FB2025_01 , released February 20, 2025
Gene: Dmel\CG30495
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General Information
Symbol
Dmel\CG30495
Species
D. melanogaster
Name
Annotation Symbol
CG30495
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050495
Gene Model Status
Current
Stock Availability
7 publicly available
Enzyme Name (EC)
NADP-retinol dehydrogenase (1.1.1.300)
Gene Summary
Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to be involved in retinal metabolic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). (Alliance, FBgn0050495 )
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Key Links
Genomic Location
Cytogenetic map
43E7-43E8
Sequence location
Recombination map
2-57
RefSeq locus
NT_033778 REGION:7656895..7659061
Sequence
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Function

GO Summary Ribbons

enzyme
regulator
receptor
receptor binding
transporter
structural molecule
cytoskeletal binding
DNA binding
RNA binding
transcription factor
small molecule binding
metal ion binding
lipid binding
carbohydrate binding
other molecular_function
molecular function
cell cycle/proliferation
cell organization/biogenesis
transport/localization
development
reproduction
immune system
nervous system process
behavior
response to stimulus
signaling
gene expression
protein metabolism
DNA metabolism
small molecule metabolism
other biological_process
biological process
extracellular region
cytosol
cytoskeleton
mitochondrion
nucleus
chromosome
membrane
cell periphery
cell junction
cell projection
endomembrane system
synapse
macromolecular complex
other cellular_component
cellular component
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Biological Process (1 term)
Cellular Component (1 term)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
all-trans-retinol dehydrogenase (NADP+) activity
all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+) (1.1.1.300)
RHEA 25033:
Summaries
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Expression Data

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Alleles, Insertions, Transgenic Constructs, and Aberrations
Variants
Phenotypes
Orthologs
Paralogs
Human Disease Associations
Functional Complementation Data
Interactions
Pathways
Class of Gene
Genomic Location and Detailed Mapping Data
Stocks and Reagents
Other Comments
Relationship to Other Genes
Nomenclature History
Synonyms and Secondary IDs (2)
Datasets (0)
External Crossreferences and Linkouts ( 31 )
References (23)