FlyBase Gene Report: Dmel\Hers

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hers using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.03

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

wing pouch | restricted

(Molnar et al., 2012)

wing hinge primordium | restricted

(Molnar et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Hers in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hers

View exonic expression by tissue for Dmel\Hers

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33000/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052529

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052529

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052529

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32529

Flygut - An atlas of the Drosophila adult midgut

FBgn0052529

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 39 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hers

Transgenic constructs containing regulatory region of Hers

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(1)amn^attP

(Rao and Deng, 2019.10.23)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Hers^EY12028

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Hers^EY12028

Other Phenotypes

Allele

suppressor of variegation, with In(1)w^m4h, Scer\GAL4^GMR.PU

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PU

Hers^UAS.Tag:FLAG

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\BAHD1

6 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PBRM1

1 of 14

Hsap\PHF13

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Bahd1

6 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (7)

Mmus\Bahd1

6 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (8)

Xtro\bahd1

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (13)

Drer\bahd1

6 of 14

Yes

Drer\LOC100331694

4 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\rerea

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\nurf-1

1 of 14

Yes

Cele\pbrm-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP004446

6 of 12

Yes

Agam\AgaP_AGAP003827

2 of 12

Agam\AgaP_AGAP004866

1 of 12

Arabidopsis thaliana (thale-cress) (12)

Atha\AT4G04260

5 of 13

Yes

Atha\EBS

4 of 13

Yes

Atha\SHL1

4 of 13

Yes

Atha\AT2G25120

2 of 13

Yes

Atha\AT3G43990

2 of 13

Yes

Atha\AT3G48060

2 of 13

Yes

Atha\AT4G11560

2 of 13

Yes

Atha\AT4G23120

2 of 13

Yes

Atha\SUO

2 of 13

Yes

Atha\AT1G63520

1 of 13

Yes

Atha\ORC1A

1 of 13

Atha\ORC1B

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\RSC1

1 of 13

Yes

Scer\RSC2

1 of 13

Yes

Scer\SPP1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\snt2

1 of 12

Yes

Spom\SPCC645.13

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hers. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

wge

2 of 13

E(bx)

1 of 13

rno

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BAHD1; bromo adjacent homology domain containing 1

6 of 14

613880

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hers - Cdk1

enzymatic study, autoradiography

(Ito et al., 2012)

Hers - Su(var)205

anti tag coimmunoprecipitation, western blot, cosedimentation, anti bait coimmunoprecipitation

(Shu et al., 2023, Ito et al., 2012)

Hers - Su(var)3-9

pull down, autoradiography, cosedimentation, western blot, anti bait coimmunoprecipitation

(Ito et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Ito et al., 2012)

enhanceable

(Ito et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59294

DroID - A comprehensive database of gene and protein interactions.

FBgn0052529

MIST (protein-protein) - An integrated Molecular Interaction Database

33000

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-64

Cytogenetic map

18F4-19A2

Sequence location

X:19,866,146..19,908,108 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18F4-19A2

Limits computationally determined from genome sequence between P{EP}EP1116&P{EP}EP1344^EP1344 and P{EP}amn^EP1649&P{EP}amn^EP1442

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-64

(FlyBase, 2016)

1-63.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (29)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

39328

w¹¹¹⁸; P{GMR65A01-GAL4}attP2

41351

w¹¹¹⁸; P{GMR64E03-GAL4}attP2

53603

w¹¹¹⁸; P{GMR64H06-lexA}attP40

68892

w¹¹¹⁸; P{R64E03-GAL4.DBD}attP2

71179

w¹¹¹⁸; P{R64H06-GAL4.DBD}attP2

Korea

13613

P{VT064508-GAL4}attP2

14964

P{VT064515-GAL4}attP2

14282

P{VT064508-lexA::GADfl}attP40

11936R-1

11936R-2

v109795

v40007

w¹¹¹⁸; P{GD9075}v40007

More stocks available...

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (37)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052529

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052529

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ito et al., 2012)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG11936 CG15619

(FlyBase, 1996-)

Additional comments

Annotations CG11936, CG15619 merged as CG32529 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG11936 CG15619 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Hers CG32529

(Ito et al., 2012)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG11936

CG15619

(Apidianakis et al., 2005)

CG32529

(Shu et al., 2023, Ito et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Carreira et al., 2011, Wasbrough et al., 2010, Campbell et al., 2009, Carreira et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Grieder et al., 2007, Laviolette et al., 2005)

GLAD

(Shu et al., 2023)

HERS

(Ito et al., 2012)

Hers

(Lee et al., 2023, Ding et al., 2022, Li and Gavis, 2022, Banho et al., 2021, Meyer-Nava et al., 2020, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2018-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, de Celis et al., 2013.9.11)

Name Synonyms

Histone gene-specific Epigenetic Repressor in late S phase

Secondary FlyBase IDs

FBgn0031075
FBgn0031076

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 87 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33000

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VWC0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VWC0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33000/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052529

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052529

FlyMine - An integrated database for Drosophila genomics

FBgn0052529

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32529

MARRVEL_MODEL - MARRVEL (model organism gene)

33000

Linkouts

BioGRID - A database of protein and genetic interactions.

59294

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052529

DroID - A comprehensive database of gene and protein interactions.

FBgn0052529

DRSC - Results frm RNAi screens

FBgn0052529

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052529

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052529

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32529

Flygut - An atlas of the Drosophila adult midgut

FBgn0052529

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032821

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

33000

References (51)

The following external sites may use different assemblies or annotations than FlyBase.

-1.03

Report Sections