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Gene Dmel\zormin

General Information
Symbol	Dmel\zormin	Species	D. melanogaster
Name	zormin	Annotation symbol	CG33484
Feature type	protein_coding_gene	FlyBase ID	FBgn0052311
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	CG5699, CG32311, CG32307
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62C4-62D1	Sequence location	3L:2,117,466..2,150,089 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene zormin is referred to in FlyBase by the symbol Dmel\zormin (CG33484, FBgn0052311). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton. The biological processes in which it is involved are not known. 18 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Spectrin repeat; Spectrin/alpha-actinin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, larval hindgut, adult heart, larval salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland, adult carcass. Gene sequence location is 3L:2117466..2150089.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 6 of adulthood day 5 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 35 of adulthood day 23 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood spermatozoon day 34 of adulthood day 44 of adulthood day 14 of adulthood male day 46 of adulthood Alleles zormin[MI03889] Insertions Mi{MIC}zormin[MI03889] References Bellen, 2011.10.10, MISet953.xml Perkins et al., 2010, Dev. Biol. 338(1): 15--27
FB2012_01	Sequence features HFA08571 HFA08212 HFA07969 BKN23439 HFA08297 BKN25824 HFA08210 BKN23726 HFA08213
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62C4-62D1   Limits computationally determined from genome sequence between P{PZ}slsrL182 and P{PZ}Spn06911
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\zormin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data DGC clone GH09541 appears problematic: incomplete CDS zormin gene may correspond to the 5' end of an alternative transcript of sls (TITIN); see FBrf0131354. Data inconclusive.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) zormin-RA FBtr0089864  NM_206240   9088   2946 zormin-RB FBtr0110856  NM_001043112   9520   3090 zormin-RC FBtr0110857  NM_001043113   8994   2947 zormin-RD FBtr0110858  NM_001043114   11203   3651
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein zormin-PA   FBpp0088803   333.5   2946   6.15     NP_995962   AAF47606 zormin-PB   FBpp0110153   349.7   3090   6.39     NP_001036577   ABI31228 zormin-PC   FBpp0110154   333.5   2947   6.07     NP_001036578   ABI31229 zormin-PD   FBpp0110155   411.4   3651   6.38     NP_001036579   ABI31230
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spectrin/alpha-actinin (IPR018159) Spectrin repeat (IPR002017) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699054   AE014296 AAF47606   AE014296 ABI31228   AE014296 ABI31229   AE014296 ABI31230   AI107850   AI110082   AI113468   AI257864   AI257971   AI258337   AI259698   AI260389   AI292795   AI387601   AJ544075 CAD66435   AW940335   AY094693 AAM11046   BF493013   BG632508   BG633012   BI229870   BI229969   BI235155   BT023905   CK131141   CK660225   CO265480   CO271935   CO292496   CO310586   CO316269   CO318859   CO319498   CO330594   CO331818   CO339958   CO343348   CZ483010   CZ483011   EC061329   EC075630   EC076081   EC089833   EC090566   EC204463   EC204970   EC220495   EC224115   EC255778   EC258471   EL883648   EL883738   EL883852   EL883959   ES690568
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7Z1Y4 Q8SXC1 Q9W053 Q0E8J5 Q0E8J4 Q0E8J3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0052311    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0052311 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0052311 expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr    3644 embryo 16-18hr    4713 embryo 18-20hr    4261 embryo 20-22hr    3894 embryo 22-24hr    4031 larva L1    2946 larva L2    1810 larva L3 12hr old    2299 larva L3 puffstage 1-2    1671 larva L3 puffstage 3-6    2793 larva L3 puffstage 7-9    3180 white prepupae new    2499 white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP    2589 pupae 3d postWPP    4062 pupae 4d postWPP    4921 adult male 01day    3185 adult male 05day    3103 adult male 30day    2608 adult female 01day    2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr  (127) embryo 10-12hr  (354) embryo 12-14hr  (1191) embryo 14-16hr  (3644) embryo 16-18hr  (4713) embryo 18-20hr  (4261) embryo 20-22hr  (3894) embryo 22-24hr  (4031) larva L1  (2946) larva L2  (1810) larva L3 12hr old  (2299) larva L3 puffstage 1-2  (1671) larva L3 puffstage 3-6  (2793) larva L3 puffstage 7-9  (3180) white prepupae new  (2499) white prepupae 12hr  (854) white prepupae 24hr  (1066) pupae 2d postWPP  (2589) pupae 3d postWPP  (4062) pupae 4d postWPP  (4921) adult male 01day  (3185) adult male 05day  (3103) adult male 30day  (2608) adult female 01day  (2062) adult female 05day  (583) adult female 30day  (586) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr  (3644) embryo 16-18hr  (4713) embryo 18-20hr  (4261) embryo 20-22hr  (3894) embryo 22-24hr  (4031) larva L1  (2946) larva L2  (1810) larva L3 12hr old  (2299) larva L3 puffstage 1-2  (1671) larva L3 puffstage 3-6  (2793) larva L3 puffstage 7-9  (3180) white prepupae new  (2499) white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP  (2589) pupae 3d postWPP  (4062) pupae 4d postWPP  (4921) adult male 01day  (3185) adult male 05day  (3103) adult male 30day  (2608) adult female 01day  (2062) adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr    3644 embryo 16-18hr    4713 embryo 18-20hr    4261 embryo 20-22hr    3894 embryo 22-24hr    4031 larva L1    2946 larva L2    1810 larva L3 12hr old    2299 larva L3 puffstage 1-2    1671 larva L3 puffstage 3-6    2793 larva L3 puffstage 7-9    3180 white prepupae new    2499 white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP    2589 pupae 3d postWPP    4062 pupae 4d postWPP    4921 adult male 01day    3185 adult male 05day    3103 adult male 30day    2608 adult female 01day    2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr    3644 embryo 16-18hr    4713 embryo 18-20hr    4261 embryo 20-22hr    3894 embryo 22-24hr    4031 larva L1    2946 larva L2    1810 larva L3 12hr old    2299 larva L3 puffstage 1-2    1671 larva L3 puffstage 3-6    2793 larva L3 puffstage 7-9    3180 white prepupae new    2499 white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP    2589 pupae 3d postWPP    4062 pupae 4d postWPP    4921 adult male 01day    3185 adult male 05day    3103 adult male 30day    2608 adult female 01day    2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0052311 expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr    3644 embryo 16-18hr    4713 embryo 18-20hr    4261 embryo 20-22hr    3894 embryo 22-24hr    4031 larva L1    2946 larva L2    1810 larva L3 12hr old    2299 larva L3 puffstage 1-2    1671 larva L3 puffstage 3-6    2793 larva L3 puffstage 7-9    3180 white prepupae new    2499 white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP    2589 pupae 3d postWPP    4062 pupae 4d postWPP    4921 adult male 01day    3185 adult male 05day    3103 adult male 30day    2608 adult female 01day    2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr  127 embryo 10-12hr  (354) embryo 12-14hr  (1191) embryo 14-16hr  (3644) embryo 16-18hr  (4713) embryo 18-20hr  (4261) embryo 20-22hr  (3894) embryo 22-24hr  (4031) larva L1  (2946) larva L2  (1810) larva L3 12hr old  (2299) larva L3 puffstage 1-2  (1671) larva L3 puffstage 3-6  (2793) larva L3 puffstage 7-9  (3180) white prepupae new  (2499) white prepupae 12hr  (854) white prepupae 24hr  (1066) pupae 2d postWPP  (2589) pupae 3d postWPP  (4062) pupae 4d postWPP  (4921) adult male 01day  (3185) adult male 05day  (3103) adult male 30day  (2608) adult female 01day  (2062) adult female 05day  (583) adult female 30day  (586) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr  (3644) embryo 16-18hr  (4713) embryo 18-20hr  (4261) embryo 20-22hr  (3894) embryo 22-24hr  (4031) larva L1  (2946) larva L2  1810 larva L3 12hr old  2299 larva L3 puffstage 1-2  1671 larva L3 puffstage 3-6  (2793) larva L3 puffstage 7-9  (3180) white prepupae new  (2499) white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP  (2589) pupae 3d postWPP  (4062) pupae 4d postWPP  (4921) adult male 01day  (3185) adult male 05day  (3103) adult male 30day  (2608) adult female 01day  2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr    3644 embryo 16-18hr    4713 embryo 18-20hr    4261 embryo 20-22hr    3894 embryo 22-24hr    4031 larva L1    2946 larva L2    1810 larva L3 12hr old    2299 larva L3 puffstage 1-2    1671 larva L3 puffstage 3-6    2793 larva L3 puffstage 7-9    3180 white prepupae new    2499 white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP    2589 pupae 3d postWPP    4062 pupae 4d postWPP    4921 adult male 01day    3185 adult male 05day    3103 adult male 30day    2608 adult female 01day    2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    15 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    127 embryo 10-12hr    354 embryo 12-14hr    1191 embryo 14-16hr    3644 embryo 16-18hr    4713 embryo 18-20hr    4261 embryo 20-22hr    3894 embryo 22-24hr    4031 larva L1    2946 larva L2    1810 larva L3 12hr old    2299 larva L3 puffstage 1-2    1671 larva L3 puffstage 3-6    2793 larva L3 puffstage 7-9    3180 white prepupae new    2499 white prepupae 12hr    854 white prepupae 24hr    1066 pupae 2d postWPP    2589 pupae 3d postWPP    4062 pupae 4d postWPP    4921 adult male 01day    3185 adult male 05day    3103 adult male 30day    2608 adult female 01day    2062 adult female 05day    583 adult female 30day    586 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0052311    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0052311 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, larval hindgut, adult heart, larval salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052311 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5699-RA;CG11953-RA;CG11952-RA;CG32309-RA;CG32310-RA;CG32307-RA;CG32311-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 zorminGD6739 zorminGD7440 zorminGD10850 zorminGD10852 zorminGD10855 zorminGD16297 Other Phenotypes Allele planar polarity defective, with Scer\GAL4pnr-MD237 zorminGD10852 visible, with Scer\GAL4pnr-MD237 zorminGD10852 zorminGD10855 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 zorminGD10855 mesothoracic tergum, with Scer\GAL4pnr-MD237 zorminGD10852 trichogen cell, with Scer\GAL4pnr-MD237 zorminGD10852
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of zormin Class Mutagen Stocks Known lesion zorminc02429 1 -- zorminf00549 piggyBac transposase 1 -- zorminf01991 1 -- zorminMB00505 1 -- zorminMB02779 1 -- zorminMI03889 1 -- zorminf06200 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of zormin Class Mutagen Stocks Known lesion zorminGD10852 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes zorminGD16297 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes zorminGD6739 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes zorminGD7440 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes zorminGD10850 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zorminGD10854 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zorminGD10855 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zorminHMS01014 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zorminKK103247 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zorminKK105824 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zorminGD10736 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6739} NA P{GD7440} NA P{GD10736} NA P{GD10850} NA P{GD10852} NA P{GD10854} NA P{GD10855} NA P{GD16297} NA P{KK103247} NA P{KK105824} NA P{TRiP.HMS01014} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}zorminMI03889 NA PBac{PB}zorminc02429 NA PBac{WH}zorminf00549 NA PBac{WH}zorminf01991 NA PBac{WH}zorminf06200 NA insertion of enhancer trap binary system Mi{ET1}zorminMB00505 No Mi{ET1}zorminMB02779 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
structural constituent of cytoskeleton inferred from sequence or structural similarity with EMBL:D83390 AND inferred from sequence or structural similarity with UniProtKB:Q10466 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions zormin allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77850 DroID - A comprehensive database of gene and protein interactions. • FBgn0052311 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2769001
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dmir\CG32311 (Thornton, 2005.12.20) Dpse\GA16821   Dpse\GA16824
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005317-PB Aedes aegypti (mosquito) AGAP007562-PA Anopheles gambiae (mosquito) XP_623653.2 Apis mellifera (honey bee) XP_001947869.1 Acyrthosiphon pisum (pea aphid) 79788 Branchiostoma floridae (lancelet) CN08532 Caenorhabditis brenneri (small nematode) CBP23877 Caenorhabditis briggsae (nematode) CE30078 Caenorhabditis elegans (worm) JA05390 Caenorhabditis japonica (nematode) ENSCPOP00000003572 Cavia porcellus (guinea pig) RP31995 Caenorhabditis remanei (nematode) 196991 Capitella spl (polychaete worm) 105670 Daphnia pulex (daphnia) ENSDARP00000093613 Danio rerio (zebra fish) ENSECAP00000005991 Equus caballus (horse) 191066 Hypsipyla robusta (cedar shoot borer) 167354 Lottia gigantea (owl limpet) XP_780570.2 Strongylocentrotus purpuratus (purple sea urchin) XP_971793.1 Tribolium castaneum (red flour beetle) ENSXETP00000032923 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15747 PB15743 NV23143 LH16004 LH15998 ISCW017766 ISCW017763 FBgn0238175 FBgn0214613 FBgn0200666 FBgn0189155 FBgn0169069 JGI_V11_53718 JGI_V11_105670 FBgn0076838 FBgn0162218 FBgn0134920 FBgn0123962 FBgn0106792 FBgn0101927 CPIJ006898 CPIJ006896 ACYPI009818 GB15230 AGAP007562 AAEL005323 AAEL005317 PHUM541100 PHUM541110 GLEAN_03989
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Harvard	- PBac{PB}zorminc02429 - PBac{WH}zorminf00549 - PBac{WH}zorminf01991
VDRC	v101304 P{KK105824}VIE-260B v104689 P{KK103247}VIE-260B v17563 w1118; P{GD6739}v17563 v17564 w1118; P{GD6739}v17564 v31601 w1118; P{GD7440}v31601 v34514 w1118 P{GD10852}v34514 v34513 w1118; P{GD10852}v34513 v34517 w1118; P{GD10855}v34517 v46682 w1118; P{GD16297}v46682
	More stocks available...
Genomic Clones ( 2 )
	BACR04A21 BACR11G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH09541 GH18167
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01382 GH15787 HL07373 LP01496 LP03171 LP04196 LP06352 LP06486 LP18595 RE27744 RE27874 RE30966
Other clones	125 32117 71980 79296 99354 174138 192668 214277.28 214503.25 274214 EK105230 EK142757 EK200321 EK222053 EK264306 EK274531 EK278370 EK295647 EK301753 EP09734 EP16626 GH05716 GH09780 IP13294 IP13394 IP13494 IP13594
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0052311 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38268 38269 38271 38272 317968 317970 317971
Antibody Information
	polyclonal (Fabian et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG5699 BcDNA:GH09541 (FlyBase, 1996-) Source for merge of: zormin CG32310 CG32307 (FlyBase Genome Annotators, 2006) Source for merge of: zormin CG32311 CG11953 CG5699 (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
Additional comments	Annotations CG33484, CG32310 and CG32307 merged as CG33484 (which corresponds to zormin) in release 5.1 of the genome annotation. (FlyBase Genome Annotators, 2006) Source for merge of CG5699 BcDNA:GH09541 was a shared cDNA (date:020730). (FlyBase Genome Annotators, 2004, FlyBase, 1996-) Annotations CG1282 and CG11850 merged as CG32311 in release 3.0 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of zormin CG32311 CG11953 CG5699 was sequence comparison (date:030610). (FlyBase, 1996-)
Other Comments
	New annotation (CG32309) in release 3 of the genome annotation. New annotation (CG32307) in release 3 of the genome annotation. New annotation (CG32310) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206240 NM_001043112 NM_001043113 NM_001043114 RefSeq (Proteins) • NP_995962 NP_001036577 NP_001036578 NP_001036579 DDBJ / EMBL / GenBank • AA699054 AAF47606 AAM11046 ABI31228 ABI31229 ABI31230 AI107850 AI110082 AI257864 AI257971 AI387601 AJ544075 AW940335 AY094693 BG633012 CAD66435 CZ483010 CZ483011 Entrez Gene - A searchable database of RefSeq genes. • 2769001 UniProtKB/TrEMBL • Q0E8J3 Q0E8J4 Q0E8J5 Q7Z1Y4 Q8SXC1 Q9W053
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spectrin/alpha-actinin (IPR018159) Spectrin repeat (IPR002017) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77850 DroID - A comprehensive database of gene and protein interactions. • FBgn0052311 DRSC - Results from RNAi screens. • FBgn0052311 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052311 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5699-RA;CG11953-RA;CG11952-RA;CG32309-RA;CG32310-RA;CG32307-RA;CG32311-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0052311 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38268 38269 38271 38272 317968 317970 317971 InParanoid A subset of ortholog calls from InParanoid. • AAEL005317-PB Aedes aegypti (mosquito) AGAP007562-PA Anopheles gambiae (mosquito) XP_623653.2 Apis mellifera (honey bee) XP_001947869.1 Acyrthosiphon pisum (pea aphid) 79788 Branchiostoma floridae (lancelet) CN08532 Caenorhabditis brenneri (small nematode) CBP23877 Caenorhabditis briggsae (nematode) CE30078 Caenorhabditis elegans (worm) JA05390 Caenorhabditis japonica (nematode) ENSCPOP00000003572 Cavia porcellus (guinea pig) RP31995 Caenorhabditis remanei (nematode) 196991 Capitella spl (polychaete worm) 105670 Daphnia pulex (daphnia) ENSDARP00000093613 Danio rerio (zebra fish) ENSECAP00000005991 Equus caballus (horse) 191066 Hypsipyla robusta (cedar shoot borer) 167354 Lottia gigantea (owl limpet) XP_780570.2 Strongylocentrotus purpuratus (purple sea urchin) XP_971793.1 Tribolium castaneum (red flour beetle) ENSXETP00000032923 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2769001 modMine - Data generated by the modENCODE project. • FBgn0052311 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15747 PB15743 NV23143 LH16004 LH15998 ISCW017766 ISCW017763 FBgn0238175 FBgn0214613 FBgn0200666 FBgn0189155 FBgn0169069 JGI_V11_53718 JGI_V11_105670 FBgn0076838 FBgn0162218 FBgn0134920 FBgn0123962 FBgn0106792 FBgn0101927 CPIJ006898 CPIJ006896 ACYPI009818 GB15230 AGAP007562 AAEL005323 AAEL005317 PHUM541100 PHUM541110 GLEAN_03989
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	BcDNA:GH09541   CG1282   CG5699 (Vogel et al., 2003, Giot et al., 2003, ) CG11850   CG11952   CG11953   CG32307 (Choksi et al., 2006, Fabian et al., 2007) CG32309   CG32310   CG32311 (Giot et al., 2003, Carrera et al., 2008) CG33484 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011) CT36990 (Hynes and Zhao, 2000) zormin (Hudson et al., 2008, Carrera et al., 2008, Baker et al., 2007, Wasbrough et al., 2010, Perkins et al., 2010)
Name Synonym	D-Titin (Machado and Andrew, 2000) D-titin (Fabian et al., 2007) titin (Fabian et al., 2007) zormin (Fabian et al., 2007, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBan0032307 FBan0032310 FBgn0035303 FBgn0035304 FBgn0035305 FBgn0035306 FBgn0035307 FBgn0052307 FBgn0052309 FBgn0052310 FBgn0053484 FBgn0062502
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 7 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Perkins et al., 2010, Dev. Biol. 338(1): 15--27 Integrin-mediated adhesion maintains sarcomeric integrity. [FBrf0215081] Show all research papers ...