Gene Dmel\Muc14A

FlyGene Wiki Help Close All Open All

General Information

Symbol

Dmel\Muc14A

Species

D. melanogaster

Name

Mucin 14A

Annotation symbol

CG32580

Feature type

protein_coding_gene

FlyBase ID

FBgn0052580

Gene Model Status

Current

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

14A6-14A6

Sequence location

X:15,903,161..15,955,708 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Mucin 14A is referred to in FlyBase by the symbol Dmel\Muc14A (CG32580, FBgn0052580). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: extracellular matrix structural constituent. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of Rab GTPase activity. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Armadillo-type fold; Rab-GTPase-TBC domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1628702_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Muc14A. Gene sequence location is X:15903161..15955708.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14A6-14A6

Limits computationally determined from genome sequence between P{EP}Gβ13F^EP1071 and P{EP}EP1458&P{EP}EP1522

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Muc14A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Muc14A-RA

FBtr0074205

NM_167482

48672

16223

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Muc14A-PA

FBpp0073985

1769.7

16223

3.91

NP_727928

AAN09382

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Rab-GTPase-TBC domain (IPR000195)

Armadillo-type fold (IPR016024)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q8IR22

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		968.3
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		(968.3)
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		968.3
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		968.3
Adult Carcass		1.8
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		968.3
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		(968.3)
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		968.3
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		2.45
Larval Midgut		12.5
Larval Hindgut		3.4
Larval Malpighian Tubules		1.4
Larval Fat Body		4.4
Larval Salivary Gland		2.3
Larval Trachea		1.65
Larval Carcass		2.825
Adult Head		4.3
Adult Eye		2.375
Adult Brain		2.2
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		3.3
Adult Midgut		31.8
Adult Hindgut		1.8
Adult Malpighian Tubules		3.6
Adult Fat Body		2.8
Adult Salivary Gland		5.2
Adult Heart		1.65
Adult VirginFemale Spermatheca		2.4
Adult InseminatedFemale Spermatheca		2.2
Adult Ovary		2.2
Adult Testis		15.3
Adult Male Accessory Gland		968.3
Adult Carcass		1.8
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	4.3
NA	Eye	2.375
NA	Brain	2.2
2.45	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	2.5
NA	Crop	3.3
12.5	Midgut	31.8
3.4	Hindgut	1.8
1.4	Malpighian Tubules	3.6
4.4	Fat Body	2.8
2.3	Salivary Gland	5.2
NA	Heart	1.65
1.65	Trachea	NA
NA	VirginFemale Spermatheca	2.4
NA	InseminatedFemale Spermatheca	2.2
NA	Ovary	2.2
NA	Testis	15.3
NA	Male Accessory Gland	968.3
2.825	Carcass	1.8

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		1
embryonic GM2		0
embryonic Kc167		0
embryonic S1		1
embryonic S3		1
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		1
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		1
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0052580

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG32580-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Muc14A^f00286

Sterility

Allele

fertile

Muc14A^f00286

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of Muc14A	Mutagen	Stocks	Known lesion
Muc14A^f00286	piggyBac transposase	2	--
Muc14A^f02698		1	--
Muc14A^MI01405		0	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Muc14A	Class	Mutagen	Stocks	Known lesion
Muc14A^KK105893		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{KK105893}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

Mi{MIC}Muc14A^MI01405

PBac{WH}Muc14A^f00286

PBac{WH}Muc14A^f02698

Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 5 terms )

Molecular Function

CV term

Evidence

References

extracellular matrix structural constituent

inferred from sequence model

(Syed et al., 2008)

Rab GTPase activator activity

inferred from electronic annotation with InterPro:IPR000195

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

regulation of Rab GTPase activity

inferred from electronic annotation with InterPro:IPR000195

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

extracellular matrix

inferred from sequence model

(Syed et al., 2008)

intracellular

inferred from electronic annotation with InterPro:IPR000195

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Muc14A allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0052580

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

318097

Orthologs

OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6DZ2G7

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

EOG6C86NR

Arthropod inclusive ortholog search

EOG6N8PP6

Metazoa inclusive ortholog search

EOG62K1JT

Orthologs in Drosophila Species (EOG6DZ2G7)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila yakuba

Drosophila yakuba

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (EOG6C86NR)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI49037

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI084203

Orthologs in non-Insect Arthropods (EOG6N8PP6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\25

Daphnia pulex

Water flea

Dpux\JGI_V11_343799

Daphnia pulex

Water flea

Dpux\JGI_V11_302596

Daphnia pulex

Water flea

Dpux\JGI_V11_279322

Daphnia pulex

Water flea

Dpux\JGI_V11_277192

Daphnia pulex

Water flea

Dpux\wsp

Daphnia pulex

Water flea

Dpux\JGI_V11_270289

Daphnia pulex

Water flea

Dpux\JGI_V11_267284

Daphnia pulex

Water flea

Dpux\Papolb

Daphnia pulex

Water flea

Dpux\JGI_V11_275708

Ixodes scapularis

Deer tick

Isca\ISCW011800

Ixodes scapularis

Deer tick

Isca\ISCW024615

Ixodes scapularis

Deer tick

Isca\ISCW005653

Ixodes scapularis

Deer tick

Isca\ISCW024041

Ixodes scapularis

Deer tick

Isca\ISCW000329

Ixodes scapularis

Deer tick

Isca\ISCW023275

Ixodes scapularis

Deer tick

Isca\ISCW015840

Ixodes scapularis

Deer tick

Isca\ISCW024780

Ixodes scapularis

Deer tick

Isca\ISCW015759

Ixodes scapularis

Deer tick

Isca\ISCW015838

Orthologs in non-Arthropod Metazoa (EOG62K1JT)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_021919gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003836gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_011929gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_018116gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007286gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027333gn

Danio rerio

Zebrafish

Drer\CABZ01085394.1

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (3) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Dsim\GD17263

Drosophila erecta

Dere\GG16589

Drosophila yakuba

Dyak\GE17247

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

18308

w¹¹¹⁸ PBac{WH}Muc14A^f00286

Harvard

PBac{WH}Muc14A^f00286

PBac{WH}Muc14A^f02698

VDRC

v105591

P{KK105893}VIE-260B

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 0 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0052580

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318097

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Muc14A CG32580

(Syed et al., 2008)

Source for database merge of

Additional comments

Other Comments

New annotation (CG32580) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_167482

RefSeq (Proteins)

•

NP_727928

DDBJ / EMBL / GenBank

•

AAN09382

Entrez Gene - A searchable database of RefSeq genes.

•

318097

UniProtKB/TrEMBL

•

Q8IR22

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Rab-GTPase-TBC domain (IPR000195)

Armadillo-type fold (IPR016024)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0052580

DRSC - Results from RNAi screens.

•

FBgn0052580

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0052580

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG32580-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0052580

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318097

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

318097

modMine - Data generated by the modENCODE project.

•

FBgn0052580

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

CG32580

(Syed et al., 2008, Keleman et al., 2009.8.5, Laflamme et al., 2012)

Muc14A

(Syed et al., 2008, Wasbrough et al., 2010)

Name Synonym

CG32580

Muc14A

Mucin 14A

(Syed et al., 2008, )

Secondary FlyBase IDs

References ( 12 )

Research paper

Laflamme et al., 2012, J. Cell Biol. 198(1): 57--67: Evi5 promotes collective cell migration through its Rab-GAP activity. [FBrf0218839]
Syed et al., 2008, PLoS ONE 3(8): e3041: A potential role for Drosophila mucins in development and physiology. [FBrf0205867]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Wasbrough et al., 2010, J. Proteomics 73(11):: Supplemental Table 1. Mass spectrometry data. [FBrf0213252]

Personal communication to FlyBase

Bellen, 2010.11.12, Set908.xml: Set908.xml [FBrf0212197]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase.: Exelixis insertion alleles that are not in FlyBase. [FBrf0179797]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]

FlyBase analysis

FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations.: Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]