FlyBase Gene Report: Dmel\CG32687

General Information

Symbol

Dmel\CG32687

Species

D. melanogaster

Name

Annotation Symbol

CG32687

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052687

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

9D2-9D2

Sequence location

X:10,482,028..10,487,205 [-]

Recombination map

1-32

RefSeq locus

NC_004354 REGION:10482028..10487205

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (1 term)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN002907894

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG32687 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Supported by strand-specific RNA-Seq data.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG32687-RA

FBtr0071458

NM_167233

2352

377

CG32687-RB

FBtr0336901

NM_001272483

2803

377

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG32687-PA

FBpp0071392

41.3

377

9.06

NP_727428

AAF46596

CG32687-PB

FBpp0307841

41.3

377

9.06

NP_001259412

AGB95255

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

377 aa isoforms: CG32687-PA, CG32687-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W2U2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG32687 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

yolk

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG32687 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG32687

View exonic expression by tissue for Dmel\CG32687

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052687

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31980/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052687

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052687

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052687

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32687

Flygut - An atlas of the Drosophila adult midgut

FBgn0052687

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG32687

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG32687

Transgenic constructs containing regulatory region of CG32687

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\LRRC58

13 of 15

Yes

Hsap\LRRC39

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Lrrc58

12 of 15

Yes

Mmus\Lrrc39

1 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Lrrc58

12 of 13

Yes

Rnor\Lrrc39

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\lrrc58

12 of 12

Yes

Xtro\lrrc39

1 of 12

Yes

Danio rerio (Zebrafish) (3)

Drer\lrrc58a

13 of 15

Yes

Drer\lrrc58b

13 of 15

Yes

Drer\lrrc39

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\Y42G9A.3

14 of 15

Yes

Arabidopsis thaliana (thale-cress) (12)

Atha\AT3G15410

1 of 9

Yes

Atha\AT5G66890

1 of 9

Yes

Atha\PIRL1

1 of 9

Yes

Atha\PIRL2

1 of 9

Yes

Atha\PIRL3

1 of 9

Yes

Atha\PIRL6

1 of 9

Yes

Atha\PIRL7

1 of 9

Yes

Atha\PIRL8

1 of 9

Yes

Atha\PIRL9

1 of 9

Yes

Atha\RLP25

1 of 9

Yes

Atha\RLP29

1 of 9

Yes

Atha\RLP38

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AZ9 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17074

Drosophila persimilis

Dper\GL14883

Drosophila willistoni

Dwil\GK17622

Drosophila virilis

Dvir\GJ14718

Drosophila mojavensis

Dmoj\GI15063

Drosophila grimshawi

Dgri\GH12711

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502O1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022167

Glossina morsitans

Tsetse fly

Gmor\GMOY012159

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08230

Mayetiola destructor

Hessian fly

Mdes\Mdes002419

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005221

Anopheles darlingi

American malaria mosquito

Adar\ADAC003872

Anopheles gambiae

Malaria mosquito

Agam\AGAP004458

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006113

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07UY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008504

Danaus plexippus

Monarch butterfly

Dple\DPOGS206672-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012309

Apis florea

Little honeybee

Aflo\2150472740

Apis mellifera

Western honey bee

Amel\GB53373

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15881

Bombus terrestris

Buff-tailed bumblebee

Bter\15207903

Linepithema humile

Argentine ant

Lhum\LH21037

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000221

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG027314

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00959

Tribolium castaneum

Red flour beetle

Tcas\TC032823

Pediculus humanus

Human body louse

Phum\PHUM286780

Rhodnius prolixus

Kissing bug

Rpro\RPRC011753

Cimex lectularius

Bed bug

Clec\CLEC008934

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003678

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02678

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07SQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000676

Ixodes scapularis

Black-legged tick

Isca\ISCW009450

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62887.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur33g00590

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308174

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BVZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Lrrc58

Gallus gallus

Domestic chicken

Ggal\LRRC58

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (11)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

ics

1 of 10

Lrr47

1 of 10

ltl

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LRRC58; leucine rich repeat containing 58

13 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58408

DroID - A comprehensive database of gene and protein interactions.

FBgn0052687

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-32

Cytogenetic map

9D2-9D2

Sequence location

X:10,482,028..10,487,205 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

9D2-9D2

Limits computationally determined from genome sequence between P{EP}PPP4R2r^EP307 and P{EP}ras^EP1235&P{EP}ras^EP1427

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-32

(FlyBase, 2016)

1-33.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

63255

w^* P{EP}CG32687^G17132

41506

y¹ w^* Mi{MIC}CG32687^MI06039

77767

y¹ w^* Mi{Trojan-GAL4.2}CG32687^{MI06039-TG4.2}

VDRC

v100795

P{KK108702}VIE-260B

v20819

w¹¹¹⁸; P{GD9736}v20819

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH29237

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052687

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052687

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31980

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG32687 BcDNA:RH29237

(FlyBase, 1996-)

Source for merge of: CG2143 CG2892

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG2143 and CG2892 merged as CG32687 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG32687 BcDNA:RH29237 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31980

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W2U2

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052687

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052687

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31980/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052687

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052687

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052687

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32687

Flygut - An atlas of the Drosophila adult midgut

FBgn0052687

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31980

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG32687

MARRVEL_MODEL - MARRVEL (model organism gene)

31980

modMine - A data warehouse for the modENCODE project

FBgn0052687

Linkouts

BioGRID - A database of protein and genetic interactions.

58408

DroID - A comprehensive database of gene and protein interactions.

FBgn0052687

DRSC - Results frm RNAi screens

FBgn0052687

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052687

FlyMine - An integrated database for Drosophila genomics

FBgn0052687

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

BcDNA:RH29237

CG2143

(Barbash et al., 2003, Zinke et al., 2002)

CG2892

(Barbash et al., 2003)

CG32687

(Wang et al., 2021, Wu et al., 2020, Gene Disruption Project members, 2016-, DeSalvo et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5)

CT6984

(Hynes and Zhao, 2000)

CT7080

(Hynes and Zhao, 2000)

Cg32687

(Asensio et al., 2010)

Name Synonyms

Secondary FlyBase IDs

FBgn0030209
FBgn0030210
FBgn0062948

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (30)

Report Sections

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