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Gene Dmel\Unc-115a

General Information
Symbol	Dmel\Unc-115a	Species	D. melanogaster
Name		Annotation symbol	CG31352
Feature type	protein_coding_gene	FlyBase ID	FBgn0051352
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	dunc-115
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85E4-85E5	Sequence location	3R:5,520,444..5,531,165 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Unc-115a (CG31352, FBgn0051352). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: axon guidance; photoreceptor cell axon guidance. 9 alleles are reported. The phenotypes of these alleles are annotated with: segmental nerve; embryonic ventral neuromere; longitudinal connective; mesothoracic tergum; eye photoreceptor cell; lamina plexus. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Villin headpiece; Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630603_at completely aligns to an exonic region of only a subset of 3 of the 4 FlyBase-annotated transcript isoforms of CG31352. Gene sequence location is 3R:5520444..5531165.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN31722 HFA12749
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E4-85E5   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Unc-115a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Unc-115a-RA FBtr0082092  NM_141673   3304   806 Unc-115a-RB FBtr0300564  NM_001170102   3022   844 Unc-115a-RC FBtr0300565  NM_001170103   3007   839 Unc-115a-RD FBtr0301833  NM_001170104   2640   768
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Unc-115a-PA   FBpp0081570   89.6   806   8.82     NP_649930   AAF54427 Unc-115a-PB   FBpp0289791   93.9   844   8.90     NP_001163573   ACZ94870 Unc-115a-PC   FBpp0289792   93.4   839   8.86     NP_001163574   ACZ94871 Unc-115a-PD   FBpp0291047   84.3   768   8.82     NP_001163575   ACZ94872
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, LIM-type (IPR001781) Villin headpiece (IPR003128)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567500   AA802590   AE014297 AAF54427   AE014297 ACZ94870   AE014297 ACZ94871   AE014297 ACZ94872   AI109325   AI135531   AI135833   AI296875   AI534599   AY052080   AY075568   BE976480   BG632755   BG632779   BG637209   BG639443   BG641302   BH214652   BI164584   BI165438   BI169151   BI172859   BI213768   BI213837   BI214313   BI214323   BI227960   BI228121   BI231691   BI237667   BI242322   BI242765   BI352964   BI356829   BI366170   BI366192   BI367240   BI367835   BI368195   BI369345   BI373200   BI373235   BI375257   BI375500   BI375574   BI483248   BI484706   BI484910   BI485229   BI486416   BI487114   BI564027   BI568090   BI568812   BI569275   BI573602   BI573603   BI574837   BI575904   BI578018   BI578794   BI579378   BI579666   BI579723   BI583979   BI584338   BI585635   BI585851   BI586352   BI586599   BI587203   BI590448   BI591956   BI606213   BI608277   BI608546   BI608819   BI609751   BI620029   BI623737   BI628179   BI630053   BI632594   BI632662   BI633064   BI636840   BI637573   BI640777   BT083441   BT099592   BT125855   CK657633   CK660807   CK661918   CK662274   CO154611   CO154875   CO155176   CO155714   CO262829   CO265045   CO266456   CO266474   CO270117   CO271987   CO276829   CO279682   CO282901   CO287230   CO289187   CO299290   CO299368   CO300123   CO306100   CO314226   CO314775   CO315508   CO318163   CO318181   CO320111   CO321141   CO322324   CO322900   CO324561   CO328682   CO332961   CO333324   CO335968   CO337171   CO339044   CZ477405   CZ478832   CZ480546   CZ490797   CZ490798   EC059171   EC061298   EC062207   EC063053   EC063508   EC076907   EC077907   EC078610   EC080067   EC081090   EC085066   EC088251   EC090688   EC197002   EC203674   EC208700   EC211508   EC212156   EC216106   EC226226   EC230692   EC231126   EC233546   EC239844   EC240474   EC240794   EC243260   EC243503   EC244156   EC244779   EC250018   EC252945   EC260804   EC261062   EC261955   EC262286   EC263779   EC264786   EC266961   EG974148   EL871564   EL871733   EL871862   EL881404   EL881405   ES695752   ES695753   ES695755   ES695757   ES695758   ES695759   ES695761   ES695762   ES695767   ES695768   ES695770   ES695771   ES695772   ES695776   ES695777   ES695779   EV589718   GH941722   GH951070   GH953565   GH954341   GH959342   GH964003   GH975069   GH975214   GH976371
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VH91 E1JIH2 E1JIH3 Q9VH92
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0051352    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0051352 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0051352 expression level Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr    1622 embryo 10-12hr    2285 embryo 12-14hr    2344 embryo 14-16hr    2406 embryo 16-18hr    2934 embryo 18-20hr    4026 embryo 20-22hr    5461 embryo 22-24hr    4348 larva L1    3023 larva L2    2089 larva L3 12hr old    2827 larva L3 puffstage 1-2    1701 larva L3 puffstage 3-6    1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr    1977 white prepupae 24hr    2199 pupae 2d postWPP    2245 pupae 3d postWPP    1305 pupae 4d postWPP    2167 adult male 01day    1960 adult male 05day    3971 adult male 30day    1698 adult female 01day    1177 adult female 05day    1130 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (136) embryo 02-04hr  (420) embryo 04-06hr  (601) embryo 06-08hr  (1108) embryo 08-10hr  (1622) embryo 10-12hr  (2285) embryo 12-14hr  (2344) embryo 14-16hr  (2406) embryo 16-18hr  (2934) embryo 18-20hr  (4026) embryo 20-22hr  (5461) embryo 22-24hr  (4348) larva L1  (3023) larva L2  (2089) larva L3 12hr old  (2827) larva L3 puffstage 1-2  (1701) larva L3 puffstage 3-6  (1903) larva L3 puffstage 7-9  (1348) white prepupae new  (1188) white prepupae 12hr  (1977) white prepupae 24hr  (2199) pupae 2d postWPP  (2245) pupae 3d postWPP  (1305) pupae 4d postWPP  (2167) adult male 01day  (1960) adult male 05day  (3971) adult male 30day  (1698) adult female 01day  (1177) adult female 05day  (1130) adult female 30day  (1418) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr  (1622) embryo 10-12hr  (2285) embryo 12-14hr  (2344) embryo 14-16hr  (2406) embryo 16-18hr  (2934) embryo 18-20hr  (4026) embryo 20-22hr  (5461) embryo 22-24hr  (4348) larva L1  (3023) larva L2  (2089) larva L3 12hr old  (2827) larva L3 puffstage 1-2  (1701) larva L3 puffstage 3-6  (1903) larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr  (1977) white prepupae 24hr  (2199) pupae 2d postWPP  (2245) pupae 3d postWPP    1305 pupae 4d postWPP  (2167) adult male 01day  (1960) adult male 05day  (3971) adult male 30day  (1698) adult female 01day    1177 adult female 05day    1130 adult female 30day  1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr    1622 embryo 10-12hr    2285 embryo 12-14hr    2344 embryo 14-16hr    2406 embryo 16-18hr    2934 embryo 18-20hr    4026 embryo 20-22hr    5461 embryo 22-24hr    4348 larva L1    3023 larva L2    2089 larva L3 12hr old    2827 larva L3 puffstage 1-2    1701 larva L3 puffstage 3-6    1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr    1977 white prepupae 24hr    2199 pupae 2d postWPP    2245 pupae 3d postWPP    1305 pupae 4d postWPP    2167 adult male 01day    1960 adult male 05day    3971 adult male 30day    1698 adult female 01day    1177 adult female 05day    1130 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr    1622 embryo 10-12hr    2285 embryo 12-14hr    2344 embryo 14-16hr    2406 embryo 16-18hr    2934 embryo 18-20hr    4026 embryo 20-22hr    5461 embryo 22-24hr    4348 larva L1    3023 larva L2    2089 larva L3 12hr old    2827 larva L3 puffstage 1-2    1701 larva L3 puffstage 3-6    1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr    1977 white prepupae 24hr    2199 pupae 2d postWPP    2245 pupae 3d postWPP    1305 pupae 4d postWPP    2167 adult male 01day    1960 adult male 05day    3971 adult male 30day    1698 adult female 01day    1177 adult female 05day    1130 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0051352 expression level Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr    1622 embryo 10-12hr    2285 embryo 12-14hr    2344 embryo 14-16hr    2406 embryo 16-18hr    2934 embryo 18-20hr    4026 embryo 20-22hr    5461 embryo 22-24hr    4348 larva L1    3023 larva L2    2089 larva L3 12hr old    2827 larva L3 puffstage 1-2    1701 larva L3 puffstage 3-6    1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr    1977 white prepupae 24hr    2199 pupae 2d postWPP    2245 pupae 3d postWPP    1305 pupae 4d postWPP    2167 adult male 01day    1960 adult male 05day    3971 adult male 30day    1698 adult female 01day    1177 adult female 05day    1130 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  136 embryo 02-04hr  (420) embryo 04-06hr  (601) embryo 06-08hr  (1108) embryo 08-10hr  (1622) embryo 10-12hr  (2285) embryo 12-14hr  (2344) embryo 14-16hr  (2406) embryo 16-18hr  (2934) embryo 18-20hr  (4026) embryo 20-22hr  (5461) embryo 22-24hr  (4348) larva L1  (3023) larva L2  (2089) larva L3 12hr old  (2827) larva L3 puffstage 1-2  (1701) larva L3 puffstage 3-6  (1903) larva L3 puffstage 7-9  (1348) white prepupae new  (1188) white prepupae 12hr  (1977) white prepupae 24hr  (2199) pupae 2d postWPP  (2245) pupae 3d postWPP  (1305) pupae 4d postWPP  (2167) adult male 01day  (1960) adult male 05day  (3971) adult male 30day  (1698) adult female 01day  (1177) adult female 05day  (1130) adult female 30day  (1418) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr  1622 embryo 10-12hr  2285 embryo 12-14hr  2344 embryo 14-16hr  2406 embryo 16-18hr  (2934) embryo 18-20hr  (4026) embryo 20-22hr  (5461) embryo 22-24hr  (4348) larva L1  (3023) larva L2  2089 larva L3 12hr old  (2827) larva L3 puffstage 1-2  1701 larva L3 puffstage 3-6  1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr  1977 white prepupae 24hr  2199 pupae 2d postWPP  2245 pupae 3d postWPP    1305 pupae 4d postWPP  2167 adult male 01day  1960 adult male 05day  (3971) adult male 30day  1698 adult female 01day    1177 adult female 05day    1130 adult female 30day  1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr    1622 embryo 10-12hr    2285 embryo 12-14hr    2344 embryo 14-16hr    2406 embryo 16-18hr    2934 embryo 18-20hr    4026 embryo 20-22hr    5461 embryo 22-24hr    4348 larva L1    3023 larva L2    2089 larva L3 12hr old    2827 larva L3 puffstage 1-2    1701 larva L3 puffstage 3-6    1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr    1977 white prepupae 24hr    2199 pupae 2d postWPP    2245 pupae 3d postWPP    1305 pupae 4d postWPP    2167 adult male 01day    1960 adult male 05day    3971 adult male 30day    1698 adult female 01day    1177 adult female 05day    1130 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    136 embryo 02-04hr    420 embryo 04-06hr    601 embryo 06-08hr    1108 embryo 08-10hr    1622 embryo 10-12hr    2285 embryo 12-14hr    2344 embryo 14-16hr    2406 embryo 16-18hr    2934 embryo 18-20hr    4026 embryo 20-22hr    5461 embryo 22-24hr    4348 larva L1    3023 larva L2    2089 larva L3 12hr old    2827 larva L3 puffstage 1-2    1701 larva L3 puffstage 3-6    1903 larva L3 puffstage 7-9    1348 white prepupae new    1188 white prepupae 12hr    1977 white prepupae 24hr    2199 pupae 2d postWPP    2245 pupae 3d postWPP    1305 pupae 4d postWPP    2167 adult male 01day    1960 adult male 05day    3971 adult male 30day    1698 adult female 01day    1177 adult female 05day    1130 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0051352    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0051352 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0051352 expression level Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0051352 expression level Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    265.6 Larval Midgut    247.4 Larval Hindgut    350.9 Larval Malpighian Tubules    160.9 Larval Fat Body    81.5 Larval Salivary Gland    331.9 Larval Trachea    241.35 Larval Carcass    192.975 Adult Head    126.2 Adult Eye    184.575 Adult Brain    232.6 Adult Thoracic-Abdominal Ganglion    212.8 Adult Crop    240.1 Adult Midgut    325.6 Adult Hindgut    346 Adult Malpighian Tubules    262.9 Adult Fat Body    122.5 Adult Salivary Gland    381.5 Adult Heart    150.425 Adult VirginFemale Spermatheca    103.6 Adult InseminatedFemale Spermatheca    112.7 Adult Ovary    13.9 Adult Testis    295 Adult Male Accessory Gland    112.2 Adult Carcass    112.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    126.2   NA  Eye    184.575   NA  Brain    232.6   265.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    212.8   NA  Crop    240.1   247.4  Midgut    325.6   350.9  Hindgut    346   160.9  Malpighian Tubules    262.9   81.5  Fat Body    122.5   331.9  Salivary Gland    381.5   NA  Heart    150.425   241.35  Trachea    NA   NA  VirginFemale Spermatheca    103.6   NA  InseminatedFemale Spermatheca    112.7   NA  Ovary    13.9   NA  Testis    295   NA  Male Accessory Gland    112.2   192.975  Carcass    112.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051352 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31352-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Unc-115aKG03651 viable, with Scer\GAL4pnr-MD237 Unc-115aGD17287 Sterility Allele fertile Unc-115aKG03651 Other Phenotypes Allele neuroanatomy defective | embryonic stage Unc-115aKG03651 neuroanatomy defective | third instar larval stage Unc-115aKG03651 visible, with Scer\GAL4pnr-MD237 Unc-115aGD17287 Phenotype manifest in Allele embryonic ventral neuromere Unc-115aKG03651 eye photoreceptor cell Unc-115aKG03651 lamina plexus Unc-115aKG03651 longitudinal connective Unc-115aKG03651 mesothoracic tergum, with Scer\GAL4pnr-MD237 Unc-115aGD17287 segmental nerve Unc-115aKG03651
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Unc-115a Class Mutagen Stocks Known lesion Unc-115aKG03651 amorphic allele - molecular evidence P-element activity 1 Yes Unc-115ad10735 P-element activity 1 -- Unc-115ae01003 piggyBac transposase 1 -- Unc-115af08096 piggyBac transposase 1 -- Unc-115aCPTI000905 piggyBac transposase 0 Yes Unc-115aCPTI100017 piggyBac transposase 0 Yes Unc-115ae02776 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Unc-115a Class Mutagen Stocks Known lesion Unc-115aGD17287 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Unc-115aKK111722 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Unc-115aKG03651 NA PBac{566.P.SVS-1}Unc-115aCPTI100017 NA PBac{602.P.SVS-1}Unc-115aCPTI000905 NA PBac{RB}Unc-115ae01003 NA PBac{RB}Unc-115ae02776 NA PBac{WH}Unc-115af08096 NA insertion of mobile activating element P{XP}Unc-115ad10735 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Garcia et al., 2007) photoreceptor cell axon guidance inferred from mutant phenotype (Garcia et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity with human VIL1 (Garcia et al., 2007) zinc ion binding inferred from electronic annotation with InterPro:IPR001781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from electronic annotation with InterPro:IPR003128 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Unc-115a allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 76449 DroID - A comprehensive database of gene and protein interactions. • FBgn0051352 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 261629
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA16202
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008358-PA Aedes aegypti (mosquito) AGAP005425-PA Anopheles gambiae (mosquito) XP_001122092.1 Apis mellifera (honey bee) XP_001949191.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000006449 Bos taurus (bovine) CN27942 Caenorhabditis brenneri (small nematode) CBP34237 Caenorhabditis briggsae (nematode) CE02176 Caenorhabditis elegans (worm) ENSCAFP00000016985 Canis familiaris (dog) JA02850 Caenorhabditis japonica (nematode) CPIJ008423 Culex pipens (mosquito) ENSCPOP00000013447 Cavia porcellus (guinea pig) RP00181 Caenorhabditis remanei (nematode) DDB0238324 Dictyostelium discoideum (amoeba) 95700 Daphnia pulex (daphnia) ENSDARP00000052588 Danio rerio (zebra fish) ENSECAP00000014315 Equus caballus (horse) ENSGACP00000004910 Gymnopilus aculeatus (mushroom) ENSGALP00000014715 Gallus gallus (chicken) ENSGALP00000025042 Gallus gallus (chicken) 191395 Hypsipyla robusta (cedar shoot borer) ENSP00000310309 Homo sapiens (human) 234877 Lottia gigantea (owl limpet) ENSMODP00000003722 Monodelphis domestica (gray opossum) ENSMODP00000007069 Monodelphis domestica (gray opossum) ENSMMUP00000029655 Macaca mulatta (rhesus monkey) ENSMUSP00000078336 Mus musculus (house mouse) XP_001607378.1 Nasonia vitripennis (wasp) ENSOANP00000002485 Ornithorynchus anatinus (platypus) ENSOANP00000025775 Ornithorynchus anatinus (platypus) ENSORLP00000016427 Oryzias latipes (japanese killifish) 13169 Ostreococcus tauri (green alga) PHUM005695-PA Pediculus humanus (human body louse) PP04333 Pristionchus pacificus (nematode) ENSPPYP00000017823 Pongo pygmaeus (orangutan) ENSPTRP00000029725 Pan troglodytes (chimpanzee) ENSRNOP00000018647 Rattus norvegicus (norway rat) XP_001181115.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000015779 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000021401 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000045002 Takifugu rubripes (pufferfish Takifugu) 3702.m00054 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000025375 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11504 NV10817 LH25150 ISCW020839 FBgn0241851 FBgn0212926 FBgn0201512 FBgn0192235 FBgn0181083 JGI_V11_95700 FBgn0248403 FBgn0164903 FBgn0144666 FBgn0260463 FBgn0129361 FBgn0109569 FBgn0088612 CPIJ008423 BGIBMGA002264 ACYPI006617 GB15905 AGAP005425 AAEL008358 PHUM432720 GLEAN_12552
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	12941 y1 w67c23; P{SUPor-P}Unc-115aKG03651 ry506
Harvard	- P{XP}Unc-115ad10735 - PBac{RB}Unc-115ae01003 - PBac{WH}Unc-115af08096
VDRC	v106405 P{KK111722}VIE-260B v49111 w1118; P{GD17287}v49111 v49112 w1118; P{GD17287}v49112/TM3
Genomic Clones ( 1 )
	BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 142 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT12452 AT12805 LP01981 SD01878 SD03267
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08475 GM05872 GM21482 HL01353 LP19682 LP21726 LP22358 LP24091 RE04284 RE05340 RE10243 RE15549 RE19262 RE19452 RE20084 RE20095 RE23309 RE25352 RE25562 RE33934 RE39622 RE40184 RE43064 RE51648 RE51674 RE52956 RE53683 RE54120 RE55491 RE60436 RE60480 RE63017 RE63338 RE63424 RE66116 RE67848 RE68094 RE68524 RE69842 RE70625 RE71811 RE72720 RE73403 RE73733 RE73795 RH04070 RH09531 RH12472 RH13115 RH13522 RH14574 RH22719 RH23518 RH25256 RH25526 RH26286 RH26669 RH27079 RH27706 RH32272 RH35703 RH39451 RH51186 RH56069 RH56510 RH59015 RH72437 SD07509 SD12621 SD15090 SD18666 SD19619 SD23773 SD26415 SD26492 SD27035
Other clones	28316 119192 280359 281281 bs52a08 Dmel_neb_009810_0403_2998 EK065253 EK070410 EK086453 EK097421 EK105405 EK122153 EK135642 EK141352 EK146455 EK146528 EK161733 EK175020 EK175156 EK177435 EK187905 EK189155 EK194237 EK235454 EK237752 EK250250 EK261712 EK270608 EK270635 EK282259 EK290401 EK291159 EK305244 EK306517 EN04449 EN04949 EN05518 EN06618 EN11559 EN13953 EP00659 GH13330 GH13731 IP03642 IP03789 IP03889 IP11179 LP11002 RC0-DP0006-150700-011-A09 RH01116 RH01395 RH09176 RP004002533 RP004115563 RP004127392 RP004160255 RP004263482 RP004320798 RP004348112 RP004350651 RP004509046
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051352 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 261629
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG31352 anon-WO0140519.21 (FlyBase, 1996-)
Additional comments	The CG31332 and CG31352 annotations represent two very similar neighbouring genes located on 3R, which are related to the C. elegans unc-115 gene. These two genes were erroneously annotated as non-overlapping transcripts of a single "CG9489" annotation in release 2 of the genome annotation, but this was subsequently corrected in release 3.2 of the genome annotation so that each gene is represented by a separate annotation (CG31332 and CG31352). (FlyBase, 2009-) FBrf0201664 uses the symbol "Dunc-115" to refer to the CG31352 annotation. However, the "unc-115" symbol was previously used in FlyBase to refer to the similar CG31332 annotation (the confusion in FlyBase probably arose due to the complex annotation history of these two very similar genes). (FlyBase, 2009-) To avoid confusion, the genes corresponding to both the CG31332 and CG31352 annotations have been renamed in FlyBase. (FlyBase, 2009-) The gene represented by CG31352 has been renamed to "Unc-115a" and the gene represented by CG31332 has been renamed to "Unc-115b" to reflect that both genes show similarity to the C. elegans unc-115 gene. (FlyBase, 2009-) Source for merge of CG31352 anon-WO0140519.21 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141673 NM_001170102 NM_001170103 NM_001170104 RefSeq (Proteins) • NP_649930 NP_001163573 NP_001163574 NP_001163575 DDBJ / EMBL / GenBank • AAF54427 ACZ94870 ACZ94871 ACZ94872 BH214652 CZ477405 CZ478832 CZ480546 CZ490797 CZ490798 Entrez Gene - A searchable database of RefSeq genes. • 261629 UniProtKB/TrEMBL • E1JIH2 E1JIH3 Q9VH91 Q9VH92
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, LIM-type (IPR001781) Villin headpiece (IPR003128)
Linkouts
	BioGRID - A database of protein and genetic interactions • 76449 DroID - A comprehensive database of gene and protein interactions. • FBgn0051352 DRSC - Results from RNAi screens. • FBgn0051352 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051352 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31352-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051352 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 261629 InParanoid A subset of ortholog calls from InParanoid. • AAEL008358-PA Aedes aegypti (mosquito) AGAP005425-PA Anopheles gambiae (mosquito) XP_001122092.1 Apis mellifera (honey bee) XP_001949191.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000006449 Bos taurus (bovine) CN27942 Caenorhabditis brenneri (small nematode) CBP34237 Caenorhabditis briggsae (nematode) CE02176 Caenorhabditis elegans (worm) ENSCAFP00000016985 Canis familiaris (dog) JA02850 Caenorhabditis japonica (nematode) CPIJ008423 Culex pipens (mosquito) ENSCPOP00000013447 Cavia porcellus (guinea pig) RP00181 Caenorhabditis remanei (nematode) DDB0238324 Dictyostelium discoideum (amoeba) 95700 Daphnia pulex (daphnia) ENSDARP00000052588 Danio rerio (zebra fish) ENSECAP00000014315 Equus caballus (horse) ENSGACP00000004910 Gymnopilus aculeatus (mushroom) ENSGALP00000014715 Gallus gallus (chicken) ENSGALP00000025042 Gallus gallus (chicken) 191395 Hypsipyla robusta (cedar shoot borer) ENSP00000310309 Homo sapiens (human) 234877 Lottia gigantea (owl limpet) ENSMODP00000003722 Monodelphis domestica (gray opossum) ENSMODP00000007069 Monodelphis domestica (gray opossum) ENSMMUP00000029655 Macaca mulatta (rhesus monkey) ENSMUSP00000078336 Mus musculus (house mouse) XP_001607378.1 Nasonia vitripennis (wasp) ENSOANP00000002485 Ornithorynchus anatinus (platypus) ENSOANP00000025775 Ornithorynchus anatinus (platypus) ENSORLP00000016427 Oryzias latipes (japanese killifish) 13169 Ostreococcus tauri (green alga) PHUM005695-PA Pediculus humanus (human body louse) PP04333 Pristionchus pacificus (nematode) ENSPPYP00000017823 Pongo pygmaeus (orangutan) ENSPTRP00000029725 Pan troglodytes (chimpanzee) ENSRNOP00000018647 Rattus norvegicus (norway rat) XP_001181115.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000015779 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000021401 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000045002 Takifugu rubripes (pufferfish Takifugu) 3702.m00054 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000025375 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 261629 modMine - Data generated by the modENCODE project. • FBgn0051352 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11504 NV10817 LH25150 ISCW020839 FBgn0241851 FBgn0212926 FBgn0201512 FBgn0192235 FBgn0181083 JGI_V11_95700 FBgn0248403 FBgn0164903 FBgn0144666 FBgn0260463 FBgn0129361 FBgn0109569 FBgn0088612 CPIJ008423 BGIBMGA002264 ACYPI006617 GB15905 AGAP005425 AAEL008358 PHUM432720 GLEAN_12552
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-WO0140519.21   CG9489 (Garcia et al., 2007) CG31352 (Edwards et al., 2006, Keleman et al., 2009.8.5, Buffin and Gho, 2010, Zhan et al., 2011, Cammarato et al., 2011) dunc-115 (Garcia and He, 2002) Dunc-115 (Garcia et al., 2007) Unc-115a
Name Synonym
Secondary FlyBase IDs
	FBgn0037733 FBgn0044663 FBgn0063633
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) Computer file  ( 3 ) Patent  ( 1 )
Recent research papers ( 2 )
	Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039] Show all research papers ...