FB2021_01, released Feb 18, 2021

Gene: Dmel\Cnot4

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General Information
Symbol
Dmel\Cnot4
Species
D. melanogaster
Name
CCR4-NOT transcription complex subunit 4
Annotation Symbol
CG31716
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051716
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

NOT4, dNOT4

Key Links
Genomic Location
Cytogenetic map
31E1-31E1
Sequence location
2L:10,396,716..10,403,206 [+]
Recombination map

2-42

RefSeq locus
NT_033779 REGION:10396716..10403206
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables metal ion binding
inferred from electronic annotation with InterPro:IPR000571
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR000504
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ubiquitin protein ligase activity
inferred from sequence or structural similarity with UniProtKB:P34909
(FlyBase Curators, 2008--)
enables ubiquitin-protein transferase activity
inferred from biological aspect of ancestor with PANTHER:PTN000288208
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000000870
(FlyBase Curators, 2008--)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in positive regulation of receptor signaling pathway via JAK-STAT
inferred from mutant phenotype
(Grönholm et al., 2012, Kallio et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein ubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN000288208
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000000870
(FlyBase Curators, 2008--)
inferred from sequence or structural similarity with UniProtKB:P34909
(FlyBase Curators, 2008--)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of CCR4-NOT complex
inferred from biological aspect of ancestor with PANTHER:PTN000288208
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasm
inferred from sequence or structural similarity with SGD:S000000870
(FlyBase Curators, 2008--)
inferred from sequence or structural similarity with UniProtKB:P34909
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER RING DOMAIN UBIQUITIN LIGASES -
The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).
Pathway (FlyBase)
Positive Regulators of JAK-STAT Signaling Pathway -
Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Cnot4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cnot4-RA
FBtr0080009
NM_164919
3615
1051
Cnot4-RB
FBtr0080013
NM_164920
3644
1051
Cnot4-RC
FBtr0080010
NM_164921
3552
1051
Cnot4-RD
FBtr0080011
NM_164922
3482
1051
Cnot4-RE
FBtr0080012
NM_164923
3554
1051
Cnot4-RG
FBtr0080014
NM_164924
3370
1047
Cnot4-RH
FBtr0304112
NM_001201847
3963
1059
Cnot4-RI
FBtr0304113
NM_001201848
3603
1047
Cnot4-RJ
FBtr0331637
NM_001273413
3826
1054
Cnot4-RK
FBtr0331638
NM_001273414
3972
1062
Cnot4-RL
FBtr0331639
NM_001273415
3612
1050
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cnot4-PA
FBpp0079599
116.6
1051
6.65
NP_723578
AAF52936
Cnot4-PB
FBpp0079603
116.6
1051
6.65
NP_723579
AAF52937
Cnot4-PC
FBpp0079600
116.6
1051
6.65
NP_723580
AAN10747
Cnot4-PD
FBpp0079601
116.6
1051
6.65
NP_723581
AAN10748
Cnot4-PE
FBpp0079602
116.6
1051
6.65
NP_723582
AAN10749
Cnot4-PG
FBpp0079604
116.2
1047
6.65
NP_723583
AAN10750
Cnot4-PH
FBpp0293055
117.3
1059
6.71
NP_001188776
ADV37026
Cnot4-PI
FBpp0293056
116.2
1047
6.65
NP_001188777
ADV37027
Cnot4-PJ
FBpp0304027
116.9
1054
6.71
NP_001260342
AGB92877
Cnot4-PK
FBpp0304028
117.6
1062
6.77
NP_001260343
AGB92878
Cnot4-PL
FBpp0304029
116.5
1050
6.71
NP_001260344
AGB92879
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1051 aa isoforms: Cnot4-PA, Cnot4-PB, Cnot4-PC, Cnot4-PD, Cnot4-PE
1047 aa isoforms: Cnot4-PG, Cnot4-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cnot4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cnot4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cnot4
Transgenic constructs containing regulatory region of Cnot4
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CNOT4
9 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cnot4
9 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Cnot4
8 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\cnot4
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\cnot4a
9 of 15
Yes
Yes
Drer\cnot4b
9 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ntl-4
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (6)
Atha\AT2G28540
4 of 9
Yes
Yes
Atha\AT3G45630
4 of 9
Yes
Yes
Atha\AT5G60170
4 of 9
Yes
Yes
Atha\AT1G74870
1 of 9
No
Yes
Atha\AT3G48070
1 of 9
No
Yes
Atha\AT5G62910
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\MOT2
9 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\mot2
7 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902F9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001798
Drosophila simulans
Dsim\GD23693
Drosophila erecta
Dere\GG10123
Drosophila yakuba
Dyak\GE18937
Drosophila ananassae
Dana\GF15780
Drosophila pseudoobscura pseudoobscura
Dpse\GA28160
Drosophila persimilis
Dper\GL19177
Drosophila willistoni
Dwil\GK28091
Drosophila willistoni
Dwil\GK18552
Drosophila virilis
Dvir\GJ21812
Drosophila mojavensis
Dmoj\GI18285
Drosophila grimshawi
Dgri\GH13370
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501D0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019357
Glossina morsitans
Tsetse fly
Gmor\GMOY005956
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03706
Mayetiola destructor
Hessian fly
Mdes\Mdes006916
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009437
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006664
Anopheles darlingi
American malaria mosquito
Adar\ADAC000539
Anopheles gambiae
Malaria mosquito
Agam\AGAP009827
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000383
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019539
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W015I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005733
Danaus plexippus
Monarch butterfly
Dple\DPOGS208624-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015851
Apis florea
Little honeybee
Aflo\3284169988
Apis mellifera
Western honey bee
Amel\GB46205
Apis mellifera
Western honey bee
Amel\GB46196
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19390
Bombus terrestris
Buff-tailed bumblebee
Bter\15210995
Linepithema humile
Argentine ant
Lhum\LH12069
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003067
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013718
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09401
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09400
Tribolium castaneum
Red flour beetle
Tcas\TC033413
Pediculus humanus
Human body louse
Phum\PHUM247100
Rhodnius prolixus
Kissing bug
Rpro\RPRC001525
Cimex lectularius
Bed bug
Clec\CLEC000436
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000173
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08749
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12767
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X013V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015517
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56824.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75389.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g04800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_323297
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03YT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unc44L_47
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unc44_118
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cnot4L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unc44_144
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unc44_229
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004364
Gallus gallus
Domestic chicken
Ggal\CNOT4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CNOT4; CCR4-NOT transcription complex subunit 4
    9 of 15
    604911
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Cnot4 - Patr-1
        anti tag coimmunoprecipitation, anti tag western blot
        (Haas et al., 2010)
        Cnot4 - Stat92E
        anti bait coimmunoprecipitation, anti tag western blot
        (Grönholm et al., 2012)
        Cnot4 - nos
        two hybrid
        (Kadyrova et al., 2007)
        Cnot4 - pAbp
        anti tag coimmunoprecipitation, anti tag western blot
        (Zekri et al., 2009)
        Cnot4 - pelo
        anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
        (Wu et al., 2018)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Positive Regulators of JAK-STAT Signaling Pathway -
        Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-42

        Cytogenetic map
        31E1-31E1
        Sequence location
        2L:10,396,716..10,403,206 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        31E1-31E1
        Limits computationally determined from genome sequence between P{lacW}RnrLk06709 and P{lacW}KdelRk00311
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-42

        (FlyBase, 2016)

        2-35.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (25)
        cDNA Clones (117)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Wu et al., 2018)

          monoclonal

          (Na et al., 2016)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Cnot4 CG31716

          (Ying et al., 2011)
          Source for database merge of

          Source for merge of: CG5244 CG5251

          (Sonoda, 2001.4.15)
          Additional comments

          Annotations CG5244, CG5251 merged as CG31716 in release 3 of the genome annotation.

          (FlyBase Genome Annotators, 2002-2003)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 79 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (13)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (74)