Gene Dmel\Ada1-2

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General Information

Symbol

Dmel\Ada1-2

Species

D. melanogaster

Name

transcriptional Adaptor 1-2

Annotation symbol

CG31866

Feature type

protein_coding_gene

FlyBase ID

FBgn0051866

Gene Model Status

Current

Stock availability

None publicly available

Also Known As

Ada1

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

33B5-33B5

Sequence location

2L:11,992,902..11,994,054 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene transcriptional Adaptor 1-2 is referred to in FlyBase by the symbol Dmel\Ada1-2 (CG31866, FBgn0051866). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Transcriptional coactivator Hfi1/Transcriptional adapter 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Ada1-2. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Ada1-2. Gene sequence location is 2L:11992906..11994054.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33B5-33B5

Limits computationally determined from genome sequence between P{EP}MESK1^EP980 and P{PZ}l(2)01810⁰¹⁸¹⁰&P{EP}CG6785^EP340

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Ada1-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.51

Gene model reviewed during 5.43

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Ada1-2-RA

FBtr0080287

NM_164980

1089

308

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Ada1-2-PA

FBpp0079871

35.4

308

7.55

NP_723703

AAN10793

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Transcriptional coactivator Hfi1/Transcriptional adapter 1 (IPR024738)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q8IPA1

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		4
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		3
head, mated 4-day female		4
head, mated 20-day female		3
head, mated 1-day male		6
head, mated 4-day male		5
head, mated 20-day male		8
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		6
digestive system, 1-day adult		5
digestive system, 4-day adult		3
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		7
carcass, larvae L3 wandering		8
carcass, 1-day adult		3
carcass, 4-day adult		3
carcass, 20-day adult		4
ovary, virgin 4-day female		11
ovary, mated 4-day female		7
testis, mated 4-day male		8
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		7
embryo 02-04hr		12
embryo 04-06hr		7
embryo 06-08hr		5
embryo 08-10hr		6
embryo 10-12hr		6
embryo 12-14hr		3
embryo 14-16hr		3
embryo 16-18hr		2
embryo 18-20hr		2
embryo 20-22hr		5
embryo 22-24hr		2
larva L1		2
larva L2		1
larva L3 12hr old		2
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		2
larva L3 puffstage 7-9		2
white prepupae new		2
white prepupae 12hr		3
white prepupae 24hr		3
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		1
adult male 05day		3
adult male 30day		1
adult female 01day		2
adult female 05day		5
adult female 30day		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		(27)
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		21
embryonic 1182-4H		17
embryonic GM2		6
embryonic Kc167		11
embryonic S1		24
embryonic S3		7
leg disc CME L1		14
wing disc CME-W2		8
wing disc ML-DmD8		5
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		10
wing disc ML-DmD21		27
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		12
antennal disc ML-DmD20-c5		16
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		9
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		8
ovary fGS/OSS		21
ovary OSC		7
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		6
cold shock, 4-day adult		5
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		8
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		1
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		6
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0051866

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31866-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Ada1-2	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Ada1-2	Class	Mutagen	Stocks	Known lesion
Ada1-2^NIG.31866R		in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)Exel6031

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{NIG.31866R}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

There is no information supporting a biological process term for this gene.

(Based on a review of available data before: 2006)

Terms Based on Experimental Evidence ( 2 terms )

Molecular Function ( 0 terms)

Biological Process ( 0 terms)

Cellular Component

CV term

Evidence

References

nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Ada1-2 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

77273

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0051866

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

318992

Orthologs

OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6ZPFFG

Dipteran inclusive ortholog search

EOG6B2T63

Insect inclusive ortholog search

EOG6547VC

Arthropod inclusive ortholog search

EOG64QRGP

Metazoa inclusive ortholog search

EOG6S2620

Orthologs in Drosophila Species (EOG6ZPFFG)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Ada1-2

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16534

Drosophila persimilis

Dper\GL18540

Drosophila willistoni

Dwil\GK14963

Drosophila virilis

Dvir\GJ22528

Drosophila mojavensis

Dmoj\GI24825

Drosophila grimshawi

Dgri\GH13820

Orthologs in non-Drosophila Dipterans (EOG6B2T63)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012438

Anopheles gambiae

Malaria mosquito

Agam\AGAP004085

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002684

Orthologs in non-Dipteran Insects (EOG6547VC)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC412199

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001970

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH15956

Atta cephalotes

Leafcutter ant

Acep\ACEP14643

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO19598

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL20957

Linepithema humile

Argentine ant

Lhum\LH12245

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB14336

Solenopsis invicta

Red fire ant

Sinv\SINV19981

Bombyx mori

Silkmoth

Bmor\BGIBMGA001264

Pediculus humanus

Human body louse

Phum\PHUM042680

Tribolium castaneum

Red flour beetle

Tcas\TC000372

Orthologs in non-Insect Arthropods (EOG64QRGP)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_260990

Ixodes scapularis

Deer tick

Isca\ISCW010082

Orthologs in non-Arthropod Metazoa (EOG6S2620)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019519gn

Danio rerio

Zebrafish

Drer\CABZ01085888.1

Xenopus tropicalis

Western clawed frog

Xtro\tada1

Gallus gallus

Domestic chicken

Ggal\TADA1

Mus musculus

House mouse

Mmus\Tada1

Rattus norvegicus

Norway rat

Rnor\Tada1

Homo sapiens

Human

Hsap\TADA1

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\TADA1

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 1 )

BACR37P12

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 9 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

FI09215

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0051866

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318992

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Ada1-2 CG31866

(Guelman et al., 2006)

Source for database merge of

Additional comments

Other Comments

New annotation (CG31866) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_164980

RefSeq (Proteins)

•

NP_723703

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

318992

UniProtKB/TrEMBL

•

Q8IPA1

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Transcriptional coactivator Hfi1/Transcriptional adapter 1 (IPR024738)

Linkouts

BioGRID - A database of protein and genetic interactions

•

77273

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0051866

DRSC - Results from RNAi screens.

•

FBgn0051866

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0051866

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31866-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0051866

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318992

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

318992

modMine - Data generated by the modENCODE project.

•

FBgn0051866

Synonyms & Secondary IDs ( 5 )

Reported As

Symbol Synonym

Ada1

(Guelman et al., 2006, Weake et al., 2011, Weake et al., 2009, Spedale et al., 2012)

Ada1-2

(Rogers et al., 2010, Neumüller et al., 2011)

ada1-2

(Hong et al., 2012)

CG31866

(Guelman et al., 2006, Akdemir et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Conrad et al., 2012, Spedale et al., 2012)

Name Synonym

Ada1

(Guelman et al., 2006)

Ada1-2

CG31866

transcriptional Adaptor 1-2

Secondary FlyBase IDs

References ( 18 )

Research paper

Conrad et al., 2012, Dev. Cell 22(3): 610--624: The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex. [FBrf0217803]
Hong et al., 2012, G3 (Bethesda) 2(8): 873--882: Microarray-Based Capture of Novel Expressed Cell Type-Specific Transfrags (CoNECT) to Annotate Tissue-Specific Transcription in Drosophila melanogaster. [FBrf0219214]
Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593: Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Weake et al., 2011, Genes Dev. 25(14): 1499--1509: Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372]
Rogers et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(24): 10943--10948: Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. [FBrf0211052]
Weake et al., 2009, Genes Dev. 23(24): 2818--2823: A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression. [FBrf0209543]
Akdemir et al., 2007, Oncogene 26(36): 5184--5193: p53 directs focused genomic responses in Drosophila. [FBrf0202061]
Guelman et al., 2006, Mol. Cell. Biol. 26(19): 7178--7189: The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation. [FBrf0192338]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]

Review

Spedale et al., 2012, Genes Dev. 26(6): 527--541: ATAC-king the complexity of SAGA during evolution. [FBrf0219841]

Personal communication to FlyBase

Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
Huen, 2002.9.22, Genuine duplication or assembly error?: Genuine duplication or assembly error? [FBrf0155350]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase, 2009-, FlyBase-actioned changes to gene nomenclature.: FlyBase-actioned changes to gene nomenclature. [FBrf0209239]
FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase.: Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]