FlyBase Gene Report: Dmel\CG31441

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CG31441 or the JBrowse view of Dmel\CG31441 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Alternative translation stop created by use of multiphasic reading frames within coding region.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG31441-RA

FBtr0082355

NM_169382

1219

341

CG31441-RB

FBtr0339400

NM_001300354

1223

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG31441-PA

FBpp0081831

40.0

341

8.49

NP_731558

AAF54620

CG31441-PB

FBpp0308492

5.6

9.90

NP_001287283

AHN57282

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG31441 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG31441_1

Linkouts

Gene Ontology (4 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

transcription regulatory region sequence-specific DNA binding

inferred from sequence or structural similarity with UniProtKB:P47043

(FlyBase Curators, 2008--)

zinc ion binding

inferred from sequence or structural similarity with UniProtKB:P47043

(FlyBase Curators, 2008--)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

regulation of transcription, DNA-templated

inferred from sequence or structural similarity with UniProtKB:P47043

(FlyBase Curators, 2008--)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

nucleus

inferred from sequence or structural similarity with UniProtKB:P47043

(FlyBase Curators, 2008--)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG31441 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG31441

View exonic expression by tissue for Dmel\CG31441

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051441

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0051441

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG31441-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31441

Flygut - An atlas of the Drosophila adult midgut

FBgn0051441

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG31441

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG31441

Transgenic constructs containing regulatory region of CG31441

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

CG31441^GD10260

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG31441^GD10260

Other Phenotypes

Allele

locomotor behavior defective | adult stage, with Scer\GAL4^Mef2.PR

CG31441^GD10260

some die during pupal stage, with Scer\GAL4^pnr-MD237

CG31441^GD10260

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (35)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RBAK-RBAKDN

1 of 15

Yes

Hsap\ZFP28

1 of 15

Yes

Hsap\ZNF8

1 of 15

Yes

Hsap\ZNF28

1 of 15

Yes

Hsap\ZNF43

1 of 15

Yes

Hsap\ZNF70

1 of 15

Yes

Hsap\ZNF98

1 of 15

Yes

Hsap\ZNF160

1 of 15

Yes

Hsap\ZNF211

1 of 15

Yes

Hsap\ZNF233

1 of 15

Yes

Hsap\ZNF254

1 of 15

Yes

Hsap\ZNF468

1 of 15

Yes

Hsap\ZNF480

1 of 15

Yes

Hsap\ZNF485

1 of 15

Yes

Hsap\ZNF492

1 of 15

Yes

Hsap\ZNF527

1 of 15

Yes

Hsap\ZNF528

1 of 15

Yes

Hsap\ZNF558

1 of 15

Yes

Hsap\ZNF560

1 of 15

Yes

Hsap\ZNF568

1 of 15

Yes

Hsap\ZNF570

1 of 15

Yes

Hsap\ZNF572

1 of 15

Yes

Hsap\ZNF582

1 of 15

Yes

Hsap\ZNF595

1 of 15

Yes

Hsap\ZNF675

1 of 15

Yes

Hsap\ZNF681

1 of 15

Yes

Hsap\ZNF708

1 of 15

Yes

Hsap\ZNF721

1 of 15

Yes

Hsap\ZNF730

1 of 15

Yes

Hsap\ZNF784

1 of 15

Yes

Hsap\ZNF792

1 of 15

Yes

Hsap\ZNF816

1 of 15

Yes

Hsap\ZNF845

1 of 15

Yes

Hsap\ZNF850

1 of 15

Yes

Hsap\ZSCAN30

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Gm13212

1 of 15

Yes

Mmus\Rbak

1 of 15

Yes

Mmus\Zfp12

1 of 15

Yes

Mmus\Zfp24

1 of 15

Yes

Mmus\Zfp62

1 of 15

Yes

Mmus\Zfp93

1 of 15

Yes

Mmus\Zfp110

1 of 15

Yes

Mmus\Zfp369

1 of 15

Yes

Mmus\Zfp445

1 of 15

Yes

Mmus\Zfp612

1 of 15

Yes

Mmus\Zfp708

1 of 15

Yes

Mmus\Zfp810

1 of 15

Yes

Mmus\Zfp945

1 of 15

Yes

Mmus\Zfp984

1 of 15

Yes

Mmus\Zscan5b

1 of 15

Yes

Rattus norvegicus (Norway rat) (4)

Rnor\LOC108348145

1 of 13

Yes

Rnor\Zfp189

1 of 13

Yes

Rnor\Zfp819

1 of 13

Yes

Rnor\Zfp958

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (2)

Drer\bcl6ab

1 of 15

Yes

Drer\znf408

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\blmp-1

1 of 15

Yes

Cele\lin-29

1 of 15

Yes

Cele\M03D4.4

1 of 15

Yes

Cele\Y55F3AM.14

1 of 15

Yes

Cele\ztf-23

1 of 15

Yes

Cele\ztf-27

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (4)

Atha\DOT5

1 of 9

Yes

Atha\TFIIIA

1 of 9

Yes

Atha\TT1

1 of 9

Yes

Atha\WIP3

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\AZF1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ace2

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190C22 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\CG31441

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008633

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila willistoni

Dwil\GK13987

Drosophila virilis

Dvir\GJ22566

Drosophila mojavensis

Dmoj\GI24615

Drosophila grimshawi

Dgri\GH22379

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (31)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

nom

3 of 10

Odj

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Zif

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CG31441 - CG32767

two hybrid array

(Shokri et al., 2019)

CG31441 - CG3995

two hybrid

(Hu et al., 2017.6.13)

CG31441 - Doc2

two hybrid array

(Shokri et al., 2019)

CG31441 - Sox21a

two hybrid array

(Shokri et al., 2019)

CG31441 - Su(H)

two hybrid array

(Shokri et al., 2019)

CG31441 - gfzf

two hybrid array

(Shokri et al., 2019)

CG31441 - mirr

two hybrid array

(Shokri et al., 2019)

CG31441 - tin

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0051441

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-50

Cytogenetic map

86D8-86D8

Sequence location

3R:11,236,286..11,237,624 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86D8-86D8

Limits computationally determined from genome sequence between P{EP}EP3340^EP3340 and P{PZ}tho¹&P{PZ}l(3)04629⁰⁵²⁷⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-50

(FlyBase, 2016)

3-47.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

81254

y¹ w^*; P{CG31441-GFP.FPTB}attP40

80258

y¹ sc^* v¹ sev²¹; P{TOE.GS02811}attP40

67285

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06388}attP40

FlyORF

F000052

M{UAS-CG31441.ORF.3xHA.GW}ZH-86Fb

VDRC

v109687

P{KK103228}VIE-260B

v21345

w¹¹¹⁸; P{GD10260}v21345

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

LD25880

Other clones

DPiM_LD25880

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051441

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051441

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

326139

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Annotation CG5135 split into CG31388 and CG31441 in release 3 of the genome annotation. In addition, release 3 annotation CG31388 contains sequences corresponding to release 2 annotation CG17722.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 30 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

326139

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051441

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051441

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG31441_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31441

Flygut - An atlas of the Drosophila adult midgut

FBgn0051441

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

326139

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG31441

modMine - A data warehouse for the modENCODE project

FBgn0051441

Linkouts

DPiM - Drosophila Protein interaction map

FBgn0051441

DroID - A comprehensive database of gene and protein interactions.

FBgn0051441

DRSC - Results frm RNAi screens

FBgn0051441

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0051441

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG31441-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0051441

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG31441

(Chai et al., 2019, Shokri et al., 2019, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Coolon et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009)

CG5135

Name Synonyms

Secondary FlyBase IDs

FBgn0037886

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (29)

Report Sections

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