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Gene Dmel\X11Lβ

General Information
Symbol	Dmel\X11Lβ	Species	D. melanogaster
Name	X11Lβ	Annotation symbol	CG32677
Feature type	protein_coding_gene	FlyBase ID	FBgn0052677
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	X11B, X11Lbeta
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	9D4-9E1	Sequence location	X:10,521,770..10,604,980 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene X11Lβ is referred to in FlyBase by the symbol Dmel\X11Lβ (CG32677, FBgn0052677). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: beta-amyloid binding. The biological processes in which it is involved are not known. 11 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: PDZ domain; Phosphotyrosine interaction domain; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Gene sequence location is X:10521770..10604900.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Polypeptides X11Lbeta-PE X11Lbeta-PD Transcripts X11Lbeta-RD X11Lbeta-RE
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 9D4-9E1
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\X11Lβ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.43 Gene model reviewed during 5.51 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) X11Lβ-RA FBtr0071493  NM_167239   8469   2139 X11Lβ-RD FBtr0343041     9687   2066 X11Lβ-RE FBtr0343042     8493   2129
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein X11Lβ-PA   FBpp0071422   231.6   2139   6.23     NP_727440   AAF46614 X11Lβ-PD   FBpp0309789   223.3   2066   6.16       X11Lβ-PE   FBpp0309790   230.5   2129   6.23
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478) Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141456   AA141593   AA141714   AA567516   AA801526   AE014298 AAF46614   AI386899   AI533463   BF489526   BG637093   BI142092   BI358319   BI367893   BI368978   BI564506   BI564869   BI564905   BI638345   BT021345 AAX33493   CK131314   CO177549   CO179410   CO190305   CO262294   CO265804   CO266528   CO267324   CO268279   CO268747   CO268775   CO268945   CO270891   CO271243   CO272166   CO273023   CO273402   CO275886   CO280947   CO281955   CO281956   CO286248   CO291601   CO294915   CO295477   CO296503   CO301624   CO301921   CO301962   CO303448   CO304688   CO306439   CO312884   CO315692   CO316223   CO321607   CO325291   CO327053   CO328882   CO329826   CO331136   CO336331   CO339033   CO339724   CO340147   CO341811   CO342049   CO344644   DQ327758   EC062534   EC067372   EC067392   EC071126   EC072961   EC075494   EC086909   EC203359   EC210539   EC211386   EC212240   EC218268   EC226294   EC235742   EC243205   EL876113   EY198689   EY198724
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W2S5 Q5BI79
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    31 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3  (31) central nervous system, pupae P8  (33) head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    31 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    31 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    31 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3  31 central nervous system, pupae P8  (33) head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    31 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    31 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    13 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    21 head, mated 4-day male    21 head, mated 20-day male    15 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    6 embryo 12-14hr    11 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    7 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    4 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052677 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • S.CX001156;CG32677-RA;S.CX001157
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 X11LβGD3302 viable, with Scer\GAL4pnr-MD237 X11LβGD6479 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 X11LβGD3302 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 X11LβGD3302
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of X11Lβ Class Mutagen Stocks Known lesion X11Lβd01854 1 -- X11Lβd11695 1 -- X11Lβe04301 1 -- X11Lβf01227 1 -- X11LβMB02137 1 -- X11Lβf08041 0 -- X11LβGG01387 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of X11Lβ Class Mutagen Stocks Known lesion X11LβGD3302 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes X11LβGD6479 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes X11LβNIG.1852R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes X11LβNIG.32677R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}X11Lβe04301 NA PBac{WH}X11Lβf01227 NA PBac{WH}X11Lβf08041 NA insertion of mobile activating element P{Mae-UAS.6.11}X11LβGG01387 NA P{XP}X11Lβd01854 NA P{XP}X11Lβd11695 NA insertion of enhancer trap binary system Mi{ET1}X11LβMB02137 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
beta-amyloid binding inferred from sequence or structural similarity with UniProtKB:O88888 (FlyBase Genome Annotators, 2002-2003)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions X11Lβ allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58420 DroID - A comprehensive database of gene and protein interactions. • FBgn0052677 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31997 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q5BI79
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GXG67 Dipteran inclusive ortholog search EOG6PCB13 Insect inclusive ortholog search EOG67SR8N Arthropod inclusive ortholog search EOG67PVMR Metazoa inclusive ortholog search EOG6B8X68
Orthologs in Drosophila Species (EOG6GXG67)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\vsg     Drosophila melanogaster fruit fly  Dmel\X11Lβ     Drosophila simulans   Dsim\GD16984 Y Y Drosophila sechellia   Dsec\GM11428 Y Y Drosophila erecta   Dere\GG18364 Y Y Drosophila yakuba   Dyak\GE17852 Y Y Drosophila ananassae   Dana\GF21435 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA22393   Y Drosophila persimilis   Dper\GL14982   Y Drosophila willistoni   Dwil\GK20104 Y Y Drosophila virilis   Dvir\GJ18807 Y Y Drosophila mojavensis   Dmoj\GI14470 Y Y Drosophila grimshawi   Dgri\GH12706 Y Y
Orthologs in non-Drosophila Dipterans (EOG6PCB13)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002883 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000452 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009921 Y
Orthologs in non-Dipteran Insects (EOG67SR8N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45795 Y Apis mellifera Western honey bee  Amel\GB54639 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011479 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19000 Y Atta cephalotes Leafcutter ant  Acep\ACEP27526 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18414 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16621 Y Linepithema humile Argentine ant  Lhum\LH21957 Y Linepithema humile Argentine ant  Lhum\LH21958 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB21915 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB21917 Y Solenopsis invicta Red fire ant  Sinv\SINV16225 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004425 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002732 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002731 Y Pediculus humanus Human body louse  Phum\PHUM593520 Y Tribolium castaneum Red flour beetle  Tcas\TC001711 Y
Orthologs in non-Insect Arthropods (EOG67PVMR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308950 Y Ixodes scapularis Deer tick  Isca\ISCW015381 Y
Orthologs in non-Arthropod Metazoa (EOG6B8X68)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lin-10 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008419gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027064gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008420gn Y Danio rerio Zebrafish  Drer\ENSDARG00000014105 Y Danio rerio Zebrafish  Drer\ENSDARG00000063314 Y Danio rerio Zebrafish  Drer\ENSDARG00000074328 Y Danio rerio Zebrafish  Drer\im:7137597 Y Danio rerio Zebrafish  Drer\apba2 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030272 Y Xenopus tropicalis Western clawed frog  Xtro\apba2 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033427 Y Gallus gallus Domestic chicken  Ggal\APBA2 Y Gallus gallus Domestic chicken  Ggal\APBA1 Y Gallus gallus Domestic chicken  Ggal\APBA3 Y Mus musculus House mouse  Mmus\Apba3 Y Mus musculus House mouse  Mmus\Apba1 Y Mus musculus House mouse  Mmus\Apba2 Y Rattus norvegicus Norway rat  Rnor\Apba2 Y Rattus norvegicus Norway rat  Rnor\Apba1 Y Rattus norvegicus Norway rat  Rnor\Apba3 Y Homo sapiens Human  Hsap\APBA1 Y Homo sapiens Human  Hsap\APBA2 Y Homo sapiens Human  Hsap\APBA3 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\APBA1     Hsap\APBA2     Hsap\APBA3
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16984 Drosophila sechellia Dsec\GM11428 Drosophila erecta Dere\GG18364 Drosophila yakuba Dyak\GE17852 Drosophila ananassae Dana\GF21435 Drosophila willistoni Dwil\GK20104 Drosophila virilis Dvir\GJ18807 Drosophila mojavensis Dmoj\GI14470 Drosophila grimshawi Dgri\GH12706
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	24180 w1118 Mi{ET1}X11LβMB02137
Harvard	- P{XP}X11Lβd01854 - P{XP}X11Lβd11695 - PBac{RB}X11Lβe04301 - PBac{WH}X11Lβf01227
VDRC	v8309 w1118; P{GD3302}v8309 v14872 w1118; P{GD6479}v14872
Genomic Clones ( 3 )
	BACR10I17 BACR48E06 CH221-17A11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP19469
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25571 GH17272 HL06545 RE45055 RE53763 RE55048 RH61807 RH62404 RH62506 SD05284 SD14952 SD16092 SD20610
Other clones	34415 37916 54912 55188 67347 74034 76853 77562 144845 146016 191125 191390 CK01.58D.H3 CK01.121A.H12 CK01.128B.G11 CK01771 CK02256 CK02693 DMG2-chrX.11.044.a EK047730 EK053803 EK059327 EK062229 EK084963 EK090809 EK092564 EK092643 EK093145 EK100937 EK102527 EK106046 EK109250 EK110833 EK119043 EK143704 EK146664 EK149444 EK155537 EK159162 EK159163 EK181731 EK182717 EK182801 EK186020 EK196037 EK197806 EK207953 EK209943 EK213836 EK230464 EK241457 EK245728 EK251037 EK262215 EK264004 EK291606 EK293945 EK298525 EN12324 EP00647 EP05631 EP10112 EP13216 EP13712 EP19647 EP22363 HL01377 IP05972
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0052677 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31997
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: X11Lβ CG32677 (Gross, 2007.2.25, Vishnu et al., 2006)
Source for database merge of	Source for merge of: CG1852 CG1861 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG1852 and CG1861 merged as CG32677 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167239 RefSeq (Proteins) • NP_727440 DDBJ / EMBL / GenBank • AA567516 AAF46614 AAX33493 AGB95268 BT021345 DQ327758 Entrez Gene - A searchable database of RefSeq genes. • 31997 UniProtKB/TrEMBL • Q5BI79 Q9W2S5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478) Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58420 DroID - A comprehensive database of gene and protein interactions. • FBgn0052677 DRSC - Results from RNAi screens. • FBgn0052677 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052677 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • S.CX001156;CG32677-RA;S.CX001157 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0052677 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31997 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31997 modMine - Data generated by the modENCODE project. • FBgn0052677 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q5BI79
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG1852 (Yano et al., 2012) CG1861 (Jasper et al., 2002, ) CG32677 (Gross, 2007.2.25, Vishnu et al., 2006, Manak et al., 2006, Ostrin et al., 2006, Buffin and Gho, 2010) Dmint2 (Vishnu et al., 2006) X11B (Gross et al., 2007, Gross, 2007.2.25) X11Lbeta (Lawlor et al., 2011, Japanese National Institute of Genetics, 2012.5.21) X11Lβ (Gross, 2007.2.25, Immonen and Ritchie, 2012, Yano et al., 2012) x11Lβ (Vishnu et al., 2006)
Name Synonym	CG32677   X11Lβ (Gross, 2007.2.25, )
Secondary FlyBase IDs
	FBgn0030225 FBgn0030226
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Immonen and Ritchie, 2012, Proc. Biol. Sci. 279(1732): 1359--1365 The genomic response to courtship song stimulation in female Drosophila melanogaster. [FBrf0217554] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Lawlor et al., 2011, Hum. Mol. Genet. 20(19): 3757--3768 Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases. [FBrf0215240] Show all research papers ...