FlyBase Gene Report: Dmel\Dh31-R

General Information

Symbol

Dmel\Dh31-R

Species

D. melanogaster

Name

Diuretic hormone 31 Receptor

Annotation Symbol

CG32843

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052843

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Snapshot

Diuretic hormone 31 Receptor (Dh31-R) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathwayS. [Date last reviewed: 2019-07-11]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dh31-R1, Dh31r

Key Links

Genomic Location

Cytogenetic map

49F15-50A1

Sequence location

2R:13,267,798..13,295,927 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13267798..13295927

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables diuretic hormone receptor activity

inferred from physical interaction with FLYBASE:Dh31; FB:FBgn0032048

(Johnson et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcitonin receptor activity

inferred from electronic annotation with InterPro:IPR003287

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(Radford et al., 2002, Brody and Cravchik, 2000)

enables G protein-coupled peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001737881

(assigned by GO_Central )

(Gaudet et al., 2011)

enables neuropeptide receptor activity

inferred from sequence model

(Hewes and Taghert, 2001)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Johnson et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001737881

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR017981

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence model

(Hewes and Taghert, 2001)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Johnson et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence model

(Hewes and Taghert, 2001)

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001737881

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CLASS B GPCRs, SUBFAMILY B1

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CLASS B GPCRs, SUBFAMILY B1 -: The B1 subfamily of Class B GPCRs are largely classical hormone receptors. (Adapted from FBrf0147071 and FBrf0221117).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dh31-R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Multiphase exon postulated: exon reading frame differs in alternative transcripts.

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dh31-R-RA

FBtr0087755

NM_165979

3269

443

Dh31-R-RB

FBtr0330735

NM_001274021

3284

431

Dh31-R-RC

FBtr0330736

NM_001274022

3269

604

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Dh31-R-PA

FBpp0086868

48.9

443

7.70

NP_725278

AAN16138

Dh31-R-PB

FBpp0303579

47.7

431

7.72

NP_001260950

AGB93482

Dh31-R-PC

FBpp0303580

65.8

604

7.51

NP_001260951

AGB93483

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dh31-R using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dh31-R_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

H-cell

(Fontana and Crews, 2012)

H-cell sib

(Fontana and Crews, 2012)

RNA-seq

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

ventral midline of embryo

(Fontana and Crews, 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval Malpighian tubule Type I cell

(Johnson et al., 2005)

neuron | subset of embryonic/larval central nervous system

(Johnson et al., 2005)

adult stage

adult Malpighian tubule principal cell

(Johnson et al., 2005)

neuron | subset of adult central nervous system

(Johnson et al., 2005)

Malpighian tubule

(Veenstra et al., 2008)

adult hindgut

(Veenstra et al., 2008)

adult midgut

(Veenstra et al., 2008)

crop

(Veenstra et al., 2008)

Additional Descriptive Data

Dh32-R protein is detected in principal cells of adult and larval Malpighian tubules. Dh32-R protein is detected in about 58 neurons of the larval central nervous system; 24 of these neurons coexpress Dh44-R1 protein and the neuropeptide corazonin (Crz). All larval Crz-positive neurons express Dh32-R protein. Both Dh32-R and Dh44-R1 proteins are detected in several somata in the dorsal part of the adult brain. All Crz-positive neurons in the adult CNS are also positive for both Dh32-R and Dh44-R1; while 2-4 Dh32-R-positive neurons do not coexpress either Dh44-R1 or Crz.

(Johnson et al., 2005)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Johnson et al., 2005)

Expression Deduced from Reporters

Reporter: P{GMR23F10-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult pacemaker neuron

(Kunst et al., 2014)

adult central complex

(Kunst et al., 2014)

adult pars intercerebralis

(Kunst et al., 2014)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dh31-R in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dh31-R

View exonic expression by tissue for Dmel\Dh31-R

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052843

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0052843

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CT30298;CG32843-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32843

Flygut - An atlas of the Drosophila adult midgut

FBgn0052843

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dh31-R

Transgenic constructs containing regulatory region of Dh31-R

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Dh31-R^f05546

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dh31-R^GD3782

viable, with Scer\GAL4^Mef2.PR

Dh31-R^GD3782

viable, with Scer\GAL4^pnr-MD237

Dh31-R^GD3782

viable, with Scer\GAL4^tin.CΔ4

Dh31-R^GD3782

Sterility

Allele

fertile

Dh31-R^f05546

Other Phenotypes

Allele

hypoactive | adult stage, with Scer\GAL4^elav.PU

Dh31-R^JF01945

temperature response defective | adult stage, with Scer\GAL4^elav-C155

temperature response defective | adult stage, with Scer\GAL4^tim.PE

temperature response defective | adult stage (with Df(2R)BSC273)

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CALCRL

14 of 15

Yes

Hsap\CALCR

11 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Calcrl

13 of 15

Yes

Mmus\Calcr

11 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Nnmt

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Calcr

10 of 13

Yes

Rnor\Calcrl

9 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Nnmt

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (21)

Xtro\calcrl

12 of 12

Yes

Xtro\calcr

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\gcgr

1 of 12

Xtro\gipr

1 of 12

Xtro\inmt

1 of 12

Yes

Xtro\LOC548368

1 of 12

Yes

Xtro\LOC594886

1 of 12

Yes

Xtro\LOC100127789

1 of 12

Yes

Xtro\LOC100145174

1 of 12

Yes

Xtro\MGC88898

1 of 12

Yes

Xtro\MGC107884

1 of 12

Yes

Xtro\nnmt

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (21)

Drer\calcr

10 of 15

Yes

Drer\calcrla

10 of 15

Yes

Drer\calcrlb

10 of 15

Yes

Drer\calcrl2

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\seb-2

4 of 15

Yes

Cele\pdfr-1

3 of 15

Cele\seb-3

3 of 15

Cele\anmt-2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919064S )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17177

Drosophila persimilis

Dper\GL11103

Drosophila willistoni

Dwil\GK17827

Drosophila virilis

Dvir\GJ21197

Drosophila mojavensis

Dmoj\GI19445

Drosophila grimshawi

Dgri\GH20277

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503U2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17024563

Glossina morsitans

Tsetse fly

Gmor\GMOY010919

Mayetiola destructor

Hessian fly

Mdes\Mdes008675

Aedes aegypti

Yellow fever mosquito

Aaeg\GPRCAL1

Anopheles darlingi

American malaria mosquito

Adar\ADAC008396

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014419

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07VW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009927

Danaus plexippus

Monarch butterfly

Dple\DPOGS205719-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS200896-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004721

Apis florea

Little honeybee

Aflo\2411846100

Apis mellifera

Western honey bee

Amel\GB47217

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17208

Bombus terrestris

Buff-tailed bumblebee

Bter\15212510

Linepithema humile

Argentine ant

Lhum\LH10572

Linepithema humile

Argentine ant

Lhum\LH13022

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0006de

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010141

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06258

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06254

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08442

Tribolium castaneum

Red flour beetle

Tcas\TC013321

Tribolium castaneum

Red flour beetle

Tcas\TC032502

Pediculus humanus

Human body louse

Phum\PHUM428070

Rhodnius prolixus

Kissing bug

Rpro\RPRC009814

Rhodnius prolixus

Kissing bug

Rpro\RPRC004735

Rhodnius prolixus

Kissing bug

Rpro\RPRC004753

Cimex lectularius

Bed bug

Clec\CLEC025204

Cimex lectularius

Bed bug

Clec\CLEC013307

Cimex lectularius

Bed bug

Clec\CLEC000667

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001361

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI086115

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI49367

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009569

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007222

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16567

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14225

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07RH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR010909

Strigamia maritima

European centipede

Smar\SMAR013272

Ixodes scapularis

Black-legged tick

Isca\ISCW012970

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72604.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g02300

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_299723

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0C0V )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Crhr1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

hec

4 of 10

Pdfr

4 of 10

Dh44-R1

3 of 10

Dh44-R2

3 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CALCR; calcitonin receptor

model of osteoporosis

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CALCRL; calcitonin receptor like receptor

14 of 15

114190

LYMPHATIC MALFORMATION 8; LMPHM8

CALCR; calcitonin receptor

11 of 15

114131

OSTEOPOROSIS

osteoporosis

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052843

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36475

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F15-50A1

Sequence location

2R:13,267,798..13,295,927 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F15-50A1

Limits computationally determined from genome sequence between P{EP}Dp^EP358 and P{lacW}drk^k13809&P{EP}mip120^EP606

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

68216

w^*; P{UAS-Dh31-R.D}2

84625

TI{2A-GAL4}Dh31-R^2A-ABC.GAL4

84491

w^*; TI{TI}Dh31-R^attP

84626

TI{2A-GAL4}Dh31-R^2A-C.GAL4/CyO

84382

TI{2A-lexA::GAD}Dh31-R^2A-C.lexA/CyO

85703

w¹¹¹⁸; PBac{WH}Dh31-R^f05546

85728

w¹¹¹⁸; PBac{WH}Dh31-R^f06589/CyO

56100

y¹ w^*; Mi{MIC}Dh31-R^MI10974

22718

y¹ w^67c23; Mi{ET1}Dh31-R^MB00175

25925

y¹ v¹; P{TRiP.JF01945}attP2/TM3, Sb¹

VDRC

v101995

P{KK108756}VIE-260B

v8777

w¹¹¹⁸; P{GD3782}v8777

Genomic Clones (39)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (112)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE24343

Other clones

FI24078

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052843

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052843

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36475

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Goda et al., 2018, Johnson et al., 2005)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Dh31-R1 CG32843

(Johnson et al., 2005)

Source for identity of: Dh31-R Dh31-R1

(FlyBase, 2009-)

Source for database merge of

Source for merge of: CG32843 anon-WO0170980.136 anon-WO0170980.137

(FlyBase, 1996-)

Source for merge of: CG17415 CG17043

(FlyBase Genome Annotators, 2002-2003)

Additional comments

FlyBase curator comment: Although named as 'DH31-R1' in FBrf0184113, a later paper by the same author (FBrf0208781) refers to the gene as 'DH31R', as it is now known to encode the only Dh31 receptor in D. melanogaster. Therefore, removed the '1' suffix from the FlyBase gene symbol as this is superfluous and wrongly suggests there are additional Dh31-R genes.

(FlyBase, 2009-)

Annotations CG17415 and CG17043 merged as CG32843 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG32843 anon-WO0170980.136 anon-WO0170980.137 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36475

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052843

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052843

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dh31-R_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32843

Flygut - An atlas of the Drosophila adult midgut

FBgn0052843

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36475

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032502

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG32843

modMine - A data warehouse for the modENCODE project

FBgn0052843

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052843

DRSC - Results frm RNAi screens

FBgn0052843

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0052843

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CT30298;CG32843-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052843

FlyMine - An integrated database for Drosophila genomics

FBgn0052843

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36475

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

CG17043

(Hauser et al., 2006, Metpally and Sowdhamini, 2005, Wang et al., 2004)

CG17415

(Liang et al., 2017, Duvall and Taghert, 2012, Nässel and Winther, 2010, Hector et al., 2009, Hauser et al., 2006, Hauser et al., 2006, Johnson et al., 2005, Mertens et al., 2005, Mertens et al., 2005, Wang et al., 2004, Radford et al., 2002, Harmar, 2001)

CG32843

(Kondo et al., 2020, Yu et al., 2016, Ashwal-Fluss et al., 2014, Li et al., 2013, Younger et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Cardoso et al., 2006, Hyun et al., 2005)

DH31

(Kula-Eversole et al., 2010)

DH31-R

(Nässel and Vanden Broeck, 2016, Hector et al., 2009)

DH31-R1

(Mazzotta et al., 2020, Johnson et al., 2005)

DH31R

(Kula-Eversole et al., 2010)

Dh31-R

(Kondo et al., 2020, Zarubin et al., 2020, Goda and Hamada, 2019, Hajji et al., 2019, Rao and Deng, 2019.10.23)

Dh31-R1

(Crocker et al., 2016, Caers et al., 2012, Jumbo-Lucioni et al., 2010, Kula-Eversole et al., 2010)

Dh31R

(Deng et al., 2019, Takeda et al., 2018)

Dh31r

(Goda et al., 2019, Goda et al., 2018)

DmeCG32843

(Cardoso et al., 2006)

anon-WO0170980.136

anon-WO0170980.137

dh31-R1

(Duvall and Taghert, 2012)

Name Synonyms

CG32843

Calcitonin-like diuretic hormone receptor

(Caers et al., 2012)

DH31 Receptor

(Choi et al., 2009)

DH31-receptor

(Veenstra et al., 2008)

DH31 receptor

(Johnson et al., 2005)

Diuretic hormone 31 Receptor

(Yu et al., 2016)

Diuretic hormone 31 receptor 1

Secondary FlyBase IDs

FBgn0033824
FBgn0033825
FBgn0046596
FBgn0046597

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (80)

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