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Gene Dmel\CG31446

General Information
Symbol	Dmel\CG31446	Species	D. melanogaster
Name		Annotation symbol	CG31446
Feature type	protein_coding_gene	FlyBase ID	FBgn0051446
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89A2-89A2	Sequence location	3R:11,518,811..11,519,920 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG31446 (FBgn0051446). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Calycin; Calycin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Comments on Affy2 ProbeSet: ProbeSet 1625985_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG31446. Gene sequence location is 3R:11518811..11519920.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN26879 HFA13111
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89A2-89A2   Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG31446 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG31446-RA FBtr0083163  NM_169666   870   232
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG31446-PA   FBpp0082617   25.3   232   3.82     NP_732053   AAN13671
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Calycin-like (IPR011038) Calycin (IPR012674)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAN13671   AY071375 AAL48997   BI242888   CO315698   CO320147   EC204516   EC204646   EC226769
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SYQ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051446 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31446-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG31446GD3004 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG31446 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG31446 Class Mutagen Stocks Known lesion CG31446GD3004 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG31446KK106879 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6175 (Ryder, 2004.4.26) Df(3R)Exel7326 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3004} NA P{KK106879} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a biological process or cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR012674 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG31446 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77041 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0051446 DroID - A comprehensive database of gene and protein interactions. • FBgn0051446 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318741
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18531 Dere\GG16938 Dgri\GH18209 Dmoj\GI10162 Dper\GL12696 Dpse\GA16255 Dsec\GM24247 Dsim\GD19036 Dvir\GJ10864 Dwil\GK11407 Dyak\GE24326
Curated drosophilid orthologs	Dpse\GA16255
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241449 FBgn0213418 FBgn0198133 FBgn0190543 FBgn0179111 FBgn0076271 FBgn0150302 FBgn0132928 FBgn0125677 FBgn0109166 FBgn0095549 CPIJ015730 CPIJ013313 AAEL009561
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v101092 P{KK106879}VIE-260B v12147 w1118 P{GD3004}v12147 v12146 w1118; P{GD3004}v12146
Genomic Clones ( 1 )
	BACR48G17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE40372
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	159290 174842 177417 EK262232 EK282523
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051446 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318741
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG31446 BcDNA:RE40372 (FlyBase, 1996-)
Additional comments	Source for merge of CG31446 BcDNA:RE40372 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	New annotation (CG31446) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169666 RefSeq (Proteins) • NP_732053 DDBJ / EMBL / GenBank • AAL48997 AAN13671 AY071375 BI242888 Entrez Gene - A searchable database of RefSeq genes. • 318741 UniProtKB/TrEMBL • Q8SYQ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Calycin-like (IPR011038) Calycin (IPR012674)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77041 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0051446 DroID - A comprehensive database of gene and protein interactions. • FBgn0051446 DRSC - Results from RNAi screens. • FBgn0051446 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051446 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31446-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051446 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318741 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318741 modMine - Data generated by the modENCODE project. • FBgn0051446 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241449 FBgn0213418 FBgn0198133 FBgn0190543 FBgn0179111 FBgn0076271 FBgn0150302 FBgn0132928 FBgn0125677 FBgn0109166 FBgn0095549 CPIJ015730 CPIJ013313 AAEL009561
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:RE40372   CG31446 (Keleman et al., 2009.8.5, Riedl et al., 2005)
Name Synonym
Secondary FlyBase IDs
	FBgn0047110
References ( 12 )
Research paper	Riedl et al., 2005, Behav. Genet. 35(3): 231--244 Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. [FBrf0187131]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]