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Gene Dmel\NLaz

General Information
Symbol	Dmel\NLaz	Species	D. melanogaster
Name	Neural Lazarillo	Annotation symbol	CG33126
Feature type	protein_coding_gene	FlyBase ID	FBgn0053126
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	22A1-22A1	Sequence location	2L:1,359,983..1,361,732 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Neural Lazarillo is referred to in FlyBase by the symbol Dmel\NLaz (CG33126, FBgn0053126). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: lipid binding. There is experimental evidence that it is involved in the biological process: triglyceride homeostasis; determination of adult lifespan; response to oxidative stress; multicellular organism reproduction; carbohydrate homeostasis. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Calycin; Calycin-like; Invertebrate colouration protein; Lipocalin, ApoD type; Lipocalin/cytosolic fatty-acid binding protein domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult hindgut, adult Malpighian tubules, larval fat body, adult salivary gland, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval Malpighian tubules, adult heart, adult spermathecae, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1630593_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of NLaz. Gene sequence location is 2L:1359983..1361732.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22A1-22A1   Limits computationally determined from genome sequence between P{PZ}l(2)1068510685&P{lacW}Tango14k00619 and P{lacW}RFeSPk11704
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\NLaz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) NLaz-RA FBtr0077942  NM_175946   914   224 NLaz-RB FBtr0329947  NM_001272938   914   245
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein NLaz-PA   FBpp0077607   24.3   224   4.67     NP_787960   AAF51378 NLaz-PB   FBpp0302979   27.1   245   4.73     NP_001259867   AGB92404
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Lipocalin/cytosolic fatty-acid binding protein domain (IPR000566) Calycin-like (IPR011038) Calycin (IPR012674) Lipocalin, ApoD type (IPR022271) Invertebrate colouration protein (IPR003057)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51378   AF276505 AAF85707   AE014134 AGB92404   AY084185 AAL89923   BE662178   BF496159   BI484476   BI626833   CA806672   CA807771   CK131396   CO181702   CO194422   CO269736   CO286747   CO342536   EC206997   EC243218   EC254858   EV578501   EV579762   EV582018   EV583049   EV592885   GH751066   GH751820   GH751986   GH752210   GH752451   GH753728   GH754017   GH754635   GH754708   GH754835   GH758561   GH760546   GH770280   GH771309   GH771513   GH772346   GH773390   GH774123   GH774222   GH775663   GH776375   GH777644   GH777741   GH778830   GH779046   GH780208   GH781898   GH783256   GH783844   GH784767   GH785371   GH786166   GH787151   GH787161   GH787325   GH791344   GH791519   GH793697   GH793774   GH793816   GH795275   GH795598   GH796003   GH796133   GH797710   GH799614   GH799771   GH799879   GH800022   GH801015   GH801651   GH802175   GH802390   GH804940   GH805830   GH807198   GH807572   GH807591   GH807741   GH807976   GH808601   GH808627   GH808718   GH808747   GH809789   GH811097   GH815240   GH815908   GH816732   GH816811   GH817080   GH817896   GH818017   GH818181   GH820038   GH820045   GH821520   GH822070   GH822779   GH823113   GH824831   GH825174   GH825379   GH825495   GH825546   GH825703   GH826406   GH827514   GH828326   GH829415   GH830061   GH830282   GH831589   GH831763   GH831914   GH832380   GH832689   GH832984   GH833065   GH835592   GH835753   GH836033   GH836226   GH836236   GH837482   GH837732   GH839714   GH840555   GH841244   GH841959   GH844310   GH845231   GH845329   GH845813   GH847849   GH849780   GH851284   GH852222   GH852374   GH852599   GH853129   GH854132   GH854369   GH854927   GH855916   GH857527   GH857938   GH858562   GH859956   GH860437   GH862852   GH863372   GH864169   GH865525   GH868446   GH868669   GH870547   GH872031   GH872420   GH873117   GH875350   GH876817   GH877681   GH878058   GH878679   GH880835   GH880875   GH882204   GH882311   GH883485   GH883873   GH885102   GH886108   GH886346   GH887019   GH887109   GH887663   GH887882   GH889273   GH889712   GH893468   GH893558   GH894017   GH895466   GH895849   GH895939   GH896240   GH902298   GH904443   GH905473   GH905530   GH905864   GH906598   GH909469   GH909899   GH910047   GH910203   GH910682   GH910758   GH910913   GH913009   GH916880   GH917679   GH918888   GH919284   GH920056   GH920527   GH920629   GH921159   GH922513   GH923328   GH925226   GH926046   GH926436   GH926809   GH928913   GH929041   GH929267   GH932244   GH932499   GH934370   GH935560   GH936343   GH936498   GH936577   GH937179   GH938076   GH938722   GH940898
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SXR1 Q9NAZ4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 11   cell | subset of visceral mesoderm | anterior & dorsal   (Sanchez et al., 2000) embryonic stage 12 -- 13   amnioserosa   (Sanchez et al., 2000) embryonic fat body   (Sanchez et al., 2000) embryonic stage 12 -- 16   embryonic/larval neuron | subset of embryonic/larval central nervous system   (Sanchez et al., 2000) embryonic neuroblast | subset of embryonic/larval central nervous system   (Sanchez et al., 2000) embryonic stage 13   midgut primordium   (Sanchez et al., 2000) embryonic hindgut   (Sanchez et al., 2000) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic midgut chamber   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 15   MP1 neuron   (Sanchez et al., 2000) aCC neuron   (Sanchez et al., 2000) embryonic stage 16 -- 17   cell | subset of embryonic/larval gut   (Sanchez et al., 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 15 -- first instar larval stage   organism   (Sanchez et al., 2000) Comment:weak expression pupal stage -- adult stage   organism   (Sanchez et al., 2000) Comment:strong expression
Additional Descriptive Data
	NLaz transcript is expressed in a subset of neurons and neuroblasts in the embryonic CNS from embryonic stages 12-16. At stages 14-15, NLaz transcript is observed in 12-15 cells/hemisegment; this expression is finely temporally regulated. Most NLaz-expressing cells are located ventral to the neuropil. NLaz-expressing neuroblasts are located at the ventral midline, and may be midline precursors. There is no expression in the PNS. Non-neuronally, NLaz transcript is expressed in a group of dorsal anterior visceral mesodermal cells at embryonic stages 10-11. These cells migrate to the amnioserosa at stages 12-13. NLaz is also expressed in groups of non-epithelial sessile cells on the surface of the gut epithelium at embryonic stage 16-17. (Sanchez et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   amnioserosa   (Sanchez et al., 2000) embryonic fat body   (Sanchez et al., 2000) ventral nerve cord   (Sanchez et al., 2000)
Additional Descriptive Data
	NLaz protein is secreted from developing axons. NLaz protein is localized to the amnioserosa and to fat body cells. Localization in the embryonic CNS is mainly restricted to the dorsal surface of the brain and ventral nerve cord. (Sanchez et al., 2000)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular space inferred from direct assay (Sanchez et al., 2000, Findlay et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult hindgut, adult Malpighian tubules, larval fat body, adult salivary gland, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval Malpighian tubules, adult heart, adult spermathecae, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body    1222.8 Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop    739 Adult Midgut    1230.4 Adult Hindgut    819.4 Adult Malpighian Tubules    1381 Adult Fat Body    49.1 Adult Salivary Gland    17761.2 Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland    511.1 Adult Carcass    522.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body  (1222.8) Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop  (739) Adult Midgut  (1230.4) Adult Hindgut  (819.4) Adult Malpighian Tubules  (1381) Adult Fat Body    49.1 Adult Salivary Gland  (17761.2) Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland  511.1 Adult Carcass  522.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body  (1222.8) Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop    739 Adult Midgut  (1230.4) Adult Hindgut    819.4 Adult Malpighian Tubules  (1381) Adult Fat Body    49.1 Adult Salivary Gland  (17761.2) Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland    511.1 Adult Carcass    522.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body    1222.8 Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop    739 Adult Midgut    1230.4 Adult Hindgut    819.4 Adult Malpighian Tubules    1381 Adult Fat Body    49.1 Adult Salivary Gland    17761.2 Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland    511.1 Adult Carcass    522.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body    1222.8 Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop    739 Adult Midgut    1230.4 Adult Hindgut    819.4 Adult Malpighian Tubules    1381 Adult Fat Body    49.1 Adult Salivary Gland    17761.2 Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland    511.1 Adult Carcass    522.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body  (1222.8) Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop  739 Adult Midgut  (1230.4) Adult Hindgut  (819.4) Adult Malpighian Tubules  (1381) Adult Fat Body    49.1 Adult Salivary Gland  (17761.2) Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland  511.1 Adult Carcass  522.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body  1222.8 Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop    739 Adult Midgut  1230.4 Adult Hindgut    819.4 Adult Malpighian Tubules  1381 Adult Fat Body    49.1 Adult Salivary Gland  (17761.2) Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland    511.1 Adult Carcass    522.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut    51 Larval Hindgut    20 Larval Malpighian Tubules    131.7 Larval Fat Body    1222.8 Larval Salivary Gland    10.5 Larval Trachea    82.875 Larval Carcass    21.775 Adult Head    431.6 Adult Eye    152.55 Adult Brain    211 Adult Thoracic-Abdominal Ganglion    349.9 Adult Crop    739 Adult Midgut    1230.4 Adult Hindgut    819.4 Adult Malpighian Tubules    1381 Adult Fat Body    49.1 Adult Salivary Gland    17761.2 Adult Heart    411.2 Adult VirginFemale Spermatheca    227.5 Adult InseminatedFemale Spermatheca    358 Adult Ovary    70.2 Adult Testis    225.5 Adult Male Accessory Gland    511.1 Adult Carcass    522.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    431.6   NA  Eye    152.55   NA  Brain    211   47.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    349.9   NA  Crop    739   51  Midgut    1230.4   no informative data  Hindgut    819.4   131.7  Malpighian Tubules    1381   1222.8  Fat Body    49.1   no informative data  Salivary Gland    17761.2   NA  Heart    411.2   82.875  Trachea    NA   NA  VirginFemale Spermatheca    227.5   NA  InseminatedFemale Spermatheca    358   NA  Ovary    70.2   NA  Testis    225.5   NA  Male Accessory Gland    511.1   no informative data  Carcass    522.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering    37 salivary gland, white prepupae    210 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    66 digestive system, 4-day adult    49 digestive system, 20-day adult    87 fat body, larvae L3 wandering    5 fat body, white prepupae    311 fat body, pupae P8    25 carcass, larvae L3 wandering    33 carcass, 1-day adult    34 carcass, 4-day adult    34 carcass, 20-day adult    49 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    185 accessory gland, mated 4-day male    124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3  26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering  (37) salivary gland, white prepupae  (210) digestive system, larvae L3 wandering    24 digestive system, 1-day adult  (66) digestive system, 4-day adult  (49) digestive system, 20-day adult  (87) fat body, larvae L3 wandering    5 fat body, white prepupae  (311) fat body, pupae P8    25 carcass, larvae L3 wandering  (33) carcass, 1-day adult  (34) carcass, 4-day adult  (34) carcass, 20-day adult  (49) ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (185) accessory gland, mated 4-day male  (124) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering    37 salivary gland, white prepupae  (210) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    66 digestive system, 4-day adult    49 digestive system, 20-day adult    87 fat body, larvae L3 wandering    5 fat body, white prepupae  (311) fat body, pupae P8    25 carcass, larvae L3 wandering    33 carcass, 1-day adult    34 carcass, 4-day adult    34 carcass, 20-day adult    49 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (185) accessory gland, mated 4-day male  (124) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering    37 salivary gland, white prepupae    210 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    66 digestive system, 4-day adult    49 digestive system, 20-day adult    87 fat body, larvae L3 wandering    5 fat body, white prepupae    311 fat body, pupae P8    25 carcass, larvae L3 wandering    33 carcass, 1-day adult    34 carcass, 4-day adult    34 carcass, 20-day adult    49 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    185 accessory gland, mated 4-day male    124 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering    37 salivary gland, white prepupae    210 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    66 digestive system, 4-day adult    49 digestive system, 20-day adult    87 fat body, larvae L3 wandering    5 fat body, white prepupae    311 fat body, pupae P8    25 carcass, larvae L3 wandering    33 carcass, 1-day adult    34 carcass, 4-day adult    34 carcass, 20-day adult    49 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    185 accessory gland, mated 4-day male    124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3  26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering  (37) salivary gland, white prepupae  (210) digestive system, larvae L3 wandering    24 digestive system, 1-day adult  (66) digestive system, 4-day adult  (49) digestive system, 20-day adult  (87) fat body, larvae L3 wandering    5 fat body, white prepupae  (311) fat body, pupae P8    25 carcass, larvae L3 wandering  (33) carcass, 1-day adult  (34) carcass, 4-day adult  (34) carcass, 20-day adult  (49) ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (185) accessory gland, mated 4-day male  (124) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering    37 salivary gland, white prepupae  (210) digestive system, larvae L3 wandering    24 digestive system, 1-day adult    66 digestive system, 4-day adult    49 digestive system, 20-day adult    87 fat body, larvae L3 wandering    5 fat body, white prepupae  (311) fat body, pupae P8    25 carcass, larvae L3 wandering    33 carcass, 1-day adult    34 carcass, 4-day adult    34 carcass, 20-day adult    49 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (185) accessory gland, mated 4-day male  124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    26 central nervous system, pupae P8    14 head, virgin 1-day female    18 head, virgin 4-day female    11 head, virgin 20-day female    22 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    25 salivary gland, larvae L3 wandering    37 salivary gland, white prepupae    210 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    66 digestive system, 4-day adult    49 digestive system, 20-day adult    87 fat body, larvae L3 wandering    5 fat body, white prepupae    311 fat body, pupae P8    25 carcass, larvae L3 wandering    33 carcass, 1-day adult    34 carcass, 4-day adult    34 carcass, 20-day adult    49 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    185 accessory gland, mated 4-day male    124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    149 white prepupae new    269 white prepupae 12hr    284 white prepupae 24hr    92 pupae 2d postWPP    91 pupae 3d postWPP    51 pupae 4d postWPP    116 adult male 01day    131 adult male 05day    89 adult male 30day    93 adult female 01day    147 adult female 05day    61 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (149) white prepupae new  (269) white prepupae 12hr  (284) white prepupae 24hr  (92) pupae 2d postWPP  (91) pupae 3d postWPP  (51) pupae 4d postWPP  (116) adult male 01day  (131) adult male 05day  (89) adult male 30day  (93) adult female 01day  (147) adult female 05day  (61) adult female 30day  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (149) white prepupae new  (269) white prepupae 12hr  (284) white prepupae 24hr    92 pupae 2d postWPP    91 pupae 3d postWPP    51 pupae 4d postWPP  (116) adult male 01day  (131) adult male 05day    89 adult male 30day    93 adult female 01day  (147) adult female 05day    61 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    149 white prepupae new    269 white prepupae 12hr    284 white prepupae 24hr    92 pupae 2d postWPP    91 pupae 3d postWPP    51 pupae 4d postWPP    116 adult male 01day    131 adult male 05day    89 adult male 30day    93 adult female 01day    147 adult female 05day    61 adult female 30day    70 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    149 white prepupae new    269 white prepupae 12hr    284 white prepupae 24hr    92 pupae 2d postWPP    91 pupae 3d postWPP    51 pupae 4d postWPP    116 adult male 01day    131 adult male 05day    89 adult male 30day    93 adult female 01day    147 adult female 05day    61 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (149) white prepupae new  (269) white prepupae 12hr  (284) white prepupae 24hr  (92) pupae 2d postWPP  (91) pupae 3d postWPP  (51) pupae 4d postWPP  (116) adult male 01day  (131) adult male 05day  (89) adult male 30day  (93) adult female 01day  (147) adult female 05day  (61) adult female 30day  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (149) white prepupae new  (269) white prepupae 12hr  (284) white prepupae 24hr    92 pupae 2d postWPP    91 pupae 3d postWPP    51 pupae 4d postWPP  116 adult male 01day  131 adult male 05day    89 adult male 30day    93 adult female 01day  (147) adult female 05day    61 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    15 embryo 12-14hr    14 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    11 larva L1    4 larva L2    6 larva L3 12hr old    12 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    149 white prepupae new    269 white prepupae 12hr    284 white prepupae 24hr    92 pupae 2d postWPP    91 pupae 3d postWPP    51 pupae 4d postWPP    116 adult male 01day    131 adult male 05day    89 adult male 30day    93 adult female 01day    147 adult female 05day    61 adult female 30day    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    39 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21  (39) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    39 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    39 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    39 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21  (39) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    39 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    39 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    11 ovary OSC    11 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (28) cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3  (37) Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult  (29) Ethanol 2.5% 3 hrs, larvae L3  (42) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (27) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3  (37) Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult  29 Ethanol 2.5% 3 hrs, larvae L3  (42) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    20 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    42 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE67583 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053126 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33126-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for NLaz Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 NLazGD12709 Other Phenotypes Allele chemical sensitive NLazNW5 courtship behavior defective NLazNW5 long lived, with Scer\GAL4da.G32 NLazScer\UAS.cHTa short lived NLazNW5 starvation stress response defective NLazNW5 stress response defective NLazNW5 stress response defective, with Scer\GAL4ppl.PP NLazScer\UAS.cHTa Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of NLaz Class Mutagen Stocks Known lesion NLazf03602 piggyBac transposase 2 -- NLazNW5 recombination SCEI endonuclease gene targeting by homologous recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of NLaz Class Mutagen Stocks Known lesion NLazGD12709 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes NLazKK107553 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NLaz5.1.Scer\SceI.RS in vitro construct 0 Yes NLazNIG.16933R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes NLazScer\UAS.cHTa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12709} NA P{KK107553} NA P{NIG.16933R} NA P{UAS-NLaz.HT} NA characterization construct P{FRT(whs.NLaz5.1.Scer\SceI.RS)} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}NLazf03602 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
carbohydrate homeostasis inferred from mutant phenotype (Hull-Thompson et al., 2009) determination of adult lifespan inferred from mutant phenotype (Hull-Thompson et al., 2009) multicellular organism reproduction inferred from expression pattern (Findlay et al., 2008) response to oxidative stress inferred from mutant phenotype (Hull-Thompson et al., 2009) triglyceride homeostasis inferred from mutant phenotype (Hull-Thompson et al., 2009)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Sanchez et al., 2000, Findlay et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
lipid binding inferred from sequence or structural similarity with UniProtKB:P37153 (FlyBase Genome Annotators, 2002-2003) pigment binding inferred from electronic annotation with InterPro:IPR003057 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions NLaz allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59572 DroID - A comprehensive database of gene and protein interactions. • FBgn0053126 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33324
Orthologs
OrthoDB Orthologs (58) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GTM0H Dipteran inclusive ortholog search EOG6Q58ZR Insect inclusive ortholog search EOG6W6MSB Arthropod inclusive ortholog search EOG698SH3 Metazoa inclusive ortholog search EOG69WF9F
Orthologs in Drosophila Species (EOG6GTM0H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\NLaz     Drosophila simulans   Dsim\GD22910 Y   Drosophila sechellia   Dsec\GM16611 Y   Drosophila erecta   Dere\GG24593 Y   Drosophila yakuba   Dyak\GE15611 Y   Drosophila ananassae   Dana\GF14723 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25349 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22440     Drosophila persimilis   Dper\GL14838 Y   Drosophila willistoni   Dwil\GK14948 Y   Drosophila virilis   Dvir\GJ10789 Y   Drosophila mojavensis   Dmoj\GI17089 Y   Drosophila grimshawi   Dgri\GH10331 Y
Orthologs in non-Drosophila Dipterans (EOG6Q58ZR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP009281   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009122   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013296
Orthologs in non-Dipteran Insects (EOG6W6MSB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC100578744   Apis mellifera Western honey bee  Amel\LOC551389   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007582   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007583   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16757   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16758   Atta cephalotes Leafcutter ant  Acep\ACEP12005   Atta cephalotes Leafcutter ant  Acep\ACEP12003   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18792   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16227   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16228   Linepithema humile Argentine ant  Lhum\LH23210   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21154   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21155   Solenopsis invicta Red fire ant  Sinv\SINV11362   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008952   Bombyx mori Silkmoth  Bmor\BGIBMGA002704   Bombyx mori Silkmoth  Bmor\Bmo.5902   Pediculus humanus Human body louse  Phum\PHUM427700   Tribolium castaneum Red flour beetle  Tcas\TC010813
Orthologs in non-Insect Arthropods (EOG698SH3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ndufb6   Daphnia pulex Water flea  Dpux\xylT   Daphnia pulex Water flea  Dpux\JGI_V11_299805   Daphnia pulex Water flea  Dpux\JGI_V11_306367   Daphnia pulex Water flea  Dpux\JGI_V11_311514   Daphnia pulex Water flea  Dpux\cytb   Daphnia pulex Water flea  Dpux\RAG2   Daphnia pulex Water flea  Dpux\JGI_V11_306369   Daphnia pulex Water flea  Dpux\JGI_V11_299882   Daphnia pulex Water flea  Dpux\JGI_V11_234666   Daphnia pulex Water flea  Dpux\Psmg1   Ixodes scapularis Deer tick  Isca\ISCW008304   Ixodes scapularis Deer tick  Isca\ISCW002611
Orthologs in non-Arthropod Metazoa (EOG69WF9F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004885gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000953gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008104gn Y Danio rerio Zebrafish  Drer\OTTDARG00000025141 Y Danio rerio Zebrafish  Drer\ENSDARG00000060345 Y Danio rerio Zebrafish  Drer\zgc:123339 Y Gallus gallus Domestic chicken  Ggal\ApoD Y Mus musculus House mouse  Mmus\Apod Y Homo sapiens Human  Hsap\APOD Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\APOD
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22910 Drosophila sechellia Dsec\GM16611 Drosophila erecta Dere\GG24593 Drosophila yakuba Dyak\GE15611 Drosophila ananassae Dana\GF14723 Drosophila pseudoobscura pseudoobscura Dpse\GA25349 Drosophila persimilis Dper\GL14838 Drosophila willistoni Dwil\GK14948 Drosophila virilis Dvir\GJ10789 Drosophila mojavensis Dmoj\GI17089 Drosophila grimshawi Dgri\GH10331
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	18673 w1118; PBac{WH}NLazf03602/CyO
Harvard	- PBac{WH}NLazf03602
VDRC	v101321 P{KK107553}VIE-260B v35558 w1118; P{GD12709}v35558 v35559 w1118; P{GD12709}v35559
Genomic Clones ( 1 )
	BACR16D07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 226 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE67583
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09888 LP01657 RH67893
Other clones	bs28b02 Dmel_dig_000548_0643_0330 Dmel_dig_003729_0604_2484 Dmel_dig_009189_0612_2122 Dmel_dig_016674_0658_1046 Dmel_neb_012657_0595_1588 EC14852 EC38535 EK063738 EK095726 EP15061 ESG014c.E21_B04 ESG019c.E21_B07 RP003000736 RP003001869 RP003014489 RP003018599 RP003024643 RP003025643 RP003035766 RP003042738 RP003045961 RP003046736 RP003047584 RP003049635 RP003052987 RP003054019 RP003057209 RP003057537 RP003060061 RP003062697 RP003064414 RP003070059 RP003071503 RP003073406 RP003073953 RP003079894 RP003083878 RP003086607 RP003090730 RP003097941 RP003100065 RP003101004 RP003101429 RP003103560 RP003106069 RP003107223 RP003108293 RP003116025 RP003117240 RP003124565 RP003126439 RP003128860 RP003130065 RP003131822 RP003137875 RP003140012 RP003140837 RP003158280 RP003158776 RP003161477 RP003162135 RP003167414 RP003168246 RP003168318 RP003171561 RP003172729 RP003173733 RP003174132 RP003176612 RP003177206 RP003177923 RP003179210 RP003179760 RP003181376 RP003185653 RP003187765 RP003192716 RP003197753 RP003197791 RP003201402 RP003204244 RP003209212 RP003212522 RP003213056 RP003218168 RP003225844 RP003226919 RP003231200 RP003232608 RP003245403 RP003245440 RP003251105 RP003251769 RP003252441 RP003253881 RP003258680 RP003261680 RP003263725 RP003265982 RP003266494 RP003276485 RP003280670 RP003283251 RP003284398 RP003284422 RP003284953 RP003288663 RP003291623 RP003294250 RP003295770 RP003296035 RP003298687 RP003299691 RP003301413 RP003303606 RP003304108 RP003309339 RP003310539 RP003311981 RP003325171 RP003325395 RP003325970 RP003338229 RP003338380 RP003341939 RP003346112 RP003349821 RP003355096 RP003355103 RP003361482 RP003369265 RP003369515 RP003375461 RP003379873 RP003389503 RP003390348 RP003391365 RP003392922 RP003396075 RP003396088 RP003397494 RP003398484 RP003400342 RP003413148 RP003414541 RP003426881 RP003427862 RP003428008 RP003429891 RP003430333 RP003435350 RP003435399 RP003435482 RP003437245 RP003445540 RP003447896 RP003448020 RP003452139 RP003454520 RP003460663 RP003462984 RP003466959 RP003475891 RP003480840 RP003490121 RP003491085 RP003493471 RP003494260 RP003494534 RP003496869 RP003503027 RP003508130 RP003509685 RP003510252 RP003514162 RP003514719 RP003524952 RP003524988 RP003526545 RP003529722 RP003531942 RP003532100 RP003535622 RP003538018 RP003545933 RP003547356 RP003548603 RP003549098 RP003550125 RP003553344 RP003557248 RP003560627 RP003561066 RP003563301 RP003566852 RP003566995 RP003573803 RP003588795 RP003595420 RP003598483 RP003608350 RP003612091 RP003613195 RP003617700 RP003623694 RP003625887 RP003626387 RP003627716 RP003629690 RP003635431 RP003635723 RP003644916 RP003645459 RP003650954 RP003651218 RP003651669 RP003654536 RP003659588 RP003665982 RP003669060 RP003670255
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0053126 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33324
Antibody Information
	polyclonal (Sanchez et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: NLaz CG16933 (FlyBase, 1996-)
Source for database merge of	Source for merge of: NLaz BcDNA:RE67583 (FlyBase, 1996-)
Additional comments	Source for identity of NLaz CG16933 was sequence comparison (date:000721). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-) Source for merge of NLaz BcDNA:RE67583 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_175946 NM_001272938 RefSeq (Proteins) • NP_787960 NP_001259867 DDBJ / EMBL / GenBank • AAF51378 AAF85707 AAL89923 AF276505 AGB92404 AY084185 BI484476 Entrez Gene - A searchable database of RefSeq genes. • 33324 UniProtKB/TrEMBL • Q8SXR1 Q9NAZ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Lipocalin/cytosolic fatty-acid binding protein domain (IPR000566) Calycin-like (IPR011038) Calycin (IPR012674) Lipocalin, ApoD type (IPR022271) Invertebrate colouration protein (IPR003057) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE67583
Linkouts
	BioGRID - A database of protein and genetic interactions • 59572 DroID - A comprehensive database of gene and protein interactions. • FBgn0053126 DRSC - Results from RNAi screens. • FBgn0053126 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053126 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33126-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053126 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33324 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33324 modMine - Data generated by the modENCODE project. • FBgn0053126
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BcDNA:RE67583   CG16933 (Spellman and Rubin, 2002) CG33126 (Keleman et al., 2009.8.5) CT33980 (Ceriani et al., 2002) DNLaz (Sanchez et al., 2000) NLaz (Spellman and Rubin, 2002, Pezzulo et al., 2012, Ruiz et al., 2012, Jungreis et al., 2011, Hull-Thompson et al., 2009, Maynard et al., 2010, Morozova et al., 2006, Japanese National Institute of Genetics, 2012.5.21) Nlaz (Rynes et al., 2012, Allen and Spradling, 2008)
Name Synonym	neural Lazarillo (Sanchez et al., 2000, Maynard et al., 2010) Neural Lazarillo (Hull-Thompson et al., 2009)
Secondary FlyBase IDs
	FBgn0031336 FBgn0063669
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Pasco and Léopold, 2012, PLoS ONE 7(5): e36583 High sugar-induced insulin resistance in Drosophila relies on the lipocalin neural lazarillo. [FBrf0218235] Pezzulo et al., 2012, PLoS ONE 7(8): e43777 Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster. [FBrf0219363] Ruiz et al., 2012, Insect Biochem. Mol. Biol. 42(10): 776--789 Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. [FBrf0219400] Rynes et al., 2012, Mol. Cell. Biol. 32(19): 3949--3962 Activating transcription factor 3 regulates immune and metabolic homeostasis. [FBrf0219385] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Ruiz et al., 2011, Exp. Gerontol. 46(7): 579--589 Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. [FBrf0213781] Show all research papers ...