2 annotations for these two genes are CG30489 (Cyp12d1-p) and CG33503 (Cyp12d1-d). Annotation CG30489 was labelled "CG18240" in release 2 of the genome annotation and "CG30489" in releases 3.0 and 3.1. Annotation CG33503 was labelled "CG18239" in release 2 of the genome annotation and "CG18240" in releases 3.0 and 3.1. (FlyBase Genome Annotators, 2004)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136791 RefSeq (Proteins) • NP_610635 DDBJ / EMBL / GenBank • AAL89789 AAM68745 AY081961 Entrez Gene - A searchable database of RefSeq genes. • 246648 UniProtKB/Swiss-Prot • P82712
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD34576
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0050489 DRSC - Results from RNAi screens. • FBgn0050489 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0050489 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30489-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0050489 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 246648 modMine - Data generated by the modENCODE project. • FBgn0050489
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	12d1 (Kasai and Tomita, 2003, Nelson, 2001.2.5) 12D1 (Tijet et al., 2001) CG18240 (Jensen et al., 2006) CG30489 (Mosallanejad et al., 2010, Ellis and Carney, 2010, Keleman et al., 2009.8.5) Cyp12d1 (Pedra et al., 2004, ffrench-Constant et al., 2004, Ranson et al., 2002, Brandt et al., 2002, Le Goff et al., 2003, Niwa et al., 2011, Willoughby et al., 2006, Chahine and O'Donnell, 2011, Daborn et al., 2007, Festucci-Buselli et al., 2005, Sun et al., 2006, Schmidt et al., 2010, Chen et al., 2010, Giraudo et al., 2010) CYP12D1 (Degtyarenko, 2000.9.19, Dunkov, 2000.10.12, Chen and Li, 2007, Jones et al., 2010) Cyp 12d1 (Jensen et al., 2006) Cyp12d1-p (Rand et al., 2012, Zraly et al., 2006, Gilchrist et al., 2008, Ayroles et al., 2009, King-Jones et al., 2006, Ellis and Carney, 2010, Japanese National Institute of Genetics, 2012.5.21, McDonnell et al., 2012, Malone et al., 2012)
Name Synonym	Cyp12d1-p   cytochrome P450 (Chung et al., 2009)
Secondary FlyBase IDs
	FBgn0033576 FBgn0041339
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] McDonnell et al., 2012, J. Mol. Evol. 74(5-6): 281--296 Evolutionary toxicogenomics: diversification of the cyp12d1 and cyp12d3 genes in Drosophila species. [FBrf0219004] Rand et al., 2012, Toxicology 300(1-2): 75--82 Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development. [FBrf0218862] Chahine and O'Donnell, 2011, J. Exp. Biol. 214(3): 462--468 Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster. [FBrf0212764] Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543 Expressions of the cytochrome P450 monooxygenase gene Cyp4g1 and its homolog in the prothoracic glands of the fruit fly Drosophila melanogaster (Diptera: Drosophilidae) and the silkworm Bombyx mori (Lepidoptera: Bombycidae). [FBrf0216541] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...