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Gene Dmel\Naam

General Information
Symbol	Dmel\Naam	Species	D. melanogaster
Name	Nicotinamide amidase	Annotation symbol	CG31216
Feature type	protein_coding_gene	FlyBase ID	FBgn0051216
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	D-NAAM
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	92A13-92B1	Sequence location	3R:15,497,172..15,524,464 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nicotinamide amidase is referred to in FlyBase by the symbol Dmel\Naam (CG31216, FBgn0051216). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: nicotinamidase activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; negative regulation of neuron apoptotic process; response to oxidative stress. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Calcium-binding EF-hand; EF-Hand 1, calcium-binding site; EF-hand-like domain; Isochorismatase-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head. Comments on Affy2 ProbeSet: ProbeSet 1640214_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Naam. Gene sequence location is 3R:15497172..15524464.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92A13-92B1   Limits computationally determined from genome sequence between P{EP}EP650 and P{PZ}l(3)1058510585
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Naam for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Naam-RA FBtr0083786  NM_169872   1817   357 Naam-RB FBtr0335415  NM_001275809   1790   357
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Naam-PA   FBpp0083200   40.1   357   4.63     NP_732446   AAF55693 Naam-PB   FBpp0307398   40.1   357   4.63     NP_001262738   AGB96118
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Isochorismatase-like (IPR000868) EF-hand domain (IPR002048) EF-Hand 1, calcium-binding site (IPR018247) EF-hand-like domain (IPR011992)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141059   AA246767   AE014297 AAF55693   AE014297 AGB96118   AW941603   AX094117   AX260097   AX260098   AY122151 AAM52663   BG637840   BP550188   BP550189   BZ665780   CO189729   CO190782   CO275346   CO290183   CO336084   CO344453   CZ484169   CZ484170   CZ488825   CZ488826   EC077462   EC083612   EC195591   EC217429   EC256303   GH943456   GH945216   GH949620   GH952877   GH954170   GH956127   GH958417   GH960088   GH961904   GH961925   GH962279   GH964910   GH976347   GH976972   GH978529   GH980771
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VDU7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic head sensory system   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    42.425 Larval Midgut    11.2 Larval Hindgut    18.7 Larval Malpighian Tubules    1.9 Larval Fat Body    9.4 Larval Salivary Gland    11.2 Larval Trachea    22.975 Larval Carcass    37.8 Adult Head    198.6 Adult Eye    34.525 Adult Brain    38.9 Adult Thoracic-Abdominal Ganglion    83.9 Adult Crop    19.5 Adult Midgut    32.5 Adult Hindgut    71 Adult Malpighian Tubules    3.7 Adult Fat Body    20.4 Adult Salivary Gland    9 Adult Heart    13.35 Adult VirginFemale Spermatheca    23.1 Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    68.8 Adult Testis    11.3 Adult Male Accessory Gland    19.7 Adult Carcass    90.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    198.6   NA  Eye    34.525   NA  Brain    38.9   42.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    83.9   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    71   1.9  Malpighian Tubules    3.7   9.4  Fat Body    no informative data   no informative data  Salivary Gland    9   NA  Heart    no informative data   22.975  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    68.8   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   no informative data  Carcass    90.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    5 ovary, mated 4-day female    3 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    6 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    4 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2    176 embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    36 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2  (176) embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2  (36) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2  (176) embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    36 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2    176 embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    36 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2    176 embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    36 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2  (176) embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2  (36) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2  (176) embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    36 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    9 embryonic 1182-4H    11 embryonic GM2    176 embryonic Kc167    24 embryonic S1    2 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    12 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    3 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    36 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • LD05707 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051216 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31216-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Naam Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 NaamGD10195 Other Phenotypes Allele auditory perception defective | adult stage NaamKG10548 long lived, with Scer\GAL4elav.PLu NaamScer\UAS.T:SV5\V5 long lived, with Scer\GAL4tub.PU NaamScer\UAS.T:SV5\V5 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Naam Class Mutagen Stocks Known lesion Naamf01701 piggyBac transposase 1 -- Naamf06173 piggyBac transposase 1 -- NaamKG10548 P-element activity 1 -- NaamMB05940 1 -- NaamMI04166 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Naam Class Mutagen Stocks Known lesion NaamGD10195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NaamKK112461 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NaamScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Naam.V5} NA GAL4 construct P{Naam-GAL4.S} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}NaamMI04166 NA P{SUPor-P}NaamKG10548 NA PBac{WH}Naamf01701 NA PBac{WH}Naamf06173 NA insertion of enhancer trap binary system Mi{ET1}NaamMB05940 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
nicotinamidase activity inferred from direct assay (Balan et al., 2008)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Balan et al., 2008) negative regulation of neuron apoptotic process inferred from direct assay (Balan et al., 2008) response to oxidative stress inferred from mutant phenotype (Balan et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR002048, InterPro:IPR011992 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
metabolic process inferred from electronic annotation with InterPro:IPR000868 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Naam - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Naam - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Naam - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Naam - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Naam - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Naam - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Naam - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Naam allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0051216 DroID - A comprehensive database of gene and protein interactions. • FBgn0051216 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42348
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6HT9C5 Dipteran inclusive ortholog search EOG66WZJ1 Insect inclusive ortholog search EOG6BCCHR Arthropod inclusive ortholog search EOG676HG0 Metazoa inclusive ortholog search EOG6RVFK8
Orthologs in Drosophila Species (EOG6HT9C5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Naam     Drosophila simulans   Dsim\GD19309 Y   Drosophila sechellia   Dsec\GM26858 Y   Drosophila erecta   Dere\GG23460 Y   Drosophila yakuba   Dyak\GE25621 Y   Drosophila ananassae   Dana\GF17613 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27584 Y   Drosophila persimilis   Dper\GL12667 Y   Drosophila willistoni   Dwil\GK22349 Y   Drosophila virilis   Dvir\GJ10980 Y   Drosophila mojavensis   Dmoj\GI22421 Y   Drosophila grimshawi   Dgri\GH15190 Y
Orthologs in non-Drosophila Dipterans (EOG66WZJ1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002995   Anopheles gambiae Malaria mosquito  Agam\AGAP001435   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010618
Orthologs in non-Dipteran Insects (EOG6BCCHR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413484   Apis mellifera Western honey bee  Amel\LOC552524   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012655   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022743   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10797   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27260   Atta cephalotes Leafcutter ant  Acep\ACEP23815   Atta cephalotes Leafcutter ant  Acep\ACEP13506   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23035   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21944   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12864   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20437   Linepithema humile Argentine ant  Lhum\LH13733   Linepithema humile Argentine ant  Lhum\LH22046   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18546   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12276   Solenopsis invicta Red fire ant  Sinv\SINV17563   Solenopsis invicta Red fire ant  Sinv\SINV13293   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000824   Bombyx mori Silkmoth  Bmor\BGIBMGA008727   Pediculus humanus Human body louse  Phum\PHUM338310   Tribolium castaneum Red flour beetle  Tcas\TC010874   Tribolium castaneum Red flour beetle  Tcas\TC014782
Orthologs in non-Insect Arthropods (EOG676HG0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\TIMM8A   Ixodes scapularis Deer tick  Isca\ISCW004189   Ixodes scapularis Deer tick  Isca\ISCW024641   Ixodes scapularis Deer tick  Isca\ISCW022272
Orthologs in non-Arthropod Metazoa (EOG6RVFK8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pnc-2   Caenorhabditis elegans Nematode  Cele\pnc-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010604gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19309 Drosophila sechellia Dsec\GM26858 Drosophila erecta Dere\GG23460 Drosophila yakuba Dyak\GE25621 Drosophila ananassae Dana\GF17613 Drosophila pseudoobscura pseudoobscura Dpse\GA27584 Drosophila persimilis Dper\GL12667 Drosophila willistoni Dwil\GK22349 Drosophila virilis Dvir\GJ10980 Drosophila mojavensis Dmoj\GI22421 Drosophila grimshawi Dgri\GH15190
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	25613 w1118; Mi{ET1}NaamMB05940 37268 y1 w*; Mi{MIC}NaamMI04166 15278 y1; ry506 P{SUPor-P}NaamKG10548
Harvard	- PBac{WH}Naamf01701 - PBac{WH}Naamf06173
VDRC	v102796 P{KK112461}VIE-260B v25718 w1118; P{GD10195}v25718/CyO
Genomic Clones ( 2 )
	BACR07I18 BACR48D03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05707
Other clones	DPiM_LD05707
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD05883
Other clones	14804 147538 214347.60 CK01.20A.D9 CK01.61D.G7 CK01128 EK045006 EK049628 EK073302 EK117227 EN11803 EP19314 FGM105G06 RP004034197 RP004084414 RP004118487 RP004138119 RP004183856 RP004233309 RP004237587 RP004250237 RP004257769 RP004305640 RP004321492 RP004497936 RP004527450 RP004530242 RP004530800 RP004549171
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051216 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42348
Antibody Information
	polyclonal (Balan et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Naam CG31216 (Balan et al., 2008)
Source for database merge of	Source for merge of: CG7444 CG7500 (FlyBase, 1996-) Source for merge of: CG31216 anon-WO0172774.59 anon-WO0172774.60 (FlyBase, 1996-)
Additional comments	Annotations CG7444, CG7500 merged as CG31216 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG31216 anon-WO0172774.59 anon-WO0172774.60 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of CG7444 CG7500 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila ESTS AA246767 and AA141059 (inverted). (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169872 NM_001275809 RefSeq (Proteins) • NP_732446 NP_001262738 DDBJ / EMBL / GenBank • AA141059 AA246767 AAF55693 AAM52663 AGB96118 AW941603 AX094117 AX260097 AX260098 AY122151 BZ665780 CZ484169 CZ484170 CZ488825 CZ488826 Entrez Gene - A searchable database of RefSeq genes. • 42348 UniProtKB/TrEMBL • Q9VDU7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Isochorismatase-like (IPR000868) EF-hand domain (IPR002048) EF-Hand 1, calcium-binding site (IPR018247) EF-hand-like domain (IPR011992) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD05707
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0051216 DroID - A comprehensive database of gene and protein interactions. • FBgn0051216 DRSC - Results from RNAi screens. • FBgn0051216 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051216 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31216-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051216 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42348 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42348 modMine - Data generated by the modENCODE project. • FBgn0051216
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	AAM52663 (Rongvaux et al., 2003) anon-WO0172774.59   anon-WO0172774.60   CG7444   CG7500   CG31216 (Keleman et al., 2009.8.5) D-NAAM (Balan et al., 2008, Lorbeck et al., 2010) Naam (Senthilan et al., 2012)
Name Synonym	Nicotinamidase (Lorbeck et al., 2010) nicotinamide amidase (Balan et al., 2008) Nicotinamide amidase
Secondary FlyBase IDs
	FBgn0038728 FBgn0038729 FBgn0046372 FBgn0046373
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 3 ) Patent  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...