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Gene Dmel\APC4

General Information
Symbol	Dmel\APC4	Species	D. melanogaster
Name	Anaphase Promoting Complex 4	Annotation symbol	CG32707
Feature type	protein_coding_gene	FlyBase ID	FBgn0052707
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	CG4350
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	8C4-8C7	Sequence location	X:8,976,964..8,979,900 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Anaphase Promoting Complex 4 is referred to in FlyBase by the symbol Dmel\APC4 (CG32707, FBgn0052707). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of mitotic metaphase/anaphase transition; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process. 2 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; tormogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Anaphase-promoting complex subunit 4; Anaphase-promoting complex subunit 4 long domain; Anaphase-promoting complex subunit 4, metazoa; WD40 repeat; WD40 repeat-like-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1637244_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of APC4. Gene sequence location is X:8976964..8979900.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN20053 HFA18360
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8C4-8C7   Limits computationally determined from genome sequence between P{EP}CG10962EP1565&P{EP}EP1030 and P{EP}EP1450&P{EP}EP1356
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\APC4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) APC4-RA FBtr0071285  NM_132294   2617   775 APC4-RC FBtr0309872     2611   773
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein APC4-PA   FBpp0071222   87.5   775   4.57     NP_572522   AAF46439 APC4-PC   FBpp0301606   87.2   773   4.58
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat-like-containing domain (IPR011046) WD40 repeat (IPR001680) Anaphase-promoting complex subunit 4, metazoa (IPR017169) WD40/YVTN repeat-like-containing domain (IPR015943) Anaphase-promoting complex subunit 4 (IPR024789) Anaphase-promoting complex subunit 4 long domain (IPR024790)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263382   AA392838   AA816925   AE014298 AAF46439   AI061912   AI515227   AI533521   AI542133   AI543608   AW944553   AY061618 AAL29166   BG638281   BI170073   BI230921   BI232858   BI361908   BI374656   BI579746   CO265700   CO274369   CO277058   CO300755   EC072057   EC084318   EC222884   GH751427   GH753920   GH757164   GH759295   GH774518   GH778297   GH780356   GH789077   GH790169   GH791666   GH793717   GH793733   GH797889   GH799082   GH802769   GH810481   GH811985   GH812986   GH814180   GH815343   GH819558   GH823008   GH823794   GH826285   GH829434   GH836119   GH839147   GH844160   GH846512   GH848403   GH850743   GH852446   GH853039   GH858280   GH870961   GH879394   GH886173   GH888227   GH890429   GH892055   GH892168   GH893308   GH896533   GH898928   GH898997   GH899094   GH899933   GH900566   GH903824   GH909716   GH915825   GH915840   GH916623   GH917376   GH919367   GH920685   GH921565   GH932213   GH932915
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95R47 Q9W395
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0052707    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0052707 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0052707 expression level Developmental Stage   Expression Level embryo 00-02hr    2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2380) embryo 02-04hr  (1325) embryo 04-06hr  (1206) embryo 06-08hr  (1013) embryo 08-10hr  (798) embryo 10-12hr  (530) embryo 12-14hr  (352) embryo 14-16hr  (298) embryo 16-18hr  (186) embryo 18-20hr  (112) embryo 20-22hr    89 embryo 22-24hr  105 larva L1  (335) larva L2  (291) larva L3 12hr old  (248) larva L3 puffstage 1-2  (312) larva L3 puffstage 3-6  (438) larva L3 puffstage 7-9  (485) white prepupae new  (456) white prepupae 12hr  (627) white prepupae 24hr  (696) pupae 2d postWPP  (429) pupae 3d postWPP  (258) pupae 4d postWPP  (218) adult male 01day  (319) adult male 05day  (472) adult male 30day  (485) adult female 01day  (670) adult female 05day  (1188) adult female 30day  (1234) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2380) embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0052707 expression level Developmental Stage   Expression Level embryo 00-02hr    2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2380) embryo 02-04hr  (1325) embryo 04-06hr  (1206) embryo 06-08hr  (1013) embryo 08-10hr  (798) embryo 10-12hr  (530) embryo 12-14hr  (352) embryo 14-16hr  (298) embryo 16-18hr  (186) embryo 18-20hr  112 embryo 20-22hr    89 embryo 22-24hr  105 larva L1  (335) larva L2  (291) larva L3 12hr old  (248) larva L3 puffstage 1-2  (312) larva L3 puffstage 3-6  (438) larva L3 puffstage 7-9  (485) white prepupae new  (456) white prepupae 12hr  (627) white prepupae 24hr  (696) pupae 2d postWPP  (429) pupae 3d postWPP  (258) pupae 4d postWPP  (218) adult male 01day  (319) adult male 05day  (472) adult male 30day  (485) adult female 01day  (670) adult female 05day  (1188) adult female 30day  (1234) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2380 embryo 02-04hr    1325 embryo 04-06hr    1206 embryo 06-08hr    1013 embryo 08-10hr    798 embryo 10-12hr    530 embryo 12-14hr    352 embryo 14-16hr    298 embryo 16-18hr    186 embryo 18-20hr    112 embryo 20-22hr    89 embryo 22-24hr    105 larva L1    335 larva L2    291 larva L3 12hr old    248 larva L3 puffstage 1-2    312 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    485 white prepupae new    456 white prepupae 12hr    627 white prepupae 24hr    696 pupae 2d postWPP    429 pupae 3d postWPP    258 pupae 4d postWPP    218 adult male 01day    319 adult male 05day    472 adult male 30day    485 adult female 01day    670 adult female 05day    1188 adult female 30day    1234 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0052707    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0052707 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0052707 expression level Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0052707 expression level Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    76.7 Larval Midgut    22.9 Larval Hindgut    25.7 Larval Malpighian Tubules    20.1 Larval Fat Body no informative data Larval Salivary Gland    40.2 Larval Trachea    37.45 Larval Carcass    28.35 Adult Head    24 Adult Eye    32.6 Adult Brain    46.5 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    32.7 Adult Midgut    22 Adult Hindgut    20.2 Adult Malpighian Tubules no informative data Adult Fat Body    17.5 Adult Salivary Gland no informative data Adult Heart    25.125 Adult VirginFemale Spermatheca    18.6 Adult InseminatedFemale Spermatheca    21.7 Adult Ovary    76 Adult Testis    32.7 Adult Male Accessory Gland    51.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    24   NA  Eye    32.6   NA  Brain    46.5   76.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    46.5   NA  Crop    32.7   22.9  Midgut    22   25.7  Hindgut    20.2   20.1  Malpighian Tubules    no informative data   no informative data  Fat Body    17.5   40.2  Salivary Gland    no informative data   NA  Heart    25.125   37.45  Trachea    NA   NA  VirginFemale Spermatheca    18.6   NA  InseminatedFemale Spermatheca    21.7   NA  Ovary    76   NA  Testis    32.7   NA  Male Accessory Gland    51.5   28.35  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32707-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 APC4GD11290 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 APC4GD11290 Phenotype manifest in Allele tormogen cell, with Scer\GAL4pnr-MD237 APC4GD11290 trichogen cell, with Scer\GAL4pnr-MD237 APC4GD11290
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of APC4 Class Mutagen Stocks Known lesion APC4G1040 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of APC4 Class Mutagen Stocks Known lesion APC4GD11290 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11290} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}APC4G1040 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000)
Biological Process
CV term Evidence References
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR017169, InterPro:IPR024789 (FlyBase Curators et al., 2004-) regulation of mitotic metaphase/anaphase transition inferred from electronic annotation with InterPro:IPR017169, InterPro:IPR024789 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
anaphase-promoting complex inferred from electronic annotation with InterPro:IPR017169, InterPro:IPR024789 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions APC4 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0052707 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31835
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19190 Dere\GG18284 Dgri\GH17803 Dmoj\GI15143 Dper\GL12977 Dpse\GA17093 Dsec\GM13713 Dsim\GD16927 Dvir\GJ19003 Dwil\GK25758 Dyak\GE15816
Curated drosophilid orthologs	Dpse\GA17093
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000116-PA Aedes aegypti (mosquito) AGAP002345-PA Anopheles gambiae (mosquito) XP_393301.2 Apis mellifera (honey bee) XP_001952722.1 Acyrthosiphon pisum (pea aphid) At4g21530.1 Arabidopsis thaliana (wall cress) 124010 Branchiostoma floridae (lancelet) 124012 Branchiostoma floridae (lancelet) BGIBMGA001208-PA Bombyx mori (silk worm) ENSBTAP00000000852 Bos taurus (bovine) ENSCAFP00000024193 Canis familiaris (dog) ENSCINP00000000838 Ciona intestinalis (sea squirt) CPIJ009644 Culex pipens (mosquito) ENSCPOP00000011812 Cavia porcellus (guinea pig) 103123 Capitella spl (polychaete worm) ENSDARP00000040775 Danio rerio (zebra fish) ENSECAP00000015893 Equus caballus (horse) ENSGACP00000018686 Gymnopilus aculeatus (mushroom) ENSGALP00000023184 Gallus gallus (chicken) 167167 Hypsipyla robusta (cedar shoot borer) ENSP00000318775 Homo sapiens (human) ISCW017613-PA Ixodes scapularis (deer tick) ENSMODP00000035606 Monodelphis domestica (gray opossum) ENSMMUP00000005939 Macaca mulatta (rhesus monkey) ENSMUSP00000031072 Mus musculus (house mouse) 131737 Nematostella vectensis (starlet anemone) XP_001602810.1 Nasonia vitripennis (wasp) ENSOANP00000010687 Ornithorynchus anatinus (platypus) ENSORLP00000000390 Oryzias latipes (japanese killifish) LOC_Os02g54490.1 Oryza sativa (asian rice) PHUM000450-PA Pediculus humanus (human body louse) 168296 Physcomitrella patens (moss) ENSPPYP00000016366 Pongo pygmaeus (orangutan) 817758 Populus trichocarpa (black cottonwood) ENSPTRP00000027484 Pan troglodytes (chimpanzee) ENSRNOP00000006093 Rattus norvegicus (norway rat) 5039130 Sorghum bicolor (sorghum) XP_001203585.1 Strongylocentrotus purpuratus (purple sea urchin) 55371 Trichoplax adhaerens (metazoa) XP_970702.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020820 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037068 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000002078 Xenopus tropicalis (frog) YALI0D12705g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15547 LH20071 LH11452 ISCW017613 FBgn0233381 FBgn0227717 FBgn0206149 FBgn0188507 FBgn0168644 JGI_V11_53934 FBgn0077107 FBgn0150583 FBgn0137893 FBgn0125273 FBgn0110500 FBgn0096201 CPIJ009644 BGIBMGA001208 ACYPI008007 GB18982 AGAP002345 AAEL000116 PB22062 PHUM419840 GLEAN_04376
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	33536 w* P{EP}APC4G1040
VDRC	v38988 w1118; P{GD11290}v38988 v38989 w1118; P{GD11290}v38989
Genomic Clones ( 2 )
	BACR04L24 BACR39L04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 80 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD08238
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD06225 LD11977 LD34976 LD46960 RE11421 RE16189 RE28985 RE46316 RE62304 RE73824 SD05376 SD10423
Other clones	12485 33090 54105 EK113915 EK122809 EK143423 EK179335 LD21736 RP003001211 RP003012139 RP003019816 RP003027650 RP003038980 RP003041833 RP003069762 RP003094894 RP003112481 RP003114236 RP003117259 RP003128962 RP003132861 RP003140969 RP003158481 RP003165160 RP003183168 RP003219622 RP003231423 RP003241568 RP003241712 RP003250672 RP003259965 RP003260674 RP003266951 RP003270125 RP003270467 RP003270502 RP003286598 RP003296615 RP003304831 RP003318980 RP003319575 RP003341933 RP003402799 RP003408656 RP003431624 RP003448599 RP003475364 RP003484000 RP003493404 RP003499467 RP003504601 RP003506456 RP003508589 RP003530850 RP003535648 RP003542354 RP003578062 RP003591153 RP003597904 RP003598375 RP003604329 RP003609162 RP003609629 RP003616970 RP003640665 RP003653057 RP003662612
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0052707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31835
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: APC4 CG32707 (Deak, 2005.9.6)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132294 RefSeq (Proteins) • NP_572522 DDBJ / EMBL / GenBank • AAF46439 AAL29166 ACZ95249 AI542133 AW944553 AY061618 Entrez Gene - A searchable database of RefSeq genes. • 31835 UniProtKB/TrEMBL • Q9W395 Q95R47
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat-like-containing domain (IPR011046) WD40 repeat (IPR001680) Anaphase-promoting complex subunit 4, metazoa (IPR017169) WD40/YVTN repeat-like-containing domain (IPR015943) Anaphase-promoting complex subunit 4 (IPR024789) Anaphase-promoting complex subunit 4 long domain (IPR024790)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0052707 DRSC - Results from RNAi screens. • FBgn0052707 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0052707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32707-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0052707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31835 InParanoid A subset of ortholog calls from InParanoid. • AAEL000116-PA Aedes aegypti (mosquito) AGAP002345-PA Anopheles gambiae (mosquito) XP_393301.2 Apis mellifera (honey bee) XP_001952722.1 Acyrthosiphon pisum (pea aphid) At4g21530.1 Arabidopsis thaliana (wall cress) 124010 Branchiostoma floridae (lancelet) 124012 Branchiostoma floridae (lancelet) BGIBMGA001208-PA Bombyx mori (silk worm) ENSBTAP00000000852 Bos taurus (bovine) ENSCAFP00000024193 Canis familiaris (dog) ENSCINP00000000838 Ciona intestinalis (sea squirt) CPIJ009644 Culex pipens (mosquito) ENSCPOP00000011812 Cavia porcellus (guinea pig) 103123 Capitella spl (polychaete worm) ENSDARP00000040775 Danio rerio (zebra fish) ENSECAP00000015893 Equus caballus (horse) ENSGACP00000018686 Gymnopilus aculeatus (mushroom) ENSGALP00000023184 Gallus gallus (chicken) 167167 Hypsipyla robusta (cedar shoot borer) ENSP00000318775 Homo sapiens (human) ISCW017613-PA Ixodes scapularis (deer tick) ENSMODP00000035606 Monodelphis domestica (gray opossum) ENSMMUP00000005939 Macaca mulatta (rhesus monkey) ENSMUSP00000031072 Mus musculus (house mouse) 131737 Nematostella vectensis (starlet anemone) XP_001602810.1 Nasonia vitripennis (wasp) ENSOANP00000010687 Ornithorynchus anatinus (platypus) ENSORLP00000000390 Oryzias latipes (japanese killifish) LOC_Os02g54490.1 Oryza sativa (asian rice) PHUM000450-PA Pediculus humanus (human body louse) 168296 Physcomitrella patens (moss) ENSPPYP00000016366 Pongo pygmaeus (orangutan) 817758 Populus trichocarpa (black cottonwood) ENSPTRP00000027484 Pan troglodytes (chimpanzee) ENSRNOP00000006093 Rattus norvegicus (norway rat) 5039130 Sorghum bicolor (sorghum) XP_001203585.1 Strongylocentrotus purpuratus (purple sea urchin) 55371 Trichoplax adhaerens (metazoa) XP_970702.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020820 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037068 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000002078 Xenopus tropicalis (frog) YALI0D12705g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31835 modMine - Data generated by the modENCODE project. • FBgn0052707 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15547 LH20071 LH11452 ISCW017613 FBgn0233381 FBgn0227717 FBgn0206149 FBgn0188507 FBgn0168644 JGI_V11_53934 FBgn0077107 FBgn0150583 FBgn0137893 FBgn0125273 FBgn0110500 FBgn0096201 CPIJ009644 BGIBMGA001208 ACYPI008007 GB18982 AGAP002345 AAEL000116 PB22062 PHUM419840 GLEAN_04376
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	APC4 (Buttitta et al., 2010) CG4350 (Harper et al., 2002, Acquaviva and Pines, 2006) CG32707 (Lasko, 2000, )
Name Synonym	Anaphase Promoting Complex 4 (Pal et al., 2005)
Secondary FlyBase IDs
	FBgn0030083
References ( 13 )
Research paper	Buttitta et al., 2010, J. Cell Biol. 189(6): 981--996 A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. [FBrf0211029] Lasko, 2000, J. Cell Biol. 150(2): F51--F56 The Drosophila melanogaster genome: translation factors and RNA binding proteins. [FBrf0129923]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Acquaviva and Pines, 2006, J. Cell Sci. 119(12): 2401--2404 The anaphase-promoting complex/cyclosome: APC/C. [FBrf0192160] Harper et al., 2002, Genes Dev. 16(17): 2179--2206 The anaphase-promoting complex: it's not just for mitosis any more. [FBrf0155357]
Personal communication to FlyBase	Bellen, 2010.12.8, BDGP_2010_1209.GenExel.xml BDGP_2010_1209.GenExel.xml [FBrf0212439] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Deak, 2005.9.6, Helping FlyBase: EDRC-CC13. Helping FlyBase: EDRC-CC13. [FBrf0188682] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Pal et al., 2005, Europ. Dros. Res. Conf. 19: CC13 Genetic analysis of the anaphase promoting complex in Drosophila melanogaster. [FBrf0186200]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]