FlyBase Gene Report: Dmel\Ir8a

General Information

Symbol

Dmel\Ir8a

Species

D. melanogaster

Name

Ionotropic receptor 8a

Annotation Symbol

CG32704

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052704

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

Ionotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

8D2-8D2

Sequence location

X:9,232,726..9,236,585 [-]

Recombination map

1-27

RefSeq locus

NC_004354 REGION:9232726..9236585

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

ANTENNAL IONOTROPIC CO-RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

coreceptor activity; contributes_tocontributes_to extracellular ligand-gated ion channel activity; contributes_to extracellular phenylacetaldehyde-gated ion channel activity; contributes_tocontributes_to olfactory receptor activity; signaling receptor binding

Predictions / Assertions

ionotropic glutamate receptor activity; ligand-gated ion channel activity; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Summaries

Gene Group (FlyBase)

ANTENNAL IONOTROPIC CO-RECEPTORS -: Ionotropic Receptors (IR) co-receptors are part of the IR family. They are broadly, but selectively, expressed in antennal sensory neurons in Drosophila. Some antenneal IRs only form functional odor-responsive ion channels as a heteromeric complex with an IR co-receptor. (Adapted from FBrf0222310).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Ir8a or the JBrowse view of Dmel\Ir8a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir8a-RA

FBtr0071333

NM_167185

2811

936

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ir8a-PA

FBpp0071268

106.3

936

5.53

NP_727328

AAF46470

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W365

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir8a using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Gene Ontology (25 terms)

Molecular Function (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

coreceptor activity

inferred from direct assay

(Abuin et al., 2011)

contributes_to extracellular ligand-gated ion channel activity

inferred from direct assay

(Ai et al., 2013, Abuin et al., 2011)

contributes_to extracellular phenylacetaldehyde-gated ion channel activity

inferred from direct assay

(Abuin et al., 2011)

contributes_to olfactory receptor activity

inferred from direct assay

(Ai et al., 2013, Abuin et al., 2011)

signaling receptor binding

inferred from physical interaction with FLYBASE:Ir84a; FB:FBgn0037501

(Abuin et al., 2011)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

ionotropic glutamate receptor activity

inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

ligand-gated ion channel activity

inferred from sequence model

(Benton et al., 2009)

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

cellular response to acetate

inferred from direct assay

(Ai et al., 2013)

detection of chemical stimulus involved in sensory perception

inferred from expression pattern

(Benton et al., 2009)

detection of chemical stimulus involved in sensory perception of smell

inferred from mutant phenotype

(Abuin et al., 2011)

olfactory behavior

inferred from mutant phenotype

(Ai et al., 2013)

positive regulation of calcium-mediated signaling

inferred from mutant phenotype

(Ai et al., 2013)

response to acetate

inferred from mutant phenotype

(Ai et al., 2013)

response to chlorate

inferred from mutant phenotype

(Ai et al., 2013)

transmission of nerve impulse

inferred from mutant phenotype

(Abuin et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

ion transport

inferred from electronic annotation with InterPro:IPR001508

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

dendrite membrane

inferred from direct assay

(Ai et al., 2013)

integral component of plasma membrane

inferred from direct assay

(Abuin et al., 2011)

plasma membrane

inferred from direct assay

(Abuin et al., 2011)

receptor complex

inferred from direct assay

(Abuin et al., 2011)

sensory dendrite

inferred from direct assay

(Ai et al., 2013, Abuin et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

integral component of membrane

inferred from sequence model

(Benton et al., 2009)

plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

postsynaptic membrane

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult antennal sense organ | restricted

(Benton et al., 2009)

neuron of sensillum coeloconicum of antennal segment 3

(Benton et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

antenna

(Croset et al., 2010)

Additional Descriptive Data

Ir8a transcript is expressed in the neurons of the sensillum coeloconicum of antennal segment 3 located throughout the antenna and around the sacculus.

(Benton et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron of sensillum coeloconicum of antennal segment 3 | subset

• cell body

(Abuin et al., 2011)

neuron of sensillum coeloconicum of antennal segment 3 | subset

• dendrite terminus

(Abuin et al., 2011)

neuron of grooved sensillum of sacculus

(Abuin et al., 2011)

adult olfactory receptor neuron Ir64a

(Ai et al., 2013)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

antenna

(Ai et al., 2013)

Additional Descriptive Data

Ir8a protein is expressed in the cell body and dendritic ends of a subset of neurons of sensillum coeloconicum of antennal segment 3 and in the neurons of the grooved sensillum of sacculus, which project to the third chamber of the sacculus. A subset of the sensilla coeloconicum labeled with Ir8a also expresses Ir25a.

(Abuin et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

dendrite membrane

inferred from direct assay

(Ai et al., 2013)

integral component of plasma membrane

inferred from direct assay

(Abuin et al., 2011)

plasma membrane

inferred from direct assay

(Abuin et al., 2011)

receptor complex

inferred from direct assay

(Abuin et al., 2011)

sensory dendrite

inferred from direct assay

(Ai et al., 2013, Abuin et al., 2011)

Expression Deduced from Reporters

Reporter: P{Ir8a-GAL4.A}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron of sensillum coeloconicum of antennal segment 3 | subset

• cell body

(Abuin et al., 2011)

neuron of sensillum coeloconicum of antennal segment 3 | subset

• cilium

(Abuin et al., 2011)

neuron of sensillum coeloconicum of antennal segment 3 | subset

• axon

(Abuin et al., 2011)

neuron of antennal coeloconic sensillum ac1

(Silbering et al., 2011)

neuron of antennal coeloconic sensillum ac2

(Silbering et al., 2011)

neuron of antennal coeloconic sensillum ac3

(Silbering et al., 2011)

neuron of antennal coeloconic sensillum ac4

(Silbering et al., 2011)

neuron of grooved sensillum of sacculus

(Silbering et al., 2011)

adult antennal lobe glomerulus | subset

(Silbering et al., 2011)

chamber II of sacculus

(Sun et al., 2018)

Reporter: P{Ir8a-GAL4.Ab}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult olfactory receptor neuron Ir64a

(Ai et al., 2013)

antennal lobe glomerulus DP1m

(Ai et al., 2013)

antennal lobe glomerulus DC4

(Ai et al., 2013)

adult antennal lobe glomerulus | restricted

(Ai et al., 2013)

Reporter: P{Ir8a-GAL4.M}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult olfactory receptor neuron Ir31a

(Menuz et al., 2014)

adult olfactory receptor neuron Ir75a

(Menuz et al., 2014)

adult olfactory receptor neuron Ir75a/b

(Menuz et al., 2014)

adult olfactory receptor neuron Ir84a

(Menuz et al., 2014)

adult olfactory receptor neuron Ir64a

(Menuz et al., 2014)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ir8a in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir8a

View exonic expression by tissue for Dmel\Ir8a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0052704

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG32704-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0052704

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 19 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir8a

Transgenic constructs containing regulatory region of Ir8a

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ir8a¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Ir8a^GD15330

viable, with Scer\GAL4^pnr-MD237

Ir8a^GD15330

Sterility

Allele

fertile

Ir8a¹

Other Phenotypes

Allele

neurophysiology defective

Ir8a¹

smell perception defective

Ir8a¹

smell perception defective, with Scer\GAL4^Ir64a.PA

Phenotype manifest in

Allele

sensillum coeloconicum of antennal segment 3

Ir8a¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRID1

2 of 15

Yes

Hsap\GRID2

2 of 15

Yes

Hsap\GRIK1

2 of 15

Yes

Hsap\GRIK2

2 of 15

Yes

Hsap\GRIK3

2 of 15

Yes

Hsap\GRIK4

2 of 15

Yes

Hsap\GRIK5

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Grid1

2 of 15

Yes

Mmus\Grid2

2 of 15

Yes

Mmus\Grik1

2 of 15

Yes

Mmus\Grik2

2 of 15

Yes

Mmus\Grik3

2 of 15

Yes

Mmus\Grik4

2 of 15

Yes

Mmus\Grik5

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (15)

Rnor\Grid2

2 of 13

Yes

Rnor\Grik2

2 of 13

Yes

Rnor\Grik3

2 of 13

Yes

Rnor\Grik4

2 of 13

Yes

Rnor\Grik5

2 of 13

Yes

Rnor\Gria3

1 of 13

Rnor\Gria4

1 of 13

Rnor\Grid1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\grid1

2 of 12

Yes

Xtro\grid2

2 of 12

Yes

Xtro\grik1

2 of 12

Yes

Xtro\grik4

2 of 12

Yes

Xtro\grik5-like.1

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (29)

Drer\grid1a

2 of 15

Yes

Drer\grid1b

2 of 15

Yes

Drer\grid2

2 of 15

Yes

Drer\grik1a

2 of 15

Yes

Drer\grik1b

2 of 15

Yes

Drer\grik4

2 of 15

Yes

Drer\LOC100334689

2 of 15

Yes

Drer\si:ch211-251b21.1

2 of 15

Yes

Drer\si:dkey-183j2.10

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\glr-7

2 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR2

3 of 9

Yes

Atha\GLR3.3

3 of 9

Yes

Atha\GLR3.4

3 of 9

Yes

Atha\GLR3.5

3 of 9

Yes

Atha\GLR3.6

3 of 9

Yes

Atha\GLR5

3 of 9

Yes

Atha\GLUR2

3 of 9

Yes

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919021G )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA28121

Drosophila persimilis

Dper\GL18283

Drosophila willistoni

Dwil\GK25795

Drosophila virilis

Dvir\GJ18802

Drosophila mojavensis

Dmoj\GI14467

Drosophila grimshawi

Dgri\GH12703

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150260 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17014596

Glossina morsitans

Tsetse fly

Gmor\GMOY012127

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07217

Mayetiola destructor

Hessian fly

Mdes\Mdes013187

Mayetiola destructor

Hessian fly

Mdes\Mdes006608

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002922

Anopheles darlingi

American malaria mosquito

Adar\ADAC001739

Anopheles gambiae

Malaria mosquito

Agam\IR8a

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ020118

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01YB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009567

Danaus plexippus

Monarch butterfly

Dple\DPOGS215108-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004578

Apis florea

Little honeybee

Aflo\3960496452

Apis mellifera

Western honey bee

Amel\LOC409777

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16722

Bombus terrestris

Buff-tailed bumblebee

Bter\15208562

Linepithema humile

Argentine ant

Lhum\LH14616

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002dae

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012080

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12359

Tribolium castaneum

Red flour beetle

Tcas\TC003572

Pediculus humanus

Human body louse

Phum\PHUM596380

Rhodnius prolixus

Kissing bug

Rpro\RPRC017357

Cimex lectularius

Bed bug

Clec\CLEC010869

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007712

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18858

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01VZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003752

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (37)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ir8a - Ir64a

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Ai et al., 2013)

Ir8a - Ir84a

fluorescence microscopy, tag visualisation

(Abuin et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Orco

suppressible

Ir8a

(Silbering et al., 2011)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052704

MIST (protein-protein) - An integrated Molecular Interaction Database

Ir8a

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-27

Cytogenetic map

8D2-8D2

Sequence location

X:9,232,726..9,236,585 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

8D2-8D2

Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912^EP912

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-27

(FlyBase, 2016)

1-28.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

25813

y¹ v¹; P{TRiP.JF01831}attP2

41731

w^*; P{Ir8a-GAL4.A}204.8; TM2/TM6B, Tb¹

41745

w^*; M{UAS-Ir8a.A}ZH-51D; TM2/TM6B, Tb⁺

41744

w^* TI{TI}Ir8a¹; Bl¹ L²/CyO

VDRC

v51067

w¹¹¹⁸; P{GD3293}v51067

v51142

w¹¹¹⁸; P{GD3293}v51142

v29917

w¹¹¹⁸; P{GD15330}v29917

v29918

w¹¹¹⁸; P{GD15330}v29918/CyO

v341801

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00940}attP40/CyO-GFP

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052704

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31867

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Abuin et al., 2011)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ir8a CG32704

(Benton et al., 2009)

Source for database merge of

Source for merge of: CG12122 CG12666

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG12122 and CG12666 merged as CG32704 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

v is required for Ir64a protein trafficking and stability.

(Ai et al., 2013)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 20 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31867

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF46470

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W365

Other crossreferences

Flygut - An atlas of the Drosophila adult midgut

FBgn0052704

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31867

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG32704

modMine - A data warehouse for the modENCODE project

FBgn0052704

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052704

DRSC - Results frm RNAi screens

FBgn0052704

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0052704

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG32704-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052704

FlyMine - An integrated database for Drosophila genomics

FBgn0052704

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

Ir8a

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG12122

CG12666

CG32704

(Tsubouchi et al., 2012, Chung et al., 2011, Croset et al., 2010, Itoh et al., 2010, Benton et al., 2009, Lee et al., 2009, Perkins et al., 2009.1.15)

CT7438

(Littleton and Ganetzky, 2000)

DmelIR8a

(Croset et al., 2010)

IR8a

(Chen et al., 2019, Gomez-Diaz et al., 2018, Rimal and Lee, 2018, Hussain et al., 2016, Chen et al., 2015, Menuz et al., 2014, Ai et al., 2013, Min et al., 2013, Ziegler et al., 2013, Abuin et al., 2011, Silbering et al., 2011, Croset et al., 2010, Benton et al., 2009)

Ir8a

(Abuin et al., 2019, Chai et al., 2019, Chakraborty et al., 2019, Abu et al., 2018, Chin et al., 2018, Ganguly et al., 2017, Enjin et al., 2016, Grabe et al., 2016, Knecht et al., 2016, Ni et al., 2016, Jung et al., 2015, Lin et al., 2015, Martin et al., 2013, Benton, 2012.10.23, Senthilan et al., 2012, Tsubouchi et al., 2012)

Name Synonyms

CG32704

Ionotropic receptor 8a

(Tsubouchi et al., 2012)

ionotropic receptor 8a

(Benton et al., 2009)

Secondary FlyBase IDs

FBgn0030110
FBgn0030111

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (65)

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