FB2021_06, released December 14, 2021

Gene: Dmel\dpr8

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General Information
Symbol
Dmel\dpr8
Species
D. melanogaster
Name
defective proboscis extension response 8
Annotation Symbol
CG32600
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052600
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

CT16867

Key Links
Genomic Location
Cytogenetic map
12E8-12E10
Sequence location
Recombination map
1-48
RefSeq locus
NC_004354 REGION:14322226..14462351
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2013-02-08 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in synapse organization
inferred from expression pattern
(Carrillo et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in sensory perception of chemical stimulus
inferred from sequence or structural similarity with FLYBASE:dpr1; FB:FBgn0040726
(Nakamura et al., 2002)
involved_in synapse organization
inferred from biological aspect of ancestor with PANTHER:PTN000589413
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from sequence model
(Ozkan et al., 2013)
is_active_in neuron projection membrane
inferred from biological aspect of ancestor with PANTHER:PTN000589413
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DEFECTIVE PROBOSCIS EXTENSION RESPONSE -
Defective proboscis extension response (Dpr) cell surface proteins are members of the immunoglobulin superfamily. They form a complex interaction network with Dpr-interacting proteins (DIPs), acting as neuronal surface labels in the specificity of synaptic connections between neurons and target cells. (Adapted from FBrf0230454 and FBrf0149073).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\dpr8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dpr8-RA
FBtr0073913
NM_167408
4958
344
dpr8-RB
FBtr0343518
NM_001298310
4837
344
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
dpr8-PA
FBpp0073730
37.6
344
7.94
NP_727781
AAF48372
dpr8-PB
FBpp0310122
37.6
344
7.94
NP_001285239
AHN59709
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

344 aa isoforms: dpr8-PA, dpr8-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dpr8 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dpr8 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dpr8
Transgenic constructs containing regulatory region of dpr8
Aberrations (Deficiencies and Duplications) ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DSCAM
1 of 15
Yes
No
3  
Hsap\DSCAML1
1 of 15
Yes
No
2  
Hsap\IGLON5
1 of 15
Yes
No
Hsap\IGSF9B
1 of 15
Yes
No
Hsap\IGSF9
1 of 15
Yes
No
2  
Hsap\KIRREL1
1 of 15
Yes
No
Hsap\KIRREL2
1 of 15
Yes
No
Hsap\KIRREL3
1 of 15
Yes
No
Hsap\LRIT1
1 of 15
Yes
Yes
Hsap\LRIT3
1 of 15
Yes
Yes
Hsap\LSAMP
1 of 15
Yes
No
Hsap\NCAM1
1 of 15
Yes
No
4  
Hsap\NCAM2
1 of 15
Yes
No
Hsap\NEGR1
1 of 15
Yes
No
1  
Hsap\NTM
1 of 15
Yes
No
Hsap\OPCML
1 of 15
Yes
No
Hsap\PAPLN
1 of 15
Yes
No
Hsap\PTPRQ
1 of 15
Yes
No
Hsap\SDK1
1 of 15
Yes
No
Hsap\SDK2
1 of 15
Yes
No
1  
Hsap\USH2A
1 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dscaml1
1 of 15
Yes
No
Mmus\Dscam
1 of 15
Yes
No
1  
Mmus\Iglon5
1 of 15
Yes
No
Mmus\Igsf9b
1 of 15
Yes
No
Mmus\Igsf9
1 of 15
Yes
No
Mmus\Jaml
1 of 15
Yes
No
Mmus\Kirrel2
1 of 15
Yes
No
1  
Mmus\Kirrel3
1 of 15
Yes
No
1  
Mmus\Kirrel
1 of 15
Yes
No
1  
Mmus\Lrit1
1 of 15
Yes
Yes
Mmus\Lrit3
1 of 15
Yes
Yes
Mmus\Lsamp
1 of 15
Yes
No
Mmus\Ncam1
1 of 15
Yes
No
Mmus\Ncam2
1 of 15
Yes
No
Mmus\Negr1
1 of 15
Yes
No
Mmus\Ntm
1 of 15
Yes
No
Mmus\Opcml
1 of 15
Yes
No
Mmus\Papln
1 of 15
Yes
No
Mmus\Ptprq
1 of 15
Yes
No
Mmus\Sdk1
1 of 15
Yes
No
Mmus\Sdk2
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (18)
Rnor\Dscaml1
1 of 13
Yes
No
Rnor\Dscam
1 of 13
Yes
No
Rnor\Hmcn1
1 of 13
Yes
No
Rnor\Iglon5
1 of 13
Yes
No
Rnor\Igsf9b
1 of 13
Yes
No
Rnor\Igsf9
1 of 13
Yes
No
Rnor\Jaml
1 of 13
Yes
No
Rnor\Kirrel1
1 of 13
Yes
No
Rnor\Kirrel2
1 of 13
Yes
No
Rnor\Kirrel3
1 of 13
Yes
No
Rnor\Lrit1
1 of 13
Yes
No
Rnor\Lsamp
1 of 13
Yes
No
Rnor\Ncam1
1 of 13
Yes
No
Rnor\Ncam2
1 of 13
Yes
No
Rnor\Ntm
1 of 13
Yes
No
Rnor\Opcml
1 of 13
Yes
No
Rnor\Sdk2
1 of 13
Yes
No
Rnor\Tyro3
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (15)
Xtro\dscaml1
1 of 12
Yes
No
Xtro\dscam
1 of 12
Yes
No
Xtro\iglon5
1 of 12
Yes
No
Xtro\igsf9b
1 of 12
Yes
No
Xtro\igsf9
1 of 12
Yes
No
Xtro\kirrel2
1 of 12
Yes
No
Xtro\LOC101734728
1 of 12
Yes
Yes
Xtro\lrit3
1 of 12
Yes
Yes
Xtro\lsamp
1 of 12
Yes
No
Xtro\ncam2
1 of 12
Yes
No
Xtro\negr1
1 of 12
Yes
No
Xtro\nfasc
1 of 12
Yes
No
Xtro\ntm
1 of 12
Yes
No
Xtro\obsl1
1 of 12
Yes
Yes
Xtro\papln
1 of 12
Yes
No
Danio rerio (Zebrafish) (35)
Drer\dscama
1 of 15
Yes
No
Drer\dscamb
1 of 15
Yes
No
Drer\dscaml1
1 of 15
Yes
No
Drer\igsf9a
1 of 15
Yes
No
Drer\igsf9ba
1 of 15
Yes
No
Drer\igsf9bb
1 of 15
Yes
No
Drer\igsf9b
1 of 15
Yes
No
Drer\itgb4
1 of 15
Yes
No
Drer\kirrel1b
1 of 15
Yes
No
Drer\kirrel3a
1 of 15
Yes
No
Drer\kirrel3b
1 of 15
Yes
No
Drer\kirrel3l
1 of 15
Yes
No
Drer\LOC101885725
1 of 15
Yes
Yes
Drer\lrit1a
1 of 15
Yes
Yes
Drer\lrit1b
1 of 15
Yes
Yes
Drer\lrit3a
1 of 15
Yes
Yes
Drer\lrit3b
1 of 15
Yes
No
Drer\ncam1a
1 of 15
Yes
No
Drer\ncam1b
1 of 15
Yes
No
Drer\negr1
1 of 15
Yes
No
Drer\ntm
1 of 15
Yes
No
Drer\opcml
1 of 15
Yes
No
Drer\paplna
1 of 15
Yes
No
Drer\ptprq
1 of 15
Yes
No
Drer\robo4
1 of 15
Yes
No
Drer\sdk1a
1 of 15
Yes
No
Drer\sdk1b
1 of 15
Yes
No
Drer\sdk2a
1 of 15
Yes
No
Drer\sdk2b
1 of 15
Yes
No
Drer\si:ch211-163c2.2
1 of 15
Yes
Yes
Drer\si:ch211-264f5.6
1 of 15
Yes
Yes
Drer\si:ch1073-459j12.1
1 of 15
Yes
No
Drer\si:dkeyp-75h12.2
1 of 15
Yes
No
Drer\ush2a
1 of 15
Yes
Yes
Drer\zgc:110372
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\zig-8
7 of 15
Yes
No
Cele\C53A5.13
1 of 15
No
Yes
Cele\igcm-2
1 of 15
No
No
Cele\lad-2
1 of 15
No
No
Cele\let-805
1 of 15
No
Yes
Cele\rig-3
1 of 15
No
No
Cele\rig-4
1 of 15
No
No
Cele\rig-5
1 of 15
No
No
Cele\syg-1
1 of 15
No
No
Cele\wrk-1
1 of 15
No
No
Cele\zig-2
1 of 15
No
No
Cele\zig-3
1 of 15
No
No
Cele\zig-4
1 of 15
No
No
Cele\zig-10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190C21 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007495
Drosophila simulans
Dsim\GD17172
Drosophila sechellia
Dsec\GM17677
Drosophila erecta
Dere\GG17844
Drosophila yakuba
Dyak\GE17141
Drosophila ananassae
Dana\GF22561
Drosophila pseudoobscura pseudoobscura
Dpse\GA26606
Drosophila persimilis
Dper\GL20141
Drosophila willistoni
Dwil\GK10319
Drosophila virilis
Dvir\GJ26510
Drosophila mojavensis
Dmoj\GI25953
Drosophila grimshawi
Dgri\GH11932
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508DA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024058
Musca domestica
House fly
Mdoa\17022953
Musca domestica
House fly
Mdoa\17017654
Musca domestica
House fly
Mdoa\17017655
Musca domestica
House fly
Mdoa\17019631
Glossina morsitans
Tsetse fly
Gmor\GMOY000994
Glossina morsitans
Tsetse fly
Gmor\GMOY009261
Glossina morsitans
Tsetse fly
Gmor\GMOY001157
Glossina morsitans
Tsetse fly
Gmor\GMOY010356
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13013
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06512
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09216
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05118
Mayetiola destructor
Hessian fly
Mdes\Mdes006646
Mayetiola destructor
Hessian fly
Mdes\Mdes007382
Mayetiola destructor
Hessian fly
Mdes\Mdes006647
Mayetiola destructor
Hessian fly
Mdes\Mdes003640
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005661
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010865
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006261
Anopheles darlingi
American malaria mosquito
Adar\ADAC003056
Anopheles darlingi
American malaria mosquito
Adar\ADAC008821
Anopheles darlingi
American malaria mosquito
Adar\ADAC002233
Anopheles darlingi
American malaria mosquito
Adar\ADAC000913
Anopheles gambiae
Malaria mosquito
Agam\AGAP009242
Anopheles gambiae
Malaria mosquito
Agam\AGAP002135
Anopheles gambiae
Malaria mosquito
Agam\GPRGR58
Anopheles gambiae
Malaria mosquito
Agam\AGAP009245
Anopheles gambiae
Malaria mosquito
Agam\AGAP009248
Anopheles gambiae
Malaria mosquito
Agam\AGAP010542
Anopheles gambiae
Malaria mosquito
Agam\AGAP009247
Anopheles gambiae
Malaria mosquito
Agam\AGAP009250
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011140
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ020173
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007088
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011144
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0PR4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012382
Bombyx mori
Silkmoth
Bmor\BGIBMGA003965
Bombyx mori
Silkmoth
Bmor\BGIBMGA007216
Bombyx mori
Silkmoth
Bmor\BGIBMGA013888
Bombyx mori
Silkmoth
Bmor\BGIBMGA010535
Bombyx mori
Silkmoth
Bmor\BGIBMGA000193
Bombyx mori
Silkmoth
Bmor\BGIBMGA014206
Bombyx mori
Silkmoth
Bmor\BGIBMGA001545
Bombyx mori
Silkmoth
Bmor\BGIBMGA001286
Bombyx mori
Silkmoth
Bmor\BGIBMGA013755
Danaus plexippus
Monarch butterfly
Dple\DPOGS208163-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205598-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203110-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209896-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206247-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211358-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209302-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206250-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS214345-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202517-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206579-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215421-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210612-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202050-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017455
Heliconius melpomene
Postman butterfly
Hmel\HMEL005895
Heliconius melpomene
Postman butterfly
Hmel\HMEL004236
Heliconius melpomene
Postman butterfly
Hmel\HMEL015385
Heliconius melpomene
Postman butterfly
Hmel\HMEL011101
Heliconius melpomene
Postman butterfly
Hmel\HMEL003046
Heliconius melpomene
Postman butterfly
Hmel\HMEL018058
Heliconius melpomene
Postman butterfly
Hmel\HMEL005985
Heliconius melpomene
Postman butterfly
Hmel\HMEL004804
Heliconius melpomene
Postman butterfly
Hmel\HMEL017922
Heliconius melpomene
Postman butterfly
Hmel\HMEL013417
Heliconius melpomene
Postman butterfly
Hmel\HMEL015365
Apis florea
Little honeybee
Aflo\2417180518
Apis florea
Little honeybee
Aflo\3131127988
Apis florea
Little honeybee
Aflo\4250949204
Apis florea
Little honeybee
Aflo\3079719972
Apis florea
Little honeybee
Aflo\2702348164
Apis florea
Little honeybee
Aflo\2396217188
Apis florea
Little honeybee
Aflo\2163659954
Apis florea
Little honeybee
Aflo\3438323492
Apis florea
Little honeybee
Aflo\2459072772
Apis florea
Little honeybee
Aflo\4806685908
Apis florea
Little honeybee
Aflo\2147492609
Apis florea
Little honeybee
Aflo\4084224804
Apis florea
Little honeybee
Aflo\2359502756
Apis florea
Little honeybee
Aflo\2147489233
Apis florea
Little honeybee
Aflo\2147491617
Apis mellifera
Western honey bee
Amel\GB47707
Apis mellifera
Western honey bee
Amel\GB53574
Apis mellifera
Western honey bee
Amel\GB51181
Apis mellifera
Western honey bee
Amel\GB40061
Apis mellifera
Western honey bee
Amel\GB41414
Apis mellifera
Western honey bee
Amel\GB54299
Apis mellifera
Western honey bee
Amel\GB51183
Apis mellifera
Western honey bee
Amel\GB44739
Apis mellifera
Western honey bee
Amel\GB42260
Apis mellifera
Western honey bee
Amel\GB53294
Apis mellifera
Western honey bee
Amel\GB55000
Apis mellifera
Western honey bee
Amel\GB42584
Apis mellifera
Western honey bee
Amel\LOC724734
Apis mellifera
Western honey bee
Amel\GB40069
Apis mellifera
Western honey bee
Amel\GB42576
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21795
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22921
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15340
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22624
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17123
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21544
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15404
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17530
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15359
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20882
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12821
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14517
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20466
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21537
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23709
Bombus terrestris
Buff-tailed bumblebee
Bter\15211856
Bombus terrestris
Buff-tailed bumblebee
Bter\15205136
Bombus terrestris
Buff-tailed bumblebee
Bter\15205403
Bombus terrestris
Buff-tailed bumblebee
Bter\15203435
Bombus terrestris
Buff-tailed bumblebee
Bter\15206820
Bombus terrestris
Buff-tailed bumblebee
Bter\15206745
Bombus terrestris
Buff-tailed bumblebee
Bter\15206693
Bombus terrestris
Buff-tailed bumblebee
Bter\15208510
Bombus terrestris
Buff-tailed bumblebee
Bter\15214139
Bombus terrestris
Buff-tailed bumblebee
Bter\15208036
Bombus terrestris
Buff-tailed bumblebee
Bter\15205025
Bombus terrestris
Buff-tailed bumblebee
Bter\15211859
Bombus terrestris
Buff-tailed bumblebee
Bter\15207219
Bombus terrestris
Buff-tailed bumblebee
Bter\15206846
Linepithema humile
Argentine ant
Lhum\LH20666
Linepithema humile
Argentine ant
Lhum\LH24144
Linepithema humile
Argentine ant
Lhum\LH15450
Linepithema humile
Argentine ant
Lhum\LH21711
Linepithema humile
Argentine ant
Lhum\LH11455
Linepithema humile
Argentine ant
Lhum\LH15813
Linepithema humile
Argentine ant
Lhum\LH24235
Linepithema humile
Argentine ant
Lhum\LH13914
Linepithema humile
Argentine ant
Lhum\LH13903
Linepithema humile
Argentine ant
Lhum\LH17266
Linepithema humile
Argentine ant
Lhum\LH11448
Linepithema humile
Argentine ant
Lhum\LH19816
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0017e5
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0015e4
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000c21
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000441
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002375
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001379
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000cea
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001a70
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0017da
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002e27
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000451
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000450
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001328
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014312
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG026492
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008252
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016852
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012731
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008188
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG031947
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014303
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010416
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012803
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009357
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG026490
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00197
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08735
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10981
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09070
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11783
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02239
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11782
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08745
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03172
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05970
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11781
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10980
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08740
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09092
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02236
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05826
Tribolium castaneum
Red flour beetle
Tcas\TC014172
Tribolium castaneum
Red flour beetle
Tcas\TC032133
Tribolium castaneum
Red flour beetle
Tcas\TC010127
Tribolium castaneum
Red flour beetle
Tcas\TC013655
Tribolium castaneum
Red flour beetle
Tcas\TC010603
Tribolium castaneum
Red flour beetle
Tcas\TC033556
Tribolium castaneum
Red flour beetle
Tcas\TC008933
Tribolium castaneum
Red flour beetle
Tcas\TC009101
Tribolium castaneum
Red flour beetle
Tcas\TC004621
Tribolium castaneum
Red flour beetle
Tcas\TC033698
Tribolium castaneum
Red flour beetle
Tcas\TC010130
Tribolium castaneum
Red flour beetle
Tcas\TC034457
Tribolium castaneum
Red flour beetle
Tcas\TC030995
Pediculus humanus
Human body louse
Phum\PHUM383040
Pediculus humanus
Human body louse
Phum\PHUM065930
Pediculus humanus
Human body louse
Phum\PHUM595090
Pediculus humanus
Human body louse
Phum\PHUM413630
Pediculus humanus
Human body louse
Phum\PHUM371260
Pediculus humanus
Human body louse
Phum\PHUM307810
Pediculus humanus
Human body louse
Phum\PHUM382820
Pediculus humanus
Human body louse
Phum\PHUM048790
Pediculus humanus
Human body louse
Phum\PHUM417160
Pediculus humanus
Human body louse
Phum\PHUM383760
Pediculus humanus
Human body louse
Phum\PHUM170650
Pediculus humanus
Human body louse
Phum\PHUM121360
Pediculus humanus
Human body louse
Phum\PHUM385160
Pediculus humanus
Human body louse
Phum\PHUM046150
Rhodnius prolixus
Kissing bug
Rpro\RPRC003049
Rhodnius prolixus
Kissing bug
Rpro\RPRC003034
Rhodnius prolixus
Kissing bug
Rpro\RPRC011156
Rhodnius prolixus
Kissing bug
Rpro\RPRC001258
Rhodnius prolixus
Kissing bug
Rpro\RPRC007179
Rhodnius prolixus
Kissing bug
Rpro\RPRC001654
Rhodnius prolixus
Kissing bug
Rpro\RPRC002071
Rhodnius prolixus
Kissing bug
Rpro\RPRC002652
Rhodnius prolixus
Kissing bug
Rpro\RPRC005435
Cimex lectularius
Bed bug
Clec\CLEC000635
Cimex lectularius
Bed bug
Clec\CLEC008185
Cimex lectularius
Bed bug
Clec\CLEC012784
Cimex lectularius
Bed bug
Clec\CLEC013183
Cimex lectularius
Bed bug
Clec\CLEC008244
Cimex lectularius
Bed bug
Clec\CLEC002918
Cimex lectularius
Bed bug
Clec\CLEC000637
Cimex lectularius
Bed bug
Clec\CLEC007277
Cimex lectularius
Bed bug
Clec\CLEC006324
Cimex lectularius
Bed bug
Clec\CLEC012689
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI37669
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001500
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005117
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085714
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000744
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007143
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006858
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000101
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005884
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003058
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI064251
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18076
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09296
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17958
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17530
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00600
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15530
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17473
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01763
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18036
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18613
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18483
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FMW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009512
Strigamia maritima
European centipede
Smar\SMAR014426
Strigamia maritima
European centipede
Smar\SMAR012075
Strigamia maritima
European centipede
Smar\SMAR012076
Strigamia maritima
European centipede
Smar\SMAR005541
Strigamia maritima
European centipede
Smar\SMAR014109
Strigamia maritima
European centipede
Smar\SMAR013494
Ixodes scapularis
Black-legged tick
Isca\ISCW023418
Ixodes scapularis
Black-legged tick
Isca\ISCW021113
Ixodes scapularis
Black-legged tick
Isca\ISCW012168
Ixodes scapularis
Black-legged tick
Isca\ISCW014701
Ixodes scapularis
Black-legged tick
Isca\ISCW008568
Ixodes scapularis
Black-legged tick
Isca\ISCW019915
Ixodes scapularis
Black-legged tick
Isca\ISCW023662
Ixodes scapularis
Black-legged tick
Isca\ISCW013590
Ixodes scapularis
Black-legged tick
Isca\ISCW012169
Ixodes scapularis
Black-legged tick
Isca\ISCW012308
Ixodes scapularis
Black-legged tick
Isca\ISCW013453
Ixodes scapularis
Black-legged tick
Isca\ISCW016670
Ixodes scapularis
Black-legged tick
Isca\ISCW019922
Ixodes scapularis
Black-legged tick
Isca\ISCW019928
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63060.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72123.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81311.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60060.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78383.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g01460
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g03340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g01450
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g01490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g01110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00020
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_316516
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_14273
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_65065
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_70078
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_28601
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_4207
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_40950
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_56750
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_4664
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312160
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300025
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_54448
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_192128
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48341
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_57343
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0QR8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kirrel2L_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022824gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kirrel2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Igsf10L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kirrel2L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcrr1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020423
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024031
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (52)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
dpr1
4 of 10
dpr2
4 of 10
dpr3
4 of 10
dpr4
4 of 10
dpr5
4 of 10
dpr6
4 of 10
dpr7
4 of 10
dpr10
4 of 10
dpr11
4 of 10
dpr12
4 of 10
dpr13
4 of 10
dpr14
4 of 10
dpr15
4 of 10
dpr18
4 of 10
dpr19
4 of 10
dpr21
4 of 10
dpr9
3 of 10
dpr16
3 of 10
dpr17
3 of 10
dpr20
3 of 10
Ama
1 of 10
babos
1 of 10
bdl
1 of 10
CG7166
1 of 10
CG13506
1 of 10
CG33543
1 of 10
CG34353
1 of 10
DIP-α
1 of 10
DIP-β
1 of 10
DIP-δ
1 of 10
DIP-ε
1 of 10
DIP-η
1 of 10
DIP-γ
1 of 10
DIP-ι
1 of 10
DIP-κ
1 of 10
DIP-θ
1 of 10
DIP-ζ
1 of 10
Dscam1
1 of 10
Dscam2
1 of 10
Dscam3
1 of 10
Dscam4
1 of 10
Fas2
1 of 10
fipi
1 of 10
ImpL2
1 of 10
kirre
1 of 10
klg
1 of 10
Lac
1 of 10
rst
1 of 10
sdk
1 of 10
Strn-Mlck
1 of 10
tutl
1 of 10
wrapper
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    dpr8
    cosedimentation, molecular weight
    (Cosmanescu et al., 2018)
    dpr8 - DIP-β
    enzyme linked immunosorbent assay, surface plasmon resonance, predetermined participant
    (Cosmanescu et al., 2018, Carrillo et al., 2015, Ozkan et al., 2013)
    dpr8 - DIP-λ
    surface plasmon resonance, predetermined participant
    (Cosmanescu et al., 2018)
    dpr8 - cDIP
    enzyme linked immunosorbent assay
    (Carrillo et al., 2015, Ozkan et al., 2013)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-48
    Cytogenetic map
    12E8-12E10
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    12E8-12E10
    Limits computationally determined from genome sequence between P{EP}l(1)G0007EP764 and P{EP}EP1599
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-48

    (FlyBase, 2016)

    1-46.3

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (11)
    Genomic Clones (53)
    cDNA Clones (39)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: dpr8 CG32600

    (Nakamura et al., 2002)
    Source for database merge of

    Source for merge of: CG14415 CG5291

    (FlyBase, 1996-)

    Source for merge of: CG11477 CG14415

    (FlyBase Genome Annotators, 2002-2003)
    Additional comments

    Annotations CG11477 and CG14415 merged as CG32600 in release 3 of the genome annotation.

    (FlyBase Genome Annotators, 2002-2003)

    Source for merge of CG14415 CG5291 was a shared cDNA ( date:010720 ).

    (FlyBase, 1996-)
    Other Comments
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 68 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL - MARRVEL (model organism gene)
    modMine - A data warehouse for the modENCODE project
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (10)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (64)