Gene Dmel\Atg8a

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General Information

Symbol

Dmel\Atg8a

Species

D. melanogaster

Name

Autophagy-specific gene 8a

Annotation symbol

CG32672

Feature type

protein_coding_gene

FlyBase ID

FBgn0052672

Gene Model Status

Current

Stock availability

6 publicly available

Also Known As

atg8, CG1534

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

9E6-9E7

Sequence location

X:10,658,911..10,662,368 [-]

Genomic Maps

Select View:

modENCODE GBrowse

Summary Information

Automatically generated summary

See sections below for more information

The gene Autophagy-specific gene 8a is referred to in FlyBase by the symbol Dmel\Atg8a (CG32672, FBgn0052672). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of protein ubiquitination; determination of adult lifespan. 18 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval salivary gland. It has one annotated transcript and one annotated polypeptide. Protein features are: Autophagy protein Atg8 ubiquitin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639467_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Atg8a. Gene sequence location is X:10658911..10662368.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2012_01

References

Williamson et al., 2010, J. Cell Biol. 189(5): 885--899

Sequence features

HFA18024

BKN22221

FB2011_10

References

Lee et al., 2011, Dev. Biol. 356(2): 588--597

Transgenic Constructs

P{UASp-mCherry-Atg8a}

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

9E6-9E7

Limits computationally determined from genome sequence between P{EP}EP1645 and P{EP}Atg8a^EP362&P{EP}CG1826^EP1098

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Atg8a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Atg8a-RA

FBtr0071498

NM_167245

1211

121

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Atg8a-PA

FBpp0071427

14.4

121

9.44

NP_727447

AAF46617

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Autophagy protein Atg8 ubiquitin-like (IPR004241)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9W2S2

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Untitled Document detailed view

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0052672

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	max expr for FBgn0052672
	Very low expression bin max
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No expression (0 - 0)
	Extremely low expression (1 - 10)
	Very low expression (11 - 100)
	Low expression (101 - 400)
	Moderate expression (401 - 1400)
	Moderately high expression (1401 - 4000)
	High expression (4001 - 10000)
	Very high expression (10001 - 100000)
	Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0052672 expression level
Developmental Stage		Expression Level
embryo 00-02hr		5834
embryo 02-04hr		11486
embryo 04-06hr		20634
embryo 06-08hr		15004
embryo 08-10hr		16369
embryo 10-12hr		13955
embryo 12-14hr		16413
embryo 14-16hr		13706
embryo 16-18hr		13938
embryo 18-20hr		11443
embryo 20-22hr		12200
embryo 22-24hr		17191
larva L1		5969
larva L2		3786
larva L3 12hr old		5832
larva L3 puffstage 1-2		15471
larva L3 puffstage 3-6		23310
larva L3 puffstage 7-9		33100
white prepupae new		37724
white prepupae 12hr		25487
white prepupae 24hr		17841
pupae 2d postWPP		13421
pupae 3d postWPP		8714
pupae 4d postWPP		14176
adult male 01day		19058
adult male 05day		16239
adult male 30day		12488
adult female 01day		13553
adult female 05day		10133
adult female 30day		8645
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

Linear, scaled to Very low expression
Developmental Stage		Expression Level
embryo 00-02hr		(5834)
embryo 02-04hr		(11486)
embryo 04-06hr		(20634)
embryo 06-08hr		(15004)
embryo 08-10hr		(16369)
embryo 10-12hr		(13955)
embryo 12-14hr		(16413)
embryo 14-16hr		(13706)
embryo 16-18hr		(13938)
embryo 18-20hr		(11443)
embryo 20-22hr		(12200)
embryo 22-24hr		(17191)
larva L1		(5969)
larva L2		(3786)
larva L3 12hr old		(5832)
larva L3 puffstage 1-2		(15471)
larva L3 puffstage 3-6		(23310)
larva L3 puffstage 7-9		(33100)
white prepupae new		(37724)
white prepupae 12hr		(25487)
white prepupae 24hr		(17841)
pupae 2d postWPP		(13421)
pupae 3d postWPP		(8714)
pupae 4d postWPP		(14176)
adult male 01day		(19058)
adult male 05day		(16239)
adult male 30day		(12488)
adult female 01day		(13553)
adult female 05day		(10133)
adult female 30day		(8645)
Expression Level Scale		None Extremely low Very low Low

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(5834)
embryo 02-04hr		(11486)
embryo 04-06hr		(20634)
embryo 06-08hr		(15004)
embryo 08-10hr		(16369)
embryo 10-12hr		(13955)
embryo 12-14hr		(16413)
embryo 14-16hr		(13706)
embryo 16-18hr		(13938)
embryo 18-20hr		(11443)
embryo 20-22hr		(12200)
embryo 22-24hr		(17191)
larva L1		(5969)
larva L2		(3786)
larva L3 12hr old		(5832)
larva L3 puffstage 1-2		(15471)
larva L3 puffstage 3-6		(23310)
larva L3 puffstage 7-9		(33100)
white prepupae new		(37724)
white prepupae 12hr		(25487)
white prepupae 24hr		(17841)
pupae 2d postWPP		(13421)
pupae 3d postWPP		(8714)
pupae 4d postWPP		(14176)
adult male 01day		(19058)
adult male 05day		(16239)
adult male 30day		(12488)
adult female 01day		(13553)
adult female 05day		(10133)
adult female 30day		(8645)
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		5834
embryo 02-04hr		(11486)
embryo 04-06hr		(20634)
embryo 06-08hr		(15004)
embryo 08-10hr		(16369)
embryo 10-12hr		(13955)
embryo 12-14hr		(16413)
embryo 14-16hr		(13706)
embryo 16-18hr		(13938)
embryo 18-20hr		(11443)
embryo 20-22hr		(12200)
embryo 22-24hr		(17191)
larva L1		5969
larva L2		3786
larva L3 12hr old		5832
larva L3 puffstage 1-2		(15471)
larva L3 puffstage 3-6		(23310)
larva L3 puffstage 7-9		(33100)
white prepupae new		(37724)
white prepupae 12hr		(25487)
white prepupae 24hr		(17841)
pupae 2d postWPP		(13421)
pupae 3d postWPP		8714
pupae 4d postWPP		(14176)
adult male 01day		(19058)
adult male 05day		(16239)
adult male 30day		(12488)
adult female 01day		(13553)
adult female 05day		10133
adult female 30day		8645
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		5834
embryo 02-04hr		11486
embryo 04-06hr		20634
embryo 06-08hr		15004
embryo 08-10hr		16369
embryo 10-12hr		13955
embryo 12-14hr		16413
embryo 14-16hr		13706
embryo 16-18hr		13938
embryo 18-20hr		11443
embryo 20-22hr		12200
embryo 22-24hr		17191
larva L1		5969
larva L2		3786
larva L3 12hr old		5832
larva L3 puffstage 1-2		15471
larva L3 puffstage 3-6		23310
larva L3 puffstage 7-9		33100
white prepupae new		37724
white prepupae 12hr		25487
white prepupae 24hr		17841
pupae 2d postWPP		13421
pupae 3d postWPP		8714
pupae 4d postWPP		14176
adult male 01day		19058
adult male 05day		16239
adult male 30day		12488
adult female 01day		13553
adult female 05day		10133
adult female 30day		8645
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to maximum FBgn0052672 expression level
Developmental Stage		Expression Level
embryo 00-02hr		5834
embryo 02-04hr		11486
embryo 04-06hr		20634
embryo 06-08hr		15004
embryo 08-10hr		16369
embryo 10-12hr		13955
embryo 12-14hr		16413
embryo 14-16hr		13706
embryo 16-18hr		13938
embryo 18-20hr		11443
embryo 20-22hr		12200
embryo 22-24hr		17191
larva L1		5969
larva L2		3786
larva L3 12hr old		5832
larva L3 puffstage 1-2		15471
larva L3 puffstage 3-6		23310
larva L3 puffstage 7-9		33100
white prepupae new		37724
white prepupae 12hr		25487
white prepupae 24hr		17841
pupae 2d postWPP		13421
pupae 3d postWPP		8714
pupae 4d postWPP		14176
adult male 01day		19058
adult male 05day		16239
adult male 30day		12488
adult female 01day		13553
adult female 05day		10133
adult female 30day		8645
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to Very low expression
Developmental Stage		Expression Level
embryo 00-02hr		(5834)
embryo 02-04hr		(11486)
embryo 04-06hr		(20634)
embryo 06-08hr		(15004)
embryo 08-10hr		(16369)
embryo 10-12hr		(13955)
embryo 12-14hr		(16413)
embryo 14-16hr		(13706)
embryo 16-18hr		(13938)
embryo 18-20hr		(11443)
embryo 20-22hr		(12200)
embryo 22-24hr		(17191)
larva L1		(5969)
larva L2		(3786)
larva L3 12hr old		(5832)
larva L3 puffstage 1-2		(15471)
larva L3 puffstage 3-6		(23310)
larva L3 puffstage 7-9		(33100)
white prepupae new		(37724)
white prepupae 12hr		(25487)
white prepupae 24hr		(17841)
pupae 2d postWPP		(13421)
pupae 3d postWPP		(8714)
pupae 4d postWPP		(14176)
adult male 01day		(19058)
adult male 05day		(16239)
adult male 30day		(12488)
adult female 01day		(13553)
adult female 05day		(10133)
adult female 30day		(8645)
Expression Level Scale		None Extremely low Very low Low

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(5834)
embryo 02-04hr		(11486)
embryo 04-06hr		(20634)
embryo 06-08hr		(15004)
embryo 08-10hr		(16369)
embryo 10-12hr		(13955)
embryo 12-14hr		(16413)
embryo 14-16hr		(13706)
embryo 16-18hr		(13938)
embryo 18-20hr		(11443)
embryo 20-22hr		(12200)
embryo 22-24hr		(17191)
larva L1		(5969)
larva L2		(3786)
larva L3 12hr old		(5832)
larva L3 puffstage 1-2		(15471)
larva L3 puffstage 3-6		(23310)
larva L3 puffstage 7-9		(33100)
white prepupae new		(37724)
white prepupae 12hr		(25487)
white prepupae 24hr		(17841)
pupae 2d postWPP		(13421)
pupae 3d postWPP		(8714)
pupae 4d postWPP		(14176)
adult male 01day		(19058)
adult male 05day		(16239)
adult male 30day		(12488)
adult female 01day		(13553)
adult female 05day		(10133)
adult female 30day		(8645)
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		5834
embryo 02-04hr		11486
embryo 04-06hr		(20634)
embryo 06-08hr		15004
embryo 08-10hr		16369
embryo 10-12hr		13955
embryo 12-14hr		16413
embryo 14-16hr		13706
embryo 16-18hr		13938
embryo 18-20hr		11443
embryo 20-22hr		12200
embryo 22-24hr		17191
larva L1		5969
larva L2		3786
larva L3 12hr old		5832
larva L3 puffstage 1-2		15471
larva L3 puffstage 3-6		(23310)
larva L3 puffstage 7-9		(33100)
white prepupae new		(37724)
white prepupae 12hr		(25487)
white prepupae 24hr		17841
pupae 2d postWPP		13421
pupae 3d postWPP		8714
pupae 4d postWPP		14176
adult male 01day		19058
adult male 05day		16239
adult male 30day		12488
adult female 01day		13553
adult female 05day		10133
adult female 30day		8645
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		5834
embryo 02-04hr		11486
embryo 04-06hr		20634
embryo 06-08hr		15004
embryo 08-10hr		16369
embryo 10-12hr		13955
embryo 12-14hr		16413
embryo 14-16hr		13706
embryo 16-18hr		13938
embryo 18-20hr		11443
embryo 20-22hr		12200
embryo 22-24hr		17191
larva L1		5969
larva L2		3786
larva L3 12hr old		5832
larva L3 puffstage 1-2		15471
larva L3 puffstage 3-6		23310
larva L3 puffstage 7-9		33100
white prepupae new		37724
white prepupae 12hr		25487
white prepupae 24hr		17841
pupae 2d postWPP		13421
pupae 3d postWPP		8714
pupae 4d postWPP		14176
adult male 01day		19058
adult male 05day		16239
adult male 30day		12488
adult female 01day		13553
adult female 05day		10133
adult female 30day		8645
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

FlyAtlas Anatomical Expression Data for FBgn0052672

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	max expr for FBgn0052672
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0052672 expression level
Tissue		Expression Level
Larval Central Nervous System		1336.5
Larval Midgut		3403.5
Larval Hindgut		2499.1
Larval Malpighian Tubules		3522.4
Larval Fat Body		3428.9
Larval Salivary Gland		2714.1
Larval Trachea		2379.75
Larval Carcass		2514.675
Adult Head		2328.8
Adult Eye		3755.525
Adult Brain		2032.6
Adult Thoracic-Abdominal Ganglion		2483.7
Adult Crop		3036.6
Adult Midgut		2452.1
Adult Hindgut		2712
Adult Malpighian Tubules		2259.9
Adult Fat Body		2906.4
Adult Salivary Gland		6446.9
Adult Heart		3715.325
Adult VirginFemale Spermatheca		2616.4
Adult InseminatedFemale Spermatheca		2349.1
Adult Ovary		1078
Adult Testis		824.3
Adult Male Accessory Gland		4099.9
Adult Carcass		2816.7
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		(1336.5)
Larval Midgut		(3403.5)
Larval Hindgut		(2499.1)
Larval Malpighian Tubules		(3522.4)
Larval Fat Body		(3428.9)
Larval Salivary Gland		(2714.1)
Larval Trachea		(2379.75)
Larval Carcass		(2514.675)
Adult Head		(2328.8)
Adult Eye		(3755.525)
Adult Brain		(2032.6)
Adult Thoracic-Abdominal Ganglion		(2483.7)
Adult Crop		(3036.6)
Adult Midgut		(2452.1)
Adult Hindgut		(2712)
Adult Malpighian Tubules		(2259.9)
Adult Fat Body		(2906.4)
Adult Salivary Gland		(6446.9)
Adult Heart		(3715.325)
Adult VirginFemale Spermatheca		(2616.4)
Adult InseminatedFemale Spermatheca		(2349.1)
Adult Ovary		(1078)
Adult Testis		(824.3)
Adult Male Accessory Gland		(4099.9)
Adult Carcass		(2816.7)
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		(1336.5)
Larval Midgut		(3403.5)
Larval Hindgut		(2499.1)
Larval Malpighian Tubules		(3522.4)
Larval Fat Body		(3428.9)
Larval Salivary Gland		(2714.1)
Larval Trachea		(2379.75)
Larval Carcass		(2514.675)
Adult Head		(2328.8)
Adult Eye		(3755.525)
Adult Brain		(2032.6)
Adult Thoracic-Abdominal Ganglion		(2483.7)
Adult Crop		(3036.6)
Adult Midgut		(2452.1)
Adult Hindgut		(2712)
Adult Malpighian Tubules		(2259.9)
Adult Fat Body		(2906.4)
Adult Salivary Gland		(6446.9)
Adult Heart		(3715.325)
Adult VirginFemale Spermatheca		(2616.4)
Adult InseminatedFemale Spermatheca		(2349.1)
Adult Ovary		1078
Adult Testis		824.3
Adult Male Accessory Gland		(4099.9)
Adult Carcass		(2816.7)
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		1336.5
Larval Midgut		3403.5
Larval Hindgut		2499.1
Larval Malpighian Tubules		3522.4
Larval Fat Body		3428.9
Larval Salivary Gland		2714.1
Larval Trachea		2379.75
Larval Carcass		2514.675
Adult Head		2328.8
Adult Eye		3755.525
Adult Brain		2032.6
Adult Thoracic-Abdominal Ganglion		2483.7
Adult Crop		3036.6
Adult Midgut		2452.1
Adult Hindgut		2712
Adult Malpighian Tubules		2259.9
Adult Fat Body		2906.4
Adult Salivary Gland		6446.9
Adult Heart		3715.325
Adult VirginFemale Spermatheca		2616.4
Adult InseminatedFemale Spermatheca		2349.1
Adult Ovary		1078
Adult Testis		824.3
Adult Male Accessory Gland		4099.9
Adult Carcass		2816.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to maximum FBgn0052672 expression level
Tissue		Expression Level
Larval Central Nervous System		1336.5
Larval Midgut		3403.5
Larval Hindgut		2499.1
Larval Malpighian Tubules		3522.4
Larval Fat Body		3428.9
Larval Salivary Gland		2714.1
Larval Trachea		2379.75
Larval Carcass		2514.675
Adult Head		2328.8
Adult Eye		3755.525
Adult Brain		2032.6
Adult Thoracic-Abdominal Ganglion		2483.7
Adult Crop		3036.6
Adult Midgut		2452.1
Adult Hindgut		2712
Adult Malpighian Tubules		2259.9
Adult Fat Body		2906.4
Adult Salivary Gland		6446.9
Adult Heart		3715.325
Adult VirginFemale Spermatheca		2616.4
Adult InseminatedFemale Spermatheca		2349.1
Adult Ovary		1078
Adult Testis		824.3
Adult Male Accessory Gland		4099.9
Adult Carcass		2816.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		(1336.5)
Larval Midgut		(3403.5)
Larval Hindgut		(2499.1)
Larval Malpighian Tubules		(3522.4)
Larval Fat Body		(3428.9)
Larval Salivary Gland		(2714.1)
Larval Trachea		(2379.75)
Larval Carcass		(2514.675)
Adult Head		(2328.8)
Adult Eye		(3755.525)
Adult Brain		(2032.6)
Adult Thoracic-Abdominal Ganglion		(2483.7)
Adult Crop		(3036.6)
Adult Midgut		(2452.1)
Adult Hindgut		(2712)
Adult Malpighian Tubules		(2259.9)
Adult Fat Body		(2906.4)
Adult Salivary Gland		(6446.9)
Adult Heart		(3715.325)
Adult VirginFemale Spermatheca		(2616.4)
Adult InseminatedFemale Spermatheca		(2349.1)
Adult Ovary		(1078)
Adult Testis		(824.3)
Adult Male Accessory Gland		(4099.9)
Adult Carcass		(2816.7)
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		1336.5
Larval Midgut		(3403.5)
Larval Hindgut		(2499.1)
Larval Malpighian Tubules		(3522.4)
Larval Fat Body		(3428.9)
Larval Salivary Gland		(2714.1)
Larval Trachea		(2379.75)
Larval Carcass		(2514.675)
Adult Head		(2328.8)
Adult Eye		(3755.525)
Adult Brain		(2032.6)
Adult Thoracic-Abdominal Ganglion		(2483.7)
Adult Crop		(3036.6)
Adult Midgut		(2452.1)
Adult Hindgut		(2712)
Adult Malpighian Tubules		(2259.9)
Adult Fat Body		(2906.4)
Adult Salivary Gland		(6446.9)
Adult Heart		(3715.325)
Adult VirginFemale Spermatheca		(2616.4)
Adult InseminatedFemale Spermatheca		(2349.1)
Adult Ovary		1078
Adult Testis		824.3
Adult Male Accessory Gland		(4099.9)
Adult Carcass		(2816.7)
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		1336.5
Larval Midgut		3403.5
Larval Hindgut		2499.1
Larval Malpighian Tubules		3522.4
Larval Fat Body		3428.9
Larval Salivary Gland		2714.1
Larval Trachea		2379.75
Larval Carcass		2514.675
Adult Head		2328.8
Adult Eye		3755.525
Adult Brain		2032.6
Adult Thoracic-Abdominal Ganglion		2483.7
Adult Crop		3036.6
Adult Midgut		2452.1
Adult Hindgut		2712
Adult Malpighian Tubules		2259.9
Adult Fat Body		2906.4
Adult Salivary Gland		6446.9
Adult Heart		3715.325
Adult VirginFemale Spermatheca		2616.4
Adult InseminatedFemale Spermatheca		2349.1
Adult Ovary		1078
Adult Testis		824.3
Adult Male Accessory Gland		4099.9
Adult Carcass		2816.7
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	2328.8
NA	Eye	3755.525
NA	Brain	2032.6
1336.5	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	2483.7
NA	Crop	3036.6
3403.5	Midgut	2452.1
2499.1	Hindgut	2712
3522.4	Malpighian Tubules	2259.9
3428.9	Fat Body	2906.4
2714.1	Salivary Gland	6446.9
NA	Heart	3715.325
2379.75	Trachea	NA
NA	VirginFemale Spermatheca	2616.4
NA	InseminatedFemale Spermatheca	2349.1
NA	Ovary	1078
NA	Testis	824.3
NA	Male Accessory Gland	4099.9
2514.675	Carcass	2816.7

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_25

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0052672

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG32672-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Atg8a^KG07569

viable, with Scer\GAL4^pnr-MD237

Atg8a^GD4654

Other Phenotypes

Allele

short lived | male, with Scer\GAL4[-]:

Atg8a^EP362

Phenotype manifest in

Allele

embryonic/larval salivary gland

Atg8a^KG07569

Classical Alleles ( 5 )

For All Classical Alleles Show

Allele of Atg8a	Mutagen	Stocks	Known lesion
Atg8a^EP362	P-element activity	1	--
Atg8a^KG07569	P-element activity	1	Yes
Atg8a²		0	--
Atg8a^ex3	P-element activity	0	Yes
Atg8a^GG01244		0	--

Alleles Carried on Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Atg8a	Mutagen	Stocks	Known lesion
Atg8a^GD4654	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Atg8a^HMS01328	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Atg8a^JF02895	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Atg8a^{hs.T:Avic\GFP}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	--
Atg8a^KK102155	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Atg8a^{Scer\UAS.P\T.T:Avic\GFP-EGFP}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Atg8a^{Scer\UAS.P\T.T:Avic\GFP}	in vitro construct - coding region fusion in vitro construct - regulatory fusion	0	Yes
Atg8a^{Scer\UAS.P\T.T:Disc\RFP-mCherry}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Atg8a^{Scer\UAS.T:Avic\GFP-EGFP,T:Disc\RFP-mCherry}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Atg8a^{Scer\UAS.T:Avic\GFP}	in vitro construct - regulatory fusion	0	Yes
Atg8a^{Scer\UAS.T:Disc\RFP-mCherry}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Atg8a^{Scer\UAS.T:Disc\RFP}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Atg8a^T:Avic\GFP	in vitro construct - coding region fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{UASp-GFP-mCherry-Atg8a}

P{UASp-mCherry-Atg8a}

heat-shock construct

P{hs-Atg8a.GFP}

characterization construct

P{GFP-Atg8a.D}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}Atg8a^EP362

P{Mae-UAS.6.11}Atg8a^GG01244

miscellaneous insertions

P{SUPor-P}Atg8a^KG07569

insertion of enhancer trap

P{lacW}l(1)G0076^G0076

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

Terms Based on Experimental Evidence ( 2 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

determination of adult lifespan

inferred from mutant phenotype

(Simonsen et al., 2007)

regulation of protein ubiquitination

inferred from mutant phenotype

(Simonsen et al., 2007)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Atg8a allele

Gene

References

unspecified

bchs

(Simonsen et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

58422

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0052672

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

32001

Orthologs

Genome-wide drosophilid orthologs

Dana\GF20824

Dere\GG18902

Dgri\GH12106

Dmoj\GI15162

Dper\GL26902

Dpse\GA22662

Dsec\GM11288

Dsim\GD16015

Dvir\GJ14868

Dwil\GK16501

Dyak\GE15373

Curated drosophilid orthologs

Dpse\GA17058

Dsim\CG32672

(FlyBase Genome Annotators, 2002-2003)

Dyak\GE15373

(Domazet-Loso, 2003.2.7)

Linkouts

InParanoid A subset of ortholog calls from InParanoid.

•

AAEL007162-PA
Aedes aegypti (mosquito)
AGAP002685-PA
Anopheles gambiae (mosquito)
XP_001120069.1
Apis mellifera (honey bee)
XP_001947026.1
Acyrthosiphon pisum (pea aphid)
At2g05630.1
Arabidopsis thaliana (wall cress)
20475
Batrachochytrium dendrobatidis (chytrid fungus)
122660
Branchiostoma floridae (lancelet)
XP_001900805.1
Brugia malayi (roundworm nematode)
BGIBMGA011783-PA
Bombyx mori (silk worm)
ENSBTAP00000019814
Bos taurus (bovine)
CAF0006954
Candida albicans (a form of yeast)
CBP06308
Caenorhabditis briggsae (nematode)
CE01849
Caenorhabditis elegans (worm)
ENSCAFP00000023725
Canis familiaris (dog)
CAGL0A04675g
Candida glabrata (haploid yeast)
Chro.70444
Cryptosporidium hominis (obligate parasite)
ENSCINP00000023257
Ciona intestinalis (sea squirt)
JA03006
Caenorhabditis japonica (nematode)
cn01788
Cryptococcus neoformans (yeast-like fungus)
cgd7_3990
Cryptosporidium parvum (protozoan parasite)
CPIJ002897
Culex pipens (mosquito)
ENSCPOP00000006053
Cavia porcellus (guinea pig)
59275
Chlamidomonas reinhardtii (green alga)
RP05250
Caenorhabditis remanei (nematode)
21814
Capitella spl (polychaete worm)
DDB0191413
Dictyostelium discoideum (amoeba)
DEHA2D03960g
Debaryomyces Hansenii (yeast)
318903
Daphnia pulex (daphnia)
ENSDARP00000068351
Danio rerio (zebra fish)
ENSECAP00000012485
Equus caballus (horse)
XP_649165
Entamoeba histolytica (anaerobic protozoan)
ENSGACP00000025635
Gymnopilus aculeatus (mushroom)
ENSGALP00000023699
Gallus gallus (chicken)
71078
Hypsipyla robusta (cedar shoot borer)
ENSP00000306866
Homo sapiens (human)
ISCW017654-PA
Ixodes scapularis (deer tick)
KLLA0E20593g
Kluyveromyces lactis (yeast)
182626
Lottia gigantea (owl limpet)
LmjF19.1630
Leishmania major (virus)
38111
Monocosta brevicollis (choanoflagellate)
ENSMODP00000008149
Monodelphis domestica (gray opossum)
ENSMMUP00000013823
Macaca mulatta (rhesus monkey)
ENSMMUP00000030224
Macaca mulatta (rhesus monkey)
ENSMUSP00000018711
Mus musculus (house mouse)
165338
Nematostella vectensis (starlet anemone)
ENSOANP00000005643
Ornithorynchus anatinus (platypus)
ENSORLP00000007791
Oryzias latipes (japanese killifish)
LOC_Os04g53240.1
Oryza sativa (asian rice)
LOC_Os08g09240.1
Oryza sativa (asian rice)
24935
Ostreococcus tauri (green alga)
PF10_0193
Plasmodium falciparum (protozoal parasite)
PHUM003568-PA
Pediculus humanus (human body louse)
PP06309
Pristionchus pacificus (nematode)
205266
Physcomitrella patens (moss)
ENSPPYP00000008889
Pongo pygmaeus (orangutan)
71390
Phytophthora ramorum (sudden oak death pathogen)
108763
Phytophthora sojae (root rot pathogen)
552018
Populus trichocarpa (black cottonwood)
ENSPTRP00000014784
Pan troglodytes (chimpanzee)
PVX_001860
Plasmodium vivax (protozoal parasite)
ENSRNOP00000023724
Rattus norvegicus (norway rat)
149157
Sorghum bicolor (sorghum)
4792731
Sorghum bicolor (sorghum)
YBL078C
Saccharomyces cerevisiae (budding yeast)
Smp_073790
Schistosoma mansoni (trematode parasite)
SPBP8B7.24c
Schizosaccharomyces pombe (fission yeast)
XP_782118.2
Strongylocentrotus purpuratus (purple sea urchin)
37901
Trichoplax adhaerens (metazoa)
XP_973073.1
Tribolium castaneum (red flour beetle)
Tc00.1047053508173.47
Trypanosoma cruzi (parasitic trypanosome)
ENSTNIP00000011130
Tetraodon nigroviridis (green spotted pufferfish)
32176
Thalassiosira pseudonana (marine diatom)
ENSTRUP00000029313
Takifugu rubripes (pufferfish Takifugu)
3717.m00061
Tetrahymena thermophila (ciliate protozoa)
3825.m02850
Tetrahymena thermophila (ciliate protozoa)
97090.m00121
Trichomonas vaginalis (parasitic flagellated protozoan)
ENSXETP00000035464
Xenopus tropicalis (frog)
YALI0E02662g
Yarrowia lipolytica (nonconventional yeast)

OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.

Stocks & Reagents

Stocks Listed in FlyBase ( 6 )

Bloomington

10107

w¹¹¹⁸ P{EP}Atg8a^EP362

14639

y¹ P{SUPor-P}Atg8a^KG07569/FM7c

34340

y¹ sc^* v¹; P{TRiP.HMS01328}attP2

28989

y¹ v¹; P{TRiP.JF02895}attP2 e^*/TM3, Sb¹

VDRC

v43096

w¹¹¹⁸; P{GD4654}v43096

v43097

w¹¹¹⁸; P{GD4654}v43097

Genomic Clones ( 1 )

CH221-17A11

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 250 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD05816

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0052672

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

32001

Antibody Information

polyclonal

(Barth et al., 2011)

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Atg8a CG32672

(Scott et al., 2004)

Source for identity of: Atg8a CG32672

(Scott, 2005.3.2)

Source for identity of: Atg8a CG32672

(Scott et al., 2004)

Source for database merge of

Source for merge of: CG32672 BcDNA:LD05816

(FlyBase, 1996-)

Additional comments

The Atg8b gene may have been derived from the Atg8a gene by retroposition.

(Dai et al., 2006)

Source for merge of CG32672 BcDNA:LD05816 was a shared cDNA (date:030728).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

"l(1)G0076" may affect "CG32672".

(Peter et al., 2002)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_167245

RefSeq (Proteins)

•

NP_727447

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

32001

UniProtKB/TrEMBL

•

Q9W2S2

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Autophagy protein Atg8 ubiquitin-like (IPR004241)

Linkouts

BioGRID - A database of protein and genetic interactions

•

58422

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0052672

DRSC - Results from RNAi screens.

•

FBgn0052672

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0052672

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG32672-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0052672

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

32001

InParanoid A subset of ortholog calls from InParanoid.

•

AAEL007162-PA
Aedes aegypti (mosquito)
AGAP002685-PA
Anopheles gambiae (mosquito)
XP_001120069.1
Apis mellifera (honey bee)
XP_001947026.1
Acyrthosiphon pisum (pea aphid)
At2g05630.1
Arabidopsis thaliana (wall cress)
20475
Batrachochytrium dendrobatidis (chytrid fungus)
122660
Branchiostoma floridae (lancelet)
XP_001900805.1
Brugia malayi (roundworm nematode)
BGIBMGA011783-PA
Bombyx mori (silk worm)
ENSBTAP00000019814
Bos taurus (bovine)
CAF0006954
Candida albicans (a form of yeast)
CBP06308
Caenorhabditis briggsae (nematode)
CE01849
Caenorhabditis elegans (worm)
ENSCAFP00000023725
Canis familiaris (dog)
CAGL0A04675g
Candida glabrata (haploid yeast)
Chro.70444
Cryptosporidium hominis (obligate parasite)
ENSCINP00000023257
Ciona intestinalis (sea squirt)
JA03006
Caenorhabditis japonica (nematode)
cn01788
Cryptococcus neoformans (yeast-like fungus)
cgd7_3990
Cryptosporidium parvum (protozoan parasite)
CPIJ002897
Culex pipens (mosquito)
ENSCPOP00000006053
Cavia porcellus (guinea pig)
59275
Chlamidomonas reinhardtii (green alga)
RP05250
Caenorhabditis remanei (nematode)
21814
Capitella spl (polychaete worm)
DDB0191413
Dictyostelium discoideum (amoeba)
DEHA2D03960g
Debaryomyces Hansenii (yeast)
318903
Daphnia pulex (daphnia)
ENSDARP00000068351
Danio rerio (zebra fish)
ENSECAP00000012485
Equus caballus (horse)
XP_649165
Entamoeba histolytica (anaerobic protozoan)
ENSGACP00000025635
Gymnopilus aculeatus (mushroom)
ENSGALP00000023699
Gallus gallus (chicken)
71078
Hypsipyla robusta (cedar shoot borer)
ENSP00000306866
Homo sapiens (human)
ISCW017654-PA
Ixodes scapularis (deer tick)
KLLA0E20593g
Kluyveromyces lactis (yeast)
182626
Lottia gigantea (owl limpet)
LmjF19.1630
Leishmania major (virus)
38111
Monocosta brevicollis (choanoflagellate)
ENSMODP00000008149
Monodelphis domestica (gray opossum)
ENSMMUP00000013823
Macaca mulatta (rhesus monkey)
ENSMMUP00000030224
Macaca mulatta (rhesus monkey)
ENSMUSP00000018711
Mus musculus (house mouse)
165338
Nematostella vectensis (starlet anemone)
ENSOANP00000005643
Ornithorynchus anatinus (platypus)
ENSORLP00000007791
Oryzias latipes (japanese killifish)
LOC_Os04g53240.1
Oryza sativa (asian rice)
LOC_Os08g09240.1
Oryza sativa (asian rice)
24935
Ostreococcus tauri (green alga)
PF10_0193
Plasmodium falciparum (protozoal parasite)
PHUM003568-PA
Pediculus humanus (human body louse)
PP06309
Pristionchus pacificus (nematode)
205266
Physcomitrella patens (moss)
ENSPPYP00000008889
Pongo pygmaeus (orangutan)
71390
Phytophthora ramorum (sudden oak death pathogen)
108763
Phytophthora sojae (root rot pathogen)
552018
Populus trichocarpa (black cottonwood)
ENSPTRP00000014784
Pan troglodytes (chimpanzee)
PVX_001860
Plasmodium vivax (protozoal parasite)
ENSRNOP00000023724
Rattus norvegicus (norway rat)
149157
Sorghum bicolor (sorghum)
4792731
Sorghum bicolor (sorghum)
YBL078C
Saccharomyces cerevisiae (budding yeast)
Smp_073790
Schistosoma mansoni (trematode parasite)
SPBP8B7.24c
Schizosaccharomyces pombe (fission yeast)
XP_782118.2
Strongylocentrotus purpuratus (purple sea urchin)
37901
Trichoplax adhaerens (metazoa)
XP_973073.1
Tribolium castaneum (red flour beetle)
Tc00.1047053508173.47
Trypanosoma cruzi (parasitic trypanosome)
ENSTNIP00000011130
Tetraodon nigroviridis (green spotted pufferfish)
32176
Thalassiosira pseudonana (marine diatom)
ENSTRUP00000029313
Takifugu rubripes (pufferfish Takifugu)
3717.m00061
Tetrahymena thermophila (ciliate protozoa)
3825.m02850
Tetrahymena thermophila (ciliate protozoa)
97090.m00121
Trichomonas vaginalis (parasitic flagellated protozoan)
ENSXETP00000035464
Xenopus tropicalis (frog)
YALI0E02662g
Yarrowia lipolytica (nonconventional yeast)

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

32001

modMine - Data generated by the modENCODE project.

•

FBgn0052672

OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.

Synonyms & Secondary IDs ( 13 )

Reported As

Symbol Synonym

atg8

(Berry and Baehrecke, 2007)

Atg8

(Haberman et al., 2010, Midorikawa et al., 2010, Köhler et al., 2009, Liu et al., 2011, Demontis and Perrimon, 2010, Lee et al., 2011, Williamson et al., 2010)

Atg8/LC3

(Juhász et al., 2008)

ATG8a

(Scott, 2005.3.2)

atg8a

(Simonsen et al., 2007, Nezis et al., 2008, Midorikawa et al., 2010)

Atg8A

(Liu et al., 2009)

BcDNA:LD05816

CG1534

(Peter et al., 2002, Betran et al., 2002, Zinke et al., 2002, )

CG32672

(FlyBase, 1996-, Dai et al., 2006, Nezis et al., 2009, Juhasz et al., 2007, Rusten et al., 2007, Perkins et al., 2009, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

DrAtg8a

(Lindmo et al., 2008)

unnamed

(Scott and Neufeld, 2003)

Name Synonym

Autophagy-specific gene 8a

(Scott et al., 2004, Scott, 2005.3.2, Scott et al., 2004)

Secondary FlyBase IDs

FBgn0030229
FBgn0063168

References ( 66 )

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All references relating to this gene ( 66 )

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Recent research papers ( 16 )

Barth et al., 2011, Cell Death Differ. 18(6): 915--924: Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. [FBrf0213616]
Lee et al., 2011, Dev. Biol. 356(2): 588--597: UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. [FBrf0214470]
Liu et al., 2011, J. Neurosci. 31(6): 2052--2063: Drosophila Acyl-CoA Synthetase Long-Chain Family Member 4 Regulates Axonal Transport of Synaptic Vesicles and Is Required for Synaptic Development and Transmission. [FBrf0212968]
Moskalev et al., 2011, Biogerontology 12(3): 253--263: Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. [FBrf0213740]
Tanner et al., 2011, Development 138(2): 327--338: Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. [FBrf0212552]
Blanco et al., 2010, BMC Dev. Biol. 10: 94: Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Demontis and Perrimon, 2010, Cell 143(5): 813--825: FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging. [FBrf0212347]
Francis et al., 2010, Curr. Biol. 20(20): 1799--1808: dDOR Is an EcR Coactivator that Forms a Feed-Forward Loop Connecting Insulin and Ecdysone Signaling. [FBrf0212109]
Haberman et al., 2010, Development 137(13): 2157--2166: Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. [FBrf0211007]
Kadandale et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10502--10507: Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. [FBrf0210996]
Li et al., 2010, J. Biol. Chem. 285(26): 19705--19709: Regulation of mTORC1 by the Rab and Arf GTPases. [FBrf0211071]
McPhee et al., 2010, Nature 465(7301): 1093--1096: Activation of autophagy during cell death requires the engulfment receptor Draper. [FBrf0211145]
Midorikawa et al., 2010, J. Neurosci. 30(32): 10703--10719: Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. [FBrf0211516]
Nezis et al., 2010, J. Cell Biol. 190(4): 523--531: Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. [FBrf0211647]
Nisoli et al., 2010, Cell Death Differ. 17(10): 1577--1587: Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. [FBrf0212035]
Williamson et al., 2010, J. Cell Biol. 189(5): 885--899: A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors. [FBrf0210877]

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