FB2019_05, released Oct 15, 2019

Gene: Dmel\Atac3

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General Information
Symbol
Dmel\Atac3
Species
D. melanogaster
Name
Ada2a-containing complex component 3
Annotation Symbol
CG32343
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052343
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation. [Date last reviewed: 2019-06-27]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
61C1-61C1
Sequence location
3L:324,985..327,992 [-]
Recombination map
3-0.5
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
transcription regulatory region DNA binding
Summaries
Gene Group (FlyBase)
ATAC COMPLEX -
The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Atac3 or the JBrowse view of Dmel\Atac3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.40
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atac3-RB
FBtr0299831
NM_167828
2263
576
Atac3-RC
FBtr0299838
NM_001144394
2110
576
Atac3-RD
FBtr0309236
NM_001259602
2233
583
Atac3-RE
FBtr0332840
NM_001274275
2131
583
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Atac3-PB
FBpp0289109
63.2
576
8.11
NP_728520
AAF47376
Atac3-PC
FBpp0289116
63.2
576
8.11
NP_001137866
ACL83222
Atac3-PD
FBpp0301175
64.0
583
8.48
NP_001246531
AFH04202
Atac3-PE
FBpp0305063
64.0
583
8.48
NP_001261204
AGB93899
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

583 aa isoforms: Atac3-PD, Atac3-PE
576 aa isoforms: Atac3-PB, Atac3-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atac3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
transcription regulatory region DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002793882
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
chromatin remodeling
inferred from direct assay
(Suganuma et al., 2008)
histone acetylation
inferred from direct assay
(Suganuma et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002793882
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Ada2/Gcn5/Ada3 transcription activator complex
inferred from direct assay
(Suganuma et al., 2012)
inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738
(Suganuma et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002793882
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Ada2/Gcn5/Ada3 transcription activator complex
inferred from direct assay
(Suganuma et al., 2012)
inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738
(Suganuma et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atac3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atac3
Transgenic constructs containing regulatory region of Atac3
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GABPB2
9 of 15
Yes
Yes
Hsap\GABPB1
8 of 15
No
Yes
Hsap\ANKRD62
1 of 15
No
Yes
Hsap\DDX54
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gabpb1
9 of 15
Yes
Yes
Mmus\Gabpb2
9 of 15
Yes
Yes
Mmus\Ddx54
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Gabpb2
8 of 13
Yes
Yes
Rnor\Gabpb1
7 of 13
No
Yes
Rnor\Gabpb1l
2 of 13
No
Yes
Rnor\Ddx54
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\gabpb1
7 of 12
Yes
Yes
Xtro\gabpb2
5 of 12
No
Yes
Xtro\ddx54
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\gabpb2a
9 of 15
Yes
Yes
Drer\gabpb2b
8 of 15
No
Yes
Drer\gabpb1
5 of 15
No
Yes
Drer\ddx54
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y94H6A.5
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\DBP10
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906V8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Atac3
Drosophila simulans
Dsim\GD25713
Drosophila sechellia
Dsec\GM14283
Drosophila erecta
Dere\GG14668
Drosophila yakuba
Dyak\GE21029
Drosophila ananassae
Dana\GF25050
Drosophila pseudoobscura pseudoobscura
Dpse\GA16837
Drosophila persimilis
Dper\GL16099
Drosophila willistoni
Dwil\GK16549
Drosophila virilis
Dvir\GJ23454
Drosophila mojavensis
Dmoj\GI24149
Drosophila grimshawi
Dgri\GH15745
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506T8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017178
Glossina morsitans
Tsetse fly
Gmor\GMOY000593
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01460
Mayetiola destructor
Hessian fly
Mdes\Mdes000864
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013278
Anopheles darlingi
American malaria mosquito
Adar\ADAC000169
Anopheles gambiae
Malaria mosquito
Agam\AGAP006384
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004983
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06ZE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002373
Danaus plexippus
Monarch butterfly
Dple\DPOGS210234-PA
Apis florea
Little honeybee
Aflo\2152281828
Apis mellifera
Western honey bee
Amel\GABP-2
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17852
Bombus terrestris
Buff-tailed bumblebee
Bter\15206357
Linepithema humile
Argentine ant
Lhum\LH23323
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003023
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010947
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01750
Tribolium castaneum
Red flour beetle
Tcas\spz5
Pediculus humanus
Human body louse
Phum\PHUM522990
Rhodnius prolixus
Kissing bug
Rpro\RPRC015349
Cimex lectularius
Bed bug
Clec\CLEC004018
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003847
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05343
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15454
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06UQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004139
Ixodes scapularis
Black-legged tick
Isca\ISCW009836
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67700.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur36g00380
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AIS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mib_8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG32344
1 of 10
CG44001
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GABPB2; GA binding protein transcription factor subunit beta 2
    9 of 15
        GABPB1; GA binding protein transcription factor subunit beta 1
        8 of 15
        600610
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-0.5
            Cytogenetic map
            61C1-61C1
            Sequence location
            3L:324,985..327,992 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            61C1-61C1
            Limits computationally determined from genome sequence between P{PZ}trh10512 and P{EP}EP3104EP3104
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location
            3-0.5
            (FlyBase, 2016)
            3-0.1
            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (8)
            Genomic Clones (13)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (14)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              polyclonal
              (Suganuma et al., 2008)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for identity of: Atac3 CG32343
              (Suganuma et al., 2008)
              Source for database merge of
              Additional comments
              Annotation CG6994 split into CG32343 and CG32344 in release 3 of the genome annotation.
              (FlyBase Genome Annotators, 2002-2003)
              Other Comments
              dsRNA made from templates generated with primers directed against this gene in combination with dsRNA against gig results in suppression of the final average cell size, with it being closer to the control average cell size, rather than the average cell size resulting from knockdown of the candidate gene alone.
              (Guertin et al., 2006)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 43 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (8)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (38)