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Gene Dmel\Drak

General Information
Symbol	Dmel\Drak	Species	D. melanogaster
Name	Death-associated protein kinase related	Annotation symbol	CG32666
Feature type	protein_coding_gene	FlyBase ID	FBgn0052666
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	CG1760
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10C1-10C5	Sequence location	X:11,387,168..11,449,078 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Death-associated protein kinase related is referred to in FlyBase by the symbol Dmel\Drak (CG32666, FBgn0052666). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: regulation of cell shape; morphogenesis of an epithelium; protein phosphorylation; cell adhesion; imaginal disc-derived wing morphogenesis; imaginal disc-derived leg morphogenesis. 17 alleles are reported. The phenotypes of these alleles are annotated with: metathoracic leg; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Myosin light chain kinase-related; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase Y2666, predicted; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult fat body. Comments on Affy2 ProbeSet: ProbeSet 1629741_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of CG32666. Gene sequence location is X:11387168..11449078.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10C1-10C5   Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Drak for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Drak-RC FBtr0301020  NM_001169252   4525   674 Drak-RD FBtr0301021  NM_001169253   4847   674 Drak-RE FBtr0340295     4274   674
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Drak-PC   FBpp0290242   73.0   674   6.29     NP_001162723   ACZ95258 Drak-PD   FBpp0290243   73.0   674   6.29     NP_001162724   ACZ95259 Drak-PE   FBpp0309256   73.0   674   6.29
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Myosin light chain kinase-related (IPR020675) Serine/threonine-protein kinase Y2666, predicted (IPR020677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 ACZ95258   AE014298 ACZ95259   AI064495   AI107985   AI296809   AI404003   AI404937   AJ783117   AJ783118   AJ783119   AJ783120   AJ783121   AJ783122   AJ783123   AJ783124   AJ783125   AJ783126   AJ783127   AJ783128   AJ783290   AQ025475   BH759378   BI170628   BI171462   BI212846   BI227948   BI363055   BI364014   BI364126   BI563657   BI588999   BI628418   BI634453   BP543581   BQ103183   BT003530 AAO39534   CO181305   CO264535   CO267039   CO271184   CO275146   CO286702   CO299899   CO305817   CO307060   CO316026   CO318605   CO322660   CO322685   CO332123   CZ475052   CZ480242   CZ480243   CZ480824   CZ490698   EC051038   EC051039   EC055253   EC055979   EC067779   EC069496   EC083845   EC084394   EC088915   EC196862   EC203957   EC208968   EC221004   EC223560   EC227197   EC229948   EC232837   EC266127   GH757061   GH772007   GH805173   GH809479   GH830132   GH830369   GH832997   GH847427   GH854795   GH863193   GH863811   GH885802   GH887378   GH897362   GH901677   GH911229   GH919331   GH921543   GH923415
UniProtKB/Swiss-Prot	Q0KHT7
UniProtKB/TrEMBL	E1JJH9 E2QD82
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.325 Larval Midgut    44.4 Larval Hindgut    44.1 Larval Malpighian Tubules    30.8 Larval Fat Body    33.5 Larval Salivary Gland    35.6 Larval Trachea    29.125 Larval Carcass    32.625 Adult Head    32.4 Adult Eye    52.95 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    45.1 Adult Crop    25.5 Adult Midgut    36.3 Adult Hindgut    41 Adult Malpighian Tubules    50.9 Adult Fat Body    121.8 Adult Salivary Gland    68.4 Adult Heart    42.05 Adult VirginFemale Spermatheca    69 Adult InseminatedFemale Spermatheca    50.9 Adult Ovary    69.5 Adult Testis    8.7 Adult Male Accessory Gland    31.9 Adult Carcass    40.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    32.4   NA  Eye    52.95   NA  Brain    64   68.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    45.1   NA  Crop    25.5   44.4  Midgut    36.3   44.1  Hindgut    41   30.8  Malpighian Tubules    50.9   33.5  Fat Body    121.8   35.6  Salivary Gland    no informative data   NA  Heart    42.05   29.125  Trachea    NA   NA  VirginFemale Spermatheca    69   NA  InseminatedFemale Spermatheca    50.9   NA  Ovary    69.5   NA  Testis    8.7   NA  Male Accessory Gland    31.9   32.625  Carcass    40.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8    42 head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    44 ovary, mated 4-day female    53 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8  (42) head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae  (52) digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae  (28) fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female  (44) ovary, mated 4-day female  (53) testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8    42 head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    44 ovary, mated 4-day female    53 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8    42 head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    44 ovary, mated 4-day female    53 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8    42 head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    44 ovary, mated 4-day female    53 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8  (42) head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae  (52) digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae  28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female  (44) ovary, mated 4-day female  (53) testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8    42 head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    44 ovary, mated 4-day female    53 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    21 central nervous system, pupae P8    42 head, virgin 1-day female    18 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    23 head, mated 4-day female    23 head, mated 20-day female    20 head, mated 1-day male    23 head, mated 4-day male    22 head, mated 20-day male    22 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    18 fat body, larvae L3 wandering    7 fat body, white prepupae    28 fat body, pupae P8    22 carcass, larvae L3 wandering    18 carcass, 1-day adult    17 carcass, 4-day adult    19 carcass, 20-day adult    18 ovary, virgin 4-day female    44 ovary, mated 4-day female    53 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    23 embryo 04-06hr    32 embryo 06-08hr    27 embryo 08-10hr    25 embryo 10-12hr    29 embryo 12-14hr    27 embryo 14-16hr    21 embryo 16-18hr    27 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day    30 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    23 embryo 04-06hr  (32) embryo 06-08hr  (27) embryo 08-10hr    25 embryo 10-12hr  (29) embryo 12-14hr  (27) embryo 14-16hr    21 embryo 16-18hr  (27) embryo 18-20hr  (30) embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day  (30) adult female 30day  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    23 embryo 04-06hr    32 embryo 06-08hr    27 embryo 08-10hr    25 embryo 10-12hr    29 embryo 12-14hr    27 embryo 14-16hr    21 embryo 16-18hr    27 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day    30 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    23 embryo 04-06hr    32 embryo 06-08hr    27 embryo 08-10hr    25 embryo 10-12hr    29 embryo 12-14hr    27 embryo 14-16hr    21 embryo 16-18hr    27 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day    30 adult female 30day    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    23 embryo 04-06hr    32 embryo 06-08hr    27 embryo 08-10hr    25 embryo 10-12hr    29 embryo 12-14hr    27 embryo 14-16hr    21 embryo 16-18hr    27 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day    30 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    23 embryo 04-06hr  32 embryo 06-08hr  27 embryo 08-10hr    25 embryo 10-12hr  29 embryo 12-14hr  27 embryo 14-16hr    21 embryo 16-18hr  27 embryo 18-20hr  30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day  30 adult female 30day  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    23 embryo 04-06hr    32 embryo 06-08hr    27 embryo 08-10hr    25 embryo 10-12hr    29 embryo 12-14hr    27 embryo 14-16hr    21 embryo 16-18hr    27 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day    30 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    23 embryo 04-06hr    32 embryo 06-08hr    27 embryo 08-10hr    25 embryo 10-12hr    29 embryo 12-14hr    27 embryo 14-16hr    21 embryo 16-18hr    27 embryo 18-20hr    30 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    15 larva L2    11 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    21 white prepupae 12hr    22 white prepupae 24hr    19 pupae 2d postWPP    25 pupae 3d postWPP    20 pupae 4d postWPP    17 adult male 01day    12 adult male 05day    10 adult male 30day    11 adult female 01day    22 adult female 05day    30 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    59 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS    40 ovary OSC    33 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8  (28) wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (48) wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1  (30) CNS ML-DmBG1-c1  (59) CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS  (40) ovary OSC  (33) ovary OSS  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    59 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS    40 ovary OSC    33 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    59 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS    40 ovary OSC    33 ovary OSS    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    59 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS    40 ovary OSC    33 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8  28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (48) wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1  30 CNS ML-DmBG1-c1  (59) CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS  (40) ovary OSC  (33) ovary OSS  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    59 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS    40 ovary OSC    33 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    10 embryonic S1    10 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    28 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    16 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    59 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    12 ovary fGS/OSS    40 ovary OSC    33 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (36) cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult  (29) Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (36) cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult  29 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    25 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE12147 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052666 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32666-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 DrakGD9422 viable Drakdel DrakKO viable (with Drakdel) DrakKO viable (with DrakKO) Drakdel Sterility Allele fertile Drakdel DrakKO Other Phenotypes Allele visible Drakdel DrakKO visible, with Scer\GAL4pnr-MD237 DrakGD9422 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 DrakGD9422 metathoracic leg Drakdel DrakKO wing Drakdel DrakKO
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Drak Class Mutagen Stocks Known lesion DrakKG03058 P-element activity 2 -- DrakBG00876 P-element activity 1 -- Drakd06322 P-element activity 1 -- Drake02427 piggyBac transposase 1 -- Drake03054 piggyBac transposase 1 -- DrakEP1452 P-element activity 1 -- Drakf08006 piggyBac transposase 1 -- DrakMB05079 1 -- DrakNP6127 1 -- Drakdel FLPase recombination 0 Yes Drakf06489 0 -- DrakKO recombination FLPase SCEI endonuclease ends-out gene targeting 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Drak Class Mutagen Stocks Known lesion DrakGD9422 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes DrakGL00087 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DrakJF03385 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DrakKK101989 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DrakGD6671 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL00087} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}CG2533BG01732 NA P{GT1}DrakBG00876 NA P{SUPor-P}DrakKG03058 NA PBac{RB}Drake02427 NA PBac{RB}Drake03054 NA PBac{WH}Drakf06489 NA PBac{WH}Drakf08006 NA insertion of mobile activating element P{EP}DrakEP1452 NA P{XP}Drakd06322 NA insertion of enhancer trap binary system Mi{ET1}DrakMB05079 No P{GawB}DrakNP6127 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2008-12-05)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from mutant phenotype (Kiger et al., 2003) imaginal disc-derived leg morphogenesis inferred from mutant phenotype (Neubueser and Hipfner, 2010) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Neubueser and Hipfner, 2010) morphogenesis of an epithelium inferred from genetic interaction with rok (Neubueser and Hipfner, 2010) protein phosphorylation inferred from mutant phenotype (Neubueser and Hipfner, 2010) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Drak allele Gene References CG32666EP1452 pnr (Pena-Rangel et al., 2002)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0052666 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32097 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KHT7
Orthologs
OrthoDB Orthologs (16) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG666W5J Dipteran inclusive ortholog search EOG6DFPX9 Insect inclusive ortholog search EOG6N8Q1J Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG666W5J)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Drak     Drosophila sechellia   Dsec\GM13087 Y   Drosophila erecta   Dere\GG18425 Y   Drosophila yakuba   Dyak\GE15943 Y   Drosophila ananassae   Dana\GF19157 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17051 Y   Drosophila persimilis   Dper\GL19896 Y   Drosophila willistoni   Dwil\GK16306 Y   Drosophila virilis   Dvir\GJ19156 Y   Drosophila mojavensis   Dmoj\GI14753 Y   Drosophila grimshawi   Dgri\GH12374 Y
Orthologs in non-Drosophila Dipterans (EOG6DFPX9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014114   Anopheles gambiae Malaria mosquito  Agam\AGAP000713   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006400
Orthologs in non-Dipteran Insects (EOG6N8Q1J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Bombyx mori Silkmoth  Bmor\BGIBMGA006640   Tribolium castaneum Red flour beetle  Tcas\TC011812
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM13087 Drosophila erecta Dere\GG18425 Drosophila yakuba Dyak\GE15943 Drosophila ananassae Dana\GF19157 Drosophila pseudoobscura pseudoobscura Dpse\GA17051 Drosophila persimilis Dper\GL19896 Drosophila willistoni Dwil\GK16306 Drosophila virilis Dvir\GJ19156 Drosophila mojavensis Dmoj\GI14753 Drosophila grimshawi Dgri\GH12374
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	11300 w1118 P{EP}DrakEP1452 12443 w1118 P{GT1}DrakBG00876 24605 w1118 Mi{ET1}DrakMB05079 29449 y1 v1; P{TRiP.JF03385}attP2
Harvard	- P{XP}Drakd06322 - PBac{RB}Drake02427 - PBac{RB}Drake03054 - PBac{WH}Drakf08006
VDRC	v107263 P{KK101989}VIE-260B v32960 w1118; P{GD9422}v32960 v32961 w1118; P{GD9422}v32961/TM3 v44374 w1118; P{GD9422}v44374/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR07P15 BACR26B05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE12147
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04941 GH05904 GH23573 GH24805 LP10891 RE13246 RE18091 RE25340 RE47770 RE49035 RE49177 RH30645 RH34332 RH38613 RH56808
Other clones	14454 28737 30350 34075 63046 147812 160192 172495 274962 569212 CK01.60C.F3 CK01.105D.E6 CK01.167B.A2 EC14015 EC051038 EC051039 EC055253 EC055979 EK063622 EK102225 EK116563 EK139514 EK148440 EK176857 EK188605 EK188640 EK249505 EK253421 EK263354 EK273204 EK302548 FGC021C04 RP003065886 RP003066929 RP003071391 RP003144538 RP003174842 RP003175944 RP003176780 RP003255888 RP003279854 RP003318713 RP003339379 RP003353619 RP003366975 RP003399116 RP003496089 RP003525485 RP003533363 RP003638152 RP003677356 UUGC0581
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0052666 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32097
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Drak CG32666 (Neubueser and Hipfner, 2010)
Source for database merge of	Source for merge of: CG11713 CG1760 (FlyBase Genome Annotators, 2002-2003) Source for merge of: CG32666 EP1452 (FlyBase, 1996-)
Additional comments	Annotations CG11713 and CG1760 merged as CG32666 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG32666 EP1452 was that EP1452 insertion is within CG32666 (and in the right orientation) (date:040519). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cells become round and detached. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001169252 NM_001169253 RefSeq (Proteins) • NP_001162723 NP_001162724 DDBJ / EMBL / GenBank • AAF48053 AAO39534 AAS65317 ACZ95258 ACZ95259 AJ783117 AJ783118 AJ783119 AJ783120 AJ783121 AJ783122 AJ783123 AJ783124 AJ783125 AJ783126 AJ783127 AJ783128 AJ783290 AQ025475 BH759378 BI170628 BT003530 CZ475052 CZ480242 CZ480243 CZ480824 CZ490698 Entrez Gene - A searchable database of RefSeq genes. • 32097 UniProtKB/Swiss-Prot • Q0KHT7 UniProtKB/TrEMBL • E1JJH9 E2QD82
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Myosin light chain kinase-related (IPR020675) Serine/threonine-protein kinase Y2666, predicted (IPR020677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE12147
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0052666 DRSC - Results from RNAi screens. • FBgn0052666 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052666 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32666-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0052666 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32097 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32097 modMine - Data generated by the modENCODE project. • FBgn0052666 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KHT7
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG1760 (Morrison et al., 2000, Champagne et al., 2000, ) CG11713   CG32666 (Luo et al., 2011, Keleman et al., 2009.8.5, Neubueser and Hipfner, 2010, Mensch et al., 2008, Perkins et al., 2009, Liebl and Featherstone, 2005, Ni et al., 2011.7.19, Takahashi et al., 2012) drak (Neubueser and Hipfner, 2010) Drak   EP1452   EP(X)1452 (Pena-Rangel et al., 2002)
Name Synonym	Death-associated protein kinase related
Secondary FlyBase IDs
	FBgn0030308 FBgn0040853 FBgn0062687
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 5 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 2 )
	Takahashi et al., 2012, Evolution 66(9): 2878--2890 Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of Drosophila melanogaster. [FBrf0219405] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Show all research papers ...