FB2019_05, released Oct 15, 2019

Gene: Dmel\Ir8a

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General Information
Symbol
Dmel\Ir8a
Species
D. melanogaster
Name
Ionotropic receptor 8a
Annotation Symbol
CG32704
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052704
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Ionotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
8D2-8D2
Sequence location
X:9,232,726..9,236,585 [-]
Recombination map
1-27
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
coreceptor activity; contributes_tocontributes_to extracellular ligand-gated ion channel activity; contributes_to extracellular phenylacetaldehyde-gated ion channel activity; contributes_tocontributes_to olfactory receptor activity; signaling receptor binding
Predictions / Assertions
glutamate receptor activity; ionotropic glutamate receptor activity; ligand-gated ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Summaries
Gene Group (FlyBase)
ANTENNAL IONOTROPIC CO-RECEPTORS -
Ionotropic Receptors (IR) co-receptors are part of the IR family. They are broadly, but selectively, expressed in antennal sensory neurons in Drosophila. Some antenneal IRs only form functional odor-responsive ion channels as a heteromeric complex with an IR co-receptor. (Adapted from FBrf0222310).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Ir8a or the JBrowse view of Dmel\Ir8a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ir8a-RA
FBtr0071333
NM_167185
2811
936
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ir8a-PA
FBpp0071268
106.3
936
5.53
NP_727328
AAF46470
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir8a using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (28 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
coreceptor activity
inferred from direct assay
(Abuin et al., 2011)
contributes_tocontributes_to extracellular ligand-gated ion channel activity
inferred from direct assay
(Ai et al., 2013, Abuin et al., 2011)
contributes_to extracellular phenylacetaldehyde-gated ion channel activity
inferred from direct assay
(Abuin et al., 2011)
contributes_tocontributes_to olfactory receptor activity
inferred from direct assay
(Ai et al., 2013, Abuin et al., 2011)
signaling receptor binding
inferred from physical interaction with FLYBASE:Ir84a; FB:FBgn0037501
(Abuin et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
glutamate receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
ionotropic glutamate receptor activity
inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ligand-gated ion channel activity
inferred from sequence model
(Benton et al., 2009)
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (11 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
cellular response to acetate
inferred from direct assay
(Ai et al., 2013)
detection of chemical stimulus involved in sensory perception
inferred from expression pattern
(Benton et al., 2009)
detection of chemical stimulus involved in sensory perception of smell
inferred from mutant phenotype
(Abuin et al., 2011)
olfactory behavior
inferred from mutant phenotype
(Ai et al., 2013)
positive regulation of calcium-mediated signaling
inferred from mutant phenotype
(Ai et al., 2013)
response to acetate
inferred from mutant phenotype
(Ai et al., 2013)
response to chlorate
inferred from mutant phenotype
(Ai et al., 2013)
transmission of nerve impulse
inferred from mutant phenotype
(Abuin et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ion transport
inferred from electronic annotation with InterPro:IPR001508
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
modulation of chemical synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
synaptic transmission, glutamatergic
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
dendrite membrane
inferred from direct assay
(Ai et al., 2013)
integral component of plasma membrane
inferred from direct assay
(Abuin et al., 2011)
plasma membrane
inferred from direct assay
(Abuin et al., 2011)
receptor complex
inferred from direct assay
(Abuin et al., 2011)
sensory dendrite
inferred from direct assay
(Ai et al., 2013, Abuin et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
integral component of membrane
inferred from sequence model
(Benton et al., 2009)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
postsynaptic density membrane
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
postsynaptic membrane
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult antennal sense organ | restricted
(Benton et al., 2009)
neuron of sensillum coeloconicum of antennal segment 3
(Benton et al., 2009)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antenna
(Croset et al., 2010)
Additional Descriptive Data
Ir8a transcript is expressed in the neurons of the sensillum coeloconicum of antennal segment 3 located throughout the antenna and around the sacculus.
(Benton et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of sensillum coeloconicum of antennal segment 3 | subset
(Abuin et al., 2011)
neuron of sensillum coeloconicum of antennal segment 3 | subset
(Abuin et al., 2011)
neuron of grooved sensillum of sacculus
(Abuin et al., 2011)
adult olfactory receptor neuron Ir64a
(Ai et al., 2013)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antenna
(Ai et al., 2013)
Additional Descriptive Data
Ir8a protein is expressed in the cell body and dendritic ends of a subset of neurons of sensillum coeloconicum of antennal segment 3 and in the neurons of the grooved sensillum of sacculus, which project to the third chamber of the sacculus. A subset of the sensilla coeloconicum labeled with Ir8a also expresses Ir25a.
(Abuin et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
dendrite membrane
inferred from direct assay
(Ai et al., 2013)
integral component of plasma membrane
inferred from direct assay
(Abuin et al., 2011)
plasma membrane
inferred from direct assay
(Abuin et al., 2011)
receptor complex
inferred from direct assay
(Abuin et al., 2011)
sensory dendrite
inferred from direct assay
(Ai et al., 2013, Abuin et al., 2011)
Expression Deduced from Reporters
Reporter: P{Ir8a-GAL4.A}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of sensillum coeloconicum of antennal segment 3 | subset
(Abuin et al., 2011)
neuron of sensillum coeloconicum of antennal segment 3 | subset
• cilium
(Abuin et al., 2011)
neuron of sensillum coeloconicum of antennal segment 3 | subset
• axon
(Abuin et al., 2011)
neuron of antennal coeloconic sensillum ac1
(Silbering et al., 2011)
neuron of antennal coeloconic sensillum ac2
(Silbering et al., 2011)
neuron of antennal coeloconic sensillum ac3
(Silbering et al., 2011)
neuron of antennal coeloconic sensillum ac4
(Silbering et al., 2011)
neuron of grooved sensillum of sacculus
(Silbering et al., 2011)
adult antennal lobe glomerulus | subset
(Silbering et al., 2011)
chamber II of sacculus
(Sun et al., 2018)
Reporter: P{Ir8a-GAL4.Ab}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult olfactory receptor neuron Ir64a
(Ai et al., 2013)
antennal lobe glomerulus DP1m
(Ai et al., 2013)
antennal lobe glomerulus DC4
(Ai et al., 2013)
adult antennal lobe glomerulus | restricted
(Ai et al., 2013)
Reporter: P{Ir8a-GAL4.M}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult olfactory receptor neuron Ir31a
(Menuz et al., 2014)
adult olfactory receptor neuron Ir75a
(Menuz et al., 2014)
adult olfactory receptor neuron Ir75a/b
(Menuz et al., 2014)
adult olfactory receptor neuron Ir84a
(Menuz et al., 2014)
adult olfactory receptor neuron Ir64a
(Menuz et al., 2014)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ir8a in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ir8a
Transgenic constructs containing regulatory region of Ir8a
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GRID1
2 of 15
No
Yes
Hsap\GRID2
2 of 15
No
Yes
Hsap\GRIA1
1 of 15
No
No
 
Hsap\GRIA2
1 of 15
No
No
 
Hsap\GRIA3
1 of 15
No
No
Hsap\GRIA4
1 of 15
No
No
Hsap\GRIK1
1 of 15
No
No
Hsap\GRIK2
1 of 15
No
No
Hsap\GRIK3
1 of 15
No
No
Hsap\GRIK4
1 of 15
No
No
Hsap\GRIK5
1 of 15
No
No
 
Hsap\GRIN1
1 of 15
No
No
Hsap\GRIN3A
1 of 15
No
No
Hsap\GRIN3B
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Grid1
2 of 15
No
Yes
Mmus\Grid2
2 of 15
Yes
Yes
Mmus\Gria1
1 of 15
No
No
Mmus\Gria2
1 of 15
No
No
Mmus\Gria3
1 of 15
No
No
Mmus\Gria4
1 of 15
No
No
Mmus\Grik2
1 of 15
No
No
Mmus\Grik4
1 of 15
No
No
Mmus\Grik5
1 of 15
No
No
Mmus\Grin1
1 of 15
No
No
Mmus\Grin3a
1 of 15
No
No
Mmus\Grin3b
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Gria1
1 of 13
Yes
No
Rnor\Gria2
1 of 13
No
Yes
Rnor\Gria3
1 of 13
No
Yes
Rnor\Gria4
1 of 13
No
Yes
Rnor\Grid2
1 of 13
Yes
Yes
Rnor\Grik2
1 of 13
Yes
No
Rnor\Grik3
1 of 13
Yes
No
Rnor\Grik4
1 of 13
No
Yes
Rnor\Grik5
1 of 13
No
Yes
Rnor\Grin1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\grid1
1 of 12
Yes
Yes
Xtro\grid2
1 of 12
Yes
Yes
Xtro\grik5
1 of 12
Yes
No
Danio rerio (Zebrafish) (15)
Drer\grid1a
2 of 15
Yes
No
Drer\grid1b
2 of 15
Yes
No
Drer\gria2a
1 of 15
No
No
Drer\gria2b
1 of 15
No
No
Drer\gria3a
1 of 15
No
No
Drer\gria3b
1 of 15
No
No
Drer\gria4a
1 of 15
No
No
Drer\gria4b
1 of 15
No
No
Drer\grid2
1 of 15
No
Yes
Drer\grik4
1 of 15
No
No
Drer\grik5
1 of 15
No
No
Drer\grin1a
1 of 15
No
No
Drer\grin1b
1 of 15
No
No
Drer\grin3bb
1 of 15
No
Yes
Drer\si:dkey-183j2.10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\glr-7
2 of 15
Yes
No
Cele\glr-3
1 of 15
No
No
Cele\glr-4
1 of 15
No
No
Cele\glr-5
1 of 15
No
No
Cele\glr-8
1 of 15
No
No
Cele\nmr-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\GLR2
4 of 9
Yes
No
Atha\GLR3.6
4 of 9
Yes
No
Atha\GLR5
4 of 9
Yes
No
Atha\GLUR2
4 of 9
Yes
No
Atha\ATGLR1.2
3 of 9
No
No
Atha\GLR1.1
3 of 9
No
No
Atha\GLR1.3
3 of 9
No
No
Atha\GLR1.4
3 of 9
No
No
Atha\GLR2.1
3 of 9
No
No
Atha\GLR2.2
3 of 9
No
No
Atha\GLR2.3
3 of 9
No
No
Atha\GLR2.5
3 of 9
No
No
Atha\GLR2.6
3 of 9
No
No
Atha\GLR2.7
3 of 9
No
No
Atha\GLR2.8
3 of 9
No
No
Atha\GLR3.3
3 of 9
No
No
Atha\GLR3.4
3 of 9
No
No
Atha\GLR3.5
3 of 9
No
No
Atha\GLR2.4
2 of 9
No
No
Atha\GLR2.9
2 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919021G )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Ir8a
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004953
Drosophila simulans
Dsim\GD28895
Drosophila sechellia
Dsec\GM22349
Drosophila erecta
Dere\GG18989
Drosophila yakuba
Dyak\GE15462
Drosophila ananassae
Dana\GF19097
Drosophila pseudoobscura pseudoobscura
Dpse\GA28121
Drosophila persimilis
Dper\GL18283
Drosophila willistoni
Dwil\GK25795
Drosophila virilis
Dvir\GJ18802
Drosophila mojavensis
Dmoj\GI14467
Drosophila grimshawi
Dgri\GH12703
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150260 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014596
Glossina morsitans
Tsetse fly
Gmor\GMOY012127
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07217
Mayetiola destructor
Hessian fly
Mdes\Mdes013187
Mayetiola destructor
Hessian fly
Mdes\Mdes006608
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002922
Anopheles darlingi
American malaria mosquito
Adar\ADAC001739
Anopheles gambiae
Malaria mosquito
Agam\IR8a
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ020118
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01YB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009567
Danaus plexippus
Monarch butterfly
Dple\DPOGS215108-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004578
Apis florea
Little honeybee
Aflo\3960496452
Apis mellifera
Western honey bee
Amel\LOC409777
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16722
Bombus terrestris
Buff-tailed bumblebee
Bter\15208562
Linepithema humile
Argentine ant
Lhum\LH14616
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002dae
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012080
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12359
Tribolium castaneum
Red flour beetle
Tcas\TC003572
Pediculus humanus
Human body louse
Phum\PHUM596380
Rhodnius prolixus
Kissing bug
Rpro\RPRC017357
Cimex lectularius
Bed bug
Clec\CLEC010869
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007712
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18858
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01VZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003752
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (24)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
clumsy
3 of 10
Ekar
3 of 10
GluRIIE
3 of 10
Grik
3 of 10
Ir25a
3 of 10
Nmdar1
3 of 10
CG11155
2 of 10
GluRIA
2 of 10
GluRIB
2 of 10
GluRIIA
2 of 10
GluRIIB
2 of 10
GluRIIC
2 of 10
GluRIID
2 of 10
KaiR1D
2 of 10
Nmdar2
2 of 10
Ir21a
1 of 10
Ir31a
1 of 10
Ir64a
1 of 10
Ir75a
1 of 10
Ir75c
1 of 10
Ir75d
1 of 10
Ir76b
1 of 10
Ir84a
1 of 10
Ir93a
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Ir8a - Ir64a
    anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
    (Ai et al., 2013)
    Ir8a - Ir84a
    fluorescence microscopy, tag visualisation
    (Abuin et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Orco
    suppressible
    Ir8a
    (Silbering et al., 2011)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-27
    Cytogenetic map
    8D2-8D2
    Sequence location
    X:9,232,726..9,236,585 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    8D2-8D2
    Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    1-27
    (FlyBase, 2016)
    1-28.4
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (1)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              polyclonal
              (Abuin et al., 2011)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for identity of: Ir8a CG32704
              (Benton et al., 2009)
              Source for database merge of
              Source for merge of: CG12122 CG12666
              (FlyBase Genome Annotators, 2002-2003)
              Additional comments
              Annotations CG12122 and CG12666 merged as CG32704 in release 3 of the genome annotation.
              (FlyBase Genome Annotators, 2002-2003)
              Other Comments
              v is required for Ir64a protein trafficking and stability.
              (Ai et al., 2013)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 19 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (9)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (62)