FB2019_05, released Oct 15, 2019

Gene: Dmel\zormin

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General Information
Symbol
Dmel\zormin
Species
D. melanogaster
Name
zormin
Annotation Symbol
CG33484
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052311
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Snapshot
zormin (zormin) encodes a protein found in the Z-disc and the M-line of muscles. It probably has a structural function. [Date last reviewed: 2019-03-21]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
62C4-62D1
Sequence location
3L:2,117,466..2,151,700 [-]
Recombination map
3-1.5
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
actin binding; protein binding
Predictions / Assertions
-
Summaries
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\zormin or the JBrowse view of Dmel\zormin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.06
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
zormin-RE
FBtr0332114
NM_001274386
11132
3536
zormin-RF
FBtr0332115
NM_206240
9329
2935
zormin-RG
FBtr0332116
NM_001043112
9761
3079
zormin-RI
FBtr0332118
NM_001043114
11444
3640
zormin-RJ
FBtr0332119
NM_001274388
11516
3664
zormin-RK
FBtr0332120
NM_001043113
9316
2960
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
zormin-PE
FBpp0304424
398.6
3536
6.19
NP_001261315
AGB94010
zormin-PF
FBpp0304425
332.0
2935
6.06
NP_995962
AAF47606
zormin-PG
FBpp0304426
348.2
3079
6.32
NP_001036577
ABI31228
zormin-PI
FBpp0304428
410.0
3640
6.32
NP_001036579
ABI31230
zormin-PJ
FBpp0304429
412.8
3664
6.42
NP_001261317
AGB94012
zormin-PK
FBpp0304430
335.0
2960
6.12
NP_001036578
ABI31229
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zormin using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
actin binding
inferred from direct assay
(Burkart et al., 2007)
protein binding
inferred from physical interaction with FLYBASE:rols; FB:FBgn0041096
(Kreiskother et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
M band
inferred from direct assay
(Burkart et al., 2007, Bullard et al., 2005)
Z disc
inferred from direct assay
(Burkart et al., 2007)
inferred from physical interaction with FLYBASE:rols; FB:FBgn0041096
(Kreiskother et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
M band
inferred from direct assay
(Burkart et al., 2007, Bullard et al., 2005)
Z disc
inferred from direct assay
(Burkart et al., 2007)
inferred from physical interaction with FLYBASE:rols; FB:FBgn0041096
(Kreiskother et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\zormin in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of zormin
Transgenic constructs containing regulatory region of zormin
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CCDC141
3 of 15
Yes
Yes
Hsap\MYPN
2 of 15
No
Yes
Hsap\PALLD
2 of 15
No
Yes
Hsap\DMP1
1 of 15
No
Yes
Hsap\IBSP
1 of 15
No
Yes
Hsap\KALRN
1 of 15
No
No
Hsap\LEO1
1 of 15
No
No
Hsap\MCF2
1 of 15
No
No
Hsap\MCF2L2
1 of 15
No
No
Hsap\MYLK
1 of 15
No
No
Hsap\MYOT
1 of 15
No
Yes
Hsap\PLEKHG4B
1 of 15
No
No
Hsap\RP1
1 of 15
No
No
Hsap\SESTD1
1 of 15
No
No
Hsap\TRIO
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mypn
2 of 15
Yes
Yes
Mmus\Palld
2 of 15
Yes
Yes
Mmus\Ccdc141
1 of 15
No
Yes
Mmus\Dmp1
1 of 15
No
Yes
Mmus\Ibsp
1 of 15
No
Yes
Mmus\Kalrn
1 of 15
No
No
Mmus\Leo1
1 of 15
No
No
Mmus\Mcf2
1 of 15
No
No
Mmus\Mylk
1 of 15
No
No
Mmus\Myot
1 of 15
No
Yes
Mmus\Rp1
1 of 15
No
No
Mmus\Sestd1
1 of 15
No
No
Mmus\Trio
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\Ccdc141
3 of 13
Yes
Yes
Rnor\Mypn
2 of 13
No
Yes
Rnor\Dmp1
1 of 13
No
Yes
Rnor\Ibsp
1 of 13
No
Yes
Rnor\Kalrn
1 of 13
No
No
Rnor\Leo1
1 of 13
No
No
Rnor\LOC100912306
1 of 13
No
Yes
Rnor\LOC100912348
1 of 13
No
Yes
Rnor\Mcf2
1 of 13
No
No
Rnor\Myot
1 of 13
No
Yes
Rnor\Rp1
1 of 13
No
No
Rnor\Sestd1
1 of 13
No
No
Rnor\Trio
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\ccdc141
1 of 12
Yes
Yes
Xtro\leo1
1 of 12
Yes
No
Xtro\myot
1 of 12
Yes
Yes
Xtro\sestd1
1 of 12
Yes
No
Xtro\trio
1 of 12
Yes
No
Danio rerio (Zebrafish) (12)
Drer\ccdc141
1 of 15
Yes
Yes
Drer\leo1
1 of 15
Yes
No
Drer\mcf2lb
1 of 15
Yes
No
Drer\myot
1 of 15
Yes
Yes
Drer\palld
1 of 15
Yes
Yes
Drer\quo
1 of 15
Yes
No
Drer\rp1
1 of 15
Yes
No
Drer\sestd1
1 of 15
Yes
No
Drer\si:dkey-65j6.2
1 of 15
Yes
No
Drer\spegb
1 of 15
Yes
No
Drer\trioa
1 of 15
Yes
No
Drer\triob
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\F21C10.7
6 of 15
Yes
Yes
Cele\sax-3
1 of 15
No
No
Cele\T24E12.10
1 of 15
No
Yes
Cele\ttn-1
1 of 15
No
No
Cele\unc-73
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\YFR016C
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919002N )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\zormin
Drosophila simulans
Dsim\GD17605
Drosophila sechellia
Dsec\GM14141
Drosophila ananassae
Dana\GF24935
Drosophila pseudoobscura pseudoobscura
Dpse\GA16824
Drosophila persimilis
Dper\GL24630
Drosophila willistoni
Dwil\GK12604
Drosophila virilis
Dvir\GJ13442
Drosophila grimshawi
Dgri\GH16491
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915008X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007188
Glossina morsitans
Tsetse fly
Gmor\GMOY001198
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07214
Mayetiola destructor
Hessian fly
Mdes\Mdes000989
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005317
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005323
Anopheles darlingi
American malaria mosquito
Adar\ADAC009645
Anopheles gambiae
Malaria mosquito
Agam\AGAP007562
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006901
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006896
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W006U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombus terrestris
Buff-tailed bumblebee
Bter\15209843
Linepithema humile
Argentine ant
Lhum\LH15998
Linepithema humile
Argentine ant
Lhum\LH16004
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002fc3
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016096
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05867
Tribolium castaneum
Red flour beetle
Tcas\TC032674
Tribolium castaneum
Red flour beetle
Tcas\TC032675
Pediculus humanus
Human body louse
Phum\PHUM541100
Rhodnius prolixus
Kissing bug
Rpro\RPRC012286
Rhodnius prolixus
Kissing bug
Rpro\RPRC012285
Cimex lectularius
Bed bug
Clec\CLEC001197
Cimex lectularius
Bed bug
Clec\CLEC001196
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009818
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03215
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X006L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008879
Ixodes scapularis
Black-legged tick
Isca\ISCW017763
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62194.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_320916
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_105670
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01R1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ttn2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003089
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006993
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Unc-89
2 of 10
Asph
1 of 10
bt
1 of 10
CG1647
1 of 10
CG14964
1 of 10
CG17839
1 of 10
CG43340
1 of 10
Cp190
1 of 10
Dtg
1 of 10
Lmpt
1 of 10
robo3
1 of 10
Strn-Mlck
1 of 10
Su(var)2-HP2
1 of 10
trio
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CCDC141; coiled-coil domain containing 141
    3 of 15
    616031
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        zormin - rols
        two hybrid
        (Kreiskother et al., 2006)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Gene Group - Pathway Membership (FlyBase)
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-1.5
        Cytogenetic map
        62C4-62D1
        Sequence location
        3L:2,117,466..2,151,700 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        62C4-62D1
        Limits computationally determined from genome sequence between P{PZ}slsrL182 and P{PZ}Spn06911
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        3-1.5
        (FlyBase, 2016)
        3-4.0
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (18)
        Genomic Clones (30)
        cDNA Clones (41)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          polyclonal
          (Fabian et al., 2007)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: zormin CG32311 CG11953 CG5699
          (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
          Source for merge of: zormin CG32310 CG32307
          (FlyBase Genome Annotators, 2006)
          Source for merge of: CG5699 BcDNA:GH09541
          (FlyBase, 1996-)
          Additional comments
          Annotations CG33484, CG32310 and CG32307 merged as CG33484 (which corresponds to zormin) in release 5.1 of the genome annotation.
          (FlyBase Genome Annotators, 2006)
          Source for merge of CG5699 BcDNA:GH09541 was a shared cDNA ( date:020730 ).
          (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
          Annotations CG1282 and CG11850 merged as CG32311 in release 3.0 of the genome annotation.
          (FlyBase Genome Annotators, 2002-2003)
          Source for merge of zormin CG32311 CG11953 CG5699 was sequence comparison ( date:030610 ).
          (FlyBase, 1996-)
          Other Comments
          New annotation (CG32309) in release 3 of the genome annotation. New annotation (CG32307) in release 3 of the genome annotation. New annotation (CG32310) in release 3 of the genome annotation.
          (FlyBase Genome Annotators, 2002-2003)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 67 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (17)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (68)