FlyBase Gene Report: Dmel\Naa30B

General Information

Symbol

Dmel\Naa30B

Species

D. melanogaster

Name

N(alpha)-acetyltransferase 30 B

Annotation Symbol

CG32319

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052319

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

62A2-62A2

Sequence location

3L:1,470,850..1,472,060 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:1470850..1472060

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables peptide alpha-N-acetyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000558222

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in N-terminal peptidyl-methionine acetylation

inferred from biological aspect of ancestor with PANTHER:PTN000558222

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of NatC complex

inferred from biological aspect of ancestor with PANTHER:PTN000558222

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

N-TERMINAL ACETYLTRANSFERASE C COMPLEX

N-TERMINAL ACETYLTRANSFERASE CATALYTIC SUBUNITS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

N-TERMINAL ACETYLTRANSFERASE C COMPLEX -: The N-terminal acetyltransferase C (NatC) complex catalyzes the acetylation of the N-terminal methionine of polypeptides with Met-Leu-, Met-Phe-, Met-Ile- and Met-Trp- N termini. (Adapted from PMID:19660096, PMID:22405572 and FBrf0234437).
N-TERMINAL ACETYLTRANSFERASE CATALYTIC SUBUNITS -: N-terminal acetyltransferases catalyze the acetylation of the N-terminal amino acid residue of a polypeptide. (Adapted from FBrf0234437, PMID:19660096, PMID:22405572).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Naa30B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8IRH2)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.46

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Naa30B-RA

FBtr0072714

NM_167877

1211

211

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Naa30B-PA

FBpp0072598

24.2

211

4.75

NP_728606

AAN11478

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8IRH2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Naa30B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG32319_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Naa30B in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Naa30B

View exonic expression by tissue for Dmel\Naa30B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

317976/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052319

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052319

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052319

Flygut - An atlas of the Drosophila adult midgut

FBgn0052319

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Naa30B

Transgenic constructs containing regulatory region of Naa30B

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Naa30B^GD10857

viable, with Scer\GAL4^Mef2.PR

Naa30B^GD10857

viable, with Scer\GAL4^pnr-MD237

Naa30B^GD10857

viable, with Scer\GAL4^tin.CΔ4

Naa30B^GD10857

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

Naa30B^GD10857

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Naa30B^GD10857

trichogen cell, with Scer\GAL4^pnr-MD237

Naa30B^GD10857

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\NAA30

9 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\NAT8L

1 of 15

Yes

Hsap\SAT2

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Naa30

8 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Nat8f2

1 of 15

Yes

Mmus\Nat8f3

1 of 15

Yes

Mmus\Nat8f4

1 of 15

Yes

Mmus\Nat8f5

1 of 15

Yes

Mmus\Nat8f6

1 of 15

Yes

Mmus\Nat8f7

1 of 15

Yes

Mmus\Nat8l

1 of 15

Yes

Mmus\Nat8

1 of 15

Yes

Rattus norvegicus (Norway rat) (14)

Rnor\Naa30

8 of 13

Yes

Rnor\Kat14

1 of 13

Rnor\LOC100910829

1 of 13

Yes

Rnor\LOC102553099

1 of 13

Rnor\LOC102556148

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Nat8f1

1 of 13

Yes

Rnor\Nat8f3

1 of 13

Yes

Rnor\Nat8f5

1 of 13

Yes

Rnor\Nat8l

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (8)

Xtro\naa30

8 of 12

Yes

Xtro\cml

1 of 12

Yes

Xtro\kat14

1 of 12

Xtro\LOC100145252

1 of 12

Yes

Xtro\naa10

1 of 12

Xtro\naa50

1 of 12

Xtro\nat8b

1 of 12

Yes

Xtro\nat8l

1 of 12

Yes

Danio rerio (Zebrafish) (9)

Drer\naa30

8 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\nat15

1 of 15

Drer\si:ch211-81n22.1

1 of 15

Yes

Drer\si:ch211-195e19.1

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\natc-2

10 of 15

Yes

Cele\daf-31

1 of 15

Cele\F16B12.1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\ATMAK3

7 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\MAK3

13 of 15

Yes

Scer\ARD1

1 of 15

Scer\NAT3

1 of 15

Scer\NAT5

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\naa30

9 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

8 of 10

2 of 10

2 of 10

2 of 10

san

2 of 10

vnc

2 of 10

Atac2

1 of 10

Naa60

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NAA30; N-alpha-acetyltransferase 30, NatC catalytic subunit

9 of 15

617989

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052319

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

62A2-62A2

Sequence location

3L:1,470,850..1,472,060 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62A2-62A2

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-2.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

FlyORF

F001318

M{UAS-Naa30B.ORF}ZH-86Fb

F001133

M{UAS-Naa30B.ORF.3xHA}ZH-86Fb

VDRC

v24728

w¹¹¹⁸; P{GD10857}v24728

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT05318

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052319

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052319

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

317976

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Naa30B CG32319

(Rathore et al., 2016)

Source for database merge of

Additional comments

3' exon of release 2 annotation CG12083 split into a new gene (CG32319) in release 3 of the genome annotation, while the 5' portion of CG12083 corresponds to part of stet (CG33166). In addition, the release 3 annotation for stet (CG33166) contains sequences corresponding to release 2 annotation CG12504.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

Named "N(alpha)-acetyltransferase 30 B" after the human ortholog.

(Rathore et al., 2016)

Identification

External Crossreferences and Linkouts ( 26 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

317976

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BF504041

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAN11478

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8IRH2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8IRH2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.