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Gene Dmel\CG31048

General Information
Symbol	Dmel\CG31048	Species	D. melanogaster
Name		Annotation symbol	CG31048
Feature type	protein_coding_gene	FlyBase ID	FBgn0051048
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98E6-98F1	Sequence location	3R:24,671,689..24,695,340 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG31048 (FBgn0051048). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: GTP binding; GTPase binding; guanyl-nucleotide exchange factor activity. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dedicator of cytokinesis; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1627763_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG31048. Gene sequence location is 3R:24671689..24695340.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20275 HFA14373 HFA14881
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98E6-98F1   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG31048 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG31048-RB FBtr0289996  NM_170379   6516   2171 CG31048-RC FBtr0289997  NM_001144646   6072   2023
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG31048-PB   FBpp0288435   245.9   2171   6.79     NP_733258   AAF56821 CG31048-PC   FBpp0288436   229.4   2023   6.85     NP_001138118   ACL83574
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) Dedicator of cytokinesis (IPR010703)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56821   AE014297 ACL83574   CO180888   CO186355   CO279212   CO320196   EC061252   EC091168   EC227567   EL874104   EL874105   EL874225   EL874226   EL874335   EL874336   ES691011   EV584111   EW712914   EW713170   FE527337   FE527401   FE527538   FE527605   FF579277   FF579301   FF579371   FF579482   GR705854
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VAS8 B7Z0R2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0051048    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0051048 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0051048 expression level Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr    1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1251) embryo 02-04hr  (194) embryo 04-06hr    84 embryo 06-08hr  (346) embryo 08-10hr  (676) embryo 10-12hr  (855) embryo 12-14hr  (1279) embryo 14-16hr  (1198) embryo 16-18hr  (975) embryo 18-20hr  (933) embryo 20-22hr  (661) embryo 22-24hr  (784) larva L1  (477) larva L2  (228) larva L3 12hr old  (216) larva L3 puffstage 1-2  (165) larva L3 puffstage 3-6  (393) larva L3 puffstage 7-9  (565) white prepupae new  (747) white prepupae 12hr  (1965) white prepupae 24hr  (1211) pupae 2d postWPP  (940) pupae 3d postWPP  (356) pupae 4d postWPP  (573) adult male 01day  (562) adult male 05day  (543) adult male 30day  (578) adult female 01day  (643) adult female 05day  (888) adult female 30day  (892) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr  (1965) white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr    1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr    1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0051048 expression level Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr    1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1251) embryo 02-04hr  (194) embryo 04-06hr    84 embryo 06-08hr  (346) embryo 08-10hr  (676) embryo 10-12hr  (855) embryo 12-14hr  (1279) embryo 14-16hr  (1198) embryo 16-18hr  (975) embryo 18-20hr  (933) embryo 20-22hr  (661) embryo 22-24hr  (784) larva L1  (477) larva L2  (228) larva L3 12hr old  (216) larva L3 puffstage 1-2  (165) larva L3 puffstage 3-6  (393) larva L3 puffstage 7-9  (565) white prepupae new  (747) white prepupae 12hr  (1965) white prepupae 24hr  (1211) pupae 2d postWPP  (940) pupae 3d postWPP  (356) pupae 4d postWPP  (573) adult male 01day  (562) adult male 05day  (543) adult male 30day  (578) adult female 01day  (643) adult female 05day  (888) adult female 30day  (892) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr  1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr    1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1251 embryo 02-04hr    194 embryo 04-06hr    84 embryo 06-08hr    346 embryo 08-10hr    676 embryo 10-12hr    855 embryo 12-14hr    1279 embryo 14-16hr    1198 embryo 16-18hr    975 embryo 18-20hr    933 embryo 20-22hr    661 embryo 22-24hr    784 larva L1    477 larva L2    228 larva L3 12hr old    216 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    393 larva L3 puffstage 7-9    565 white prepupae new    747 white prepupae 12hr    1965 white prepupae 24hr    1211 pupae 2d postWPP    940 pupae 3d postWPP    356 pupae 4d postWPP    573 adult male 01day    562 adult male 05day    543 adult male 30day    578 adult female 01day    643 adult female 05day    888 adult female 30day    892 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0051048    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0051048 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0051048 expression level Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0051048 expression level Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.65 Larval Midgut no informative data Larval Hindgut    19.7 Larval Malpighian Tubules    26.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    17.925 Larval Carcass    17.65 Adult Head    38.3 Adult Eye    17.65 Adult Brain    84.5 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    63.1 Adult Midgut no informative data Adult Hindgut    28 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    48 Adult Heart    19.2 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    55.2 Adult Testis    12.8 Adult Male Accessory Gland    24.9 Adult Carcass    31.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    38.3   NA  Eye    17.65   NA  Brain    84.5   68.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    75   NA  Crop    63.1   no informative data  Midgut    no informative data   19.7  Hindgut    28   26.7  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    48   NA  Heart    19.2   17.925  Trachea    NA   NA  VirginFemale Spermatheca    8.2   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    55.2   NA  Testis    12.8   NA  Male Accessory Gland    24.9   17.65  Carcass    31.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31048-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 CG31048GD10145 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG31048 Class Mutagen Stocks Known lesion CG31048c04614 1 -- CG31048e03183 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG31048 Class Mutagen Stocks Known lesion CG31048GD10145 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG31048GL00316 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG31048HMS01356 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6210 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10145} NA P{TRiP.GL00316} NA P{TRiP.HMS01356} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG31048c04614 NA PBac{RB}CG31048e03183 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
GTPase binding inferred from electronic annotation with InterPro:IPR010703 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR010703 (FlyBase Curators et al., 2004-) guanyl-nucleotide exchange factor activity inferred from electronic annotation with InterPro:IPR010703 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG31048 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68279 DroID - A comprehensive database of gene and protein interactions. • FBgn0051048 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43404
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17014 Dere\GG11617 Dgri\GH18332 Dmoj\GI23312 Dper\GL24194 Dpse\GA15964 Dsec\GM12740 Dsim\GD21384 Dvir\GJ24168 Dwil\GK13307 Dyak\GE23804
Curated drosophilid orthologs	Dpse\GA15964
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011258-PA Aedes aegypti (mosquito) AGAP004507-PA Anopheles gambiae (mosquito) XP_001121716.1 Apis mellifera (honey bee) XP_001943146.1 Acyrthosiphon pisum (pea aphid) 23562 Batrachochytrium dendrobatidis (chytrid fungus) 66495 Branchiostoma floridae (lancelet) ENSCAFP00000015060 Canis familiaris (dog) CPIJ014746 Culex pipens (mosquito) ENSCPOP00000005550 Cavia porcellus (guinea pig) 227090 Capitella spl (polychaete worm) DDB0233625 Dictyostelium discoideum (amoeba) 323931 Daphnia pulex (daphnia) ENSDARP00000082250 Danio rerio (zebra fish) ENSECAP00000012436 Equus caballus (horse) ENSGACP00000025019 Gymnopilus aculeatus (mushroom) ENSGALP00000003671 Gallus gallus (chicken) ENSP00000385673 Homo sapiens (human) ISCW021297-PA Ixodes scapularis (deer tick) 34527 Monocosta brevicollis (choanoflagellate) ENSMODP00000019937 Monodelphis domestica (gray opossum) ENSMMUP00000005723 Macaca mulatta (rhesus monkey) ENSMUSP00000047652 Mus musculus (house mouse) XP_001602554.1 Nasonia vitripennis (wasp) ENSOANP00000020241 Ornithorynchus anatinus (platypus) ENSORLP00000012502 Oryzias latipes (japanese killifish) PHUM008701-PA Pediculus humanus (human body louse) ENSPPYP00000015480 Pongo pygmaeus (orangutan) ENSPTRP00000025843 Pan troglodytes (chimpanzee) ENSRNOP00000006709 Rattus norvegicus (norway rat) ENSTNIP00000021047 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019278 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024486 Xenopus tropicalis (frog) YALI0B22484g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16335 NV17104 LH12202 ISCW021297 FBgn0240959 FBgn0215316 FBgn0211252 FBgn0192820 FBgn0167676 JGI_V11_323931 FBgn0075980 FBgn0161784 FBgn0146039 FBgn0131268 FBgn0125800 FBgn0103914 FBgn0094033 CPIJ014746 BGIBMGA000242 BGIBMGA000241 ACYPI001490 GB19101 AGAP004507 AAEL011258 PHUM336900 GLEAN_12780
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	35396 y1 sc* v1; P{TRiP.GL00316}attP2 34367 y1 sc* v1; P{TRiP.HMS01356}attP2/TM3, Sb1
Harvard	- PBac{PB}CG31048c04614 - PBac{RB}CG31048e03183
VDRC	v21293 w1118 P{GD10145}v21293 v47316 w1118; P{GD10145}v47316/TM3
Genomic Clones ( 2 )
	BACR13H19 BACR48K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	19902 177806 Cauquenes_24_H02 CK01.117D.E8 Diego_25_B06 Dmel_dig_019719_0611_3133 DMG1-chr3R.25.057.a DMG3-chr3R.10865.pred.a DMG3-chr3R.10867.pred.a EC13093 EK019009 EK133813 EK282664 Elena_26_A02 Fernando_27_C04 IP14158 IP14258 IP14358 MB6-CG31048.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43404
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG11754 CG14530 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG11754 and CG14530 merged as CG31048 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_170379 NM_001144646 RefSeq (Proteins) • NP_733258 NP_001138118 DDBJ / EMBL / GenBank • AAF56821 ACL83574 Entrez Gene - A searchable database of RefSeq genes. • 43404 UniProtKB/TrEMBL • B7Z0R2 Q9VAS8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) Dedicator of cytokinesis (IPR010703)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68279 DroID - A comprehensive database of gene and protein interactions. • FBgn0051048 DRSC - Results from RNAi screens. • FBgn0051048 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31048-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43404 InParanoid A subset of ortholog calls from InParanoid. • AAEL011258-PA Aedes aegypti (mosquito) AGAP004507-PA Anopheles gambiae (mosquito) XP_001121716.1 Apis mellifera (honey bee) XP_001943146.1 Acyrthosiphon pisum (pea aphid) 23562 Batrachochytrium dendrobatidis (chytrid fungus) 66495 Branchiostoma floridae (lancelet) ENSCAFP00000015060 Canis familiaris (dog) CPIJ014746 Culex pipens (mosquito) ENSCPOP00000005550 Cavia porcellus (guinea pig) 227090 Capitella spl (polychaete worm) DDB0233625 Dictyostelium discoideum (amoeba) 323931 Daphnia pulex (daphnia) ENSDARP00000082250 Danio rerio (zebra fish) ENSECAP00000012436 Equus caballus (horse) ENSGACP00000025019 Gymnopilus aculeatus (mushroom) ENSGALP00000003671 Gallus gallus (chicken) ENSP00000385673 Homo sapiens (human) ISCW021297-PA Ixodes scapularis (deer tick) 34527 Monocosta brevicollis (choanoflagellate) ENSMODP00000019937 Monodelphis domestica (gray opossum) ENSMMUP00000005723 Macaca mulatta (rhesus monkey) ENSMUSP00000047652 Mus musculus (house mouse) XP_001602554.1 Nasonia vitripennis (wasp) ENSOANP00000020241 Ornithorynchus anatinus (platypus) ENSORLP00000012502 Oryzias latipes (japanese killifish) PHUM008701-PA Pediculus humanus (human body louse) ENSPPYP00000015480 Pongo pygmaeus (orangutan) ENSPTRP00000025843 Pan troglodytes (chimpanzee) ENSRNOP00000006709 Rattus norvegicus (norway rat) ENSTNIP00000021047 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019278 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024486 Xenopus tropicalis (frog) YALI0B22484g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43404 modMine - Data generated by the modENCODE project. • FBgn0051048 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16335 NV17104 LH12202 ISCW021297 FBgn0240959 FBgn0215316 FBgn0211252 FBgn0192820 FBgn0167676 JGI_V11_323931 FBgn0075980 FBgn0161784 FBgn0146039 FBgn0131268 FBgn0125800 FBgn0103914 FBgn0094033 CPIJ014746 BGIBMGA000242 BGIBMGA000241 ACYPI001490 GB19101 AGAP004507 AAEL011258 PHUM336900 GLEAN_12780
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG11754   CG14530   CG31048 (Stuart et al., 2007, Ni et al., 2010.12.1, Ni et al., 2011.7.19) Dm Dock4 (Meller et al., 2005)
Name Synonym
Secondary FlyBase IDs
	FBgn0039605 FBgn0039607
References ( 15 )
Research paper	Stuart et al., 2007, Nature 445(7123): 95--101 A systems biology analysis of the Drosophila phagosome. [FBrf0195342] Brody et al., 2002, Mech. Dev. 113(1): 41--59 Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. [FBrf0147137]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Review	Meller et al., 2005, J. Cell Sci. 118(21): 4937--4946 CZH proteins: a new family of Rho-GEFs. [FBrf0190957]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]