FB2020_06, released Dec 22, 2020

Gene: Dmel\ZnT33D

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General Information
Symbol
Dmel\ZnT33D
Species
D. melanogaster
Name
Zinc transporter 33D
Annotation Symbol
CG31860
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051860
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

dZnT33D

Key Links
Genomic Location
Cytogenetic map
33D2-33D2
Sequence location
2L:12,164,241..12,166,704 [+]
Recombination map

2-46

RefSeq locus
NT_033779 REGION:12164241..12166704
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables zinc ion transmembrane transporter activity
inferred by curator from GO:0016323
(Lye et al., 2013)
inferred from sequence or structural similarity with UniProtKB:Q62941
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000169409
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in cellular zinc ion homeostasis
inferred from mutant phenotype
(Qin et al., 2013)
involved_in detoxification of zinc ion
inferred from mutant phenotype
(Lye et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in regulation of sequestering of zinc ion
inferred from biological aspect of ancestor with PANTHER:PTN000169310
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in response to zinc ion
inferred from biological aspect of ancestor with PANTHER:PTN000169310
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in zinc ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000169409
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in zinc ion transport
inferred from sequence or structural similarity with UniProtKB:Q62941
(FlyBase Curators, 2008--)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in basolateral plasma membrane
inferred from direct assay
(Lye et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR002524
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000169409
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC30 FAMILY OF ZINC TRANSPORTERS -
Solute carrier family 30 (SLC30) or Zinc Transporters (ZnT) proteins transport Zn2+ from the cytosol across the plasma membrane or organelle membranes allowing accumulation into intracellular compartments. (Adapted from FBrf0220942).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\ZnT33D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Alternative translation stop created by use of multiphasic reading frames within coding region.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ZnT33D-RB
FBtr0302984
NM_164998
2257
701
ZnT33D-RC
FBtr0302985
NM_001201864
2264
436
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ZnT33D-PB
FBpp0292109
78.1
701
7.23
NP_723732
AAF53175
ZnT33D-PC
FBpp0292110
48.7
436
7.43
NP_001188793
ADV37043
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ZnT33D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in basolateral plasma membrane
inferred from direct assay
(Lye et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ZnT33D in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ZnT33D
Transgenic constructs containing regulatory region of ZnT33D
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC30A2
10 of 15
Yes
No
1  
Hsap\SLC30A3
9 of 15
No
Yes
Hsap\SLC30A8
8 of 15
No
Yes
1  
Hsap\SLC30A4
3 of 15
No
No
1  
Hsap\SLC30A1
1 of 15
No
No
2  
Hsap\SLC30A5
1 of 15
No
No
1  
Hsap\SLC30A6
1 of 15
No
Yes
Hsap\SLC30A7
1 of 15
No
No
2  
Hsap\SLC30A10
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc30a2
9 of 15
Yes
No
Mmus\Slc30a3
9 of 15
Yes
Yes
Mmus\Slc30a8
8 of 15
No
Yes
Mmus\Slc30a4
2 of 15
No
No
Mmus\Slc30a1
1 of 15
No
No
Mmus\Slc30a5
1 of 15
No
No
Mmus\Slc30a6
1 of 15
No
Yes
Mmus\Slc30a7
1 of 15
No
No
Mmus\Slc30a10
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
Rnor\Slc30a3
10 of 13
Yes
Yes
Rnor\Slc30a8
8 of 13
No
Yes
Rnor\Slc30a2
7 of 13
No
No
Rnor\Slc30a4
3 of 13
No
No
Rnor\Slc30a1
1 of 13
No
No
Rnor\Slc30a5
1 of 13
No
No
Rnor\Slc30a6
1 of 13
No
Yes
Rnor\Slc30a7
1 of 13
No
No
Rnor\Slc30a10
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\slc30a2
9 of 12
Yes
No
Xtro\slc30a8
8 of 12
No
Yes
Xtro\slc30a3
6 of 12
No
Yes
Xtro\slc30a4
3 of 12
No
No
Xtro\slc30a1
1 of 12
No
No
Xtro\slc30a5
1 of 12
No
No
Xtro\slc30a6
1 of 12
No
Yes
Xtro\slc30a7
1 of 12
No
No
Xtro\slc30a10
1 of 12
No
No
Danio rerio (Zebrafish) (9)
Drer\slc30a2
8 of 15
Yes
No
Drer\slc30a8
6 of 15
No
No
Drer\slc30a4
3 of 15
No
No
Drer\LOC100002134
1 of 15
No
No
Drer\slc30a1a
1 of 15
No
No
Drer\slc30a1b
1 of 15
No
No
Drer\slc30a5
1 of 15
No
No
Drer\slc30a6
1 of 15
No
Yes
Drer\slc30a7
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\cdf-2
8 of 15
Yes
No
Cele\ttm-1
3 of 15
No
No
Cele\cdf-1
1 of 15
No
No
Cele\toc-1
1 of 15
No
Yes
Cele\Y105E8A.3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\MTPA1
7 of 9
Yes
Yes
Atha\MTPA2
6 of 9
No
No
Atha\MTPB1
6 of 9
No
No
Atha\ZAT
6 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\COT1
1 of 15
Yes
No
Scer\MMT1
1 of 15
Yes
No
Scer\MMT2
1 of 15
Yes
No
Scer\MSC2
1 of 15
Yes
No
Scer\ZRC1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905Z9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD28826
Drosophila erecta
Dere\GG26451
Drosophila yakuba
Dyak\GE28410
Drosophila ananassae
Dana\GF27654
Drosophila pseudoobscura pseudoobscura
Dpse\GA16530
Drosophila willistoni
Dwil\GK19068
Drosophila virilis
Dvir\GJ26732
Drosophila mojavensis
Dmoj\GI25803
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505CR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016141
Glossina morsitans
Tsetse fly
Gmor\GMOY005720
Glossina morsitans
Tsetse fly
Gmor\GMOY006123
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12640
Mayetiola destructor
Hessian fly
Mdes\Mdes009635
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001239
Anopheles darlingi
American malaria mosquito
Adar\ADAC003249
Anopheles gambiae
Malaria mosquito
Agam\AGAP009005
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002493
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0591 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005779
Danaus plexippus
Monarch butterfly
Dple\DPOGS206381-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009009
Apis florea
Little honeybee
Aflo\2161482308
Apis mellifera
Western honey bee
Amel\Ame.7852
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25710
Bombus terrestris
Buff-tailed bumblebee
Bter\15213909
Linepithema humile
Argentine ant
Lhum\LH15061
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0030fe
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002069
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02506
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05378
Tribolium castaneum
Red flour beetle
Tcas\TC009310
Pediculus humanus
Human body louse
Phum\PHUM090400
Pediculus humanus
Human body louse
Phum\PHUM503490
Rhodnius prolixus
Kissing bug
Rpro\RPRC005619
Cimex lectularius
Bed bug
Clec\CLEC002322
Cimex lectularius
Bed bug
Clec\CLEC001837
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008732
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068433
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085119
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03804
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11187
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06Q8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013468
Ixodes scapularis
Black-legged tick
Isca\ISCW013141
Ixodes scapularis
Black-legged tick
Isca\ISCW013980
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72121.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g08300
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_191209
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07UN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc30a3_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc30a3_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc30a3
Ciona intestinalis
Vase tunicate
Cint\LOC100178917
Gallus gallus
Domestic chicken
Ggal\SLC30A2
Gallus gallus
Domestic chicken
Ggal\SLC30A8
Gallus gallus
Domestic chicken
Ggal\LOC776399
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ZnT35C
6 of 10
ZnT41F
4 of 10
ZnT63C
2 of 10
ZnT77C
2 of 10
ZnT86D
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SLC30A8; solute carrier family 30 member 8
    model of  type 2 diabetes mellitus
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC30A2; solute carrier family 30 member 2
    10 of 15
    609617
       
      SLC30A3; solute carrier family 30 member 3
      9 of 15
      602878
          SLC30A8; solute carrier family 30 member 8
          8 of 15
          611145
           
          SLC30A4; solute carrier family 30 member 4
          3 of 15
          602095
               
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Interactions Browser
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Zip42C.1|ZnT63C
              suppressible
              ZnT33D
              (Lye et al., 2013)
              Zip71B
              suppressible
              ZnT33D
              (Dechen et al., 2015)
              Zip71B
              enhanceable
              ZnT33D
              (Dechen et al., 2015)
              ZnT86D
              enhanceable
              ZnT33D
              (Dechen et al., 2015)
              External Data
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (genetic) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2L
              Recombination map

              2-46

              Cytogenetic map
              33D2-33D2
              Sequence location
              2L:12,164,241..12,166,704 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              33D2-33D2
              Limits computationally determined from genome sequence between P{PZ}Rab608323 and P{EP}ElfEP476&P{EP}bunEP488
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              2-46

              (FlyBase, 2016)

              2-39.7

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (5)
              Genomic Clones (12)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (5)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: ZnT33D CG31860

                  (Lye et al., 2012)
                  Source for database merge of
                  Additional comments

                  Annotation CG17215 split into CG31860, CG31861 and CG31760 in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)
                  Other Comments
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 29 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (7)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (34)