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Gene Dmel\CG31198

General Information
Symbol	Dmel\CG31198	Species	D. melanogaster
Name		Annotation symbol	CG31198
Feature type	protein_coding_gene	FlyBase ID	FBgn0051198
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93F8-93F9	Sequence location	3R:17,580,046..17,583,490 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG31198 (FBgn0051198). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: metallopeptidase activity; zinc ion binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: proteolysis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase; Peptidase M1, membrane alanine aminopeptidase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1631537_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG31198. Gene sequence location is 3R:17580046..17583490.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Antosh et al., 2011, Aging 3(6): 576--583 Sequence features HFA15891 BKN26388
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93F8-93F9   Limits computationally determined from genome sequence between P{PZ}InR05545 and P{PZ}tsl00617
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG31198 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG31198-RA FBtr0084128  NM_169966   3029   940
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG31198-PA   FBpp0083526   106.7   940   5.10     NP_732654   AAN13881
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (IPR001930) Peptidase M1, membrane alanine aminopeptidase, N-terminal (IPR014782)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAN13881   AI061816   AI063574   AI106687   AI135222   AI257424   AI257495   AI293638   AI293844   AI294670   AI295360   AI296138   AI297914   AX154663   AX154675   BI231617   BI235332   BI240653   BI241258   BI242577   BI243670   BI355983   BI375651   BI577740   BI578897   BT016070 AAV36955   CK445273   CK657019   CK657365   CK658051   CK658576   CK658835   CK660236   CK660477   CO292276   CO304208   CO313417   CO332786   EC202583   EC212450   EC228237   EC246987   EV579936   EV581621
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IN25
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0051198    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0051198 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0051198 expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr    5692 embryo 18-20hr    16232 embryo 20-22hr    30762 embryo 22-24hr    29241 larva L1    16769 larva L2    27374 larva L3 12hr old    15151 larva L3 puffstage 1-2    22568 larva L3 puffstage 3-6    4479 larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP    7435 adult male 01day    16395 adult male 05day    17048 adult male 30day    14051 adult female 01day    19696 adult female 05day    10368 adult female 30day    12009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr  (974) embryo 16-18hr  (5692) embryo 18-20hr  (16232) embryo 20-22hr  (30762) embryo 22-24hr  (29241) larva L1  (16769) larva L2  (27374) larva L3 12hr old  (15151) larva L3 puffstage 1-2  (22568) larva L3 puffstage 3-6  (4479) larva L3 puffstage 7-9  (1039) white prepupae new  (706) white prepupae 12hr  (330) white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP  (150) pupae 4d postWPP  (7435) adult male 01day  (16395) adult male 05day  (17048) adult male 30day  (14051) adult female 01day  (19696) adult female 05day  (10368) adult female 30day  (12009) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr  (5692) embryo 18-20hr  (16232) embryo 20-22hr  (30762) embryo 22-24hr  (29241) larva L1  (16769) larva L2  (27374) larva L3 12hr old  (15151) larva L3 puffstage 1-2  (22568) larva L3 puffstage 3-6  (4479) larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP  (7435) adult male 01day  (16395) adult male 05day  (17048) adult male 30day  (14051) adult female 01day  (19696) adult female 05day  (10368) adult female 30day  (12009) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr    5692 embryo 18-20hr  (16232) embryo 20-22hr  (30762) embryo 22-24hr  (29241) larva L1  (16769) larva L2  (27374) larva L3 12hr old  (15151) larva L3 puffstage 1-2  (22568) larva L3 puffstage 3-6    4479 larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP    7435 adult male 01day  (16395) adult male 05day  (17048) adult male 30day  (14051) adult female 01day  (19696) adult female 05day  10368 adult female 30day  (12009) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr    5692 embryo 18-20hr    16232 embryo 20-22hr    30762 embryo 22-24hr    29241 larva L1    16769 larva L2    27374 larva L3 12hr old    15151 larva L3 puffstage 1-2    22568 larva L3 puffstage 3-6    4479 larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP    7435 adult male 01day    16395 adult male 05day    17048 adult male 30day    14051 adult female 01day    19696 adult female 05day    10368 adult female 30day    12009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0051198 expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr    5692 embryo 18-20hr    16232 embryo 20-22hr    30762 embryo 22-24hr    29241 larva L1    16769 larva L2    27374 larva L3 12hr old    15151 larva L3 puffstage 1-2    22568 larva L3 puffstage 3-6    4479 larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP    7435 adult male 01day    16395 adult male 05day    17048 adult male 30day    14051 adult female 01day    19696 adult female 05day    10368 adult female 30day    12009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr  (974) embryo 16-18hr  (5692) embryo 18-20hr  (16232) embryo 20-22hr  (30762) embryo 22-24hr  (29241) larva L1  (16769) larva L2  (27374) larva L3 12hr old  (15151) larva L3 puffstage 1-2  (22568) larva L3 puffstage 3-6  (4479) larva L3 puffstage 7-9  (1039) white prepupae new  (706) white prepupae 12hr  (330) white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP  (150) pupae 4d postWPP  (7435) adult male 01day  (16395) adult male 05day  (17048) adult male 30day  (14051) adult female 01day  (19696) adult female 05day  (10368) adult female 30day  (12009) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr  (5692) embryo 18-20hr  (16232) embryo 20-22hr  (30762) embryo 22-24hr  (29241) larva L1  (16769) larva L2  (27374) larva L3 12hr old  (15151) larva L3 puffstage 1-2  (22568) larva L3 puffstage 3-6  (4479) larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP  (7435) adult male 01day  (16395) adult male 05day  (17048) adult male 30day  (14051) adult female 01day  (19696) adult female 05day  (10368) adult female 30day  (12009) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr    5692 embryo 18-20hr  16232 embryo 20-22hr  (30762) embryo 22-24hr  (29241) larva L1  16769 larva L2  (27374) larva L3 12hr old  15151 larva L3 puffstage 1-2  (22568) larva L3 puffstage 3-6    4479 larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP    7435 adult male 01day  16395 adult male 05day  17048 adult male 30day  14051 adult female 01day  19696 adult female 05day  10368 adult female 30day  12009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    13 embryo 04-06hr    12 embryo 06-08hr    27 embryo 08-10hr    40 embryo 10-12hr    55 embryo 12-14hr    73 embryo 14-16hr    974 embryo 16-18hr    5692 embryo 18-20hr    16232 embryo 20-22hr    30762 embryo 22-24hr    29241 larva L1    16769 larva L2    27374 larva L3 12hr old    15151 larva L3 puffstage 1-2    22568 larva L3 puffstage 3-6    4479 larva L3 puffstage 7-9    1039 white prepupae new    706 white prepupae 12hr    330 white prepupae 24hr    33 pupae 2d postWPP    69 pupae 3d postWPP    150 pupae 4d postWPP    7435 adult male 01day    16395 adult male 05day    17048 adult male 30day    14051 adult female 01day    19696 adult female 05day    10368 adult female 30day    12009 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0051198    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0051198 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0051198 expression level Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut    4702.6 Larval Hindgut    3005.2 Larval Malpighian Tubules    2237.6 Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut    5055.8 Adult Hindgut    3581.5 Adult Malpighian Tubules    4892.2 Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut  (4702.6) Larval Hindgut  (3005.2) Larval Malpighian Tubules  (2237.6) Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut  (5055.8) Adult Hindgut  (3581.5) Adult Malpighian Tubules  (4892.2) Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut  (4702.6) Larval Hindgut  (3005.2) Larval Malpighian Tubules  (2237.6) Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut  (5055.8) Adult Hindgut  (3581.5) Adult Malpighian Tubules  (4892.2) Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut    4702.6 Larval Hindgut    3005.2 Larval Malpighian Tubules    2237.6 Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut    5055.8 Adult Hindgut    3581.5 Adult Malpighian Tubules    4892.2 Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0051198 expression level Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut    4702.6 Larval Hindgut    3005.2 Larval Malpighian Tubules    2237.6 Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut    5055.8 Adult Hindgut    3581.5 Adult Malpighian Tubules    4892.2 Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut  (4702.6) Larval Hindgut  (3005.2) Larval Malpighian Tubules  (2237.6) Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut  (5055.8) Adult Hindgut  (3581.5) Adult Malpighian Tubules  (4892.2) Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut  (4702.6) Larval Hindgut  (3005.2) Larval Malpighian Tubules  (2237.6) Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut  (5055.8) Adult Hindgut  (3581.5) Adult Malpighian Tubules  (4892.2) Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.425 Larval Midgut    4702.6 Larval Hindgut    3005.2 Larval Malpighian Tubules    2237.6 Larval Fat Body    3.6 Larval Salivary Gland    1 Larval Trachea    1.025 Larval Carcass    1.45 Adult Head    5.3 Adult Eye    5.775 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    1.1 Adult Midgut    5055.8 Adult Hindgut    3581.5 Adult Malpighian Tubules    4892.2 Adult Fat Body no informative data Adult Salivary Gland    2.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    2.5 Adult Testis    1.7 Adult Male Accessory Gland    3.5 Adult Carcass    5.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.3   NA  Eye    5.775   NA  Brain    0.9   1.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2   NA  Crop    1.1   4702.6  Midgut    5055.8   3005.2  Hindgut    3581.5   2237.6  Malpighian Tubules    4892.2   3.6  Fat Body    no informative data   1  Salivary Gland    2.7   NA  Heart    4.55   1.025  Trachea    NA   NA  VirginFemale Spermatheca    7.3   NA  InseminatedFemale Spermatheca    6.3   NA  Ovary    2.5   NA  Testis    1.7   NA  Male Accessory Gland    3.5   1.45  Carcass    5.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_16
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051198 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31198-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG31198GD3678 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG31198 Class Mutagen Stocks Known lesion CG31198MB08005 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG31198 Class Mutagen Stocks Known lesion CG31198GD3678 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG31198KK106388 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6187 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3678} NA P{KK106388} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG31198MB08005 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
NOT aminopeptidase activity non-traceable author statement (FlyBase Genome Annotators, 2002-2003) metallopeptidase activity inferred from electronic annotation with InterPro:IPR014782 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR014782 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001930 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG31198 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 76937 DroID - A comprehensive database of gene and protein interactions. • FBgn0051198 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318622
Orthologs
Genome-wide drosophilid orthologs	Dere\GG17479 Dmoj\GI24289 Dper\GL23790 Dpse\GA16085 Dsec\GM26371 Dsim\GD20894 Dvir\GJ23068 Dwil\GK12889 Dyak\GE10238
Curated drosophilid orthologs	Dpse\GA16085
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005821-PA Aedes aegypti (mosquito) BGIBMGA008062-PA Bombyx mori (silk worm) XP_972987.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228112 FBgn0214898 FBgn0210170 FBgn0192354 FBgn0181224 FBgn0076101 FBgn0161380 FBgn0147012 FBgn0126720 FBgn0126088 FBgn0109704 FBgn0095060 FBgn0095058 AGAP013393 AGAP013188 AGAP013146 AAEL015247 AAEL005821 GLEAN_01259
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	26093 w1118; Mi{ET1}CG31198MB08005
VDRC	v107738 P{KK106388}VIE-260B v8624 w1118; P{GD3678}v8624 v8627 w1118; P{GD3678}v8627
Genomic Clones ( 2 )
	BACR16N15 BACR42I20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP07754
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02922 GH03462 GH06764 GH12884 LP05783 LP05883 LP06819 LP07085 LP08094 LP08964 LP09962 LP12358 LP14152 LP14574 LP15590 LP16089 LP18633 LP19089 LP22955 LP23583 RE22910 RE31163 RE37057 RE37548 RE38285 RE39956 RE41377 RE63513 RE71465 RE72843
Other clones	71443 71807 105820 277428 Dmel_dig_000719_0646_0311 Dmel_dig_001904_0705_3246 EK199657 EK232906 EK244115 EK304539
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051198 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318622
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG31198 anon-WO0140519.24 (FlyBase, 1996-)
Additional comments	Source for merge of CG31198 anon-WO0140519.24 was sequence comparison (date:051113). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169966 RefSeq (Proteins) • NP_732654 DDBJ / EMBL / GenBank • AAN13881 AAV36955 AX154663 AX154675 BT016070 Entrez Gene - A searchable database of RefSeq genes. • 318622 UniProtKB/TrEMBL • Q8IN25
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (IPR001930) Peptidase M1, membrane alanine aminopeptidase, N-terminal (IPR014782)
Linkouts
	BioGRID - A database of protein and genetic interactions • 76937 DroID - A comprehensive database of gene and protein interactions. • FBgn0051198 DRSC - Results from RNAi screens. • FBgn0051198 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051198 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31198-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051198 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318622 InParanoid A subset of ortholog calls from InParanoid. • AAEL005821-PA Aedes aegypti (mosquito) BGIBMGA008062-PA Bombyx mori (silk worm) XP_972987.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318622 modMine - Data generated by the modENCODE project. • FBgn0051198 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228112 FBgn0214898 FBgn0210170 FBgn0192354 FBgn0181224 FBgn0076101 FBgn0161380 FBgn0147012 FBgn0126720 FBgn0126088 FBgn0109704 FBgn0095060 FBgn0095058 AGAP013393 AGAP013188 AGAP013146 AAEL015247 AAEL005821 GLEAN_01259
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	anon-WO0140519.12   anon-WO0140519.24   CG5845 (Schulz et al., 2001, ) CG31198 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0038899 FBgn0044630 FBgn0044763
References ( 16 )
Research paper	Antosh et al., 2011, Aging 3(6): 576--583 New comparative genomics approach reveals a conserved health span signature across species. [FBrf0216594] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Schulz et al., 2001, Dev. Genes Evol. 211(12): 581--588 Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. [FBrf0144810]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Bellen, 2008.11.7, set816.xml set816.xml [FBrf0206132] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Gong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126669]
Patent	Greenspan, 2001.6.7, World Patent 0140519-A: Methods for identifying modulators for balance related disorders. [FBrf0141245]