A2bp1
RNA-binding protein - homolog of an autism-susceptibility gene - targets pumilio mRNA for destabilization and translational silencing, thereby promoting germ cell development, oogenesis
Please see the JBrowse view of Dmel\Rbfox1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.19
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbfox1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: haltere pouch only; excluded from D/V boundary
Rbfox1 transcript is expressed in the wing pouch, where it is excluded from the dorsal/ventral compartment boundary, and in the posterior compartment of the presumptive capitellum (haltere pouch), where it is also excluded from the dorsal/ventral compartment boundary. Rbfox1 transcript is expressed in presumptive distal segments of the leg and antennal discs, and at the morphogenetic furrow of the eye disc.
Comment: germarium region 2b on
Expression of Rbfox1 protein as detected by immunolocalization has the same pattern as the protein trap expression. It is first observed in the cytoplasm of early germline cysts. In germarium region 3, expression shifts from the cytoplasmic to the nucleus of germline cells where it persists until the end of oogenesis. Expression is observed in follicle cells beginning in germarium region 2b. Comparison to other germ cell markers shows that Rbfox1 has a novel expression pattern. It is observed in 4-cell, 8-cell, and 16-cell cysts and bridges the gap between early and late germ cell differentiation markers.
Rbfox1 protein is expressed in all imaginal discs. In the wing disc, expression is observed in the wing pouch and in myoblast cells (adepithelial cells) of the presumptive notum. Rbfox1 protein is expressed in the central regions of the antennal and leg discs, and in cells posterior to the morphogenetic furrow in the eye disc. Rbfox1 is also expressed in the CNS, PNS, and pericardial cells starting at the extended germ band stages of embryogenesis through larval stages, and in larval trachea and muscle cells. Rbfox1 protein is primarily localized to the nucleus in all tissues examined.
Comment: haltere pouch only; excluded from D/V boundary
Comment: germarium region 2b on
JBrowse - Visual display of RNA-Seq signals
View Dmel\Rbfox1 in JBrowse3-33
3-26.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Source for merge of: CG14155 CG18441
Annotations CG14155 and CG18441 merged as CG32062 in release 3 of the genome annotation.
Source for identity of: A2bp1 CG32062
Source for identity of: Rbfox1 A2bp1
