FB2020_06, released Dec 22, 2020

Gene: Dmel\Cda4

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General Information
Symbol
Dmel\Cda4
Species
D. melanogaster
Name
Chitin deacetylase-like 4
Annotation Symbol
CG32499
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052499
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:22,583,634..22,632,710 [-]
Recombination map

1-66

RefSeq locus
NC_004354 REGION:22583634..22632710
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables chitin binding
inferred from electronic annotation with InterPro:IPR002557, InterPro:IPR036508
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
NOT enables chitin deacetylase activity
inferred from key residues
(Dixit et al., 2008)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in carbohydrate metabolic process
inferred from electronic annotation with InterPro:IPR002509, InterPro:IPR011330
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in chitin metabolic process
inferred from electronic annotation with InterPro:IPR002557, InterPro:IPR036508
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in perivitelline space
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from electronic annotation with InterPro:IPR002557, InterPro:IPR036508
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CHITIN DEACETYLASE-LIKE FAMILY -
Chitin deacetylases are secreted enzymes that deacetylate chitin to chitosan. Several members of the chitin deacetylase-like family are thought to be catalytically inactive and may provide a structural role by binding cuticular chitin. (Adapted from FBrf0204376.)
CHITIN BINDING DOMAIN-CONTAINING PROTEINS -
Chitin binding domains are found in certain classes of chitin binding proteins and chitin-active enzymes. (Adapted from FBrf0108362.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cda4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cda4-RA
FBtr0077362
NM_167788
1934
486
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cda4-PA
FBpp0077054
55.4
486
4.74
NP_728468
AAF50937
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cda4 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in perivitelline space
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{681.P.FSVS-1}Cda4CPTI002501
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cda4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cda4
Transgenic constructs containing regulatory region of Cda4
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CHI3L1
1 of 15
Yes
No
Hsap\CHI3L2
1 of 15
Yes
No
Hsap\CHIA
1 of 15
Yes
No
1  
Hsap\CHIT1
1 of 15
Yes
No
Hsap\OVGP1
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Chia1
1 of 15
Yes
No
Mmus\Chil1
1 of 15
Yes
No
Mmus\Chil3
1 of 15
Yes
No
Mmus\Chil4
1 of 15
Yes
No
Mmus\Chil5
1 of 15
Yes
No
Mmus\Chil6
1 of 15
Yes
No
Mmus\Chit1
1 of 15
Yes
No
Mmus\Ovgp1
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (5)
Rnor\Chi3l1
1 of 13
Yes
No
Rnor\Chi3l3
1 of 13
Yes
No
Rnor\Chia
1 of 13
Yes
No
Rnor\Chit1
1 of 13
Yes
No
Rnor\RGD1309110
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\chia
1 of 12
Yes
No
Xtro\chit1
1 of 12
Yes
No
Xtro\LOC548945
1 of 12
Yes
No
Danio rerio (Zebrafish) (5)
Drer\chia.1
1 of 15
Yes
No
Drer\chia.2
1 of 15
Yes
No
Drer\chia.5
1 of 15
Yes
No
Drer\chia.6
1 of 15
Yes
No
Drer\ovgp1
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\F48E3.8
5 of 15
Yes
Yes
Cele\lgx-1
3 of 15
No
Yes
Cele\chil-1
1 of 15
No
No
Cele\chil-2
1 of 15
No
No
Cele\chil-3
1 of 15
No
No
Cele\chil-4
1 of 15
No
No
Cele\chil-5
1 of 15
No
No
Cele\chil-6
1 of 15
No
No
Cele\chil-7
1 of 15
No
No
Cele\chil-8
1 of 15
No
No
Cele\chil-9
1 of 15
No
No
Cele\chil-11
1 of 15
No
No
Cele\chil-12
1 of 15
No
No
Cele\chil-13
1 of 15
No
No
Cele\chil-15
1 of 15
No
No
Cele\chil-16
1 of 15
No
No
Cele\chil-17
1 of 15
No
No
Cele\chil-18
1 of 15
No
No
Cele\chil-19
1 of 15
No
No
Cele\chil-20
1 of 15
No
No
Cele\chil-21
1 of 15
No
No
Cele\chil-22
1 of 15
No
No
Cele\chil-23
1 of 15
No
No
Cele\chil-24
1 of 15
No
No
Cele\chil-25
1 of 15
No
No
Cele\lmd-4
1 of 15
No
No
Cele\lmd-5
1 of 15
No
No
Cele\R09D1.14
1 of 15
No
No
Cele\T01C4.8
1 of 15
No
No
Cele\T19H5.6
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906VB )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD15482
Drosophila sechellia
Dsec\GM11719
Drosophila erecta
Dere\GG17509
Drosophila yakuba
Dyak\GE15265
Drosophila ananassae
Dana\GF22163
Drosophila pseudoobscura pseudoobscura
Dpse\GA23092
Drosophila willistoni
Dwil\GK20034
Drosophila virilis
Dvir\GJ18931
Drosophila mojavensis
Dmoj\GI14970
Drosophila grimshawi
Dgri\GH12870
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503J1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017232
Glossina morsitans
Tsetse fly
Gmor\GMOY003039
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00958
Mayetiola destructor
Hessian fly
Mdes\Mdes012730
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005530
Anopheles darlingi
American malaria mosquito
Adar\ADAC004514
Anopheles gambiae
Malaria mosquito
Agam\AGAP000359
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006311
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04YF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010573
Danaus plexippus
Monarch butterfly
Dple\DPOGS214075-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005413
Apis florea
Little honeybee
Aflo\3948954692
Apis mellifera
Western honey bee
Amel\Cda4
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19984
Bombus terrestris
Buff-tailed bumblebee
Bter\15211840
Linepithema humile
Argentine ant
Lhum\LH24130
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00134b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006165
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04205
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00734
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07635
Pediculus humanus
Human body louse
Phum\PHUM351560
Rhodnius prolixus
Kissing bug
Rpro\RPRC003005
Cimex lectularius
Bed bug
Clec\CLEC011086
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002929
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01905
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0388 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002937
Ixodes scapularis
Black-legged tick
Isca\ISCW013984
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79433.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73579.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g06230
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300968
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01IQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1529
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023038gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prtelsn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009631
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (18)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cda5
3 of 10
Cda9
2 of 10
ChLD3
2 of 10
serp
2 of 10
verm
2 of 10
CG8460
1 of 10
Cht4
1 of 10
Cht7
1 of 10
Cht8
1 of 10
Cht9
1 of 10
Cht10
1 of 10
Cht12
1 of 10
Idgf1
1 of 10
Idgf2
1 of 10
Idgf3
1 of 10
Idgf4
1 of 10
Idgf5
1 of 10
Idgf6
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map

    1-66

    Cytogenetic map
    20C3-20D1
    Sequence location
    X:22,583,634..22,632,710 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    20C3-20D1
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-66

    (FlyBase, 2016)

    1-66.3

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (215)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Cda4 CG32499

      (Dixit et al., 2008)
      Source for database merge of

      Source for merge of: CG32499 BcDNA:RE51076

      (FlyBase, 1996-)

      Source for merge of: CG12447 CG13238 CG9557 CG9558

      (FlyBase Genome Annotators, 2002-2003)
      Additional comments

      Annotations CG12447, CG13238, CG9557 and CG9558 merged as CG32499 in release 3 of the genome annotation.

      (FlyBase Genome Annotators, 2002-2003)

      "CG13238" may correspond to "Scim7". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim7" near/in "CG13238".

      (Dobie and Karpen, 2001.4.18)

      Source for merge of CG32499 BcDNA:RE51076 was a shared cDNA ( date:030728 ).

      (FlyBase, 1996-)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 30 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (9)
      Reported As
      Symbol Synonym
      BcDNA:RE51076
      CG12447
      CG13238
      (Dobie and Karpen, 2001.4.18)
      CG32499
      (Hosono et al., 2015, Potier et al., 2014, Huang et al., 2013, Chung et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lebo et al., 2009, Perkins et al., 2009, Stahl et al., 2007)
      CG9557
      CG9558
      Cda4
      (Chandran et al., 2014)
      DmCDA4
      (Dixit et al., 2008)
      Name Synonyms
      CG32499
      Chitin deacetylase-like 4
      (Chandran et al., 2014)
      Secondary FlyBase IDs
      • FBgn0031198
      • FBgn0031199
      • FBgn0031200
      • FBgn0040520
      • FBgn0063002
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (42)