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Gene Dmel\Ir31a

General Information
Symbol	Dmel\Ir31a	Species	D. melanogaster
Name	Ionotropic receptor 31a	Annotation symbol	CG31718
Feature type	protein_coding_gene	FlyBase ID	FBgn0051718
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	IR31a
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31E1-31E1	Sequence location	2L:10,405,565..10,408,197 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 31a is referred to in FlyBase by the symbol Dmel\Ir31a (CG31718, FBgn0051718). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: glutamate receptor activity; ligand-gated ion channel activity. There is experimental evidence that it is involved in the biological process: detection of chemical stimulus involved in sensory perception. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ionotropic glutamate receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed within 00-12 hour embryonic stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1640705_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ir31a. Gene sequence location is 2L:10405565..10408197.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31E1-31E1   Limits computationally determined from genome sequence between P{lacW}RnrLk06709 and P{lacW}KdelRk00311
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir31a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir31a-RC FBtr0336967  NM_001273417   2203   648 Ir31a-RD FBtr0336968  NM_164926   2263   629
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir31a-PC   FBpp0307910   73.7   648   7.61     NP_001260346   AGB92881 Ir31a-PD   FBpp0307911   71.6   629   7.65     NP_723585   AAN10751
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAN10751   AE014134 AGB92881   CZ489024   CZ489025   FE527567   GH291349
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IPB8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   neuron of antennal coeloconic sensillum ac1   (Benton et al., 2009)
Additional Descriptive Data
	Ir31a transcript is expressed in the neurons of antennal coeloconic sensillum ac1. It is co-expressed with Ir75d, Ir92a and Ir76b. (Benton et al., 2009)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.925 Larval Midgut    1.1 Larval Hindgut    1.8 Larval Malpighian Tubules    2.8 Larval Fat Body    3.3 Larval Salivary Gland    3.8 Larval Trachea    2.175 Larval Carcass    1.075 Adult Head    19.5 Adult Eye    1.7 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    1.9 Adult Midgut    1 Adult Hindgut    2.5 Adult Malpighian Tubules    3 Adult Fat Body    7.2 Adult Salivary Gland    12.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    4 Adult Ovary    4.2 Adult Testis    3.7 Adult Male Accessory Gland    7.9 Adult Carcass    5.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    19.5   NA  Eye    1.7   NA  Brain    4.9   3.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.1   NA  Crop    1.9   1.1  Midgut    1   1.8  Hindgut    2.5   2.8  Malpighian Tubules    3   3.3  Fat Body    7.2   3.8  Salivary Gland    no informative data   NA  Heart    0.425   2.175  Trachea    NA   NA  VirginFemale Spermatheca    2.7   NA  InseminatedFemale Spermatheca    4   NA  Ovary    4.2   NA  Testis    3.7   NA  Male Accessory Gland    7.9   1.075  Carcass    5.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed within 00-12 hour embryonic stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051718 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31718-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Ir31af06333 viable, with Scer\GAL4pnr-MD237 Ir31aGD14774 Sterility Allele fertile Ir31af06333 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ir31a Class Mutagen Stocks Known lesion Ir31af06333 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir31a Class Mutagen Stocks Known lesion Ir31aGD14774 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ir31aKK106002 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ir31aScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK106002} NA P{UAS-Ir31a.B} NA GAL4 construct P{Ir31a-GAL4.583} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Ir31af06333 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
detection of chemical stimulus involved in sensory perception inferred from expression pattern (Benton et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
extracellular-glutamate-gated ion channel activity inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-) glutamate receptor activity inferred from sequence or structural similarity with EMBL:AF318608 (FlyBase Genome Annotators, 2004) ionotropic glutamate receptor activity inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-) ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009) membrane inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir31a allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0051718
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X6CV2 Dipteran inclusive ortholog search EOG6M39HX Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search EOG669P93 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6X6CV2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir31a     Drosophila simulans   Dsim\GD23694 Y   Drosophila sechellia   Dsec\GM18317     Drosophila erecta   Dere\GG10125 Y   Drosophila ananassae   Dana\GF15781 Y   Drosophila mojavensis   Dmoj\GI18170 Y   Drosophila grimshawi   Dgri\GH13307 Y
Orthologs in non-Drosophila Dipterans (EOG6M39HX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013155   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013153   Anopheles gambiae Malaria mosquito  Agam\AGAP009014   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018714   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018715   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010930
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23694 Drosophila erecta Dere\GG10125 Drosophila ananassae Dana\GF15781 Drosophila mojavensis Dmoj\GI18170 Drosophila grimshawi Dgri\GH13307
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	18963 w1118; PBac{WH}Ir31af06333
Harvard	- PBac{WH}Ir31af06333
VDRC	v100345 P{KK106002}VIE-260B v39079 w1118; P{GD14774}v39079 v39080 w1118; P{GD14774}v39080
Genomic Clones ( 1 )
	BACR48K04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG3-chr2L.1313.pred.a DMG6-chr2L.19.016.pred.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051718 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318912
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir31a CG31718 (Benton et al., 2009)
Source for database merge of
Additional comments
Other Comments
	New annotation (CG31718) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164926 NM_001273417 RefSeq (Proteins) • NP_723585 NP_001260346 DDBJ / EMBL / GenBank • AAN10751 AGB92881 CZ489024 CZ489025 Entrez Gene - A searchable database of RefSeq genes. • 318912 UniProtKB/TrEMBL • Q8IPB8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0051718 DRSC - Results from RNAi screens. • FBgn0051718 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051718 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31718-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051718 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318912 modMine - Data generated by the modENCODE project. • FBgn0051718
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG31718 (Lee et al., 2009, Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5) DmelIR31a (Croset et al., 2010) IR31a (Silbering et al., 2011, Marshall et al., 2010, Benton et al., 2009, Benton et al., 2009, Croset et al., 2010) Ir31a
Name Synonym	CG31718   ionotropic receptor 31a (Benton et al., 2009) Ionotropic receptor 31a
Secondary FlyBase IDs
References ( 17 )
Research paper	Silbering et al., 2011, J. Neurosci. 31(38): 13357--13375 Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. [FBrf0215822] Croset et al., 2010, PLoS Genet. 6(8): e1001064 Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681] Marshall et al., 2010, Chem. Senses 35(7): 613--625 Detection of volatile indicators of illicit substances by the olfactory receptors of Drosophila melanogaster. [FBrf0211577] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496] Lee et al., 2009, Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 150(4): 546--557 Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. [FBrf0209026]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Croset et al., 2010, PLoS Genet. 6(8): Supporting Information: Table S3. [FBrf0219605] Benton et al., 2009, Cell 136(1): Supplemental Experimental Procedures. [FBrf0207607] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]
FlyBase analysis	FlyBase Genome Annotators, 2004, Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. [FBrf0166453] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]