FlyBase Gene Report: Dmel\Hsp70Bbb

General Information

Symbol

Dmel\Hsp70Bbb

Species

D. melanogaster

Name

Hsp70Bbb

Annotation Symbol

CG5834

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051354

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Hsp70Bbb (Hsp70Bbb) encodes a protein involved in response to heat shock and hypoxia. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Hsp70, heat-shock protein 70, hsp70B

Key Links

Genomic Location

Cytogenetic map

87B14-87B14

Sequence location

3R:12,502,510..12,504,856 [+]

Recombination map

3-52

RefSeq locus

NT_033777 REGION:12502510..12504856

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

enables ATP binding

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ATP hydrolysis activity

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ATP-dependent protein folding chaperone

inferred from electronic annotation with InterPro:IPR013126

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables heat shock protein binding

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

enables misfolded protein binding

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein folding chaperone

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

enables unfolded protein binding

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in heat shock-mediated polytene chromosome puffing

inferred from mutant phenotype

(Gong and Golic, 2006)

involved_in response to heat

inferred from mutant phenotype

(Gong and Golic, 2006)

involved_in response to hypoxia

inferred from expression pattern

(Azad et al., 2009)

inferred from mutant phenotype

(Azad et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cellular response to unfolded protein

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in chaperone cofactor-dependent protein refolding

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein refolding

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN002500132

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002321897

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN002500132

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002500132

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002500132

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

HEAT SHOCK PROTEIN 70 CHAPERONES

Protein Family (UniProt)

Belongs to the heat shock protein 70 family. (Q9VG58)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Hsp70Bbb (Hsp70Bbb) encodes a protein involved in response to heat shock and hypoxia. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

HEAT SHOCK PROTEIN 70 CHAPERONES -: The Heat Shock Protein 70 (Hsp70) superfamily of chaperones assist in numerous folding processes and are upregulated by heat stress and toxic chemicals. Hsp70 chaperones share a highly conserved bipartite domain structure composed of an ATPase domain and a substrate-binding domain. (Adapted from PMID:17441502, FBrf0232269 and FBrf0174945).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Hsp70Bbb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VG58)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

This duplication of the Hsp70Bb gene is present in certain strains including y; cn bw sp, which was sequenced in the Drosophila genome project, but not others. See FBrf0137034 and personal communication of Brian Bettencourt to FlyBase for details.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Hsp70Bbb-RA

FBtr0082636

NM_176486

2347

641

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Hsp70Bbb-PA

FBpp0082105

70.3

641

5.39

NP_788663

AAF54830

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VG58

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp70Bbb using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Dorus et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hsp70Bbb in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hsp70Bbb

View exonic expression by tissue for Dmel\Hsp70Bbb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50022/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051354

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051354

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051354

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsp70Bbb

Transgenic constructs containing regulatory region of Hsp70Bbb

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel7317

(Ryder, 2004.4.26)

Df(3R)Hsp70B

(Gong and Golic, 2005.6.2, Gong and Golic, 2004)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal neuroanatomy, with Scer\GAL4^7B

Hsp70Bbb^UY2168

Phenotype manifest in

Allele

adult mushroom body, with Scer\GAL4^7B

Hsp70Bbb^UY2168

Kenyon cell, with Scer\GAL4^7B

Hsp70Bbb^UY2168

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HSPA1B

6 of 15

Yes

5 of 15

5 of 15

5 of 15

5 of 15

5 of 15

4 of 15

3 of 15

2 of 15

Yes

Hsap\ANKRD45

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Hspa1a

6 of 15

Yes

5 of 15

5 of 15

5 of 15

5 of 15

3 of 15

3 of 15

2 of 15

Yes

Mmus\Ankrd45

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (19)

Rnor\Hspa2

5 of 13

Yes

Rnor\Hspa8

5 of 13

Yes

Rnor\Hspa1a

4 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (16)

Xtro\hsp70

5 of 12

Yes

Xtro\hspa1b

5 of 12

Yes

Xtro\hspa1l

5 of 12

Yes

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

2 of 12

Yes

Xtro\ankrd45

1 of 12

Yes

Xtro\hspa4

1 of 12

Xtro\hspa12a

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (21)

Drer\hsc70

6 of 15

Yes

Drer\hsp70.3

5 of 15

Drer\hsp70l

5 of 15

Drer\hspa8

5 of 15

Drer\si:ch211-199o1.2

5 of 15

5 of 15

4 of 15

4 of 15

3 of 15

3 of 15

2 of 15

Yes

Drer\hspa13

2 of 15

Yes

Drer\ankrd45

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-250m6.2

1 of 15

Yes

Drer\si:dkey-61p9.6

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\F44E5.5

5 of 15

Yes

Cele\hsp-70

5 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

Yes

Cele\F11F1.1

1 of 15

Cele\T14G8.3

1 of 15

Cele\T24H7.2

1 of 15

Arabidopsis thaliana (thale-cress) (14)

Atha\Hsp70-2

5 of 9

Yes

4 of 9

4 of 9

4 of 9

4 of 9

4 of 9

2 of 9

2 of 9

2 of 9

2 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (14)

Scer\SSA3

7 of 15

Yes

Scer\SSA4

7 of 15

Yes

6 of 15

6 of 15

5 of 15

5 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\ssa1

4 of 12

Yes

Spom\ssa2

4 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

7 of 10

7 of 10

7 of 10

7 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

5 of 10

3 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HSPA1B; heat shock protein family A (Hsp70) member 1B

6 of 15

603012

HSPA1A; heat shock protein family A (Hsp70) member 1A

5 of 15

140550

HSPA1L; heat shock protein family A (Hsp70) member 1 like

5 of 15

140559

HSPA2; heat shock protein family A (Hsp70) member 2

5 of 15

140560

HSPA6; heat shock protein family A (Hsp70) member 6

5 of 15

140555

HSPA8; heat shock protein family A (Hsp70) member 8

5 of 15

600816

HSPA5; heat shock protein family A (Hsp70) member 5

4 of 15

138120

HSPA9; heat shock protein family A (Hsp70) member 9

3 of 15

600548

autosomal dominant sideroblastic anemia 4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsp70Bbb - Nrd1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Yoon et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

72503

DroID - A comprehensive database of gene and protein interactions.

FBgn0051354

MIST (protein-protein) - An integrated Molecular Interaction Database

Hsp70Bbb

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0051354

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-52

Cytogenetic map

87B14-87B14

Sequence location

3R:12,502,510..12,504,856 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87B14-87B14

Limits computationally determined from genome sequence between P{PZ}svp⁰⁷⁸⁴² and P{lacW}Vha55^j2E9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-52

(FlyBase, 2016)

3-49.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28787

y¹ v¹; P{TRiP.JF03215}attP2

7349

y¹ w^67c23; P{Mae-UAS.6.11}Hsp70Bbb^UY2168

33000

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00800}attP2

33916

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00859}attP2

VDRC

v330687

P{VSH330687}attP40

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (94)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051354

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051354

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

50022

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Member gene of

Hsp70

(Takahashi et al., 2010)

Additional comments

Other Comments

Flies with no copies of the Hsp70 genes (Hsp70Aa, Hsp70Ab, Hsp70Ba, Hsp70Bb, Hsp70Bbb and Hsp70Bc) are unable to survive a severe heat shock. These flies show a lengthened heat-shock response and developmental delay following a non-lethal heat shock.

(Gong and Golic, 2006)

Flies with no copies of the Hsp70 genes (Hsp70Aa, Hsp70Ab, Hsp70Ba, Hsp70Bb, Hsp70Bbb and Hsp70Bc) are viable and fertile.

(Gong and Golic, 2004)

Some Drosophila strains, including that sequenced in the Drosophila genome project have three, not two, tandemly repeated Hsp70 genes at 87C1 (in addition to a reverse orientation Hsp70 gene, Hsp70Ba, approximately 40kb upstream). The distal-most gene of the three tandem copies is Hsp70Bc. The inner two tandem copies are Hsp70Bb and Hsp70Bbb.

(Bettencourt, 2002.1.16)

The D.melanogaster strain used for sequencing the genome contains an additional, third tandem copy of an Hsp70 gene at 87C as well as the two tandemly repeated copies (Hsp70Bb and Hsp70Bc) which are found in many strains. This additional copy is named "Hsp70Bbb" (see FBrf0137034 and Bettencourt, 2002.1.16, personal communication to FlyBase).

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

50022

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF54830

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VG58

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VG58

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VG58

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051354

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50022/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051354

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051354

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051354

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0051354

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

50022

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5834

MARRVEL_MODEL - MARRVEL (model organism gene)

50022

modMine - A data warehouse for the modENCODE project

FBgn0051354

Linkouts

BioGRID - A database of protein and genetic interactions.

72503

DroID - A comprehensive database of gene and protein interactions.

FBgn0051354

DRSC - Results frm RNAi screens

FBgn0051354

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051354

FlyMine - An integrated database for Drosophila genomics

FBgn0051354

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Hsp70Bbb

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG31354

(Nicolai et al., 2003)

CG5834

(Meadows, 2018.10.31, Hoffmann et al., 2013, Ni et al., 2010.12.1, Seinen et al., 2010, Perkins et al., 2009, Hughes et al., 2008, Wayne and McIntyre, 2002)

Dm-hsp70

(Hernandez et al., 2004)

HSP70Bbb

(Rehwinkel et al., 2004)

Hsp-70

(Pimenta de Castro et al., 2012)

Hsp70

(Prasad et al., 2019, Berson et al., 2017, Li et al., 2017, Donovan and Marr, 2016, Hosamani et al., 2016, Zatsepina et al., 2016, Zhang et al., 2016, Alaraby et al., 2015, Funikov et al., 2015, Marr et al., 2014, Shukla et al., 2014, Tower et al., 2014, Zhang et al., 2014, Calabria et al., 2012, Schneiderman et al., 2012, Azad et al., 2011, Morettini et al., 2011, Takahashi et al., 2011, Ahamed et al., 2010, Bartkowiak et al., 2010, Demontis and Perrimon, 2010, Hrizo and Palladino, 2010, Jensen et al., 2010, Kwon et al., 2010, Tian et al., 2010, Udaka et al., 2010, Zobeck et al., 2010, Zobeck et al., 2010, Ardehali et al., 2009, Baker and Russell, 2009, Chopra et al., 2009, Posgai et al., 2009, Bhargav et al., 2008, Brandt and Corces, 2008, Cai et al., 2008, Casas-Tinto et al., 2008, Cobreros et al., 2008, Duncan, 2008, Fujikake et al., 2008, Gilchrist et al., 2008, Hanyu-Nakamura et al., 2008, Ni et al., 2008, Smith et al., 2008, Ahrens et al., 2007, Eissenberg et al., 2007, Fernandez-Funez et al., 2007, Mito et al., 2007, Pappas et al., 2007, Rezaval et al., 2007, Yao et al., 2007, Behr et al., 2006, Kalosaka et al., 2006, Papaconstantinou et al., 2006, Sengupta and Lakhotia, 2006, Shilova et al., 2006, Tenney et al., 2006, Auluck et al., 2005, Duncan, 2005, Gupta et al., 2005, Huen and Chan, 2005, Iijima-Ando et al., 2005, Newman et al., 2005, Nielsen et al., 2005, Overgaard et al., 2005, Scholz et al., 2005, Ahmed and Duncan, 2004, Jennings et al., 2004, Morrow et al., 2004, Sathyanarayanan et al., 2004, Temme et al., 2004, Auluck and Bonini, 2003, Caletka and Fry, 2003, Canamasas et al., 2003, Gruntenko et al., 2003, Jin et al., 2003, Kristensen et al., 2003, Norry and Loeschcke, 2003, Rutherford, 2003, Sejerkilde et al., 2003, Bonini, 2002, Isaenko et al., 2002, Lakhotia et al., 2002, Kelty and Lee, 2001, Krebs and Holbrook, 2001, Rajendra et al., 2001, Sorensen and Loeschcke, 2001, Zatsepina et al., 2001, Bettencourt and Feder, 1999, Krebs, 1999, Lerman and Feder, 1999)

Hsp70B

(Buchon et al., 2009, Chen et al., 2008)

Hsp70Bb

(Maside et al., 2002)

dHsp70

(Bell et al., 2007)

hsp70

(Sharma et al., 2018, Pereira and Paro, 2017, Xu et al., 2016, Kust et al., 2014, Shukla et al., 2014, Lagha et al., 2013, Ardehali et al., 2011, Boeke et al., 2011, Chan et al., 2011, Ghosh et al., 2011, Juge et al., 2010, Kopytova et al., 2010, Kotova et al., 2010, Pankotai et al., 2010, Tombácz et al., 2009, Yang and Tower, 2009, Grover et al., 2008, Hsu et al., 2008, Lee et al., 2008, Piel et al., 2008, Siddique et al., 2008, Smith et al., 2008, Behm-Ansmant et al., 2007, Halfon and Arnosti, 2007, Ivaldi et al., 2007, Kurshakova et al., 2007, Lebedeva et al., 2007, Ullah et al., 2007, Vazquez-Pianzola et al., 2007, Buszczak and Spradling, 2006, Graves and Tamkun, 2006, Zhao et al., 2006, Adelman et al., 2005, Kim and Lis, 2005, Saunders et al., 2005, Wu et al., 2005, Zhao et al., 2005, Goodman et al., 2004, Landis et al., 2004, Lehmann, 2004, Matsumoto and Hirose, 2004, Poels et al., 2004, Poels et al., 2004, Smith et al., 2004, Venkaiah et al., 2004, Wang et al., 2004, Feder, 2003, Gilmour, 2003.4.18, Gong and Golic, 2003, Goodman et al., 2003, Helfand and Rogina, 2003, Kellum, 2003, Saunders et al., 2003, Shaw and Franken, 2003, Tulin and Spradling, 2003, Viswanathan et al., 2003, Wimmer, 2003, Aigaki et al., 2002, Andrulis et al., 2002, Lakhotia and Prasanth, 2002, Li et al., 2001, Mahowald, 2001, Tatar and Yin, 2001, Bettencourt and Feder, 2000, Geyer et al., 2000)

hsp70B

(Huang et al., 2008, Gong and Golic, 2004)

hsp70Bb-prime

(Bettencourt, 2002.1.16)

hsp70bBb

(Ryazansky et al., 2016)

hsp70bbb

(Ou et al., 2016)

Name Synonyms

Hsp70Bbb

(Bettencourt et al., 2008)

heat shock protein 70