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Gene Dmel\CG31759

General Information
Symbol	Dmel\CG31759	Species	D. melanogaster
Name		Annotation symbol	CG31759
Feature type	protein_coding_gene	FlyBase ID	FBgn0051759
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33D3-33D3	Sequence location	2L:12,207,627..12,210,110 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG31759 (FBgn0051759). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Endonuclease/exonuclease/phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1631299_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG31759. Gene sequence location is 2L:12207627..12210110.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN60513 BKN60556 BKN28598 HFA01230
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33D3-33D3   Limits computationally determined from genome sequence between P{PZ}Rab608323 and P{EP}ElfEP476&P{EP}bunEP488
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG31759 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG31759-RC FBtr0290239  NM_165000   2192   564 CG31759-RD FBtr0290240  NM_165001   2324   564
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG31759-PC   FBpp0288678   64.2   564   5.54     NP_723735   AAN10808 CG31759-PD   FBpp0288679   64.2   564   5.54     NP_723736   AAN10809
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Endonuclease/exonuclease/phosphatase (IPR005135)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246591   AE014134 AAN10808   AE014134 AAN10809   AQ026400   AW941589   AY069343 AAL39488   AY089324 AAL90062   BF499107   BI214376   BI230956   BI369244   BI481853   BI578502   BT044416   CO265118   CO278088   CO285706   CO309692   CO321250   CO328797   CO331149   EC066189   EC084042   EC197379   EC207378   EC216438   EC233302   EC236449   EC244431   GH948008   GH948907   GH955954   GH956222   GH978335
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IP91 Q8T0G0 Q8T471
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0051759    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0051759 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0051759 expression level Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (439) embryo 02-04hr  (449) embryo 04-06hr  (121) embryo 06-08hr    58 embryo 08-10hr  (134) embryo 10-12hr  (132) embryo 12-14hr  (239) embryo 14-16hr  (114) embryo 16-18hr  (151) embryo 18-20hr    56 embryo 20-22hr  (116) embryo 22-24hr  (179) larva L1  (143) larva L2  (254) larva L3 12hr old  (187) larva L3 puffstage 1-2    91 larva L3 puffstage 3-6  (159) larva L3 puffstage 7-9  (214) white prepupae new  (237) white prepupae 12hr  (151) white prepupae 24hr  (184) pupae 2d postWPP  (251) pupae 3d postWPP  (168) pupae 4d postWPP    76 adult male 01day  (182) adult male 05day  (190) adult male 30day  (138) adult female 01day  (164) adult female 05day  (489) adult female 30day  (418) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0051759 expression level Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (439) embryo 02-04hr  (449) embryo 04-06hr  121 embryo 06-08hr    58 embryo 08-10hr  134 embryo 10-12hr  132 embryo 12-14hr  (239) embryo 14-16hr  114 embryo 16-18hr  (151) embryo 18-20hr    56 embryo 20-22hr  116 embryo 22-24hr  (179) larva L1  143 larva L2  (254) larva L3 12hr old  (187) larva L3 puffstage 1-2    91 larva L3 puffstage 3-6  (159) larva L3 puffstage 7-9  (214) white prepupae new  (237) white prepupae 12hr  (151) white prepupae 24hr  (184) pupae 2d postWPP  (251) pupae 3d postWPP  (168) pupae 4d postWPP    76 adult male 01day  (182) adult male 05day  (190) adult male 30day  138 adult female 01day  (164) adult female 05day  (489) adult female 30day  (418) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    439 embryo 02-04hr    449 embryo 04-06hr    121 embryo 06-08hr    58 embryo 08-10hr    134 embryo 10-12hr    132 embryo 12-14hr    239 embryo 14-16hr    114 embryo 16-18hr    151 embryo 18-20hr    56 embryo 20-22hr    116 embryo 22-24hr    179 larva L1    143 larva L2    254 larva L3 12hr old    187 larva L3 puffstage 1-2    91 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    214 white prepupae new    237 white prepupae 12hr    151 white prepupae 24hr    184 pupae 2d postWPP    251 pupae 3d postWPP    168 pupae 4d postWPP    76 adult male 01day    182 adult male 05day    190 adult male 30day    138 adult female 01day    164 adult female 05day    489 adult female 30day    418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0051759    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0051759 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0051759 expression level Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0051759 expression level Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    41.25 Larval Midgut    8 Larval Hindgut no informative data Larval Malpighian Tubules    4.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    22.75 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    93.5 Adult InseminatedFemale Spermatheca    85.8 Adult Ovary    57.5 Adult Testis    57.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    no informative data   41.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   8  Midgut    no informative data   no informative data  Hindgut    no informative data   4.1  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   22.75  Trachea    NA   NA  VirginFemale Spermatheca    93.5   NA  InseminatedFemale Spermatheca    85.8   NA  Ovary    57.5   NA  Testis    57.2   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051759 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31759-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | recessive CG3175901284 viable, with Scer\GAL4pnr-MD237 CG31759GD10359 Sterility Allele male sterile | recessive CG3175901284 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG31759 Class Mutagen Stocks Known lesion CG3175901284 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG31759 Class Mutagen Stocks Known lesion CG31759GD10359 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG31759KK108598 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6032 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10359} NA P{KK108598} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}aretc00280 NA PBac{WH}aretf03220 NA insertion of enhancer trap P{PZ}aret01284 No
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG31759 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77412 DroID - A comprehensive database of gene and protein interactions. • FBgn0051759 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 326158
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA16453
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004708-PA Aedes aegypti (mosquito) AGAP009079-PA Anopheles gambiae (mosquito) XP_001121328.1 Apis mellifera (honey bee) XP_001942566.1 Acyrthosiphon pisum (pea aphid) 212438 Branchiostoma floridae (lancelet) BGIBMGA005936-PA Bombyx mori (silk worm) ENSBTAP00000020675 Bos taurus (bovine) CAL0006120 Candida albicans (a form of yeast) CBP36948 Caenorhabditis briggsae (nematode) CE16315 Caenorhabditis elegans (worm) ENSCAFP00000011525 Canis familiaris (dog) CAGL0B02387g Candida glabrata (haploid yeast) Chro.40217 Cryptosporidium hominis (obligate parasite) ENSCINP00000014187 Ciona intestinalis (sea squirt) cgd4_1920 Cryptosporidium parvum (protozoan parasite) CPIJ019439 Culex pipens (mosquito) ENSCPOP00000001461 Cavia porcellus (guinea pig) RP42669 Caenorhabditis remanei (nematode) 132833 Capitella spl (polychaete worm) DDB0237634 Dictyostelium discoideum (amoeba) 328284 Daphnia pulex (daphnia) ENSDARP00000067607 Danio rerio (zebra fish) ENSECAP00000003951 Equus caballus (horse) ENSGACP00000005141 Gymnopilus aculeatus (mushroom) ENSGALP00000009004 Gallus gallus (chicken) 75620 Hypsipyla robusta (cedar shoot borer) ENSP00000309142 Homo sapiens (human) ISCW020142-PA Ixodes scapularis (deer tick) 201951 Lottia gigantea (owl limpet) LmjF34.2220 Leishmania major (virus) ENSMODP00000000179 Monodelphis domestica (gray opossum) ENSMMUP00000005410 Macaca mulatta (rhesus monkey) ENSMUSP00000059666 Mus musculus (house mouse) 91194 Nematostella vectensis (starlet anemone) ENSOANP00000020380 Ornithorynchus anatinus (platypus) ENSORLP00000021812 Oryzias latipes (japanese killifish) 36828 Ostreococcus tauri (green alga) PFC0850c Plasmodium falciparum (protozoal parasite) PHUM004286-PA Pediculus humanus (human body louse) PP05690 Pristionchus pacificus (nematode) ENSPPYP00000015404 Pongo pygmaeus (orangutan) 80336 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000025996 Pan troglodytes (chimpanzee) PVX_095275 Plasmodium vivax (protozoal parasite) ENSRNOP00000043554 Rattus norvegicus (norway rat) YMR285C Saccharomyces cerevisiae (budding yeast) 20232 Trichoplax adhaerens (metazoa) TA12335 Theileria annulata (apicomplexan parasite) XP_972708.1 Tribolium castaneum (red flour beetle) Tc00.1047053506557.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506559.220 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020641 Tetraodon nigroviridis (green spotted pufferfish) TP02_0287 Theileria parva (parasitic protozoan) 11199 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012370 Takifugu rubripes (pufferfish Takifugu) 246.m00029 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000018928 Xenopus tropicalis (frog) YALI0C08657g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14656 LH10955 ISCW020142 JGI_V11_328284 JGI_V11_112677 CPIJ019439 BGIBMGA005936 ACYPI008982 GB12823 AGAP009079 AAEL004708 PHUM074520 GLEAN_14029
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	11755 P{PZ}aret01284 CG3175901284 cn1/CyO; ry506
VDRC	v106772 P{KK108598}VIE-260B v21421 w1118 P{GD10359}v21421 v47321 w1118; P{GD10359}v47321
Genomic Clones ( 1 )
	BACR19C12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13596 LD05405
Other clones	FI09011
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE16630 RE20157 RE55365 RE64460 RE72378
Other clones	17104 17173 31459 84087 152943 211042.1 CK01.77C.D8 CK01.130D.F4 EK060448 EK128717 EK141553 EK218920 EK290562 EK291429 EK298639 RP004083141 RP004088189 RP004192400 RP004203080 RP004260913
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0051759 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 326158
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG31759 BcDNA:AT13596 (FlyBase, 1996-) Source for merge of: CG31759 BcDNA:LD05405 (FlyBase, 1996-)
Additional comments	Source for merge of CG31759 BcDNA:LD05405 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of CG31759 BcDNA:AT13596 was shared cDNA (AT13596) (date:030602). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165000 NM_165001 RefSeq (Proteins) • NP_723735 NP_723736 DDBJ / EMBL / GenBank • AA246591 AAL39488 AAL90062 AAN10808 AAN10809 AQ026400 AW941589 AY069343 AY089324 BF499107 Entrez Gene - A searchable database of RefSeq genes. • 326158 UniProtKB/TrEMBL • Q8IP91 Q8T0G0 Q8T471
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Endonuclease/exonuclease/phosphatase (IPR005135)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77412 DroID - A comprehensive database of gene and protein interactions. • FBgn0051759 DRSC - Results from RNAi screens. • FBgn0051759 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0051759 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31759-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0051759 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 326158 InParanoid A subset of ortholog calls from InParanoid. • AAEL004708-PA Aedes aegypti (mosquito) AGAP009079-PA Anopheles gambiae (mosquito) XP_001121328.1 Apis mellifera (honey bee) XP_001942566.1 Acyrthosiphon pisum (pea aphid) 212438 Branchiostoma floridae (lancelet) BGIBMGA005936-PA Bombyx mori (silk worm) ENSBTAP00000020675 Bos taurus (bovine) CAL0006120 Candida albicans (a form of yeast) CBP36948 Caenorhabditis briggsae (nematode) CE16315 Caenorhabditis elegans (worm) ENSCAFP00000011525 Canis familiaris (dog) CAGL0B02387g Candida glabrata (haploid yeast) Chro.40217 Cryptosporidium hominis (obligate parasite) ENSCINP00000014187 Ciona intestinalis (sea squirt) cgd4_1920 Cryptosporidium parvum (protozoan parasite) CPIJ019439 Culex pipens (mosquito) ENSCPOP00000001461 Cavia porcellus (guinea pig) RP42669 Caenorhabditis remanei (nematode) 132833 Capitella spl (polychaete worm) DDB0237634 Dictyostelium discoideum (amoeba) 328284 Daphnia pulex (daphnia) ENSDARP00000067607 Danio rerio (zebra fish) ENSECAP00000003951 Equus caballus (horse) ENSGACP00000005141 Gymnopilus aculeatus (mushroom) ENSGALP00000009004 Gallus gallus (chicken) 75620 Hypsipyla robusta (cedar shoot borer) ENSP00000309142 Homo sapiens (human) ISCW020142-PA Ixodes scapularis (deer tick) 201951 Lottia gigantea (owl limpet) LmjF34.2220 Leishmania major (virus) ENSMODP00000000179 Monodelphis domestica (gray opossum) ENSMMUP00000005410 Macaca mulatta (rhesus monkey) ENSMUSP00000059666 Mus musculus (house mouse) 91194 Nematostella vectensis (starlet anemone) ENSOANP00000020380 Ornithorynchus anatinus (platypus) ENSORLP00000021812 Oryzias latipes (japanese killifish) 36828 Ostreococcus tauri (green alga) PFC0850c Plasmodium falciparum (protozoal parasite) PHUM004286-PA Pediculus humanus (human body louse) PP05690 Pristionchus pacificus (nematode) ENSPPYP00000015404 Pongo pygmaeus (orangutan) 80336 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000025996 Pan troglodytes (chimpanzee) PVX_095275 Plasmodium vivax (protozoal parasite) ENSRNOP00000043554 Rattus norvegicus (norway rat) YMR285C Saccharomyces cerevisiae (budding yeast) 20232 Trichoplax adhaerens (metazoa) TA12335 Theileria annulata (apicomplexan parasite) XP_972708.1 Tribolium castaneum (red flour beetle) Tc00.1047053506557.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506559.220 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020641 Tetraodon nigroviridis (green spotted pufferfish) TP02_0287 Theileria parva (parasitic protozoan) 11199 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012370 Takifugu rubripes (pufferfish Takifugu) 246.m00029 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000018928 Xenopus tropicalis (frog) YALI0C08657g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 326158 modMine - Data generated by the modENCODE project. • FBgn0051759 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14656 LH10955 ISCW020142 JGI_V11_328284 JGI_V11_112677 CPIJ019439 BGIBMGA005936 ACYPI008982 GB12823 AGAP009079 AAEL004708 PHUM074520 GLEAN_14029
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	3635 (Temme et al., 2010) BcDNA:AT13596   BcDNA:LD05405   CG31759 (Keleman et al., 2009.8.5, Temme et al., 2010) d3635 (Temme et al., 2010) ms(2)01284
Name Synonym
Secondary FlyBase IDs
	FBgn0047228 FBgn0063734
References ( 16 )
Research paper	Temme et al., 2010, RNA 16(7): 1356--1370 Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. [FBrf0211004] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]