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Gene Dmel\4EHP

General Information
Symbol	Dmel\4EHP	Species	D. melanogaster
Name	eIF4E-Homologous Protein	Annotation symbol	CG33100
Feature type	protein_coding_gene	FlyBase ID	FBgn0053100
Gene Model Status	Current	Stock availability	26 publicly available
Also Known As	d4EHP, eIF4E-8, 4E-HP
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95E1-95E1	Sequence location	3R:19,888,799..19,934,682 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eIF4E-Homologous Protein is referred to in FlyBase by the symbol Dmel\4EHP (CG33100, FBgn0053100). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; translation repressor activity; RNA 7-methylguanosine cap binding. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; imaginal disc-derived wing morphogenesis; negative regulation of translation; neurogenesis. 33 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Translation Initiation factor eIF- 4e; Translation Initiation factor eIF- 4e-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary, adult testis. Gene sequence location is 3R:19888799..19934682.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95E1-95E1   Limits computationally determined from genome sequence between P{PZ}Atg600096 and P{PZ}Syx1A06737&P{PZ}Syx1A10660
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\4EHP for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Shares 3' UTR sequences with downstream gene.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) 4EHP-RA FBtr0084587  NM_176552   1855   223 4EHP-RB FBtr0300475  NM_001170239   2401   248 4EHP-RC FBtr0303159  NM_001202345   4539   186 4EHP-RD FBtr0303160  NM_001202346   1324   242
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein 4EHP-PA   FBpp0083972   25.8   223   7.88     NP_788729   AAF56233 4EHP-PB   FBpp0289702   28.7   248   8.72     NP_001163710   ACZ95004 4EHP-PC   FBpp0292258   21.6   186   7.03     NP_001189274   ADV37364 4EHP-PD   FBpp0292259   28.3   242   9.09     NP_001189275   ADV37365
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Translation Initiation factor eIF- 4e (IPR001040) Translation Initiation factor eIF- 4e-like domain (IPR023398)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202578   AA390938   AA695692   AA696579   AA696739   AA801576   AA802918   AE014297 AAF56233   AE014297 ACZ95004   AE014297 ADV37364   AE014297 ADV37365   AI534253   AY094966 AAM11319   BE977497   BG636425   BH011415   BI167832   BI170786   BI227807   BI361393   BI609938   BP555759   BT022089   BT081409   BT124868   CL610208   CO152804   CO156046   CO178132   CO178385   CO178476   CO180081   CO187630   CO190344   CO190502   CO269613   CO272170   CO273968   CO277312   CO278893   CO280225   CO283252   CO284447   CO287246   CO293783   CO296139   CO297939   CO298760   CO299358   CO299629   CO302018   CO302806   CO305111   CO306121   CO313477   CO314474   CO319025   CO324772   CO325488   CO330141   CO331239   CO331960   CO337424   CO338481   CO341557   CZ466579   CZ466580   CZ467648   CZ467649   CZ470291   CZ470376   CZ470983   CZ475362   CZ478980   CZ482174   CZ482175   CZ485394   CZ485595   EC060572   EC062428   EC065841   EC065887   EC067437   EC067758   EC068022   EC069792   EC071404   EC073684   EC084755   EC084936   EC086327   EC088112   EC195761   EC202932   EC204512   EC206574   EC207198   EC211842   EC212674   EC214198   EC214228   EC221703   EC224749   EC226426   EC229977   EC232325   EC234155   EC237775   EC241356   EC241612   EC245056   EC248816   EC252204   EC258947   EC259108   EC263945   EC264293   EC265330   EV578649   GH755221   GH760233   GH771743   GH773125   GH776785   GH782246   GH787484   GH787673   GH792872   GH801489   GH804601   GH807607   GH814048   GH819356   GH819532   GH824825   GH829026   GH829910   GH830720   GH833111   GH843488   GH843490   GH855970   GH860004   GH862291   GH865053   GH873718   GH878833   GH880250   GH880647   GH885425   GH887392   GH895350   GH900997   GH904069   GH904654   GH913594   GH914409   GH920201   GH921525   GH922090   GH929027   GH931354   GH937359   GH938502   GH938839   GH940719
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T3K5 E1JIV5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    47 central nervous system, pupae P8    169 head, virgin 1-day female    100 head, virgin 4-day female    87 head, virgin 20-day female    17 head, mated 1-day female    109 head, mated 4-day female    68 head, mated 20-day female    22 head, mated 1-day male    131 head, mated 4-day male    124 head, mated 20-day male    67 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    37 carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3  (47) central nervous system, pupae P8  (169) head, virgin 1-day female  (100) head, virgin 4-day female  (87) head, virgin 20-day female    17 head, mated 1-day female  (109) head, mated 4-day female  (68) head, mated 20-day female    22 head, mated 1-day male  (131) head, mated 4-day male  (124) head, mated 20-day male  (67) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8  (37) carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female  (74) ovary, mated 4-day female  (85) testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    47 central nervous system, pupae P8  (169) head, virgin 1-day female    100 head, virgin 4-day female    87 head, virgin 20-day female    17 head, mated 1-day female  (109) head, mated 4-day female    68 head, mated 20-day female    22 head, mated 1-day male  (131) head, mated 4-day male  (124) head, mated 20-day male    67 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    37 carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    47 central nervous system, pupae P8    169 head, virgin 1-day female    100 head, virgin 4-day female    87 head, virgin 20-day female    17 head, mated 1-day female    109 head, mated 4-day female    68 head, mated 20-day female    22 head, mated 1-day male    131 head, mated 4-day male    124 head, mated 20-day male    67 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    37 carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    47 central nervous system, pupae P8    169 head, virgin 1-day female    100 head, virgin 4-day female    87 head, virgin 20-day female    17 head, mated 1-day female    109 head, mated 4-day female    68 head, mated 20-day female    22 head, mated 1-day male    131 head, mated 4-day male    124 head, mated 20-day male    67 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    37 carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3  (47) central nervous system, pupae P8  (169) head, virgin 1-day female  (100) head, virgin 4-day female  (87) head, virgin 20-day female    17 head, mated 1-day female  (109) head, mated 4-day female  (68) head, mated 20-day female    22 head, mated 1-day male  (131) head, mated 4-day male  (124) head, mated 20-day male  (67) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8  (37) carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female  (74) ovary, mated 4-day female  (85) testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    47 central nervous system, pupae P8  (169) head, virgin 1-day female    100 head, virgin 4-day female    87 head, virgin 20-day female    17 head, mated 1-day female  109 head, mated 4-day female    68 head, mated 20-day female    22 head, mated 1-day male  131 head, mated 4-day male  124 head, mated 20-day male    67 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    37 carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    47 central nervous system, pupae P8    169 head, virgin 1-day female    100 head, virgin 4-day female    87 head, virgin 20-day female    17 head, mated 1-day female    109 head, mated 4-day female    68 head, mated 20-day female    22 head, mated 1-day male    131 head, mated 4-day male    124 head, mated 20-day male    67 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    9 digestive system, 4-day adult    16 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    37 carcass, larvae L3 wandering    17 carcass, 1-day adult    17 carcass, 4-day adult    23 carcass, 20-day adult    13 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    17 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    9 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    9 embryo 18-20hr    8 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    11 larva L2    9 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    7 adult female 01day    6 adult female 05day    12 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167    37 embryonic S1    11 embryonic S3    29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    29 ovary fGS/OSS    25 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167  (37) embryonic S1    11 embryonic S3  (29) leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32  (28) haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (29) ovary fGS/OSS    25 ovary OSC  (37) ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167    37 embryonic S1    11 embryonic S3    29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    29 ovary fGS/OSS    25 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167    37 embryonic S1    11 embryonic S3    29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    29 ovary fGS/OSS    25 ovary OSC    37 ovary OSS    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167    37 embryonic S1    11 embryonic S3    29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    29 ovary fGS/OSS    25 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167  (37) embryonic S1    11 embryonic S3  29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32  28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  29 ovary fGS/OSS    25 ovary OSC  (37) ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167    37 embryonic S1    11 embryonic S3    29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    29 ovary fGS/OSS    25 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    12 embryonic 1182-4H    10 embryonic GM2    16 embryonic Kc167    37 embryonic S1    11 embryonic S3    29 leg disc CME L1    18 wing disc CME-W2    24 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    10 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    29 ovary fGS/OSS    25 ovary OSC    37 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    62 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    38 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (100) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  (62) Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult  (38) Paraquat 5 mM 48 hrs, 4-day adult  (47) Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    62 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    38 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    62 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    38 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    62 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    38 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (100) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  (62) Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult  (38) Paraquat 5 mM 48 hrs, 4-day adult  (47) Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    62 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    38 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    24 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    62 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    38 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • SD07020 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053100 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33100-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for 4EHP Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal 4EHPGD7071 lethal | recessive 4EHP05b partially lethal - majority die | embryonic stage | maternal effect 4EHPCP53 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 4EHPGD7071 viable 4EHPCB05417 4EHPCP53 4EHPe03164 4EHPEY08369 Sterility Allele fertile 4EHPe03164 4EHPEY08369 Other Phenotypes Allele behavior defective | recessive 4EHPBG01713 neuroanatomy defective | larval stage 4EHPGD7071 visible, with Scer\GAL4pnr-MD237 4EHPGD7071 Phenotype manifest in Allele embryonic head segment | maternal effect 4EHPCP53 ganglion mother cell | larval stage 4EHPGD7071 mesothoracic tergum, with Scer\GAL4pnr-MD237 4EHPGD7071 trichogen cell, with Scer\GAL4pnr-MD237 4EHPGD7071
Classical Alleles ( 28 )
For All Classical Alleles Show
Allele of 4EHP Class Mutagen Stocks Known lesion 4EHPe03164 piggyBac transposase 2 -- 4EHP05b 1 Yes 4EHP06737 P-element activity 1 Yes 4EHP5-HA-1159 1 -- 4EHPBG01713 P-element activity 1 -- 4EHPc00588 piggyBac transposase 1 -- 4EHPc02059 piggyBac transposase 1 -- 4EHPc05841 piggyBac transposase 1 -- 4EHPc05943 piggyBac transposase 1 -- 4EHPc06768 piggyBac transposase 1 -- 4EHPd02782 1 -- 4EHPd06795 P-element activity 1 -- 4EHPe01165 piggyBac transposase 1 -- 4EHPe04417 piggyBac transposase 1 -- 4EHPe04418 piggyBac transposase 1 -- 4EHPEY08369 P-element activity 1 -- 4EHPf01079 1 -- 4EHPf02839 piggyBac transposase 1 -- 4EHPf03038 piggyBac transposase 1 -- 4EHPMI03197 1 -- 4EHPNP0665 1 -- 4EHPNP5345 1 -- 4EHP10660 P-element activity 0 Yes 4EHPCB05417 P-element activity 0 Yes 4EHPCP53 hypomorphic allele - genetic evidence P-element activity 0 Yes 4EHPd06886 0 -- 4EHPDG10811 0 -- 4EHPEP3215 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of 4EHP Class Mutagen Stocks Known lesion 4EHPGD7071 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes 4EHPGL01035 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 4EHPScer\UAS.P\T.cCa in vitro construct - regulatory fusion 0 Yes 4EHPW114A.Scer\UAS.P\T in vitro construct - site directed mutagenesis 0 Yes 4EHPW85F.Scer\UAS.P\T in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7071} NA P{TRiP.GL01035} NA P{UASp-4EHP.C} NA P{UASp-4EHP.W85F} NA P{UASp-4EHP.W114A} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Syx1AEP3215 NA P{EPgy2}4EHPEY08369 NA P{XP}4EHPd02782 NA P{XP}4EHPd06795 NA P{XP}4EHPd06886 NA insertion of enhancer trap P{PZ}Syx1A06737 No P{PZ}Syx1A10660 No miscellaneous insertions Mi{MIC}4EHPMI03197 NA P{GT1}4EHPBG01713 NA P{PTT-GB}4EHPCB05417 NA P{RS5}4EHP5-HA-1159 NA P{UASp-YFP.Rab3}4EHP05b NA P{wHy}4EHPDG10811 NA PBac{PB}4EHPc00588 NA PBac{PB}4EHPc02059 NA PBac{PB}4EHPc05841 NA PBac{PB}4EHPc05943 NA PBac{PB}4EHPc06768 NA PBac{PB}Syx1Ac05841 NA PBac{RB}4EHPe01165 NA PBac{RB}4EHPe03164 NA PBac{RB}4EHPe04417 NA PBac{RB}4EHPe04418 NA PBac{WH}4EHPf01079 NA PBac{WH}4EHPf02839 NA PBac{WH}4EHPf03038 NA insertion of enhancer trap binary system P{GawB}4EHPNP0665 No P{GawB}4EHPNP5345 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
NOT eukaryotic initiation factor 4G binding inferred from direct assay (Hernandez et al., 2005) protein binding inferred from physical interaction with bcd (Cho et al., 2005) inferred from physical interaction with brat (Cho et al., 2006) RNA 7-methylguanosine cap binding inferred from direct assay (Hernandez et al., 2005, Cho et al., 2005) translation repressor activity inferred from genetic interaction with bcd (Cho et al., 2005)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) negative regulation of translation inferred from genetic interaction with bcd (Cho et al., 2005) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
translation initiation factor activity inferred from sequence or structural similarity with EMBL:AF038957 (FlyBase Genome Annotators, 2002-2003)
Biological Process
CV term Evidence References
translational initiation inferred from sequence or structural similarity with EMBL:AF038957 (FlyBase Genome Annotators, 2002-2003)
Cellular Component
CV term Evidence References
eukaryotic translation initiation factor 4F complex inferred from sequence or structural similarity with EMBL:AF038957 (FlyBase Genome Annotators, 2002-2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
4EHP - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - CG11148 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) 4EHP - CG1532 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Dlc90F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Oscillin experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) 4EHP - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Prosα6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Prosα7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Prosβ3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - TFAM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - Tim8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - abs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 4EHP - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions 4EHP allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77505 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0053100 DroID - A comprehensive database of gene and protein interactions. • FBgn0053100 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 326255
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66WZVQ Dipteran inclusive ortholog search EOG6WM53S Insect inclusive ortholog search EOG66HF6V Arthropod inclusive ortholog search EOG61NS35 Metazoa inclusive ortholog search EOG67Q91P
Orthologs in Drosophila Species (EOG66WZVQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\4EHP     Drosophila simulans   Dsim\GD18325 Y   Drosophila sechellia   Dsec\GM23515 Y   Drosophila erecta   Dere\GG12377 Y   Drosophila yakuba   Dyak\GE10831 Y   Drosophila ananassae   Dana\GF23230 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26519 Y   Drosophila persimilis   Dper\GL24147 Y   Drosophila willistoni   Dwil\GK11937 Y   Drosophila virilis   Dvir\GJ14537 Y   Drosophila mojavensis   Dmoj\GI23433 Y   Drosophila grimshawi   Dgri\GH19097 Y
Orthologs in non-Drosophila Dipterans (EOG6WM53S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005796   Anopheles gambiae Malaria mosquito  Agam\AGAP002948   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012031
Orthologs in non-Dipteran Insects (EOG66HF6V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\4EHP   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010640   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19644   Atta cephalotes Leafcutter ant  Acep\ACEP16284   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15870   Linepithema humile Argentine ant  Lhum\LH23481   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10924   Solenopsis invicta Red fire ant  Sinv\SINV14953   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000423   Bombyx mori Silkmoth  Bmor\BGIBMGA013605   Pediculus humanus Human body louse  Phum\PHUM529670   Tribolium castaneum Red flour beetle  Tcas\eIF-4E
Orthologs in non-Insect Arthropods (EOG61NS35)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_231617   Ixodes scapularis Deer tick  Isca\ISCW006138
Orthologs in non-Arthropod Metazoa (EOG67Q91P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ife-4   Strongylocentrotus purpuratus Purple sea urchin  Spur\eif4e2   Danio rerio Zebrafish  Drer\eif4e2   Danio rerio Zebrafish  Drer\eif4e2rs1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000027885   Xenopus tropicalis Western clawed frog  Xtro\eif4e2   Gallus gallus Domestic chicken  Ggal\EIF4E2   Mus musculus House mouse  Mmus\Eif4e2   Rattus norvegicus Norway rat  Rnor\Eif4e2   Homo sapiens Human  Hsap\tmp_locus_9
Human Orthologs (1)
Gene OMIM HGNC Hsap\tmp_locus_9
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18325 Drosophila sechellia Dsec\GM23515 Drosophila erecta Dere\GG12377 Drosophila yakuba Dyak\GE10831 Drosophila ananassae Dana\GF23230 Drosophila pseudoobscura pseudoobscura Dpse\GA26519 Drosophila persimilis Dper\GL24147 Drosophila willistoni Dwil\GK11937 Drosophila virilis Dvir\GJ14537 Drosophila mojavensis Dmoj\GI23433 Drosophila grimshawi Dgri\GH19097
Stocks & Reagents
Stocks Listed in FlyBase ( 26 )
Harvard	- P{XP}4EHPd02782 - P{XP}4EHPd06795 - PBac{PB}4EHPc00588 - PBac{PB}4EHPc02059 - PBac{PB}4EHPc05841 - PBac{PB}4EHPc05943 - PBac{PB}4EHPc06768 - PBac{RB}4EHPe01165 - PBac{RB}4EHPe03164 - PBac{RB}4EHPe04417 - PBac{RB}4EHPe04418 - PBac{WH}4EHPf01079
	More stocks available...
Genomic Clones ( 2 )
	BACR15J11 BACR29F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 145 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE12368 SD07020
Other clones	DPiM_SD07020 MIP06235 MIP18429
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM04306 GM06566 GM07927 GM08313 HL02321 LD02719 LD11779 RE08313 RE25062 RE45584 RH14789
Other clones	8104 12250 32087 37992 39958 43454 47282 49943 53579 61590 66898 80490 107267 117416 117762 118061 119354 125118 144439 144971 148705 174794 191903 214377.18 214479.19 214539.17 274537 283563 527088 569091 572715 bs64g04 CK01.36B.F6 CK01.59A.C6 CK01.61C.C11 CK01.69B.F5 CK01.69B.G2 CK01.71C.G9 CK01.132B.G8 Dmel_dig_018620_0635_1020 EC00872 EC212674 EK030942 EK047833 EK048412 EK055423 EK056604 EK056826 EK065318 EK095160 EK106054 EK112759 EK123807 EK132107 EK153430 EK162715 EK166102 EK170947 EK173816 EK175146 EK175960 EK182906 EK184930 EK194817 EK196635 EK204814 EK212817 EK233038 EK236612 EK247443 EK250312 EK276022 EK294612 EK298860 EK302136 EN00461 EN07243 EN14526 EN16911 EP12653 FGM237A04 RP003034253 RP003050837 RP003065398 RP003074380 RP003080439 RP003088519 RP003089334 RP003092496 RP003138673 RP003143564 RP003154820 RP003195400 RP003200767 RP003207185 RP003214416 RP003215934 RP003220404 RP003226443 RP003291959 RP003302014 RP003306174 RP003310923 RP003317256 RP003321769 RP003332532 RP003344940 RP003347444 RP003376703 RP003384679 RP003403859 RP003414446 RP003415445 RP003429373 RP003437381 RP003447515 RP003480808 RP003490785 RP003521648 RP003528370 RP003562990 RP003580186 RP003580201 RP003580496 RP003589801 RP003639542 RP003647125 RP003653110 SD14138
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053100 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 326255
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: 4EHP CG33100 (Lasko, 2005.9.7)
Source for database merge of
Additional comments	Annotation CG10716 split into CG33100 and CG31136 (Syx1A) in release 3 of the genome annotation. In addition release 3 annotation CG31136 (Syx1A) contains sequences corresponding to release 2 annotation CG18615. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	brat and 4EHP interact physically and both play a role in hb regulation. (Cho et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176552 NM_001170239 NM_001202345 NM_001202346 RefSeq (Proteins) • NP_788729 NP_001163710 NP_001189274 NP_001189275 DDBJ / EMBL / GenBank • AAF56233 AAM11319 ACZ95004 ADV37364 ADV37365 AI534253 AY094966 BH011415 BI170786 CL610208 CZ466579 CZ466580 CZ467648 CZ467649 CZ470291 CZ470376 CZ470983 CZ475362 CZ478980 CZ482174 CZ482175 CZ485394 CZ485595 Entrez Gene - A searchable database of RefSeq genes. • 326255 UniProtKB/TrEMBL • E1JIV5 Q8T3K5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Translation Initiation factor eIF- 4e (IPR001040) Translation Initiation factor eIF- 4e-like domain (IPR023398) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD07020
Linkouts
	BioGRID - A database of protein and genetic interactions • 77505 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0053100 DroID - A comprehensive database of gene and protein interactions. • FBgn0053100 DRSC - Results from RNAi screens. • FBgn0053100 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053100 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33100-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053100 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 326255 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/fourehp_translation.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 326255 modMine - Data generated by the modENCODE project. • FBgn0053100
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	4EHP (Buszczak et al., 2007, Zhang et al., 2007, Tadros et al., 2007, Ayroles et al., 2009, Edwards et al., 2009, Temme et al., 2010, Cho et al., 2005, Reis et al., 2010, Carreira et al., 2011) 4E-HP (Hernandez et al., 2012, Tettweiler et al., 2012) CG10716 (Robertson, 2001.5.6, ) CG33100 (Hernandez et al., 2005, Myrick et al., 2005.5.16, Hernandez and Vazquez-Pianzola, 2005, Ni et al., 2011.7.19, Hazelett et al., 2009, Tettweiler et al., 2012) CT30033 (Xie and Ding, 2000) d4EHP (Cho et al., 2005, Cho et al., 2005, Cho et al., 2006, Okumura et al., 2007, Hernandez and Vazquez-Pianzola, 2005, Singh et al., 2011, Yarunin et al., 2011) eIF4E-8 (Hernandez et al., 2005, Hernandez et al., 2006, Hernandez and Vazquez-Pianzola, 2005)
Name Synonym	4EHP (Lasko, 2005.9.7, Cho et al., 2005) eIF4E-Homologous Protein
Secondary FlyBase IDs
	FBgn0039148
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 7 ) Review  ( 2 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 4 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Hernandez et al., 2012, Development 139(17): 3211--3220 Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. [FBrf0219080] Tettweiler et al., 2012, Comp. Funct. Genomics 2012: 960420 The Distribution of eIF4E-Family Members across Insecta. [FBrf0218730] Weidmann and Goldstrohm, 2012, Mol. Cell. Biol. 32(2): 527--540 Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor. [FBrf0217089] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Singh et al., 2011, Dev. Biol. 352(1): 104--115 The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo. [FBrf0213172] Yarunin et al., 2011, RNA Biol. 8(5): 904--912 Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors. [FBrf0217939] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...