FB2020_03, released Jun 16, 2020

Gene: Dmel\Hsp70Bbb

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General Information
Symbol
Dmel\Hsp70Bbb
Species
D. melanogaster
Name
Hsp70Bbb
Annotation Symbol
CG5834
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051354
Gene Model Status
Current
Stock Availability
5 publicly available
Enzyme Name (EC)
Adenosinetriphosphatase (3.6.1.3)
Gene Snapshot
Hsp70Bbb (Hsp70Bbb) encodes a protein involved in response to heat shock and hypoxia. [Date last reviewed: 2019-08-01]
Other Summaries
Also Known As

Hsp70, heat-shock protein 70, hsp70B

Key Links
Genomic Location
Cytogenetic map
87B14-87B14
Sequence location
3R:12,502,510..12,504,856 [+]
Recombination map

3-52

RefSeq locus
NT_033777 REGION:12502510..12504856
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
ATP binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
ATPase activity
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
heat shock protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
misfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
protein folding chaperone
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
unfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
heat shock-mediated polytene chromosome puffing
inferred from mutant phenotype
(Gong and Golic, 2006)
response to heat
inferred from mutant phenotype
(Gong and Golic, 2006)
response to hypoxia
inferred from expression pattern
(Azad et al., 2009)
inferred from mutant phenotype
(Azad et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
cellular response to unfolded protein
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
chaperone cofactor-dependent protein refolding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
protein refolding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
response to unfolded protein
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
cytosol
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the heat shock protein 70 family. (Q9VG58)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.1.3)
Summaries
Gene Group (FlyBase)
HEAT SHOCK PROTEIN 70 CHAPERONES -
The Heat Shock Protein 70 (Hsp70) superfamily of chaperones assist in numerous folding processes and are upregulated by heat stress and toxic chemicals. Hsp70 chaperones share a highly conserved bipartite domain structure composed of an ATPase domain and a substrate-binding domain. (Adapted from PMID:17441502, FBrf0232269 and FBrf0174945).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Hsp70Bbb or the JBrowse view of Dmel\Hsp70Bbb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

This duplication of the Hsp70Bb gene is present in certain strains including y; cn bw sp, which was sequenced in the Drosophila genome project, but not others. See FBrf0137034 and personal communication of Brian Bettencourt to FlyBase for details.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hsp70Bbb-RA
FBtr0082636
NM_176486
2347
641
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hsp70Bbb-PA
FBpp0082105
70.3
641
5.39
NP_788663
AAF54830
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp70Bbb using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hsp70Bbb in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsp70Bbb
Transgenic constructs containing regulatory region of Hsp70Bbb
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Other Phenotypes
Allele
neuroanatomy defective, with Scer\GAL47B
Phenotype manifest in
Allele
adult mushroom body, with Scer\GAL47B
Kenyon cell, with Scer\GAL47B
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HSPA1B
6 of 15
Yes
No
Hsap\HSPA1A
5 of 15
No
No
3  
Hsap\HSPA1L
5 of 15
No
No
9  
Hsap\HSPA2
5 of 15
No
No
Hsap\HSPA6
5 of 15
No
No
Hsap\HSPA8
5 of 15
No
No
1  
Hsap\HSPA5
4 of 15
No
No
Hsap\HSPA9
3 of 15
No
No
Hsap\HSPA13
2 of 15
No
Yes
Hsap\ANKRD45
1 of 15
No
Yes
Hsap\HSPA4
1 of 15
No
No
1  
Hsap\HSPA4L
1 of 15
No
No
1  
Hsap\HSPA7
1 of 15
No
No
Hsap\HSPA12A
1 of 15
No
No
Hsap\HSPA12B
1 of 15
No
No
Hsap\HSPA14
1 of 15
No
No
Hsap\HSPH1
1 of 15
No
No
1  
Hsap\HYOU1
1 of 15
No
No
1  
Hsap\NKX2-6
1 of 15
No
No
Hsap\SLC9C2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hspa1a
6 of 15
Yes
No
Mmus\Hspa1b
5 of 15
No
No
Mmus\Hspa1l
5 of 15
No
No
Mmus\Hspa2
5 of 15
No
No
Mmus\Hspa8
5 of 15
No
No
Mmus\Hspa5
3 of 15
No
No
Mmus\Hspa9
3 of 15
No
No
Mmus\Hspa13
2 of 15
No
Yes
Mmus\Ankrd45
1 of 15
No
Yes
Mmus\Hspa4l
1 of 15
No
No
Mmus\Hspa4
1 of 15
No
No
Mmus\Hspa12a
1 of 15
No
No
Mmus\Hspa12b
1 of 15
No
No
Mmus\Hspa14
1 of 15
No
No
Mmus\Hsph1
1 of 15
No
No
Mmus\Hyou1
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Hspa2
5 of 13
Yes
No
Rnor\Hspa8
5 of 13
Yes
No
Rnor\Hspa1a
4 of 13
No
Yes
Rnor\Hspa1l
4 of 13
No
No
Rnor\Hspa5
4 of 13
No
No
Rnor\Hspa1b
3 of 13
No
No
Rnor\Hspa9
3 of 13
No
No
Rnor\LOC689955
2 of 13
No
Yes
Rnor\LOC108348108
2 of 13
No
No
Rnor\Hspa4l
1 of 13
No
No
Rnor\Hspa4
1 of 13
No
No
Rnor\Hspa12a
1 of 13
No
No
Rnor\Hspa12b
1 of 13
No
No
Rnor\Hspa13
1 of 13
No
Yes
Rnor\Hspa14
1 of 13
No
No
Rnor\Hsph1
1 of 13
No
No
Rnor\Hyou1
1 of 13
No
No
Rnor\LOC680121
1 of 13
No
No
Rnor\LOC100912578
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (16)
Xtro\hsp70
5 of 12
Yes
No
Xtro\hspa1b
5 of 12
Yes
No
Xtro\hspa1l
5 of 12
Yes
No
Xtro\hspa1a
4 of 12
No
No
Xtro\hspa2
4 of 12
No
No
Xtro\hspa8
4 of 12
No
No
Xtro\hspa5
3 of 12
No
No
Xtro\hspa9
3 of 12
No
No
Xtro\hspa13
2 of 12
No
Yes
Xtro\ankrd45
1 of 12
No
Yes
Xtro\hspa4
1 of 12
No
No
Xtro\hspa12a
1 of 12
No
Yes
Xtro\hspa12b
1 of 12
No
No
Xtro\hspa14
1 of 12
No
No
Xtro\hsph1
1 of 12
No
No
Xtro\hyou1
1 of 12
No
No
Danio rerio (Zebrafish) (21)
Drer\hsc70
6 of 15
Yes
No
Drer\hsp70.3
5 of 15
No
No
Drer\hsp70l
5 of 15
No
No
0  
Drer\hspa8
5 of 15
No
No
Drer\si:ch211-199o1.2
5 of 15
No
No
Drer\si:dkey-4p15.3
5 of 15
No
No
Drer\hsp70.2
4 of 15
No
No
Drer\hspa5
4 of 15
No
No
Drer\hsp70.1
3 of 15
No
No
Drer\hspa9
3 of 15
No
No
Drer\hspa12a
2 of 15
No
Yes
Drer\hspa13
2 of 15
No
Yes
Drer\ankrd45
1 of 15
No
Yes
Drer\hspa4a
1 of 15
No
No
Drer\hspa4b
1 of 15
No
No
Drer\hspa4l
1 of 15
No
No
Drer\hspa14
1 of 15
No
No
Drer\hsph1
1 of 15
No
No
Drer\hyou1
1 of 15
No
No
Drer\si:ch211-250m6.2
1 of 15
No
Yes
Drer\si:dkey-61p9.6
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\F44E5.5
5 of 15
Yes
Yes
Cele\hsp-70
5 of 15
Yes
Yes
Cele\hsp-1
4 of 15
No
No
Cele\F44E5.4
3 of 15
No
No
Cele\hsp-3
3 of 15
No
No
Cele\hsp-4
3 of 15
No
No
Cele\hsp-6
3 of 15
No
No
Cele\stc-1
2 of 15
No
Yes
Cele\F11F1.1
1 of 15
No
No
Cele\T14G8.3
1 of 15
No
No
Cele\T24H7.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\Hsp70-2
5 of 9
Yes
No
Atha\AT3G09440
4 of 9
No
No
Atha\ERD2
4 of 9
No
No
Atha\HSC70-1
4 of 9
No
No
Atha\HSP70
4 of 9
No
No
Atha\Hsp70b
4 of 9
No
No
Atha\BIP1
2 of 9
No
No
Atha\BIP2
2 of 9
No
No
Atha\BIP3
2 of 9
No
No
Atha\HSP70T-2
2 of 9
No
Yes
Atha\cpHsc70-1
1 of 9
No
No
Atha\cpHsc70-2
1 of 9
No
No
Atha\mtHsc70-1
1 of 9
No
No
Atha\MTHSC70-2
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (14)
Scer\SSA3
7 of 15
Yes
No
Scer\SSA4
7 of 15
Yes
No
Scer\SSA1
6 of 15
No
No
Scer\SSA2
6 of 15
No
No
Scer\SSB1
5 of 15
No
No
Scer\SSB2
5 of 15
No
No
Scer\KAR2
3 of 15
No
No
Scer\ECM10
2 of 15
No
No
Scer\LHS1
2 of 15
No
No
Scer\SSC1
2 of 15
No
No
Scer\SSQ1
2 of 15
No
No
Scer\SSE1
1 of 15
No
No
Scer\SSE2
1 of 15
No
No
Scer\SSZ1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\ssa1
4 of 12
Yes
No
Spom\ssa2
4 of 12
Yes
No
Spom\sks2
3 of 12
No
No
Spom\bip1
2 of 12
No
No
Spom\lsh1
1 of 12
No
No
Spom\ssc1
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905D7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010335
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013303
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013301
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012259
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013302
Drosophila simulans
Dsim\Hsp70Ba
Drosophila simulans
Dsim\Hsp70Ab
Drosophila simulans
Dsim\GD27509
Drosophila simulans
Dsim\GD28100
Drosophila simulans
Dsim\Hsp70Bb
Drosophila simulans
Dsim\Hsp70Aa
Drosophila sechellia
Dsec\GM23988
Drosophila sechellia
Dsec\GM26058
Drosophila erecta
Dere\GG17178
Drosophila erecta
Dere\GG19049
Drosophila erecta
Dere\GG18520
Drosophila erecta
Dere\GG17119
Drosophila erecta
Dere\GG19004
Drosophila yakuba
Dyak\GE28717
Drosophila yakuba
Dyak\GE29027
Drosophila ananassae
Dana\GF18384
Drosophila ananassae
Dana\GF16630
Drosophila ananassae
Dana\GF18385
Drosophila ananassae
Dana\GF16631
Drosophila ananassae
Dana\GF19283
Drosophila ananassae
Dana\GF16629
Drosophila ananassae
Dana\GF15894
Drosophila pseudoobscura pseudoobscura
Dpse\GA19632
Drosophila persimilis
Dper\GL27169
Drosophila willistoni
Dwil\GK27741
Drosophila willistoni
Dwil\GK13736
Drosophila virilis
Dvir\GJ25783
Drosophila virilis
Dvir\Hsp70g
Drosophila virilis
Dvir\Hsp70e
Drosophila virilis
Dvir\Hsp70f
Drosophila virilis
Dvir\Hsp70b
Drosophila virilis
Dvir\GJ10098
Drosophila virilis
Dvir\GJ14116
Drosophila virilis
Dvir\GJ10102
Drosophila virilis
Dvir\GJ18387
Drosophila virilis
Dvir\GJ16355
Drosophila mojavensis
Dmoj\GI10253
Drosophila mojavensis
Dmoj\GI10256
Drosophila mojavensis
Dmoj\GI22499
Drosophila mojavensis
Dmoj\GI10255
Drosophila mojavensis
Dmoj\GI10254
Drosophila grimshawi
Dgri\GH17332
Drosophila grimshawi
Dgri\GH15224
Drosophila grimshawi
Dgri\GH23796
Drosophila grimshawi
Dgri\GH15213
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502IF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008612
Musca domestica
House fly
Mdoa\17013981
Musca domestica
House fly
Mdoa\17005774
Musca domestica
House fly
Mdoa\17008614
Musca domestica
House fly
Mdoa\17006254
Musca domestica
House fly
Mdoa\17008613
Glossina morsitans
Tsetse fly
Gmor\GMOY009493
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03660
Mayetiola destructor
Hessian fly
Mdes\Mdes000202
Mayetiola destructor
Hessian fly
Mdes\Mdes011175
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Ba
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Ab
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Ab_prime_
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Aa
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Cb
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Aa_prime_
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Bb
Anopheles darlingi
American malaria mosquito
Adar\ADAC003118
Anopheles darlingi
American malaria mosquito
Adar\ADAC005660
Anopheles darlingi
American malaria mosquito
Adar\ADAC004661
Anopheles darlingi
American malaria mosquito
Adar\ADAC002898
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014283
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011082
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011083
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011081
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02J2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002428
Bombyx mori
Silkmoth
Bmor\BGIBMGA014536
Bombyx mori
Silkmoth
Bmor\BmHSC70-4
Danaus plexippus
Monarch butterfly
Dple\DPOGS208954-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210048-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213900-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212775-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213925-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210250-PA
Heliconius melpomene
Postman butterfly
Hmel\Hem
Heliconius melpomene
Postman butterfly
Hmel\HMEL010425
Heliconius melpomene
Postman butterfly
Hmel\HMEL014657
Heliconius melpomene
Postman butterfly
Hmel\HMEL014163
Heliconius melpomene
Postman butterfly
Hmel\HMEL006064
Apis florea
Little honeybee
Aflo\2484227444
Apis florea
Little honeybee
Aflo\2994796276
Apis florea
Little honeybee
Aflo\2354233092
Apis mellifera
Western honey bee
Amel\LOC410620
Apis mellifera
Western honey bee
Amel\GB50246
Apis mellifera
Western honey bee
Amel\Hsc70-4
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16151
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14904
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25428
Bombus terrestris
Buff-tailed bumblebee
Bter\15203980
Bombus terrestris
Buff-tailed bumblebee
Bter\15207411
Bombus terrestris
Buff-tailed bumblebee
Bter\15209666
Linepithema humile
Argentine ant
Lhum\LH12354
Linepithema humile
Argentine ant
Lhum\LH21302
Linepithema humile
Argentine ant
Lhum\LH21803
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e42
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002430
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c83
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ed9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008319
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002344
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002830
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007999
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003712
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002346
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11145
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06831
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06803
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01683
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06804
Tribolium castaneum
Red flour beetle
Tcas\TC033493
Tribolium castaneum
Red flour beetle
Tcas\TC010172
Tribolium castaneum
Red flour beetle
Tcas\TC031639
Tribolium castaneum
Red flour beetle
Tcas\hsp68b
Tribolium castaneum
Red flour beetle
Tcas\Hem
Tribolium castaneum
Red flour beetle
Tcas\TC000188
Pediculus humanus
Human body louse
Phum\PHUM126800
Pediculus humanus
Human body louse
Phum\PHUM333930
Pediculus humanus
Human body louse
Phum\PHUM588610
Pediculus humanus
Human body louse
Phum\PHUM018540
Rhodnius prolixus
Kissing bug
Rpro\RPRC004310
Rhodnius prolixus
Kissing bug
Rpro\RPRC009759
Rhodnius prolixus
Kissing bug
Rpro\RPRC012193
Cimex lectularius
Bed bug
Clec\CLEC002869
Cimex lectularius
Bed bug
Clec\CLEC002762
Cimex lectularius
Bed bug
Clec\CLEC010952
Cimex lectularius
Bed bug
Clec\CLEC025196
Cimex lectularius
Bed bug
Clec\CLEC010950
Cimex lectularius
Bed bug
Clec\CLEC005841
Cimex lectularius
Bed bug
Clec\CLEC025196-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007961
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000474
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000903
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001597
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080190
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008763
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004809
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI067751
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073873
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080139
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05273
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04366
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06862
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02GG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004960
Strigamia maritima
European centipede
Smar\SMAR013707
Strigamia maritima
European centipede
Smar\SMAR004796
Ixodes scapularis
Black-legged tick
Isca\ISCW009279
Ixodes scapularis
Black-legged tick
Isca\ISCW024910
Ixodes scapularis
Black-legged tick
Isca\ISCW017456
Ixodes scapularis
Black-legged tick
Isca\ISCW011425
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80380.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78034.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83474.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76829.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83484.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78035.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69762.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83486.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57777.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69761.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g01700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_227800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302856
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303127
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_256736
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03SF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701E
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701C
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701D
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp703A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nckap1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nckap1
Ciona intestinalis
Vase tunicate
Cint\LOC100187210
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003184
Ciona intestinalis
Vase tunicate
Cint\hsp70
Gallus gallus
Domestic chicken
Ggal\NCKAP1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027417
Gallus gallus
Domestic chicken
Ggal\HSP70
Gallus gallus
Domestic chicken
Ggal\HSPA8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Hsc70-2
7 of 10
Hsp68
7 of 10
Hsp70Aa
7 of 10
Hsp70Ba
7 of 10
Hsc70-1
6 of 10
Hsc70-3
6 of 10
Hsc70-4
6 of 10
Hsp70Ab
6 of 10
Hsp70Bb
6 of 10
Hsp70Bc
6 of 10
Hsc70-5
5 of 10
CG7182
3 of 10
CG2918
2 of 10
Hsc70Cb
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HSPA1B; heat shock protein family A (Hsp70) member 1B
    6 of 15
    603012
        HSPA1A; heat shock protein family A (Hsp70) member 1A
        5 of 15
        140550
             
            HSPA1L; heat shock protein family A (Hsp70) member 1 like
            5 of 15
            140559
                 
                HSPA2; heat shock protein family A (Hsp70) member 2
                5 of 15
                140560
                    HSPA6; heat shock protein family A (Hsp70) member 6
                    5 of 15
                    140555
                        HSPA8; heat shock protein family A (Hsp70) member 8
                        5 of 15
                        600816
                             
                            HSPA5; heat shock protein family A (Hsp70) member 5
                            4 of 15
                            138120
                                HSPA9; heat shock protein family A (Hsp70) member 9
                                3 of 15
                                600548
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                esyN Network Diagram
                                Show neighbor-neighbor interactions:
                                Select Layout:
                                Legend:
                                Protein
                                RNA
                                Selected Interactor(s)
                                Interactions Browser
                                View in Interactions Browser
                                Please see the Physical Interaction reports below for full details
                                protein-protein
                                Physical Interaction
                                Assay
                                References
                                Hsp70Bbb - Nrd1
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Yoon et al., 2017)
                                Summary of Genetic Interactions
                                esyN Network Diagram
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                External Data
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                External Data
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3R
                                Recombination map

                                3-52

                                Cytogenetic map
                                87B14-87B14
                                Sequence location
                                3R:12,502,510..12,504,856 [+]
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                87B14-87B14
                                Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                Experimentally Determined Recombination Data
                                Location

                                3-52

                                (FlyBase, 2016)

                                3-49.5

                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (5)
                                Genomic Clones (13)
                                 

                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                cDNA Clones (94)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                Antibody Information
                                Laboratory Generated Antibodies
                                 
                                Commercially Available Antibodies
                                 
                                Other Information
                                Relationship to Other Genes
                                Source for database identify of
                                Source for database merge of
                                Member gene of
                                Hsp70
                                (Takahashi et al., 2010)
                                Additional comments
                                Other Comments

                                Flies with no copies of the Hsp70 genes (Hsp70Aa, Hsp70Ab, Hsp70Ba, Hsp70Bb, Hsp70Bbb and Hsp70Bc) are unable to survive a severe heat shock. These flies show a lengthened heat-shock response and developmental delay following a non-lethal heat shock.

                                (Gong and Golic, 2006)

                                Flies with no copies of the Hsp70 genes (Hsp70Aa, Hsp70Ab, Hsp70Ba, Hsp70Bb, Hsp70Bbb and Hsp70Bc) are viable and fertile.

                                (Gong and Golic, 2004)

                                Some Drosophila strains, including that sequenced in the Drosophila genome project have three, not two, tandemly repeated Hsp70 genes at 87C1 (in addition to a reverse orientation Hsp70 gene, Hsp70Ba, approximately 40kb upstream). The distal-most gene of the three tandem copies is Hsp70Bc. The inner two tandem copies are Hsp70Bb and Hsp70Bbb.

                                (Bettencourt, 2002.1.16)

                                The D.melanogaster strain used for sequencing the genome contains an additional, third tandem copy of an Hsp70 gene at 87C as well as the two tandemly repeated copies (Hsp70Bb and Hsp70Bc) which are found in many strains. This additional copy is named "Hsp70Bbb" (see FBrf0137034 and Bettencourt, 2002.1.16, personal communication to FlyBase).

                                (FlyBase Genome Annotators, 2002-2003)
                                Origin and Etymology
                                Discoverer
                                Etymology
                                Identification
                                External Crossreferences and Linkouts ( 31 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                Other crossreferences
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                modMine - A data warehouse for the modENCODE project
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                FlyMine - An integrated database for Drosophila genomics
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Synonyms and Secondary IDs (18)
                                Reported As
                                Symbol Synonym
                                CG31354
                                (Nicolai et al., 2003)
                                CG5834
                                (Meadows, 2018.10.31, Hoffmann et al., 2013, Ni et al., 2010.12.1, Seinen et al., 2010, Perkins et al., 2009, Hughes et al., 2008, Wayne and McIntyre, 2002)
                                Dm-hsp70
                                (Hernandez et al., 2004)
                                HSP70
                                (Nelson et al., 2016, Doganlar and Doganlar, 2015, Marr et al., 2014, Olalekan Abolaji et al., 2014, Schriner et al., 2014, Todd et al., 2013, Hurt et al., 2009, Farny et al., 2008, Sakaguchi et al., 2008, Chartier et al., 2006, Folk et al., 2006, Warrick and Boyd, 2006, Gerber et al., 2005, Papaconstantinou et al., 2005, Driscoll and Gerstbrein, 2003, Bondinas et al., 2002, Garbuz et al., 2002, Zoghbi and Botas, 2002, Bondinas et al., 2001, Foley and Luckinbill, 2001, Aalfs and Kingston, 2000)
                                HSP70Bbb
                                (Rehwinkel et al., 2004)
                                Hsp-70
                                (Pimenta de Castro et al., 2012)
                                Hsp70
                                (Prasad et al., 2019, Berson et al., 2017, Li et al., 2017, Donovan and Marr, 2016, Hosamani et al., 2016, Zatsepina et al., 2016, Zhang et al., 2016, Alaraby et al., 2015, Funikov et al., 2015, Marr et al., 2014, Shukla et al., 2014, Tower et al., 2014, Zhang et al., 2014, Calabria et al., 2012, Schneiderman et al., 2012, Azad et al., 2011, Morettini et al., 2011, Takahashi et al., 2011, Ahamed et al., 2010, Bartkowiak et al., 2010, Demontis and Perrimon, 2010, Hrizo and Palladino, 2010, Jensen et al., 2010, Kwon et al., 2010, Tian et al., 2010, Udaka et al., 2010, Zobeck et al., 2010, Zobeck et al., 2010, Ardehali et al., 2009, Baker and Russell, 2009, Chopra et al., 2009, Posgai et al., 2009, Bhargav et al., 2008, Brandt and Corces, 2008, Cai et al., 2008, Casas-Tinto et al., 2008, Cobreros et al., 2008, Duncan, 2008, Fujikake et al., 2008, Gilchrist et al., 2008, Hanyu-Nakamura et al., 2008, Ni et al., 2008, Smith et al., 2008, Ahrens et al., 2007, Eissenberg et al., 2007, Fernandez-Funez et al., 2007, Mito et al., 2007, Pappas et al., 2007, Rezaval et al., 2007, Yao et al., 2007, Behr et al., 2006, Kalosaka et al., 2006, Papaconstantinou et al., 2006, Sengupta and Lakhotia, 2006, Shilova et al., 2006, Tenney et al., 2006, Auluck et al., 2005, Duncan, 2005, Gupta et al., 2005, Huen and Chan, 2005, Iijima-Ando et al., 2005, Newman et al., 2005, Nielsen et al., 2005, Overgaard et al., 2005, Scholz et al., 2005, Ahmed and Duncan, 2004, Jennings et al., 2004, Morrow et al., 2004, Sathyanarayanan et al., 2004, Temme et al., 2004, Auluck and Bonini, 2003, Caletka and Fry, 2003, Canamasas et al., 2003, Gruntenko et al., 2003, Jin et al., 2003, Kristensen et al., 2003, Norry and Loeschcke, 2003, Rutherford, 2003, Sejerkilde et al., 2003, Bonini, 2002, Isaenko et al., 2002, Lakhotia et al., 2002, Kelty and Lee, 2001, Krebs and Holbrook, 2001, Rajendra et al., 2001, Sorensen and Loeschcke, 2001, Zatsepina et al., 2001, Bettencourt and Feder, 1999, Krebs, 1999, Lerman and Feder, 1999)
                                Hsp70B
                                (Buchon et al., 2009, Chen et al., 2008)
                                Hsp70Bb
                                (Maside et al., 2002)
                                Hsp70Bbb
                                (Kordyukova et al., 2020, Michalak et al., 2019, Leow et al., 2018, Yoon et al., 2017, Marr et al., 2014, Azad and Haddad, 2013, Hoffmann et al., 2013, Paré et al., 2012, Azad et al., 2011, Cernilogar et al., 2011, Friedman et al., 2011, Shieh and Bonini, 2011, Zhao and Haddad, 2011, Kong et al., 2010, Mosqueira et al., 2010, Takahashi et al., 2010, Tian et al., 2010, Azad et al., 2009, Bartkuhn et al., 2009, Haney and Feder, 2009, Kuan et al., 2009, Bettencourt et al., 2008, Fisher et al., 2008, Xi et al., 2008, Zeitlinger et al., 2007, Beller et al., 2006, Dorus et al., 2006, Shilova et al., 2006, Rehwinkel et al., 2004)
                                dHsp70
                                (Bell et al., 2007)
                                hsp70
                                (Sharma et al., 2018, Pereira and Paro, 2017, Xu et al., 2016, Kust et al., 2014, Shukla et al., 2014, Lagha et al., 2013, Ardehali et al., 2011, Boeke et al., 2011, Chan et al., 2011, Ghosh et al., 2011, Juge et al., 2010, Kopytova et al., 2010, Kotova et al., 2010, Pankotai et al., 2010, Tombácz et al., 2009, Yang and Tower, 2009, Grover et al., 2008, Hsu et al., 2008, Lee et al., 2008, Piel et al., 2008, Siddique et al., 2008, Smith et al., 2008, Behm-Ansmant et al., 2007, Halfon and Arnosti, 2007, Ivaldi et al., 2007, Kurshakova et al., 2007, Lebedeva et al., 2007, Ullah et al., 2007, Vazquez-Pianzola et al., 2007, Buszczak and Spradling, 2006, Graves and Tamkun, 2006, Zhao et al., 2006, Adelman et al., 2005, Kim and Lis, 2005, Saunders et al., 2005, Wu et al., 2005, Zhao et al., 2005, Goodman et al., 2004, Landis et al., 2004, Lehmann, 2004, Matsumoto and Hirose, 2004, Poels et al., 2004, Poels et al., 2004, Smith et al., 2004, Venkaiah et al., 2004, Wang et al., 2004, Feder, 2003, Gilmour, 2003.4.18, Gong and Golic, 2003, Goodman et al., 2003, Helfand and Rogina, 2003, Kellum, 2003, Saunders et al., 2003, Shaw and Franken, 2003, Tulin and Spradling, 2003, Viswanathan et al., 2003, Wimmer, 2003, Aigaki et al., 2002, Andrulis et al., 2002, Lakhotia and Prasanth, 2002, Li et al., 2001, Mahowald, 2001, Tatar and Yin, 2001, Bettencourt and Feder, 2000, Geyer et al., 2000)
                                hsp70B
                                (Huang et al., 2008, Gong and Golic, 2004)
                                hsp70Bb-prime
                                (Bettencourt, 2002.1.16)
                                hsp70bBb
                                (Ryazansky et al., 2016)
                                hsp70bbb
                                (Ou et al., 2016)
                                Name Synonyms
                                Hsp70Bbb
                                (Bettencourt et al., 2008)
                                heat shock protein 70
                                (Lagha et al., 2013)
                                heat-shock protein 70
                                (Farny et al., 2008, Iijima-Ando et al., 2005)
                                Secondary FlyBase IDs
                                • FBgn0040549
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (264)